Lee Yung Seng is a paediatric endocrinologist practicing at Khoo Teck Puat-National University Children's Medical Institute, National University Hospital (NUH). He’s also the head of NUH’s Department of Paediatrics, a professor at the NUS Yong Long Lin School of Medicine, and a principal investigator at SICS – an appointment he has held since 2009.
Intrigued by the increasing numbers of obese young children visiting his clinic, Lee’s research interests lie within paediatrics and endocrinology, particularly in monogenic forms of childhood obesity, complications of childhood obesity, developmental origins of adiposity and obesity risk. He’s one of the lead investigators for the GUSTO birth cohort study and led a study on sleep in children in association with adiposity.
Over the last decade, he and his team(s) have successfully identified rare and common genetic variants in their paediatric cohort with early-onset obesity using a candidate gene approach, with the pathogenic roles supported by in-vitro functional studies. They were the first in the world to report an MC3R (a protein in humans encoded by the MC3R gene) mutation associated with human obesity. He has won awards for scientific papers such as Prevalence of Overweight and Obesity in Chinese Preschoolers in Singapore and Normative Data for Quantitative Calcaneal Ultrasound in Asian Children.
Lee received his MBBS, MMed (Paediatrics) and PhD from the National University of Singapore, and his MRCP and FRCPCH from the United Kingdom’s Royal College of Physicians and Royal College of Paediatrics and Child Health respectively.