Introduction

Chen Li is currently a research scientist, under the Systems Biology Research Group. She obtained her PhD from the department of chemical & biomolecular engineering in the National University of Singapore. Her PhD project was the chemometric studies of chemical processes. She is familiar with computational analysis in analytical chemistry and different kinds of applied spectroscopy i.e HPLC, FTIR, UV-CD, Raman and MS etc.

After her PhD, Chen Li joined the Bioinformatics Institute and worked there for seven years. Her research focused on data analysis in genomics, proteomics and metabolomics. She did a lot of methodology development for these three areas. Her projects included gene expression analysis, biomarker discovery, protein identification and peptide sequencing using mass spectrometry, metabolic fingerprinting and metabolite pathway study.

Research Overview

Her research interests at SICS are clinical data analysis, gene expression analysis, DNA methylation analysis, metabolomics, SNP and copy number variation analysis, and NGS data analysis.

Projects

Bioinformatics and epigenetic study of biological data on GUSTO birth cohort.
Metabolomic analysis on pre-eclampsia collaboration project.
Epigenetic study on MAVAN (Maternal Adversity Vulnerability and Neurodevelopment) and NFP (Nurse Family Partnership) collaboration projects.
Independent research focusing on data mining and analysis within translational clinical datasets.

SICS offers a great opportunity for me to work closely with biologists and clinicians, and I would like to make my contribution for formulating biological hypotheses from complex datasets.

Selected Publications

Stünkel W, Pan H, Chew SB, Tng E, Tan JH, Chen L, Joseph R, Cheong CY, Ong ML, Lee YS, Chong YS, Saw SM, Meaney MJ, Kwek K, Sheppard AM, Gluckman PD, Holbrook JD. "Transcriptome changes affecting hedgehog and cytokine signalling in the umbilical cord: implications for disease risk". Plos one. 07 Oct 2012. 7(7):e39744 .doi:10.1371/journal.pone.0039744.
Teh AL, Pan H, Chen L, Ong ML, Dogra S, Wong J, Macisaac JL, Mah SM, McEwen LM, Saw SM, Godfrey KM, Chong YS, Kwek K, Kwoh CK, Soh SE, Chong MF, Barton S, Karnani N, Cheong CY, Buschdorf JP, Stunkel W, Kobor MS, Meaney MJ, Gluckman PD, Holbrook JD. "The effect of genotype and in utero environment on inter-individual variation in neonate DNA methylomes". Genome Res. 07 Apr 2014. 24(7):1064-74. doi: 10.1101/gr.171439.113.
Cheong CY, Chng K, Lim MK, Amrithraj AI, Joseph R, Sukarieh R, Tan YC, Chan L, Tan JH, Chen L, Pan H, Holbrook JD, Meaney MJ, Chong YS, Gluckman PD, Stünkel W. "Alterations to DNA methylation and expression of CXCL14 are associated with suboptimal birth outcomes". J Hum Genet. 07 Aug 2014. 59(9):504-11. doi:10.1038/jhg.2014.63.
Sukarieh R, Joseph R, Leow SC, Ying L, Löffler M, Aris IM, Tan JH, The AL, Chen L, Holbrook JD, Ng KL, Lee YS, Chong YS, Summers SA, Gluckman PD, Stünkel W. "Molecular pathways reflecting poor intrauterine growth are found in Wharton’s jelly derived Mesenchymal Stem Cells". Hum Reprod. 16 Aug 2014. 29(9):1-15. doi:10.1093/humrep/deu209.
Pan H, Lin X, Wu Y, Chen L, Teh AL, Soh SE, Lee YS, Tint MT, MacIsaac JL, Morin AM, Tan KH, Yap F, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Gluckman PD, Karnani N, Holbrook JD. "HIF3A association with adiposity: the story begins before birth". Epigenomics. 25 May 2015. 7(6):937-50. doi:10.2217/epi.15.45.
Chen L, Pan H, Tuan TA, Teh AL, MacIsaac JL, Mah SM, McEwen LM, Li Y, Chen H, Broekman BF, Buschdorf JP, Chong YS, Kwek K, Saw SM, Gluckman PD, Fortier MV, Rifkin-Graboi A, Kobor MS, Qiu A, Meaney MJ, Holbrook JD. "Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes". Dev Psychopathol. 01 Feb 2015. 27(1):137-50. doi:10.1017/S0954579414001357.
Sukarieh R, Joseph R, Leow SC, Li Y, Löffler M, Aris IM, Tan JH, Teh AL, Chen L, Holbrook JD, Ng KL, Lee YS, Chong YS, Summers SA, Gluckman PD, Stünkel W. "Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells". Hum Reprod. 16 Aug 2014. 29(10):2287-301. doi:10.1093/humrep/deu209.

Introduction

Research Overview

Projects

Selected Publications

Singapore Institute for Clinical Sciences