REVERSE-DM (pREVEntion progRamme in women at high riSk for type 2 DIABETES) Study


What is Type 2 diabetes?
Type 2 diabetes is the most common type of diabetes and is a disease that occurs when glucose levels in your blood are too high (hyperglycaemia). Glucose is a simple sugar, often broken down from carbohydrates in your diet, and is your body’s preferred source of energy because it is small enough to enter your cells and be used as fuel for your body to function well. In order for this to happen, your pancreas produces an essential hormone called insulin. In Type 2 diabetes, your body either does not make enough insulin or is not able to utilise it well, which causes a great increase in glucose that remains circulating in your blood.

Why is Type 2 diabetes bad?   
Type 2 diabetes, if left untreated or is ill-managed, can lead to detrimental long-term health problems such as heart disease, kidney disease and stroke.

Who is at risk?
People who are/have:

  • Aged 25 years old and above
  • Classed as overweight
  • A greater level of physical inactivity (sedentary lifestyle) or those who have a familial or personal history of diabetes.

What is GDM and who is at risk?
GDM stands for Gestational Diabetes Mellitus and can occur in some pregnant women, usually from week 24 of pregnancy. It occurs when there is a build-up of glucose in the blood (hyperglycaemia) because either the body does not produce enough of the hormone insulin or is not able to process the insulin adequately, inhibiting the body’s ability to utilise glucose effectively for the body to function.

Why the focus on women with GDM?
Type 2 diabetes is often related to lifestyle and develops over time; with proper interventions, it could be avoided in some cases; and with proper management, it can lead to an improved quality and longevity of life.

Women with a history of GDM have also been connected to a lifetime risk of developing type 2 diabetes and cardiovascular disease. In Singapore, it is estimated that 4 in 10 women with GDM could develop pre-diabetes or diabetes within five years of their pregnancy. Therefore, postpartum follow-up is essential in early detection of, preventing or delaying the development of Type 2 diabetes in this group; regular check-ups with trained healthcare providers will also be important in managing the disease well, contributing to a better quality and longevity of life even if a woman does develop the disease post-GDM.

However, most of these women are often lost to follow-up after the birth of the child for many reasons, such as having a busy lifestyle with work, children and other familial commitments.


What does SICS hope to do?
SICS hopes to understand whether a lifestyle intervention utilising a mobile health (mHealth) application for this group of women can contribute in the prevention of Type 2 diabetes.

How can you help?
You can participate in our upcoming pilot study if you are a woman who fits the following criteria:

  • A healthy female with a previous history of GDM
  • Aged 21 to 45 years old
  • Has an android device

What should you expect?

  • 2 in-person sessions over 10 weeks
  • 2 weeks (monitoring of glucose levels using CGMS sensor, online e-diary)
  • Complete sets of questionnaires and surveys

Reimbursements will be provided for your time and participation in the study.

To find out more or to register your interest, simply fill in the form below.

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