Prebiotic Intervention Study on Microbiome in Adults (PRISMA)


Prebiotic Effects on Gut Microbiota, Gut Comfort and Immune Function

What are Human Milk Oligosaccharides?
Human Milk Oligosaccharides (HMOs) are a major component of human breastmilk. Research suggests that HMOs may play a role in the development of healthy gut microbiome and immunity in young children.

How does HMOs benefit us?
In infants, dietary HMOs have been found to possess health and developmental benefits. However, in adults, limited studies have been conducted to show the potential benefits of HMOs such as promoting growth of beneficial bacteria in the gut and reduction of stomach-related issues such as abnormal stool consistency, abdominal pain, and bloating. Due to recent advancement in industry-scale HMO production, HMOs have become available, providing opportunities to investigate their effects in adults.

What does SICS hope to do?
At SICS, we hope to study whether the consumption of HMOs influences the bacteria in the gut, immune function and gastrointestinal symptoms in adults.

Who are we looking for?
We are looking for healthy adults experiencing mild to moderate gastrointestinal complaints such as abdominal pain, passage of gas, bloating and feeling of fullness. Consumption of HMOs may benefit these individuals by improving their poor gut microbiome composition and reducing their elevated gut inflammatory state.


How can I help?
You can participate if you meet the following criteria:

  • Aged 40 to 55 years old
  • Have been experiencing gastrointestinal symptoms such abdominal pain, passage of gas, bloating and feeling of fullness
  • Own device like a computer, smartphone or tablet (with internet access) to complete online questionnaires

What should I expect?
By participating in the study, you will:

  • Visit the research facility twice
  • Provide blood and stool samples during your visit to the research facility
  • Consume the assigned study product once each day for 28 days
  • Complete online questionnaires

Reimbursements will be given for your time. There are no additional costs associated with participating in this project.

To find out more, call (+65) 9838 7412, email, or simply fill in the form below.

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