Co-ordinator: Dr Joanes Grandjean

Research Overview

About 100 billion neurons in the human brain are tightly organized into functional networks responsible for the integration and processing of complex information. Yet, our understanding of the brain is hindered by its complexity and limited access to the tissue. In particular, neuronal networks are strongly interconnected and their functions can only be fully understood through their integrated activity across the whole intact brain.


3D-rendered map representing the evoked BOLD fMRI response to ontogenetically-mediated stimulation of parahippocampal neurons. In collaboration with LBOI.

To understand the nature of circuit alterations underpinning mental health disorders, we develop and implement non-invasive neuroimaging methods, in particular Magnetic Resonance Imaging (MRI), to investigate the brain with a variety of contrasts. Using dedicated small animal imaging platforms at SBIC, we are at the crossroad between clinical neuroscience observations stemming from neuroimaging studies with modern cellular/molecular biology tools available in rodents. We are implementing these methods to identify the mechanisms for large-scale neuronal network re-organisations in affective and neurodegenerative diseases and in circuits regulating energy homeostasis.



Voxel-based morphometry is used to phenotype animal models of metabolic disorders and map volume changes across the whole brain. In collaboration with NMNC group.


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