Melvin Khee Shing LEOW
Clinical PI, Singapore Institute for Clinical Sciences
Deputy Director, Clinical Nutrition Research Centre (Core Labs/Platforms)
Member, Nutritional Sciences and Human Physiology (Research Groups)
Melvin Leow is a senior consultant endocrinologist who is an elected fellow of the American College of Endocrinology, the American College of Physicians, the Royal College of Physicians of Edinburgh and the Academy of Medicine (Singapore). He is a clinical faculty member of the Yong Loo Lin School of Medicine at NUS where he is clinical associate professor and is also an adjunct associate professor at Duke-NUS Graduate Medical School. A/Prof. Leow is a member of the Department of Endocrinology at Tan Tock Seng Hospital since 1999. His field of interests includes thyroidology, metabolic syndrome/diabetes, adipocyte biology, endocrine manifestations of systemic disorders and mathematical modeling of endocrine physiology , in which he has published works in both local and international refereed journals. His present focus is on brown adipose tissue, thermogenesis and the browning of white adipocytes with nutraceuticals, pharmaceuticals and endogenous peptides and hormones. He is the deputy director of the Clinical Nutrition Research Centre that houses a twin-chamber whole body calorimeter uniquely suited to the study of energy metabolism of brown fat in humans and now engaged in a research project that utilises infrared imaging to evaluate brown fat activity. His achievements in recent years include the NHG Doctor Award, Researcher-Investigator-Scientist Enabler (RISE) Award, Investigator-Clinician Award, Best Teacher Award and the Dean’s Award for Teaching Excellence.
The Nutritional Sciences and Human Physiology research group of SICS is devoted to translational and clinical research that helps in elucidating the answers to clinically relevant questions of fundamental and applied human nutrition as well as the pathophysiological basis of metabolic disorders in humans, such as obesity and type 2 diabetes mellitus. The major focus of our group is to understand the control over energy balance, neuroendocrine function and metabolism that is exerted through the critical centers of the brain and feedback loops involving the intricate network of the gastrointestinal tract, pancreas, adipose tissue, liver and skeletal muscles. Given the diverse scientific and clinical expertise available within SICS, we collaborate extensively within the SICS framework with basic scientists as well as with clinical colleagues from the local teaching hospitals to achieve our objectives. The different research groups work closely together and use a variety of approaches to address this central theme, including studies of appropriate cell lines, animal models, molecular techniques investigating epigenetic regulation and human clinical studies. In this regard, we undertake clinical nutrition and physiological studies which have the collective goal of understanding better the contributory factors to the emergent pattern of metabolic disease in the different ethnic populations in Singapore.
Ang QY, Goh HJ, Cao Y, Li Y, Chan SP, Swain JL, Henry CJ, Leow MK. ''A new method of infrared thermography for quantification of brown adipose tissue activation in healthy adults (TACTICAL): a randomized trial''. J Physiol Sci. 21 Jul 2016. doi: 10.1007/s12576-016-0472-1.
Leow MK. ''A Review of the Phenomenon of Hysteresis in the Hypothalamus-Pituitary-Thyroid Axis''. Front Endocrinol (Lausanne). 14 Jun 2016. 7:64. doi: 10.3389/fendo.2016.00064.
Soong YY, Lim WX, Leow MK, Siow PC, Teh AL, Henry CJ. ''Combination of soya protein and polydextrose reduces energy intake and glycaemic response via modulation of gastric emptying rate, ghrelin and glucagon-like peptide-1 in Chinese''. Br J Nutr. 01 Jun 2016. 115(12):2130-7. doi: 10.1017/S0007114516001689.
Dalan R, Liew H, Goh LL, Gao X, Chew DE, Boehm BO, Leow MK. ''The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness''. Diab Vasc Dis Res. 16 May 2016. 13(5):373-6. doi: 10.1177/1479164116645247.
Ong C, Lee JH, Leow MK, Puthucheary ZA. ''Functional Outcomes and Physical Impairments in Pediatric Critical Care Survivors: A Scoping Review''. Pediatr Crit Care Med. 01 May 2016. 17(5):e247-59. doi: 10.1097/PCC.0000000000000706.
Mok A, Haldar S, Lee JC, Leow MK, Henry CJ. ''Postprandial changes in cardiometabolic disease risk in young Chinese men following isocaloric high or low protein diets, stratified by either high or low meal frequency - a randomized controlled crossover trial''. Nutr J. 15 Mar 2016. 15(1):27. doi: 10.1186/s12937-016-0141-5.
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