Principal Investigator

Adj. Ast/Prof (NUS, NTU), Adj. A/Prof (DUKE-NUS), Joint Scientist (KKH),
Adj. Senior Principal Investigator (IMB), A*STAR, Singapore
Adj. Visiting A/Prof, Shanghai Institute of Immunology at Shanghai Jiao Tong University School of Medicine.

  • Svetoslav CHAKAROV, Ph.D
  • Baptiste JANELA, Ph.D (GALDERMA Collaboration)
  • Camille BLERIOT, Ph.D
  • Charles-Antoine DUTERTRE, Ph.D
  • Chyan Ying KE, Ph.D
  • Alicia WONG, Ph.D
  • Peter SEE, Ph.D
  • Regine DRESS, Ph.D
  • Rasha MSALLAM, Ph.D
  • Tatsuya KOZAKI, Ph.D MERCK MSD collaboration
  • AYMERIC Silvin, Ph.D
  • Gillian LOW
  • Christopher LEE
  • Weida NGAN
  • Zainab Binte YASIN
  • Pei Yi NG
  • Dong Shin PARK Ph.D student


Research Focus

Dendritic Cell and Macrophage Ontogeny

Dendritic cells (DCs), monocytes and macrophages play crucial and distinct roles in tissue homeostasis and immunity, but also contribute to a broad spectrum of pathologies and are thus attractive therapeutic targets. Potential intervention strategies aiming at manipulation of these cells will require in-depth insights of their origins and the mechanisms that govern their homeostasis.

The focus of the laboratory is to understand the ontogeny of DCs, monocytes and macrophages, their differentiation pathways and how their unique ontogeny dictates their immune functions. Our approach encompasses the integration of high dimensional platforms such as RNAseq, single cell transcriptome analysis using microfluidic RNA sequencing and deep immunophenotypic assessment using state of the art 18 parameters flow cytometry or Cytometry by Time-Of-Flight mass spectrometry (CyTOF) (In collaboration with Dr Evan Newell, SIgN). Such high density molecular profiling at the single level and at unprecedented dimensionality and complexity will provide new insights in the biology of DC, monocyte and macrophage cell populations. Defining macrophage and DC populations on the criteria of their origin may aid our understanding of their discrete roles in tissue immunity and homeostasis, as ontogeny of DC and macrophage subsets likely underlie their functional specializations. 


Florent Ginhoux graduated in Biochemistry from the University Pierre et Marie CURIE (UPMC), Paris VI, obtained a Masters degree in Immunology from the Pasteur Institute in 2000 and his PhD in 2004 from UPMC, Paris VI. As a postdoctoral fellow, he joined the Laboratory of Miriam Merad in the Mount Sinai School of Medicine (MSSM), New York. In 2008, he became an Assistant Professor in the Department of Gene and Cell Medicine, MSSM and member of the Immunology Institute of MSSM. He joined the Singapore Immunology Network (SIgN), A*STAR in May 2009 as a Junior Principal Investigator. He is now a Senior Principal Investigator and an EMBO Young Investigator and his laboratory is focusing on the ontogeny and differentiation of macrophages and dendritic cells in both humans and mice. 


  • Ontogeny and Immune Functions of Dendritic Cells

    DCs form a heterogeneous group of antigen presenting cells that are critical agents in the induction and regulation of immune responses and potential targets of immunotherapeutic interventions. Several studies in mice and humans have revealed the complexity of DC origin and life cycle. In a similar manner to T cell subsets, DCs have been shown to be heterogeneous implicating functional specializations that are starting to be unravelled.

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  • Ontogeny of Macrophages

    Macrophages and DCs are highly heterogeneous in phenotype and function and multiple subsets of these cells have been described. Our findings show that heterogeneity is also reflected in the origin of DCs and macrophages. Recent evidence from our laboratory and others have showed that monocytes do not substantially contribute to all tissue macrophage populations in steady state and inflammatory conditions.

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  • Aligning Dendritic Cell, Monocyte and Macrophage Populations across Species

    Much of DC, monocyte and macrophage research so far has been carried out in mice and increasing efforts are now being devoted to translating the findings into humans and other species. Recent studies have aligned these cellular networks across species at multiple levels from phenotype, gene expression program, ontogeny and functional specializations. In this project, we aim to advance our understanding of the organization of DC subsets, monocytes and macrophages across species, including mouse, macaque and human.

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Dress RJ, Wong AYW, Ginhoux F. Homeostatic control of dendritic cell numbers and differentiation. Immunol Cell Biol. 2018 Feb 23.[Epub ahead of print]

Evrard M, Kwok IWH, Chong SZ, Teng KWW, Becht E, Chen J, Sieow JL, Penny HL, Ching GC, Devi S, Adrover JM, Li JLY, Liong KH, Tan L, Poon Z, Foo S, Chua JW, Su IH, Balabanian K, Bachelerie F, Biswas SK, Larbi A, Hwang WYK, Madan V, Koeffler HP, Wong SC, Newell EW, Hidalgo A, Ginhoux F, Ng LG. Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. Immunity. 2018 Feb 20;48(2):364-379.e8.

Hoeffel G, Ginhoux F. Fetal monocytes and the origins of tissue-resident macrophages. Cell Immunol. 2018 Jan 12. [Epub ahead of print]

Low D, Ginhoux F. Recent advances in the understanding of microglial development and homeostasis. Cell Immunol. 2018 Jan 10. [Epub ahead of print]

Braza MS, Conde P, Garcia M, Cortegano I, Brahmachary M, Pothula V, Fay F, Boros P, Werner SA, Ginhoux F, Mulder WJM, Ochando J. Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance. Am J Transplant. 2018 Jan 4. [Epub ahead of print]


Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J, Blecher R, Ulas T, Squarzoni P, Hoeffel G, Coulpier F, Siopi E, David FS, Scholz C, Shihui F, Lum J, Amoyo AA, Larbi A, Poidinger M, Buttgereit A, Lledo PM, Greter M, Chan JKY, Amit I, Beyer M, Schultze JL, Schlitzer A, Pettersson S, Ginhoux F, Garel S. Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner. Cell. 2017 Dec 21. [Epub ahead of print]

Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity. 2017 Dec 19;47(6):1051-1066.e12.

Saili KS, Zurlinden TJ, Schwab AJ, Silvin A, Baker NC, Hunter ES 3rd, Ginhoux F, Knudsen TB. Blood-brain barrier development: Systems modeling and predictive toxicology. Birth Defects Res. 2017 Dec 1;109(20):1680-1710.

Ginhoux F. New beginnings. Nat Rev Immunol. 2017 Dec;17(12):732.

Tien BYQ, Goh HMS, Chong KKL, Bhaduri-Tagore S, Holec S, Dress R, Ginhoux F, Ingersoll MA, Williams RBH, Kline KA. Enterococcus faecalis promotes innate immune suppression and polymicrobial catheter-associated urinary tract infection. Infect Immun. 2017 Nov 17;85(12).

Chen J, Rénia L, Ginhoux F. Constructing cell lineages from single-cell transcriptomes. Mol Aspects Med. 2017 Oct 28. [Epub ahead of print]

Nakamizo S, Honda T, Adachi A, Nagatake T, Kunisawa J, Kitoh A, Otsuka A, Dainichi T, Nomura T, Ginhoux F, Ikuta K, Egawa G, Kabashima K. High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells. Sci Rep. 2017 Oct 26;7(1):14076.

Chong KKL, Tay WH, Janela B, Yong AMH, Liew TH, Madden L, Keogh D, Barkham TMS, Ginhoux F, Becker DL, Kline KA. Enterococcus faecalis modulates immune activation and slows healing during wound infection. J Infect Dis. 2017 Oct 17. [Epub ahead of print]

Tenno M, Shiroguchi K, Muroi S, Kawakami E, Koseki K, Kryukov K, Imanishi T, Ginhoux F, Taniuchi I. Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling. J Exp Med. 2017 Oct 2;214(10):2933-2946.

Ginhoux F, Bleriot C, Lecuit M. Dying for a Cause: Regulated Necrosis of Tissue-Resident Macrophages upon Infection. Trends Immunol. 2017 Oct;38(10):693-695.

Fehlings M, Chakarov S, Simoni Y, Shivshankar B, Ginhoux F, Newell EW. Multiplex peptide-MHC tetramer staining using mass cytometry for deep analysis of the influenza-specific T-cell response in mice. J Immunol Methods. 2017 Sep 30. [Epub ahead of print]

Tan-Garcia A, Wai LE, Zheng D, Ceccarello E, Jo J, Banu N, Khakpoor A, Chia A, Y L Tham C, Tan AT, Hong M, Keng CT, Rivino L, Tan KC, Hoe Lee K, Lim SG, Newell EW, Pavelka N, Chen J, Ginhoux F, Chen Q, Bertoletti A, Dutertre CA. Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease. J Hepatol. 2017 Sep;67(3):490-500.

Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell AJ, Florido M, Beattie L, Walters SB, Tay SS, Lu B, Holz LE, Roediger B, Wong YC, Warren A, Ritchie W, McGuffog C, Weninger W, Le Couteur DG, Ginhoux F, Britton WJ, Heath WR, Saunders BM, McCaughan GW, Luciani F, MacDonald KPA, Ng LG, Bowen DG, Bertolino P. A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment. Immunity. 2017 Aug 15;47(2):374-388.e6.

Takata K, Kozaki T, Lee CZW, Thion MS, Otsuka M, Lim S, Utami KH, Fidan K, Park DS, Malleret B, Chakarov S, See P, Low D, Low G, Garcia-Miralles M, Zeng R, Zhang J, Goh CC, Gul A, Hubert S, Lee B, Chen J, Low I, Shadan NB, Lum J, Wei TS, Mok E, Kawanishi S, Kitamura Y, Larbi A, Poidinger M, Renia L, Ng LG, Wolf Y, Jung S, Önder T, Newell E, Huber T, Ashihara E, Garel S, Pouladi MA, Ginhoux F. Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function. Immunity. 2017 Jul 18;47(1):183-198.e6.

McGovern N, Shin A, Low G, Low D, Duan K, Yao LJ, Msallam R, Low I, Shadan NB, Sumatoh HR, Soon E, Lum J, Mok E, Hubert S, See P, Kunxiang EH, Lee YH, Janela B, Choolani M, Mattar CNZ, Fan Y, Lim TKH, Hong DK, Tan KK, Tam JKC, Schuster C, Elbe-Bürger A, Wang XN, Bigley V, Collin M, Haniffa M, Schlitzer A, Poidinger M, Albani S, Larbi L, Newell EW, Chan JKY, Ginhoux F. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature. 2017 Jun 29;546(7660):662-666.

See P, Dutertre CA, Chen J, Günther P, McGovern N, Irac SE, Gunawan M, Beyer M, Händler K, Duan K, Sumatoh HRB, Ruffin N, Jouve M, Gea-Mallorquí E, Hennekam RCM, Lim T, Yip CC, Wen M, Malleret B, Low I, Shadan NB, Fen CFS, Tay A, Lum J, Zolezzi F, Larbi A, Poidinger M, Chan JKY, Chen Q, Renia L, Haniffa M, Benaroch P, Schlitzer A, Schultze JL, Newell EW, Ginhoux F. Mapping the human DC lineage through the integration of high-dimensional techniques. Science. 2017 Jun 9;356(6342).

Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z, Liu Z, Cai W, Ke F, Zhang L, Zhou H, Wang H, Wang G, Chen X, Zhang H, Wang Z, Ginhoux F, Lu C, Su B, Wang H. RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease. EMBO Mol Med. 2017 May;9(5):589-604.

Kam YW, Lee CY, Teo TH, Howland SW, Amrun SN, Lum FM, See P, Kng NQ, Huber RG, Xu MH, Tan HL, Choo A, Maurer-Stroh S, Ginhoux F, Fink K, Wang CI, Ng LFP, Rénia L. Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections. JCI Insight. 2017 Apr 20;2(8). [Epub ahead of print]

Lum FM, Low DK, Fan Y, Tan JJ, Lee B, Chan JK, Rénia L, Ginhoux F, Ng LF. Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation. Clin Infect Dis. 2017 Apr 1;64(7):914-920.

Sabatel C, Radermecker C, Fievez L, Paulissen G, Chakarov S, Fernandes C, Olivier S, Toussaint M, Pirottin D, Xiao X, Quatresooz P, Sirard JC, Cataldo D, Gillet L, Bouabe H, Desmet CJ, Ginhoux F, Marichal T, Bureau F. Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages. Immunity. 2017 Mar 21;46(3):457-473.

Xu X, Tay Y, Sim B, Yoon SI, Huang Y, Ooi J, Utami KH, Ziaei A, Ng B, Radulescu C, Low D, Ng AY, Loh M, Venkatesh B, Ginhoux F, Augustine GJ, Pouladi MA. Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Mar 14;8(3):619-633.

Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo SL, Loh CY, Lim S, Kurioka A, Fergusson JR, Tang CL, Kam MH, Dennis K, Lim TK, Fui AC, Hoong CW, Chan JK, Curotto de Lafaille M, Narayanan S, Baig S, Shabeer M, Toh SE, Tan HK, Anicete R, Tan EH, Takano A, Klenerman P, Leslie A, Tan DS, Tan IB, Ginhoux F, Newell EW. Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency. Immunity. 2017 Jan 17;46(1):148-161.


Heidkamp GF, Sander J, Lehmann CHK, Heger L, Eissing N, Baranska A, Lühr JJ, Hoffmann A, Reimer KC, Lux A, Söder S, Hartmann A, Zenk J, Ulas T, McGovern N, Alexiou C, Spriewald B, Mackensen A, Schuler G, Schauf B, Forster A, Repp R, Fasching PA, Purbojo A, Cesnjevar R, Ullrich E, Ginhoux F, Schlitzer A, Nimmerjahn F, Schultze JL, Dudziak D. Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment. Sci Immunol. 2016 Dec 16;1(6).

Cerny D, Thi Le DH, The TD, Zuest R, Kg S, Velumani S, Khor CC, Mori L, Simmons CP, Poidinger M, Zolezzi F, Ginhoux F, Haniffa M, Wills B, Fink K. Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence. J Allergy Clin Immunol. 2016 Dec;138(6):1709-1712.e11.

Zhou P, Chionh YT, Irac SE, Ahn M, Jia Ng JH, Fossum E, Bogen B, Ginhoux F, Irving AT, Dutertre CA, Wang LF. Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages. Sci Rep. 2016 Dec 9;6:38597.

Martínez Gómez JM, Periasamy P, Dutertre CA, Irving AT, Ng JH, Crameri G, Baker ML, Ginhoux F, Wang LF, Alonso S. Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto. Sci Rep. 2016 Nov 24;6:37796.

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 Oct 17;213(11):2293-2314.

Egeler RM, Katewa S, Leenen PJ, Beverley P, Collin M, Ginhoux F, Arceci RJ, Rollins BJ. Langerhans cell histiocytosis is a neoplasm and consequently its recurrence is a relapse: In memory of Bob Arceci. Pediatr Blood Cancer. 2016 Oct;63(10):1704-12.

Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GH, Chung TJ, Chan DK, Tan KK, Hon TL, Fossum E, Bogen B, Choolani M, Chan JK, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B, Ginhoux F. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species. Immunity. 2016 Sep 20;45(3):669-84.

Chauhan S, Diril MK, Lee JH, Bisteau X, Manoharan V, Adhikari D, Ratnacaram CK, Janela B, Noffke J, Ginhoux F, Coppola V, Liu K, Tessarollo L, Kaldis P. Cdk2 catalytic activity is essential for meiotic cell division in vivo. Biochem J. 2016 Sep 15;473(18):2783-98.

Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica MB, Takata K, Teeling J, Town T, Van Eldik LJ. Targeting innate immunity for neurodegenerative disorders of the central nervous system. J Neurochem. 2016 Sep;138(5):653-93.

Wong MT, Ong DE, Lim FS, Teng KW, McGovern N, Narayanan S, Ho WQ, Cerny D, Tan HK, Anicete R, Tan BK, Lim TK, Chan CY, Cheow PC, Lee SY, Takano A, Tan EH, Tam JK, Tan EY, Chan JK, Fink K, Bertoletti A, Ginhoux F, Curotto de Lafaille MA, Newell EW. A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures. Immunity. 2016 Aug 16;45(2):442-56.

Chng KR, Tay AS, Li C, Ng AH, Wang J, Suri BK, Mata SA, McGovern N, Janela B, Wong XF, Sio YY, Au BV, Wilm A, De Sessions PF, Lim TC, Tang MB, Ginhoux F, Connolly JE, Lane EB, Chew FT, Common JE, Nagarajan N. Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare. Nat Microbiol. 2016 Jul 11;1(9):16106.

Chen J, Schlitzer A, Chakarov S, Ginhoux F, Poidinger M. Mpath maps multi-branching single-cell trajectories revealing progenitor cell progression during development. Nat Commun. 2016 Jun 30;7:11988.

Penny HL, Sieow JL, Adriani G, Yeap WH, See Chi Ee P, San Luis B, Lee B, Lee T, Mak SY, Ho YS, Lam KP, Ong CK, Huang RY, Ginhoux F, Rotzschke O, Kamm RD, Wong SC. Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology. 2016 Jun 21;5(8):e1191731.

Ginhoux F, Guilliams M, Naik SH. Editorial: Dendritic Cell and Macrophage Nomenclature and Classification. Front Immunol. 2016 May 2;7:168.

Carpentier S, Vu Manh TP, Chelbi R, Henri S, Malissen B, Haniffa M, Ginhoux F, Dalod M. Comparative genomics analysis of mononuclear phagocyte subsets confirms homology between lymphoid tissue-resident and dermal XCR1+ DCs in mouse and human and distinguishes them from Langerhans cells. J Immunol Methods. 2016 May;432:35-49. 

McGovern N, Schlitzer A, Janela B, Ginhoux F. Protocols for the Identification and Isolation of Antigen-Presenting Cells in Human and Mouse Tissues. Methods Mol Biol. 2016;1423:169-80.

Lau J, Goh CC, Devi S, Keeble J, See P, Ginhoux F, Ng LG. Intravital multiphoton imaging of mouse tibialis anterior muscle. IntraVital. 2016 Apr 8; 5:2, e1156272

Salmon H, Idoyaga J, Rahman A, Leboeuf M, Remark R, Jordan S, Casanova-Acebes M, Khudoynazarova M, Agudo J, Tung N, Chakarov S, Rivera C, Hogstad B, Bosenberg M, Hashimoto D, Gnjatic S, Bhardwaj N, Palucka AK, Brown BD, Brody J, Ginhoux F, Merad M. Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition. Immunity. 2016 Apr 19;44(4):924-38.

Ochando J, Kwan WH, Ginhoux F, Hutchinson JA, Hashimoto D, Collin M. The mononuclear phagocyte system in organ transplantation. Am J Transplant. 2016 Apr;16(4):1053-69. 

Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep. 2016 Mar 23;6:23505.

Ginhoux F, Guilliams M. Tissue-Resident Macrophage Ontogeny and Homeostasis. Immunity. 2016 Mar 15;44(3):439-49.


Ginhoux F, Schultze JL, Murray PJ, Ochando J, Biswas SK. New insights into the multidimensional concept of macrophage ontogeny, activation and function. Nat Immunol. 2015 Dec 17;17(1):34-40. 

Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I. Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell. 2015 Dec 17;163(7):1663-77.

Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, Poirier-Colame V, Roux A, Becharef S, Formenti S, Golden E, Cording S, Eberl G, Schlitzer A, Ginhoux F, Mani S, Yamazaki T, Jacquelot N, Enot DP, Bérard M, Nigou J, Opolon P, Eggermont A, Woerther PL, Chachaty E, Chaput N, Robert C, Mateus C, Kroemer G, Raoult D, Boneca IG, Carbonnel F, Chamaillard M, Zitvogel L. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015 Nov 27;350(6264):1079-84.

Waisman A, Ginhoux F, Greter M, Bruttger J. Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems. Trends Immunol. 2015 Oct;36(10):625-36.  

Hoeffel G, Ginhoux F. Ontogeny of Tissue-Resident Macrophages. Front Immunol. 2015 Sep 22;6:486.  

Almeida FF, Tenno M, Brzostek J, Li JL, Allies G, Hoeffel G, See P, Ng LG, Fehling HJ, Gascoigne NR, Taniuchi I, Ginhoux F. Identification of a novel lymphoid population in the murine epidermis. Sci Rep. 2015 Jul 30;5:12554.

Schlitzer A, Sivakamasundari V, Chen J, Sumatoh HR, Schreuder J, Lum J, Malleret B, Zhang SQ, Larbi A, Zolezzi F, Renia L, Poidinger M, Naik S, Newell EW, Robson P, Ginhoux F. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat Immunol. 2015 Jul;16(7):718-28.

Ginhoux F and Prinz M. Origin of Microglia: Currents Concepts and Past Controversies. Cold Spring Harb Perspect Biol. 2015 Jul 1;7(8).

Heymann F, Peusquens J, Ludwig-Portugall I, Kohlhepp M, Ergen C, Niemietz P, Martin C, van Rooijen N, Ochando JC, Randolph GJ, Luedde T, Ginhoux F, Kurts C, Trautwein C, Tacke F. Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology. 2015 Jul;62(1):279-91.

Li L, Ng DS, Mah W, Almeida FF, Rahmat SA, Rao VK, Leow SC, Laudisi F, Peh MT, Goh AM, Lim JS, Wright GD, Mortellaro A, Taneja R, Ginhoux F, Lee CG, Moore PK, Lane DP. A unique role for p53 in the regulation of M2 macrophage polarization. Cell Death Differ. 2015 Jul;22(7):1081-93. 

Conde P, Rodriguez M, van der Touw W, Jimenez A, Burns M, Miller J, Brahmachary M, Chen HM, Boros P, Rausell-Palamos F, Yun TJ, Riquelme P, Rastrojo A, Aguado B, Stein-Streilein J, Tanaka M, Zhou L, Zhang J, Lowary TL, Ginhoux F, Park CG, Cheong C, Brody J, Turley SJ, Lira SA, Bronte V, Gordon S, Heeger PS, Merad M, Hutchinson J, Chen SH, Ochando J. DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance. Immunity. 2015 Jun 16;42(6):1143-58.

Takata K, Ginhoux F. Poised for action: USP18 restrains microglial activation in the white matter. EMBO J. 2015 Jun 12;34(12):1603-5.

Schlitzer A, McGovern N, Ginhoux F. Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems. Semin Cell Dev Biol. 2015 May;41:9-22.

Gunawan M, Venkatesan N, Loh JT, Wong JF, Berger H, Neo WH, Li LY, Win MK, Yau YH, Guo T, See PC, Yamazaki S, Chin KC, Gingras AR, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH. The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat Immunol. 2015 May;16(5):505-16.

Hoeffel G, Chen J, Lavin Y, Low D, Almeida FF, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poidinger M, Zolezzi F, Larbi A, Ng LG, Chan JK, Greter M, Becher B, Samokhvalov IM, Merad M, Ginhoux F. C-myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity. 2015 Apr 21;42(4):665-78.

Goh CC, Li JL, Devi S, Bakocevic N, See P, Larbi A, Weninger W, Ginhoux F, Angeli V, Ng LG. Real-time Imaging of Dendritic Cell Responses To Sterile Tissue Injury. J Invest Dermatol. 2015 Apr;135(4):1181-4.  

Evrard M, Chong SZ, Devi S, Chew WK, Lee B, Poidinger M, Ginhoux F, Tan SM, Ng LG. Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopy. J Leukoc Biol. 2015 Mar;97(3):611-9.

Malleret B, Li A, Zhang R, Tan KS, Suwanarusk R, Claser C, Cho JS, Koh EG, Chu CS, Pukrittayakamee S, Ng ML, Ginhoux F, Ng LG, Lim CT, Nosten F, Snounou G8, Rénia L, Russell B. Plasmodium vivax: restricted tropism and rapid remodelling of CD71 positive reticulocytes. Blood. 2015 Feb 19;125(8):1314-24. 

McGovern N, Chan JK, Ginhoux F. Dendritic cells in humans-from fetus to adult. Int Immunol. 2015 Feb;27(2):65-72.


Hoeffel G, Squarzoni P, Garel S and Ginhoux F. Microglial ontogeny and functions in shaping brain circuits: implication for CNS developmental diseases. Book chapter “Macrophages: Biology and Role in the Pathology of Diseases (SPRINGER)" 2014

Cerny D, Haniffa M, Shin A, Bigliardi P, Tan BK, Lee B, Poidinger M, Tan EY, Ginhoux F, Fink K. Selective Susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection. PLoS Pathog. 2014 Dec 4;10(12):e1004548. 

Becher B, Schlitzer A, Chen J, Mair F, Sumatoh HR, Teng KW, Low D, Ruedl C, Riccardi-Castagnoli P, Poidinger M, Greter M, Ginhoux F, Newell EW. High-dimensional analysis of the murine myeloid cell system. Nat Immunol. 2014 Dec;15(12):1181-9.

Ginhoux F. Fate PPAR-titioning: PPAR-γ 'instructs' alveolar macrophage development. Nat Immunol. 2014 Oct 20;15(11):1005-7.

Alexander KA, Flynn R, Lineburg KE, Kuns RD, Teal BE, Olver SD, Lor M, Raffelt NC, Koyama M, Leveque L, Le Texier L, Melino M, Markey KA, Varelias A, Engwerda C, Serody JS, Janela B, Ginhoux F, Clouston AD, Blazar BR, Hill GR, MacDonald KP. CSF-1–dependant donor-derived macrophages mediate chronic graft-versus-host disease. J Clin Invest. 2014 Oct 1;124(10):4266-80.

Dutertre CA, Wang LF, Ginhoux F. Aligning bona fide dendritic cell populations across species. Cell Immunol. 2014 September - October;291(1-2):3-10.

McGovern N, Schlitzer A, Gunawan M, Jardine L, Shin A, Poyner E, Green K, Dickinson R, Wang XN, Low D, Best K, Covins S, Milne P, Pagan S, Aljefri K, Windebank M, Saavedra DM, Larbi A, Wasan PS, Duan KB, Poidinger M, Bigley V, Ginhoux F, Collin M, Haniffa M. Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages. Immunity. 2014 Sep 18;41(3):465-77.

Squarzoni P, Oller G, Hoeffel G, Pont-Lezica L, Rostaing P, Low D, Bessis A, Ginhoux F, Garel S. Microglia Modulate Wiring of the Embryonic Forebrain. Cell Rep. 2014 Sep 11;8(5):1271-9.

Guilliams M, Ginhoux F, Jakubzick C, Naik SH, Onai N, Schraml BU, Segura E, Tussiwand R, Yona S. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat Rev Immunol. 2014 Aug;14(8):571-8.

Zhou Q, Ho AW, Schlitzer A, Tang Y, Wong KH, Wong FH, Chua YL, Angeli V, Mortellaro A, Ginhoux F, Kemeny DM. GM-CSF-Licensed CD11b+ Lung Dendritic Cells Orchestrate Th2 Immunity to Blomia tropicalis. J Immunol. 2014 Jul 15;193(2):496-509

Bakocevic N, Claser C, Yoshikawa S, Jones LA, Chew S, Goh CC, Malleret B, Larbi A, Ginhoux F, de Lafaille MC, Karasuyama H, Renia L, Ng LG. CD41 is a reliable identification and activation marker for murine basophils in the steady-state and during helminth and malarial infections. Eur J Immunol. 2014 Jun;44(6):1823-34.

Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014 May 23;14(6):392-404.

Ginhoux F, Schlitzer A. CD11b(+) DCs rediscovered: implications for vaccination. Expert Rev Vaccines. 2014 Apr;13(4):445-7.

Wang XN, McGovern N, Gunawan M, Richardson C, Windebank M, Siah TW, Lim HY, Fink K, Li JL, Ng LG, Ginhoux F, Angeli V, Collin M, Haniffa M. A three-dimensional atlas of human dermal leukocytes, lymphatics, and blood vessels. J Invest Dermatol. 2014 Apr;134(4):965-74.

Schlitzer A, Ginhoux F. Organization of the mouse and human DC network. Curr Opin Immunol. 2014 Feb;26C:90-99.

Leong C, Lee SC, Ock J, Li X, See P, Park SJ, Ginhoux F, Yun SW, Chang YT. Microglia specific fluorescent probes for live cell imaging. Chem Commun (Camb). 2014 Feb 4;50(9):1089-91.


Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, Schlitzer A, Ginhoux F, Apetoh L, Chachaty E, Woerther PL, Eberl G, Bérard M, Ecobichon C, Clermont D, Bizet C, Gaboriau-Routhiau V, Cerf-Bensussan N, Opolon P, Yessaad N, Vivier E, Ryffel B, Elson CO, Doré J, Kroemer G, Lepage P, Boneca IG, Ghiringhelli F, Zitvogel L. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013 Nov 22;342(6161):971-6.

Devi S, Wang Y, Chew WK, Lima R, A-González N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S, Keeble JL, Goh CC, Li JL, Evrard M, Malleret B, Larbi A, Renia L, Haniffa M, Tan SM, Chan JK, Balabanian K, Nagasawa T, Bachelerie F, Hidalgo A, Ginhoux F, Kubes P, Ng LG. Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med. 2013 Oct 21;210(11):2321-36.

Haniffa M, Collin M, Ginhoux F. Ontogeny and functional specialization of dendritic cells in human and mouse. Adv Immunol. 2013;120:1-49.

Jakubzick C, Gautier EL, Gibbings SL, Sojka DK, Schlitzer A, Johnson TE, Ivanov S, Duan Q, Bala S, Condon T, van Rooijen N, Grainger JR, Belkaid Y, Ma'ayan A, Riches DW, Yokoyama WM, Ginhoux F, Henson PM, Randolph GJ. Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes. Immunity. 2013 Sep 19;39(3):599-610.

Schlitzer A, Ginhoux F. DNGR-ing the dendritic cell lineage. EMBO Rep. Sep 30 2013; 14(10):850-851.

Gehring AJ, Haniffa M, Kennedy PT, Ho ZZ, Boni C, Shin A, Banu N, Chia A, Lim SG, Ferrari C, Ginhoux F, Bertoletti A. Mobilizing monocytes to cross-present circulating viral antigen in chronic infection. J Clin Invest. 2013 Sep 3;123(9):3766-76.

Howland SW, Poh CM, Gun SY, Claser C, Malleret B, Shastri N, Ginhoux F, Grotenbreg GM, Rénia L. Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria. EMBO Mol Med. 2013 Jul;5(7):984-99.

Guermonprez P, Helft J, Claser C, Deroubaix S, Karanje H, Gazumyan A, Darasse-Jèze G, Telerman SB, Breton G, Schreiber HA, Frias-Staheli N, Billerbeck E, Dorner M, Rice CM, Ploss A, Klein F, Swiecki M, Colonna M, Kamphorst AO, Meredith M, Niec R, Takacs C, Mikhail F, Hari A, Bosque D, Eisenreich T, Merad M, Shi Y, Ginhoux F, Rénia L, Urban BC, Nussenzweig MC. Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat Med. 2013 Jun;19(6):730-8.

Schlitzer A, McGovern N, Teo P, Zelante T, Atarashi K, Low D, Ho AW, See P, Shin A, Wasan PS, Hoeffel G,  Malleret B, Heiseke A, Chew S, Jardine L, Purvis HA, Hilkens CM, John Tam J, Poidinger M, Stanley RE, Krug AB, Renia L, Sivasankar B, Ng LG, Collin M, Ricciardi-Castagnoli P, Honda K, Haniffa M, Ginhoux F. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity. 2013 May 23;38(5):970-983.

Ginhoux F, Lim S, Hoeffel G, Low D, Huber T. Origin and differentiation of microglia. Front Cell Neurosci. 2013 Apr 17;7:45.

Hashimoto D, Chow A, Noiza C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M. Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes. Immunity. 2013 Apr 18;38(4):792-804.

Haniffa M, Collin M, Ginhoux F. Identification of human tissue cross-presenting dendritic cells: A new target for cancer vaccines. Oncoimmunology. 2013 Mar 1;2(3):e23140.

Kandasamy M, Ying PC, Ho AW, Sumatoh HR, Schlitzer A, Hughes TR, Kemeny DM, Morgan BP, Ginhoux F, Sivasankar B. Complement mediated signaling on pulmonary CD103+ dendritic cells is critical for their migratory function in response to influenza infection. PLoS Pathog. 2013 Jan; 9(1):e1003115.


Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, Leboeuf M, Kündig TM, Frei K, Ginhoux F, Merad M, Becher B. Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia. Immunity. 2012 Dec 14;37():1-11.

de Gruijl TD, Ginhoux F, Bousso P, Bieber T, Piguet V, von Stebut E, Dudziak D, Chakraverty R. Fondation rene touraine pour la dermatologie. Exp Dermatol. 2012 Oct;21(10):802-14.

Mauduit M, See P, Peng K, Rénia L, Ginhoux F. Dendritic cells and the malaria pre-erythrocytic stage. Immunol Res. 2012 Sep;53(1-3):115-26.

Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, Wasan PS, Wang XN, Malinarich F, Malleret B, Larbi A, Tan P, Zhao H, Poidinger M, Pagan S, Cookson S, Dickinson R, Dimmick I, Jarrett RF, Renia L, Tam J, Song C, Connolly J, Chan JK, Gehring A, Bertoletti A, Collin M, Ginhoux F. Human Tissues Contain CD141(hi) Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103(+) Nonlymphoid Dendritic Cells. Immunity. 2012 Jul 27;37(1):60-73.

Hoeffel G, Wang Y, Greter M, See P, Teo P, Malleret B, Leboeuf M, Low D, Oller G, Almeida F, Choy SH, Grisotto M, Renia L, Conway SJ, Stanley ER, Chan JK, Ng LG, Samokhvalov IM, Merad M, Ginhoux F. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages. J Exp Med. 2012 Jun 4;209(6):1167-81.

Schlitzer A, Heiseke AF, Einwächter H, Reindl W, Schiemann M, Manta CP, See P, Niess JH, Suter T, Ginhoux F, Krug AB. Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor. Blood. 2012 Jun 21;119(25):6063-71.

Yin N, Xu J, Ginhoux F, Randolph GJ, Merad M, Ding Y, Bromberg JS. Functional Specialization of Islet Dendritic Cell Subsets. J Immunol. 2012 May 15;188(10):4921-30.

Jiao J, Sastre D, Isabel Fiel M, Lee UE, Ghiassi-Nejad Z, Ginhoux F, Vivier E, Friedman SL, Merad M, Aloman C. Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression. Hepatology. 2012 Jan;55(1):244-55.

Ginhoux F, Ng LG, Merad M. Understanding the Murine Cutaneous Dendritic Cell Network to Improve Intradermal Vaccination Strategies. Curr Top Microbiol Immunol. 2012; 351:1-24.


Ginhoux F, Merad M. [Microglia arise from extra-embryonic yolk sac primitive progenitors]. [Article in French] Med Sci (Paris). 2011 Aug-Sep;27(8-9):719-24.

Luche H, Ardouin L, Teo P, See P, Henri S, Merad M, Ginhoux F, Malissen B. The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells. Eur J Immunol. 2011 Aug;41(8):2165-75.

Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez L, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong XF, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova JL, Gros P. IRF8 Mutations and Human Dendritic-Cell Immunodeficiency. N Engl J Med. 2011 Jul 14;365(2):127-38.

Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med. 2011 May 9;208(5):1069-82.

Claser C, Malleret B, Gun SY, Wong AY, Chang ZW, Teo P, See PC, Howland SW, Ginhoux F, Renia L. CD8 T Cells and IFN-gamma Mediate the Time-Dependent Accumulation of Infected Red Blood Cells in Deep Organs during Experimental Cerebral Malaria. PLoS One. 2011; 6(4):e18720.


Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley RE, Samokhvalov IM, Merad M. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. Nov 5 2010; 330(6005):841-845.

Garcia MR, Ledgerwood L, Yang Y, Xu J, Lal G, Burrell B, Ma G, Hashimoto D, Li Y, Boros P, Grisotto M, Rooijen NV, Matesanz R, Tacke F, Ginhoux F, Ding Y, Chen SH, Randolph G, Merad M, Bromberg JS, Ochando JC. Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. J Clin Invest. 2010 Jul 1;120(7):2486-96.

Ginhoux F, Merad M. Ontogeny and homeostasis of Langerhans cells. Immunol Cell Biol. 2010 May;88(4):387-92.

Helft J, Ginhoux F, Bogunovic M, Merad M. Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunol Rev. 2010 Mar;234(1):55-75.


Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D, Price P, Yin N, Bromberg J, Lira S.A, Stanley E.R, Nussenzweig M, Merad M. The Origin and Development of Non-Lymphoid Tissue CD103+DCs. J Exp Med. 2009. Dec 21;206(13):3115-30.

Bogunovic M, Ginhoux F, Helft J, Limin C, Hashimoto D, Greter M, Jacubzick C, Ingersoll M, Leboeuf M, Stanley E.R, Lira S, Randolph G, Merad M. Origin of the Lamina Propria Dendritic Cell Network. Immunity. 2009. Sep 18;31(3):513-25.

Karlmark KR, Weiskirchen R, Zimmermann HW, Gassler N, Ginhoux F, Weber C, Merad M, Luedde T, Trautwein C and Tacke F. Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology. 2009. Jul;50(1):261-74.

Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Pirault J, Deswaerte V, Ginhoux F, Miller ER, Witztum JL, Chapman MJ and Lesnik P. Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis. Circulation. 2009. May 5;119(17):2367-75.

Nagao K, Ginhoux F, Leitner WW, Motegi S, Bennett CL, Clausen BE, Merad M, Udey MC. Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A. 2009. Mar 3;106(9):3312-7.

Haniffa M, Ginhoux F, Wang XN, Bigley V, Abel M, Dimmick I, Bullock S, Grisotto M, Booth T, Taub P, Hilkens C, Merad M, Collin M. Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation. J Exp Med. 2009. Feb 16;206(2):371-85.


Merad M, Ginhoux F, Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol. 2008. Dec;8(12):935-47.

Waskow C, Liu K, Darrasse-Jèze G, Guermonprez P, Ginhoux F, Merad M, Shengelia T, Yao K, Nussenzweig M. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol. 2008. Jun;9(6):676-83. 11.

Jakubzick C, Tacke F, Ginhoux F, Wagers AJ, van Rooijen N, Mack M, Merad M, Randolph GJ. Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103- Pulmonary Dendritic Cell Populations. J Immunol. 2008. Mar 1;180(5):3019-27.

Ledgerwood LG, Lal G, Zhang N, Garin A, Esses SJ, Ginhoux F, Merad M, Peche H, Lira SA, Ding Y, Yang Y, He X, Schuchman EH, Allende ML, Ochando JC and Bromberg JS. The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat Immunol. 2008. Jan;9(1):42-53.


Ginhoux F, Collin MP, Bogunovic M, Abel M, Leboeuf M, Helft J, Ochando J, Kissenpfennig A, Malissen B, Grisotto M, Snoeck H, Randolph G and Merad M. Blood-Derived Dermal Langerin+ Dendritic Cells Survey the Skin in the Steady State. J Exp Med. 2007. Dec 24;204(13):3133-46.

Merad M and Ginhoux F. Dendritic cells genealogy: a new stem or just another branch? Nat Immunol. 2007. Nov;8(11):1199-201.


Bogunovic M, Ginhoux F, Frenette P, Wagers A, Loubeau M and Merad M. Identification of a population of radio-resistant dermal dendritic cells in Mice and Man. J Exp Med. 2006. Nov 27;203(12):2627 38.

Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai X, Stanley E, Randolph G, Merad. Langerhans Cells Arise from Monocytes in Vivo. Nat Immunol. 2006. Mar; 7(3):265-73.

Tacke F, Ginhoux F, Jakubzick C, Van Rooijen N, Merad M, Randolph G. Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery. J Exp Med. 2006. Mar 20; 203(3):583-97.

Angeli V, Ginhoux F, Llodra J, Frenette P, Skobe M, Merad M, and Randolph G. Lymph node B cells enhance dendritic cell migration by promoting lymphangiogenesis. Immunity. 2006. Feb; 24(2):203-15.


Rohrlich PS, Fazilleau N, Ginhoux F, Firat H, Michel F, Cochet M, Laham N, Roth MP, Pascolo S, Nato F, Coppin H, Charneau P, Danos O, Acuto O, Ehrlich R, Kanellopoulos J, Lemonnier FA. Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen presenting function. Proc Natl Acad Sci U S A. 2005. Sep 6; 102(36): 12855-60.

Pascolo S, Ginhoux F, Laham N, Walter S, Schoor O, Probst J, Rohrlich P, Obermayr F, Fisch P, Danos O, Ehrlich R, Lemonnier FA, Rammensee HG. The non-classical HLA class I molecule HFE does not influence the NK-like activity contained in fresh human PBMCs and does not interact with NK cells. Int Immunol. 2005. Feb; 17(2): 117-22.


Ginhoux F, Turbant S, Gross DA, Poupiot J, Marais T, Lone Y, Lemonnier FA, Firat H, Perez N, Danos O, Davoust J. HLA-A*0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline ON system. MolTher. 2004. Aug; 10(2): 279-89.


Ginhoux F, Doucet C, Leboeuf M, Lemonnier F, Danos O, Davoust J, Firat H. Identification of an HLA-A*0201 restricted epitopic peptide from human dystrophin: application in Duchenne Muscular Dystrophy gene therapy. MolTher. 2003. Aug; 8(2): 274-83.

Fruci D, Lauvau G, Saveanu L, Amicosante M, Butler RH, Polack A, Ginhoux F, Lemonnier F., Firat H, van Endert PM. Quantifying recruitment of cytosolic peptides for HLA class I presentation: impact of TAP transport. J Immunol. 2003. Mar; 170(6): 2977-84.


Firat H, Zennou V, Garcia-Pons F, Ginhoux F, Cochet M, Danos O, Lemonnier FA, Langlade-Demoyen P, Charneau P. Use of a lentiviral flap vector for induction of CTL immunity against melanoma. Perspectives for immunotherapy. J Gene Med. 2002. Jan-Feb; 4(1): 38-45.


Education & Position

Present: Senior Principal Investigator

Singapore Immunology Network (SIgN), Singapore

May 2009/April 2014: Junior Principal Investigator
Singapore Immunology Network (SIgN), Singapore

July 2008/May 2009: Assistant Professor
Department of Gene and Cell Medicine and The Immunology Institute
Mount Sinai School of Medicine, New York

Jan.2007/June 2008: Instructor
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York

Sept. 2004/Dec.2006: Postdoctoral fellow
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York

June 2004: Ph.D. in Immunology
Immunology Unit, GENETHON, CNRS UMR 8115, University of Paris VI

2000: Master of Advanced Studies in Fundamental Immunology
PASTEUR Institute, University Pierre et Marie CURIE (Paris VI)

1999: Certificate of Biochemistry

Faculty of Science, University Pierre et Marie CURIE (Paris VI)

1998: Master Degree of Biochemistry
Faculty of Science, University Pierre et Marie CURIE (Paris VI)

1997: Bachelor Degree of Biochemistry
Faculty of Science, University Pierre et Marie CURIE (Paris VI)

Research Background

Sept. 2004/May 2009: Dr. M. Merad, Gene and Cell Medicine Department, Mount Sinai School of Medicine, New York, USA
Post-doctoral research: Homeostasis and functions of dendritic cells and implication for the treatment of graft-versus-host disease

Nov. 2000/June 2004: Dr. O. Danos / Dr. H. Firat / Dr. J. Davoust, Immunology Unit, CNRS UMR 8115, GENETHON, Evry, France
Ph.D. program: Evaluation of the immune responses against transgenes of clinical interest

Feb./Sept. 2000: Dr. L. Zitvogel, Immunology Unit, Institut Gustave Roussy, Villejuif, France
Master of Advanced Studies (DEA) program: Immunogenicity of MHC class I peptides complexes from dendritic cells derived exosomes

July/August 1999: Pr. Vu-Trieu-An, Clinical Immunology Unit, Faculty of Medicine, Hanoi, Vietnam
Volunteer work in clinical immunology

July/August 1998: Dr. A.M. Prêt, Developmental Genetics Laboratory, Institut J. Monod, Paris. 
Summer student work: Molecular characterization of the phenotype of ovary tumors in D. Melanogaster fused mutants

Teaching Experience

2014: Lecturer for the 

1) third IFReC-SIgN Winter School on Advanced Immunology, Iwaji, Japan, 
2) the National University of Singapore (NUS) Immunology Course, Singapore, 
3) the Hong Kong University (HKU) Pasteur Immunology Course, Hong Kong, 
4) Examiner for a PhD entitled “Interplay of innate and adaptive systems in influenza A infection and pulmonary inflammation ” by Dr Ge Qing and delivered by National University of Singapore (NUS), 
5) Examiner for a PhD entitled “The Role and Life Cycle of DNA in Cancer ” by Dr Koo Xing’er Christine and delivered by National University of Singapore (NUS)

2013: Lecturer for the 

1) 8th European Network of Immunology Institutes (ENII) Summer School on Advanced Immunology,
2) the National University of Singapore (NUS) Immunology Course, Singapore and 
3) the Hong Kong University (HKU) Pasteur Immunology Course, Hong Kong and 4) Examiner for a PhD entitled “Influence of CD137L reverse signaling on myelopoiesis in acute and chronic inflammation” by Dr Tang QuianQiao and delivered by National University of Singapore (NUS)

2012: Lecturer for the 

1) the Hong Kong University (HKU) Pasteur Immunology Course, Hong Kong,
2) the National University of Singapore (NUS) Immunology Course, Singapore,
3) first IFReC-SIgN Winter School on Advanced Immunology, Iwaji, Japan,
4) the Flow Cytometry Seminar of the 5rth International Symposium of the Singapore Society for Immunology (SgSI)

2011: Lecturer for

1) the Hong Kong University (HKU) Pasteur Immunology Course, Hong Kong,
2) the National University of Singapore (NUS) Immunology Course, Singapore,
3) Examiner for a PhD entitled “Homeostasis of Langerhans and dendritic cells in health and disease” by Dr Venetia Hart Bigley and delivered by Newcastle University and
4) Examiner for a PhD entitled “The identification of Cis-regulatory elements of Runx3” by Dr Giselle Nah Sek Suan and delivered by Nanyang Technological University (NTU)

2010: Lecturer for

1) the Hong Kong University (HKU) Pasteur Immunology Course, Hong Kong,
2) the National University of Singapore (NUS) Immunology Course, Singapore,
3) the Nanyang Technological University (NTU) Advanced Immunology Course, Singapore,
4) the Singapore Immunology Network (SIgN) Immunotechnologies Training Course (ITTC), Singapore 

2009: Lecturer for

1) the Hong Kong University (HKU) Pasteur Immunology Course, Hong Kong,
2) the Nanyang Technological University (NTU) Advanced Immunology Course, Singapore and
3) the Singapore Immunology Network (SIgN) Immunotechnologies Training Course (ITTC), Singapore

2003: Teacher for the Experimental Virology Course for Certificate Level, Faculty of Science, Evry University, France

2001: Teacher in Genetics for Bachelor Degree Level, Faculty of Science, Evry University, France

Honours & Awards

2014: European Macrophage and Dendritic Cell Society Junior Prize

2013: EMBO Young Investigator (YIP)

2011: RIKEN Research Center for Allergy and Immunology RCAI International Collaboration Award

2008:  Best Paper Award of the 10th International Symposium on Dendritic Cells (DC2008)

2008: Travel Award for the 8th Annual Meeting of the Federation of Clinical Immunology Societies, (FOCIS 2008)

2008: J. Pritchard Award, 18th Nicholas Symposium

2007: SID Eugene M. Farber Travel Award, Montagna Symposium on the Biology of Skin

2007: Special fellow Award (3 years grant) from the Leukemia and Lymphoma Society

2006: Keystone Symposia Scholarship Award

2006: One year postdoctoral grant from the Philippe Foundation

2004: One year postdoctoral research fellowship from the “Association de la Recherche contre le Cancer” (ARC)

2003: Member of the “French Society of Immunology” (SFI)

1999: Student fellowship from the “Association des Anciens Eleves de l’Institut Pasteur” (AAEIP)