Yung Seng LEE
Principal Investigator - Nutritional Sciences & Human Physiology
Yung Seng is a paediatric endocrinologist practicing at the University Children’s Medical Institute, National University Hospital, and also an academic staff of the Yong Long Lin School School of Medicine, National University of Singapore. His clinical and research interest lies within the intersect of paediatrics and endocrinology, especially obesity, diabetes, and growth. Intrigued by the severely obese young children in his clinics, Yung Seng started his research foray into the realms of human monogenic obesity and childhood obesity, which also led to a clinical and research stint in Cambridge, UK. Yung Seng joined SICS in 2009 as clinical investigator (joint appointment).
His current research interests are appetite regulation, obesity, metabolic disorders, and growth. He is a co-investigator of the Singapore Adult Metabolic Study (SAMS) and also the birth cohort study (GUSTO) of the Translational Clinical Research programme on developmental pathways to metabolic diseases, and his current research activities revolve around these projects.
GUSTO is Singapore’s largest and most comprehensive birth cohort study which provided unique opportunities to study developmental plasticity and the role of epigenetics. A/P Lee research focus is on the impact of maternal and prenatal factors on the subsequent growth of the offspring, and developmental origins of taste and food preference, and appetite regulation.
Fogel A, Goh AT, Fries LR, Sadananthan SA, Sendhil Velan S, Michael N, Tint MT, Fortier MV, Chan MJ, Toh JY, Chong YS, Tan KH, Yap F, Shek LP, Meaney MJ, Broekman BF, Lee YS, Godfrey KM, Chong MF, Forde CG. ''A description of an 'obesogenic' eating style that promotes higher energy intake and is associated with greater adiposity in 4.5year-old children: Results from the GUSTO cohort''. Physiol Behav. 14 Feb 2017. doi: 10.1016/j.physbeh.2017.02.013.
Aris IM, Bernard JY, Chen LW, Tint MT, Lim WY, Soh SE, Saw SM, Shek LC, Godfrey KM, Gluckman PD, Chong YS, Yap F, Kramer MS, Lee YS. ''Postnatal height and adiposity gain, childhood blood pressure and prehypertension risk in an Asian birth cohort''. Int J Obes (Lond). 10 Feb 2017. 2016.
Chen LW, Aris IM, Bernard JY, Tint MT, Chia A, Colega M, Gluckman PD, Shek LP, Saw SM, Chong YS, Yap F, Godfrey KM, van Dam RM, Chong MF, Lee YS. ''Associations of Maternal Dietary Patterns during Pregnancy with Offspring Adiposity from Birth Until 54 Months of Age''. Nutrients. 22 Dec 2016. 9(1):E2. doi: 10.3390/nu9010002.
Ooi DS, Ong SG, Heng CK, Loke KY, Lee YS. ''In-vitro function of upstream visfatin polymorphisms that are associated with adverse cardiometabolic parameters in obese children''. BMC Genomics. 25 Nov 2016. 17(1):974. doi: 10.1186/s12864-016-3315-9.
Chia AR, de Seymour JV, Colega M, Chen LW, Chan YH, Aris IM, Tint MT, Quah PL, Godfrey KM, Yap F, Saw SM, Baker PN, Chong YS, van Dam RM, Lee YS, Chong MF. ''A vegetable, fruit, and white rice dietary pattern during pregnancy is associated with a lower risk of preterm birth and larger birth size in a multiethnic Asian cohort: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study''. Am J Clin Nutr. 12 Oct 2016. 104(5):1416-1423. doi: 10.3945/ajcn.116.133892.
van Lee L, Tint MT, Aris IM, Quah PL, Fortier MV, Lee YS, Yap FK, Saw SM, Godfrey KM, Gluckman PD, Chong YS, Kramer MS, Chong MF. ''Prospective associations of maternal betaine status with offspring weight and body composition at birth: the GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort study''. Am J Clin Nutr. 21 Sep 2016. 104(5):1327-1333. doi: 10.3945/ajcn.116.138818.
Aris IM, Bernard JY, Chen LW, Tint MT, Pang YW, Lim WY, Soh SE, Saw SM, Godfrey KM, Gluckman PD, Chong YS, Yap F, Kramer MS, Lee YS. ''Infant body mass index peak and early childhood cardio-metabolic risk markers in a multi-ethnic Asian birth cohort''. Int J Epidemiol. 20 Sep 2016. doi: 10.1093/ije/dyw232.
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