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Asian Metabolic Phenotyping Singapore

In 2008, the Asian Metabolic Phenotyping Singapore (AMPS) platform was developed in tandem with the GUSTO and SAMS cohort studies, providing a standardized framework for the intense clinical phenotyping required of some study participants. Headed by clinician-scientists with endocrinology specialties and closely linked to the National University Health System (NUHS), Clinical Imaging Research Center (CIRC), as well as Singapore Health Services (SingHealth), the AMPS platform is poised to provide detailed anthropometric data, imaging and biopsy specimens for extensive metabolic studies.

Milestones
We have recruited a sizeable cohort of over 200 Asian men (Chinese, Malay & Indian ethnicities, SAMS1 study) for detailed anthropometric and insulin-sensitivity measures. Once completed, our current molecular analysis of blood samples and muscle biopsies from this cohort will allows us to identify the key epigenetic differences of our different ethnic groups on metabolic disease profiles.

Key Collaborations
The AMPS platform will work closely with the new Clinical Nutrition Research Center (CNRC), a partnership between SICS and the National University Health System (NUHS). Through this collaborative effort, we can conduct comprehensive monitoring and analyses of the nutritional impact of novel food products via in-house clinical studies. The AMPS platform brings together experts in metabolic health, diagnostics, systems and molecular biology to address fundamental problems in metabolic disease today.

Capabilities
AMPS research capabilities include:

  • Hyperinsulinemic euglycemic clamp for insulin sensitivity
  • MRI for visceral and subcutaneous fat volumes
  • MRS for muscle and liver metabolites
  • Indirect calorimetry for resting metabolic rate and diet induce thermogenesis
  • VO2 max
  • Doubly-labeled water for total energy expenditure
  • Percutaneous muscle biopsy/myocytes culture for in vitro studies
  • Subcutaneous and visceral fat harvesting and in vitro culture
  • Body composition assessment by bioelectrical impedance and plethysmography
  • Whole-body MRI in newborn/infants
  • Nutritional assessment

Lead

Deputy Lead