Singapore study reveals impact of early life adversity on a child’s brain development


Singapore study reveals impact of early life adversity on a child’s brain development

Leveraging neuroimaging data from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort, researchers from A*STAR’s Singapore Institute for Clinical Sciences (SICS) identified an association between early life adversity and the pace of brain development in childhood.

Brain development

SINGAPORE – A study led by researchers from A*STAR’s Singapore Institute for Clinical Sciences (SICS) has found evidence suggesting that children exposed to elevated levels of early life adversity (ELA) exhibit an accelerated pattern of brain development during the preschool years. When exposed to ELA, such as a mother's mental and physical health challenges during pregnancy, the child’s brain undergoes accelerated development in order to adapt to the adverse circumstances. This hastened pace of brain development could lead to a higher risk of adverse cognitive and mental health outcomes. The paper, “The influence of early-life adversity on the coupling of structural and functional brain connectivity across childhood” was published in Nature Mental Health on 4 January 2024. 

Exposure to ELA is a recognised risk factor for poor health outcomes throughout life. This includes an increased risk of cognitive impairment as well as the development of mental health disorders such as major depressive disorders. Exposure to ELA in the prenatal period triggers changes in the pace of brain development across childhood, most prominent during the preschool period – a crucial time window whereby experience-dependent learning and adaptation set the stage for future brain function. Previous studies suggest that ‘accelerated brain development’ is an adaptive mechanism to early life challenges and may mediate the association between ELA and poor mental health and cognitive outcomes.

To effectively quantify the impact of ELA, the research team adopted a scoring framework created by Professor Patricia Silveira at McGill University, to produce a composite score of ELA which considered factors that extend across a population. These factors focused on exposures experienced before birth, encompassing the mother's mental and physical health during pregnancy as well as the family’s structure and financial circumstances. When we add up or combine different risk factors, it gives us a better prediction of child’s outcome. Using this composite score, the study team stratified the GUSTO cohort into different levels of cumulative ELA exposure. The pace of brain development was then examined across children exposed to different levels of ELA.

To model the pace of brain development across childhood, the study team utilised multi-modal MRI scans from the GUSTO birth cohort. These MRI brain scans were acquired from 549 children at three time-points, ages 4.5, 6.0 and 7.5 years, allowing the study team to examine the link between ELA and brain development in a longitudinal manner. As most mental health disorders have roots in childhood, the study of developmental trajectories in a longitudinal manner is strongly relevant. In this study, a measure which combines structural connectivity and functional connectivity of the brain was used to provide insights into the association between brain structure and function. This measure, known as structure-function coupling (SC-FC), reflects a child’s potential for neuroplasticity, the brain's ability to adapt and reorganise itself to learn, recover from injury, and adjust to new experiences. In early childhood, the brain is expected to be less specialised and more adaptable, matching a decreasing trajectory of SC-FC over childhood.

Led by Dr Tan Ai Peng, Principal Investigator with A*STAR’s SICS and clinician with National University Hospital, along with Dr Chan Shi Yu, a researcher at A*STAR’s SICS, the study found that exposure to high levels of ELA is linked to a faster decline in SC-FC between ages 4.5 and 6, indicating accelerated brain development. This accelerated pattern of brain development is likely an adaptive mechanism when exposed to environmental cues that requires ‘maturity’. Although this is meant to be a ‘protective mechanism’ against adversity, it does have negative implications in the long term as it results in a shorter window of neuroplasticity and adaptive-learning. Notably, results from this study pinpoint the period between ages 4.5 and 6 years as a potential window for early intervention to improve outcomes for children who were exposed to ELA.

“Our study provided evidence that exposure to early-life challenges affects the pace of brain development across childhood. This, in turn, has significant effects on future cognitive and mental health outcomes. If we can develop screening tools to detect accelerated brain development, we will be able to implement interventions earlier, and prevent cascading consequences of accelerated brain development for mental health.” said, Dr Tan Ai Peng.

Already looking forward, the researchers have identified important areas for future investigation – determining whether ELA’s effects on accelerated brain development across childhood set the stage for premature brain ageing in later stages of life, and the effectiveness of intervention strategies that could mitigate the effects of ELA exposure such as the promotion of psychological resilience through cognitive behavioural therapy.

About A*STAR’s Singapore Institute for Clinical Sciences (SICS)
Founded in 2007, the Singapore Institute for Clinical Sciences’ (SICS) mission is to promote health and human capacity in Singapore, Asia and globally. The first institute within the Agency for Science, Technology and Research (A*STAR) to focus on clinical sciences and translational research, SICS posits that health has its origins in good beginnings and continued interactions between our physiological makeup and environment. To fulfil our vision of building gateways and an evidence base for positive health, our institute strongly promotes clinical research that supports the understanding of metabolism, neuroscience and how they impact human development. To take our research into the real world, we launched seminal nationwide birth cohort studies such as Growing Up in Singapore Towards healthy Outcomes (GUSTO) and Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO). By paving the way for scientific research to make a difference to the social and economic fabric of our communities, we are committed to ‘Changing Tomorrow’s Health, Today’. For more information, visit

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About the Agency for Science, Technology and Research (A*STAR)
The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector R&D agency. Through open innovation, we collaborate with our partners in both the public and private sectors to benefit the economy and society. As a Science and Technology Organisation, A*STAR bridges the gap between academia and industry. Our research creates economic growth and jobs for Singapore, and enhances lives by improving societal outcomes in healthcare, urban living, and sustainability. A*STAR plays a key role in nurturing scientific talent and leaders for the wider research community and industry. A*STAR’s R&D activities span biomedical sciences to physical sciences and engineering, with research entities primarily located in Biopolis and Fusionopolis. For ongoing news, visit

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