Laurent RÉNIA

Principal Investigator

Executive Director of SIgN; Adj. Prof (NUS), Adj. Prof (NTU)


  • Carla CLASER, Ph.D
  • Teck Hui TEO, Ph.D
  • Yun Shan GOH, Ph.D
  • Wenn Chyau LEE, Ph.D
  • Khairunnisa GHAFFAR, Ph.D
  • Cheryl CHIA, Ph.D
  • Alice ONG
  • Zi Wei CHANG
  • Daniel MCQUIRE Ph.D Student
  • Samantha NGUEE Ph.D Student
  • Yew Wai LEONG Ph.D Student

Profile

Research Focus

Malaria is one of the most serious infectious diseases of humans, with 300–600 million clinical cases and 1-2 million deaths annually. Adaptive immune responses in the host limit the clinical impact of infection and provide partial protection against pathogen replication; most infections are clinically silent, as a result. In non-immune individuals, infections are more clinically overt, and a minority of these can become severe or life threatening, manifesting a range of overlapping syndromes with complex aetiologies. Our objectives are two fold: firstly, to identify correlates of protection or pathology during Plasmodium infection.

This will allow us to determine whether the immune responses associated with specific antigens play a role in protection, and subsequently to identify the mechanisms of this protection. Secondly we aim to define the basis of parasite sequestration and how the immune system can participate or interfere with this process.

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Biography

Laurent Renia obtained his PhD in 1991 at the Universite Pierre et Marie Curie in Paris, France where he studied the immune response against the pre-ertythrocytic phase of malaria. He continued to work on malaria immunology in New York University (1991-1992).

He then returned to Paris in 1993 where he obtained a permanent position as junior research scientist at the French National Institute of Health (INSERM) studying malaria immunology at the INSERM Unit 313 of the Hopital Pitie-Salpetriere in Paris. He moved to the INSERM Unit 445 at the Institut Cochin in Paris where he started his own group in 1997. Between 2001-2006, he became research director at INSERM, and co-director and director of the Department of Immunology at the Institut Cochin. He joined SIgN in 2007.

Projects

  • Elucidating the mechanisms of malaria immunopathology

    The objective of this work is to define the basis of parasite sequestration and understand how the immune system can participate or interfere with this process. To answer these questions, we are using human parasites in vitro alongside a rodent malaria model, complimented with a novel set of tools and techniques.

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  • Identification and validation of immune correlates of protection against malaria infection

    Our project focuses on the identification of correlates of immune protection against blood stage malaria. We aim to identify the antigens involved in natural immunity or in protection after vaccination, and to study the T lymphocytes and antibodies that are involved.

    read more

Publications

2018

Lum FM, Couderc T, Chia BS, Ong RY, Her Z, Chow A, Leo YS, Kam YW, Rénia L, Lecuit M, Ng LFP. Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity. Sci Rep. 2018 Jan 30;8(1):1860.

de Camargo TM, de Freitas EO, Gimenez AM, Lima LC, de Almeida Caramico K, Françoso KS, Bruna-Romero O, Andolina C, Nosten F, Rénia L, Ertl HCJ, Nussenzweig RS, Nussenzweig V, Rodrigues MM, Reyes-Sandoval A, Soares IS. Prime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge. Sci Rep. 2018 Jan 18;8(1):1118.

Cravo P, Machado RB, Leite JA, Leda T, Suwanarusk R, Bittencourt N, Albrecht L, Judice C, Lopes SCP, Lacerda MVG, Ferreira MU, Soares IS, Goh YS, Bargieri D, Nosten F, Russell B, Rénia L, Costa FTM. In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate. Malar J. 2018 Jan 10;17(1):20.

Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. 2018 Jan 5;359(6371):48-55.

Feng G, Li JLY, Claser C, Balachander A, Tan Y, Goh CC, Kwok IWH, Rénia L, Tang BZ, Ng LG, Liu B. Dual modal ultra-bright nanodots with aggregation-induced emission and gadolinium-chelation for vascular integrity and leakage detection. Biomaterials. 2018 Jan;152:77-85.

2017

Gun SY, Claser C, Teo TH, Howland SW, Poh CM, Chye RRY, Ng LFP, Rénia L. Interferon Regulatory Factor 1 is essential for pathogenic CD8+ T cell migration and retention in the brain during experimental cerebral malaria. Cell Microbiol. 2017 Dec 27. [Epub ahead of print]

Basilico N, Parapini S, Sparatore A, Romeo S, Misiano P, Vivas L, Yardley V, Croft SL, Habluetzel A, Lucantoni L, Renia L, Russell B, Suwanarusk R, Nosten F, Dondio G, Bigogno C, Jabes D, Taramelli D. In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial. Molecules. 2017 Dec 1;22(12).

Pang SC, Andolina C, Malleret B, Christensen PR, Lam-Phua SG, Razak MABA, Chong CS, Li D, Chu CS, Russell B, Rénia L, Ng LC, Nosten F. Singapore's Anopheles sinensis Form A is susceptible to Plasmodium vivax isolates from the western Thailand-Myanmar border. Malar J. 2017 Nov 16;16(1):465.

Teo TH, Howland SW, Claser C, Gun SY, Poh CM, Lee WW, Lum FM, Ng LF, Rénia L. Co-infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium-induced neuropathology. EMBO Mol Med. 2017 Nov 7. [Epub ahead of print]

Chu TTT, Sinha A, Malleret B, Suwanarusk R, Park JE, Naidu R, Das R, Dutta B, Ong ST, Verma NK, Chan JK, Nosten F, Rénia L, Sze SK, Russell B, Chandramohanadas R. Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 2017 Nov 2. [Epub ahead of print]

Claser C, Chang ZW, Russell B, Renia L. Adaptive immunity is essential in preventing recrudescence of Plasmodium yoelii malaria parasites after artesunate treatment. Cell Microbiol. 2017 Nov;19(11). 

Chen J, Rénia L, Ginhoux F. Constructing cell lineages from single-cell transcriptomes. Mol Aspects Med. 2017 Oct 28. [Epub ahead of print]

Gimenez AM, Lima LC, Françoso KS, Denapoli PMA, Panatieri R, Bargieri DY, Thiberge JM, Andolina C, Nosten F, Renia L, Nussenzweig RS, Nussenzweig V, Amino R, Rodrigues MM, Soares IS. Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite. Front Immunol. 2017 Oct 11;8:1275.

Kosaisavee V, Suwanarusk R, Chua ACY, Kyle DE, Malleret B, Zhang R, Imwong M, Imerbsin R, Ubalee R, Sámano-Sánchez H, Yeung BKS, Ong J, Lombardini E, Nosten F, Tan KSW, Bifani P, Snounou G, Rénia L, Russell B. Strict Tropism for CD71+/ CD234+ Human Reticulocytes Limits Plasmodium cynomolgi's Zoonotic Potential. Blood. 2017 Sep 14;130(11):1357-1363.

Landier J, Kajeechiwa L, Thwin MM, Parker DM, Chaumeau V, Wiladphaingern J, Imwong M, Miotto O, Patumrat K, Duanguppama J, Cerqueira D, Malleret B, Rénia L, Nosten S, von Seidlein L, Ling C, Proux S, Corbel V, Simpson JA, Dondorp AM, White NJ, Nosten FH. Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: A pilot trial in four villages of Eastern Myanmar. Wellcome Open Res. 2017 Sep 6. [Epub ahead of print]

Bancone G, Kalnoky M, Chu CS, Chowwiwat N, Kahn M, Malleret B, Wilaisrisak P, Rénia L, Domingo GJ, Nosten F. The G6PD flow-cytometric assay is a reliable tool for diagnosis of G6PD deficiency in women and anaemic subjects. Sci Rep. 2017 Aug 29;7(1):9822.

Carroll MW, Haldenby S, Rickett NY, Pályi B, Garcia-Dorival I, Liu X, Barker G, Bore JA, Koundouno FR, Williamson ED, Laws TR, Kerber R, Sissoko D, Magyar N, Di Caro A, Biava M, Fletcher TE, Sprecher A, Ng LFP, Rénia L, Magassouba N, Günther S, Wölfel R, Stoecker K, Matthews DA, Hiscox JA. Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut. mSphere. 2017 Aug 23;2(4).

Takata K, Kozaki T, Lee CZW, Thion MS, Otsuka M, Lim S, Utami KH, Fidan K, Park DS, Malleret B, Chakarov S, See P, Low D, Low G, Garcia-Miralles M, Zeng R, Zhang J, Goh CC, Gul A, Hubert S, Lee B, Chen J, Low I, Shadan NB, Lum J, Wei TS, Mok E, Kawanishi S, Kitamura Y, Larbi A, Poidinger M, Renia L, Ng LG, Wolf Y, Jung S, Önder T, Newell E, Huber T, Ashihara E, Garel S, Pouladi MA, Ginhoux F. Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function. Immunity. 2017 Jul 18;47(1):183-198.e6.

Bancone G, Malleret B, Suwanarusk R, Chowwiwat N, Chu CS, McGready R, Rénia L, Nosten F, Russell B. Asian G6PD-Mahidol reticulocytes sustain normal Plasmodium vivax development. J Infect Dis. 2017 Jul 15;216(2):263-266.

Kam YW, Leite JA, Lum FM, Tan JJL, Lee B, Judice CC, Teixeira DAT, Andreata-Santos R, Vinolo MA, Angerami R, Resende MR, Freitas ARR, Amaral E, Junior RP, Costa ML, Guida JP, Arns CW, Ferreira LCS, Rénia L, Proença-Modena JL, Ng LFP, Costa FTM, Zika-Unicamp Network. Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil. J Infect Dis. 2017 Jul 15;216(2):172-181.

See P, Dutertre CA, Chen J, Günther P, McGovern N, Irac SE, Gunawan M, Beyer M, Händler K, Duan K, Sumatoh HRB, Ruffin N, Jouve M, Gea-Mallorquí E, Hennekam RCM, Lim T, Yip CC, Wen M, Malleret B, Low I, Shadan NB, Fen CFS, Tay A, Lum J, Zolezzi F, Larbi A, Poidinger M, Chan JKY, Chen Q, Renia L, Haniffa M, Benaroch P, Schlitzer A, Schultze JL, Newell EW, Ginhoux F. Mapping the human DC lineage through the integration of high-dimensional techniques. Science. 2017 Jun 9;356(6342).

Malleret B, Rénia L, Russell B. The unhealthy attraction of Plasmodium vivax to reticulocytes expressing transferrin receptor 1 (CD71). Int J Parasitol. 2017 Jun;47(7):379-383.

Preiser P, Renia L, Bozdech Z, Tan K, Russell B, Cooke BM. Singapore Malaria Network Meeting (SingMalNet) 2016. Int J Parasitol. 2017 Jun;47(7):369-370.

Claser C, De Souza JB, Thorburn SG, Grau GE, Riley EM, Rénia L, Hafalla JC. Host resistance to Plasmodium-induced acute immune pathology is regulated by IL-10 receptor signalling. Infect Immun. 2017 May 23;85(6).

Rocha MV, Françoso KS, Lima LC, Camargo TM, Machado RL, Costa FT, Rénia L, Nosten F, Russell B, Rodrigues MM, Soares IS. Generation, characterization and immunogenicity of a novel chimeric recombinant protein based on Plasmodium vivax AMA-1 and MSP119. Vaccine. 2017 Apr 25;35(18):2463-2472.

Kam YW, Lee CY, Teo TH, Howland SW, Amrun SN, Lum FM, See P, Kng NQ, Huber RG, Xu MH, Tan HL, Choo A, Maurer-Stroh S, Ginhoux F, Fink K, Wang CI, Ng LFP, Rénia L. Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections. JCI Insight. 2017 Apr 20;2(8). [Epub ahead of print]

Srisutham S, Saralamba N, Malleret B, Rénia L, Dondorp AM, Imwong M. Four human Plasmodium species quantification using droplet digital PCR. PLoS One. 2017 Apr 19;12(4):e0175771.

Lum FM, Low DK, Fan Y, Tan JJ, Lee B, Chan JK, Rénia L, Ginhoux F, Ng LF. Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation. Clin Infect Dis. 2017 Apr 1;64(7):914-920.

Teo TH, Chan YH, Lee WW, Lum FM, Amrun SN, Her Z, Rajarethinam R, Merits A, Rötzschke O, Rénia L, Ng LF. Fingolimod treatment abrogates chikungunya virus-induced arthralgia. Sci Transl Med. 2017 Feb 1;9(375).

Cho JS, Russell B, Kosaisavee V, Zhang R, Colin Y, Bertrand O, Chandramohanadas R, Chu CS, Nosten F, Renia L, Malleret B. Corrigendum to "Unambiguous determination of Plasmodium vivax reticulocyte invasion by flow cytometry" [Int. J. Parasitol. 46 (2016) 31-39]. Int J Parasitol. 2017 Jan 13. [Epub ahead of print]

Her Z, Kam YW, Gan VC, Lee B, Thein TL, Tan JJ, SIgN Immunomonitoring Platform, Lee LK, Fink K, Lye DC, Renia L, Leo YS, Ng LF. Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection. J Infect Dis. 2017 Jan 1;215(1):42-51

2016

Peng K, Goh YS, Siau A, Franetich JF, Chia WN, Ong AS, Malleret B, Wu YY, Snounou G, Hermsen CC, Adams JH, Mazier D, Preiser PR, Sauerwein RW, Grüner AC, Rénia L. Breadth of humoral response and antigenic targets of sporozoite-inhibitory antibodies associated with sterile protection induced by controlled human malaria infection. Cell Microbiol. 2016 Dec;18(12):1739-1750.

Lee WW, Teo TH, Lum FM, Andiappan AK, Amrun SN, Rénia L, Rötzschke O, Ng LF. Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice. Sci Rep. 2016 Nov 25;6:37603.

Rénia L, Goh YS. Malaria Parasites: The Great Escape. Front Immunol. 2016 Nov 7;7:463.

Chang ZW, Malleret B, Russell B, Renia L, Claser C. An ex-vivo maturation assay for testing antimalarial sensitivity of rodent malaria parasites. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6859-6866.

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 Oct 17;213(11):2293-2314.

Lim MY, LaMonte G, Lee MC, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A, Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GM, Ho PC, Yeung BK, Chow ED, Lim L, Fidock DA, Diagana TT, Winzeler EA, Bifani P. UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nat Microbiol. 2016 Sep 19;1:16166.

Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, Yarski M, Poh CM, Lee JS, Cooper MA, Rénia L, Richard D, McCarthy JS, Sharpe AH, Wykes MN. Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity. Immunity. 2016 Aug 16;45(2):333-45.

Zhang R, Lee WC, Lau YL, Albrecht L, Lopes SC, Costa FT, Suwanarusk R, Nosten F, Cooke BM, Rénia L, Russell B. Rheopathologic Consequence of Plasmodium vivax Rosette Formation. PLoS Negl Trop Dis. 2016 Aug 10;10(8):e0004912.

Gupta P, Lai SM, Sheng J, Tetlak P, Balachander A, Claser C, Renia L, Karjalainen K, Ruedl C. Tissue-Resident CD169(+) Macrophages Form a Crucial Front Line against Plasmodium Infection. Cell Rep. 2016 Aug 9;16(6):1749-61.

Goh YS, Peng K, Chia WN, Siau A, Chotivanich K, Gruner AC, Preiser P, Mayxay M, Pukrittayakamee S, Sriprawat K, Nosten F, White NJ, Renia L. Neutralizing Antibodies against Plasmodium falciparum Associated with Successful Cure after Drug Therapy. PLoS One. 2016 Jul 18;11(7):e0159347.

Horne-Debets JM, Karunarathne DS, Faleiro RJ, Poh CM, Renia L, Wykes MN. Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria. Sci Rep. 2016 May 24;6:26210.

Russell B, Rénia L, Malleret B. Reply to "Flow Cytometry for Antimalarial Drug Testing: More than Meets the Eye". J Clin Microbiol. 2016 Mar;54(3):818-9.

Li JL, Lim CH, Tay FW, Goh CC, Devi S, Malleret B, Lee B, Bakocevic N, Chong SZ, Evrard M, Tanizaki H, Lim HY, Russell B, Renia L, Zolezzi F, Poidinger M, Angeli V, John AL, Harris JE, Tey HL, Tan SM, Kabashima K, Weninger W, Larbi A, Ng LG. Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation Through CXCL2. J Invest Dermatol. 2016 Feb;136(2):416-24.

Cho JS, Russell B, Kosasaivee V, Zhang R, Colin Y, Bertrand O, Chandramohanadas R, Chu CS, Nosten F, Renia L, Malleret B. Unambiguous determination of Plasmodium vivax reticulocyte invasion by flow cytometry. Int J Parasitol. 2016 Jan;46(1):31-9.

Zhang R, Suwanarusk R, Malleret B, Cooke BM, Nosten F, Ling LY, Dao M, Lim CT, Renia L, Tan KS, Russell B. A basis for rapid clearance of circulating ring-stage malaria parasites by the spiroindolone KAE609. J Infect Dis. 2016 Jan 1;213(1):100-4.

2015

Howland SW, Gun SY, Claser C, Poh CM, Rénia L. Measuring antigen presentation in mouse brain endothelial cells ex vivo and in vitro. Nat Protoc. 2015 Dec;10(12):2016-2026. 

Howland SW, Ng GX, Chia SK, Rénia L. Investigating proteasome inhibitors as potential adjunct therapies for experimental cerebral malaria. Parasite Immunol. 2015 Nov;37(11):599-604.

Woodrow CJ, Wangsing C, Sriprawat K, Christensen P, Nosten F, Rénia L, Russell B, Malleret B. A comparison between flow cytometry, microscopy and lactate dehydrogenase ELISA for Plasmodium falciparum drug-susceptibility testing under field conditions. J Clin Microbiol. 2015 Oct;53(10):3296-303.

Leite JA, Bargieri DY, Carvalho BO, Albrecht L, Lopes SC, Kayano AC, Farias AS, Chia WN, Claser C, Malleret B, Russell B, Castiñeiras C, Santos LM, Brocchi M, Wunderlich G, Soares IS, Rodrigues MM, Rénia L, Costa FT. Immunization with the MAEBL M2 domain protects against lethal Plasmodium yoelii infection. Infect Immun. 2015 Oct;83(10):3781-92.

Imwong M, Nguyen TN, Tripura R, Peto TJ, Lee SJ, Lwin KM, Suangkanarat P, Jeeyapant A, Vihokhern B, Wongsaen K, Van Hue D, Dong le T, Nguyen TU, Lubell Y, von Seidlein L, Dhorda M, Promnarate C, Snounou G, Malleret B, Rénia L, Keereecharoen L, Singhasivanon P, Sirithiranont P, Chalk J, Nguon C, Hien TT, Day N, White NJ, Dondorp A, Nosten F. The epidemiology of subclinical malaria infections in South-East Asia: findings from cross-sectional surveys in Thailand-Myanmar border areas, Cambodia, and Vietnam. Malar J. 2015 Sep 30;14(1):381.

Andolina C, Landier J, Carrara V, Chu CS, Franetich JF, Roth A, Rénia L, Roucher C, White NJ, Snounou G, Nosten F. The suitability of laboratory-bred Anopheles cracens for the production of Plasmodium vivax sporozoites. Malar J. 2015 Aug 12;14:312. 

Teo TH, Her Z, Tan JJ, Lum FM, Lee WW, Chan YH, Ong RY, Kam YW, Leparc-Goffart I, Gallian P, Rénia L, de Lamballerie X, Ng LF. Caribbean and La Réunion Chikungunya virus isolates differ in their capacity to induce pro-inflammatory Th1 and NK cell responses and acute joint pathology. J Virol. 2015 Aug 1;89(15):7955-69. 

de Cassan SC, Shakri AR, Llewellyn D, Elias SC, Cho JS, Goodman AL, Jin J, Douglas AD, Suwanarusk R, Nosten FH, Rénia L, Russell B, Chitnis CE, Draper SJ. Preclinical Assessment of Viral Vectored and Protein Vaccines Targeting the Duffy-Binding Protein Region II of Plasmodium Vivax. Front Immunol. 2015 Jul 8;6:348. 

Schlitzer A, Sivakamasundari V, Chen J, Sumatoh HR, Schreuder J, Lum J, Malleret B, Zhang SQ, Larbi A, Zolezzi F, Renia L, Poidinger M, Naik S, Newell EW, Robson P, Ginhoux F. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat Immunol. 2015 Jul;16(7):718-28.

Howland SW, Poh CM, Rénia L. Activated Brain Endothelial Cells Cross-Present Malaria Antigen. PLoS Pathog. 2015 Jun 5;11(6):e1004963. 

Lee WW, Teo TH, Her Z, Lum FM, Kam YW, Haase D, Rénia L, Rötzschke O, Ng LF. Expanding regulatory T cells alleviates chikungunya virus-induced pathology in mice. J Virol. 2015 May 20. [Epub ahead of print] 

Howland SW, Claser C, Poh CM, Gun SY, Rénia L. Pathogenic CD8+ T cells in experimental cerebral malaria. Semin Immunopathol. 2015 May;37(3):221-31.

Lee KG, Kim SS, Kui L, Voon DC, Mauduit M, Bist P, Bi X, Pereira NA, Liu C, Sukumaran B, Rénia L, Ito Y, Lam KP. Bruton's Tyrosine Kinase Phosphorylates DDX41 and Activates Its Binding of dsDNA and STING to Initiate Type 1 Interferon Response. Cell Rep. 2015 Feb 24;10(7):1055-65.

Teng Y, Suwanarusk R, Ngai MH, Srinivasan R, Ong AS, Ho B, Rénia L, Chai CL. An amidation/cyclization approach to the synthesis of N-hydroxyquinolinones and their biological evaluation as potential anti-plasmodial, anti-bacterial, and iron(II)-chelating agents. Bioorg Med Chem Lett. 2015 Feb 1;25(3):607-10.

Malmquist NA, Sundriyal S, Caron J, Chen P, Witkowski B, Menard D, Suwanarusk R, Renia L, Nosten F, Jiménez-Díaz MB, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Wittlin S, Duffy S, Avery VM, Ruecker A, Delves MJ, Sinden RE, Fuchter MJ, Scherf A. Histone methyltransferase inhibitors: orally bioavailable, fast acting molecules with activity against different human malaria species. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9.

Malleret B, Li A, Zhang R, Tan KS, Suwanarusk R, Claser C, Cho JS, Koh EG, Chu CS, Pukrittayakamee S, Ng ML, Ginhoux F, Ng LG, Lim CT, Nosten F, Snounou G8, Rénia L, Russell B. Plasmodium vivax: restricted tropism and rapid remodelling of CD71 positive reticulocytes. Blood. 2015 Feb 19;125(8):1314-24.

Edwards CL, Best SE, Gun SY, Claser C, James KR, de Oca MM, Sebina I, de Labastida Rivera F, Amante FH, Hertzog PJ, Engwerda CR, Renia L, Haque A. Spatio-temporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection. Eur J Immunol. 2015 Jan;45(1):130-41.

Suwanarusk R, Russell B, Ong A, Sriprawat K, Chu SC, PyaePhyo A, Malleret B, Nosten F, Renia L. Methylene blue inhibits the asexual development of vivax malaria parasites from a region of increasing chloroquine resistance. J Antimicrob Chemoth. 2015 Jan;70(1):124-9.

2014

Her Z, Teng TS, Tan JJ, Teo TH, Kam YW, Lum FM, Lee WW, Gabriel C, Melchiotti R, Andiappan AK, Lulla V, Lulla A, Win MK, Chow A, Biswas SK, Leo YS, Lecuit M, Merits A, Rénia L, Ng LF. Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response. EMBO Mol Med. 2014 Dec 1;7(1):24-41.

Chia WN, Goh YS, Renia L. Novel approaches to identify protective malaria vaccine candidates. Front Microbiol. 2014 Nov 17;5:586.

Poh CM, Howland SW, Grotenbreg GM, Rénia L. Damage to the blood-brain barrier during experimental cerebral malaria results from the synergistic effects of CD8+ T cells with different specificities. Infect Immun. 2014 Nov;82(11):4854-64.

Chandramohanadas R, Basappa, Russell B, Liew K, Yau YH, Chong A, Min L, Gunalan K, Raman R, Renia L, Nosten F, Geifman Shochat S, Dao M, Sasisekharan R, Suresh S, Preiser P. Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevent Host Invasion of Divergent Plasmodial Species. J Infect Dis. 2014 Nov 15;210(10):1616-26.

Loh CC, Suwanarusk R, Lee YQ, Chan KW, Choy KY, Rénia L, Russell B, Lear MJ, Nosten FH, Tan KS, Chow LM. Characterization of the Commercially-Available Fluorescent Chloroquine-BODIPY Conjugate, LynxTag-CQGREEN, as a Marker for Chloroquine Resistance and Uptake in a 96-Well Plate Assay. PLoS One. 2014 Oct 24;9(10):e110800. 

Gun SY, Claser C, Tan K, Renia L. Interferons and Interferon Regulatory Factors in Malaria. Mediat Inflamm. 2014;2014:243713.

Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, Vd Vegte-Bolmer M, V Gemert GJ, Wirjanata G, Sebayang B, Marfurt J, Russell B, Suwanarusk R, Price RN, Nosten F, Tungtaeng A, Gettayacamin M, Sattabongkot J, Taylor J, Walker JR, Tully D, Patra KP, Flannery EL, Vinetz JM, Renia L, Sauerwein RW, Winzeler EA, Glynne RJ, Diagana TT. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission. Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7

Imwong M, Hanchana S, Malleret B, Rénia L, Day NP, Dondorp A, Nosten F, Snounou G, White NJ. High throughput ultra-sensitive molecular techniques to quantify low density malaria parasitaemias. J Clin Microbiol. 2014 Sep;52(9):3303-9.

Rénia L, Howland SW. Targeting the olfactory bulb during experimental cerebral malaria. Trends Parasitol. 2014 Aug;30(8):375-6.

Tan JJ, Capozzoli M, Sato M, Watthanaworawit W, Ling CL, Mauduit M, Malleret B, Grüner AC, Tan R, Nosten FH, Snounou G, Rénia L, Ng LF. An integrated lab-on-chip for rapid identification and simultaneous differentiation of tropical pathogens. PLoS Negl Trop Dis. 2014 Jul 31;8(7):e3043. 

Ch'ng JH, Lee YQ, Gun SY, Chia WN, Chang ZW, Wong LK, Batty KT, Russell B, Nosten F, Renia L, Tan KS. Validation of a chloroquine-induced cell death mechanism for clinical use against malaria. Cell Death Dis. 2014 Jun 26;5:e1305.

Haque A, Best SE, Montes de Oca M, James KR, Ammerdorffer A, Edwards CL, de Labastida Rivera F, Amante FH, Bunn PT, Sheel M, Sebina I, Koyama M, Varelias A, Hertzog PJ, Kalinke U, Gun SY, Rénia L, Ruedl C, Macdonald KP, Hill GR, Engwerda CR. Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity. J Clin Invest. 2014 Jun 2;124(6):2483-96.

Bakocevic N, Claser C, Yoshikawa S, Jones LA, Chew S, Goh CC, Malleret B, Larbi A, Ginhoux F, de Lafaille MC, Karasuyama H, Renia L, Ng LG. CD41 is a reliable identification and activation marker for murine basophils in the steady-state and during helminth and malarial infections. Eur J Immunol. 2014 Jun;44(6):1823-34.

Lee WC, Malleret B, Lau YL, Mauduit M, Fong MY, Cho JS, Suwanarusk R, Zhang R, Albrecht L, Costa FT, Preiser P, McGready R, Renia L, Nosten F, Russell B. Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes. Blood. 2014 May 1;123(18):e100-9.

Siau A, Huang X, Yam XY, Bob NS, Sun H, Rajapakse JC, Renia L, Preiser PR. Identification of a new export signal in Plasmodium Yoelii: identification of a new exportome. Cell Microbiol. 2014 May;16(5):673-86.  

Lopes SC, Albrecht L, Carvalho BO, Siqueira AM, Thomson-Luque R, Nogueira PA, Fernandez-Becerra C, Del Portillo HA, Russell BM, Rénia L, Lacerda MV, Costa FT. Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential. J Infect Dis. 2014 May 1;209(9):1403-7.

Vicentin EC, Françoso KS, Rocha MV, Iourtov D, Dos Santos FL, Kubrusly FS, Sakauchi MA, Raw I, Nosten F, Rénia L, Rodrigues MM, Russell B, Soares IS. Invasion-Inhibitory Antibodies Elicited by Immunization with Plasmodium vivax Apical Membrane Antigen-1 Expressed in Pichia pastoris Yeast. Infect Immun. 2014 Mar;82(3):1296-307.

Claser C, Malleret B, Peng K, Bakocevic N, Gun SY, Russell B, Ng LG, Rénia L. Rodent Plasmodium-infected red blood cells: Imaging their fates and interactions within their hosts. Parasitol Int. 2014 Feb;63(1):187-94. 

2013

Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, Macdonald KP, Good MF, Renia L, Ahmed R, Sharpe AH, Wykes MN. PD-1 Dependent Exhaustion of CD8(+) T Cells Drives Chronic Malaria. Cell Rep. 2013 Dec 12;5(5):1204-13.

McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Nagle A, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman A-M, Dechering KJ, Kumar TR, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013 Dec 12;504(7479):248-53.

Malleret B, Xu F, Mohandas N, Suwanarusk R, Chu C, Leite JA, Low K, Turner C, Sriprawat K, Zhang R, Bertrand O, Colin Y, Costa FT, Ong CN, Ng ML, Lim CT, Nosten F, Rénia L, Russell B. Significant Biochemical, Biophysical and Metabolic Diversity in Circulating Human Cord Blood Reticulocytes. PLoS One. 2013 Oct 8;8(10):e76062.

Devi S, Wang Y, Chew WK, Lima R, A-González N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S, Keeble JL, Goh CC, Li JL, Evrard M, Malleret B, Larbi A, Renia L, Haniffa M, Tan SM, Chan JK, Balabanian K, Nagasawa T, Bachelerie F, Hidalgo A, Ginhoux F, Kubes P, Ng LG. Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med. 2013 Oct 21;210(11):2321-36.

Russell B, Malleret B, Suwanarusk R, Anthony C, Kanlaya S, Lau YL, Woodrow CJ, Nosten F, Renia L. Field-based flow cytometry for ex vivo characterization of Plasmodium vivax and P. falciparum antimalarial sensitivity. Antimicrob Agents Chemother. 2013 Oct;57(10):5170-4.

Koh S, Shimasaki N, Suwanarusk R, Ho ZZ, Chia A, Banu N, Wu Howland S, Ong AS, Gehring AJ, Stauss H, Renia L, Sällberg M, Campana D, Bertoletti A. A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus. Mol Ther Nucleic Acids. 2013 Aug 13;2:e114.

Howland SW, Poh CM, Gun SY, Claser C, Malleret B, Shastri N, Ginhoux F, Grotenbreg GM, Rénia L. Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria. EMBO Mol Med. 2013 Jul;5(7):984-99.

Lum FM, Teo TH, Lee WW, Kam YW, Rénia L, Ng LF. An Essential Role of Antibodies in the Control of Chikungunya Virus Infection. J Immunol. 2013 Jun 15;190(12):6295-302.

Guermonprez P, Helft J, Claser C, Deroubaix S, Karanje H, Gazumyan A, Darasse-Jèze G, Telerman SB, Breton G, Schreiber HA, Frias-Staheli N, Billerbeck E, Dorner M, Rice CM, Ploss A, Klein F, Swiecki M, Colonna M, Kamphorst AO, Meredith M, Niec R, Takacs C, Mikhail F, Hari A, Bosque D, Eisenreich T, Merad M, Shi Y, Ginhoux F, Rénia L, Urban BC, Nussenzweig MC. Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat Med. 2013 Jun;19(6):730-8.

SchlitzerA, McGovern N, Teo P, Zelante T, Atarashi K, Low D, Ho AW, See P, Shin A, Wasan PS, Hoeffel G,  Malleret B, Heiseke A, Chew S, Jardine L, Purvis HA, Hilkens CM, John Tam J, Poidinger M, Stanley RE, Krug AB, Renia L, Sivasankar B, Ng LG, Collin M, Ricciardi-Castagnoli P, Honda K, Haniffa M, Ginhoux F. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity. 2013 May 23;38(5):970-983. 

Lee WC, Russell B, Lau YL, Fong MY, Chu C, Sriprawat K, Suwanarusk R, Nosten F, Renia L. Giemsa-stained wet mount based method for reticulocyte quantification: a viable alternative in resource limited or malaria endemic settings. PLoS One. 2013;8(4):e60303.

Bittencourt AR, Vicentin EC, Jimenez MC, Ricci R, Leite JA, Costa FT, Ferreira LC, Russell B, Nosten F, Rénia L, Galinski MR, Barnwell JW, Rodrigues MM, Soares IS. Antigenicity and Immunogenicity of Plasmodium vivax Merozoite Surface Protein-3. PLoS One. 2013;8(2):e56061.

Rénia L, Grüner AC, Mauduit M, Snounou G. Vaccination using normal live sporozoites under drug treatment. Methods Mol Biol. 2013;923:567-76.

Li A, Rénia L, Lim CT, Russell B. Atomic force microscopy of Plasmodium-infected red blood cells: detecting and localizing single molecular recognition events. Methods Mol Biol. 2013;923:299-305.

2012

Teo TH, Lum FM, Claser C, Lulla V, Lulla A, Merits A, Rénia L, Ng LF. A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice. J Immunol. 2012 Dec 3. [Epub ahead of print]

Kam YW, Lee WW, Simarmata D, Harjanto S, Teng TS, Tolou H, Chow A, Lin RT, Leo YS, Rénia L, Ng LF. Longitudinal analysis of the human antibody response to chikungunya virus infection: implications for sero-diagnosis assays and vaccine development. J Virol. 2012 Dec;86(23):13005-15.

Russell B, Suwanarusk R, Malleret B, Costa FT, Snounou G, Kevin Baird J, Nosten F, Rénia L. Human ex vivo studies on asexual Plasmodium vivax: the best way forward. Int J Parasitol. 2012 Nov;42(12):1063-70.

Costa FT, Lopes SC, Albrecht L, Ataíde R, Siqueira AM, Souza RM, Russell B, Renia L, Marinho CR, Lacerda MV. On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field. Int J Parasitol. 2012 Nov;42(12):1099-105.

Snounou G, Escalante A, Kasenene J, Rénia L, Grüner AC, Krief S. [Malaria in hominids]. (Article in French) Bull Acad Natl Med. 2012 Nov;195(8):1945-54.

Phanpoowong T, Lek-Uthai U, Thongrungkiat S, Komalamisra N, Srisawat R, Russell B, Renia L. Dengue-2 Virus Carrying Capacity of Thai Aedes Aegypti Strains with Different Susceptibility to Deltamethrin. Southeast Asian J Trop Med Public Health 2012;43(3):634-40.

Mauduit M, See P, Peng K, Rénia L, Ginhoux F. Dendritic cells and the malaria pre-erythrocytic stage. Immunol Res. 2012 Sep;53(1-3):115-26.

Piva L, Tetlak P, Claser C, Karjalainen K, Renia L, Ruedl C. Cutting Edge: Clec9A+ Dendritic Cells Mediate the Development of Experimental Cerebral Malaria. J Immunol. 2012 Aug 1;189(3):1128-32.

Her Z, Lum FM, Chow A, Leo YS, Rénia L, Chiocchia G, Ng LF. Reply - Involvement of RANKL and Osteoprotegerin in Chikungunya Fever. J Infect Dis. 2012 Aug;206(3):457-9.

Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, Wasan PS, Wang XN, Malinarich F, Malleret B, Larbi A, Tan P, Zhao H, Poidinger M, Pagan S, Cookson S, Dickinson R, Dimmick I, Jarrett RF, Renia L, Tam J, Song C, Connolly J, Chan JK, Gehring A, Bertoletti A, Collin M, Ginhoux F. Human Tissues Contain CD141(hi) Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103(+) Nonlymphoid Dendritic Cells. Immunity. 2012 Jul 27;37(1):60-73.

Chan CL, Rénia L, Tan KS. A Simplified, Sensitive Phagocytic Assay for Malaria Cultures Facilitated by Flow Cytometry of Differentially-Stained Cell Populations. PLoS ONE. 2012; 7(6):e38523.

Ch'ng JH, Renia L, Nosten F, Tan KS. Can we teach an old drug new tricks? Trends Parasitol. 2012 2012 Jun;28(6):220-4.

Hoeffel G, Wang Y, Greter M, See P, Teo P, Malleret B, Leboeuf M, Low D, Oller G, Almeida F, Choy SH, Grisotto M, Renia L, Conway SJ, Stanley ER, Chan JK, Ng LG, Samokhvalov IM, Merad M, Ginhoux F. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages. J Exp Med. 2012 Jun 4;209(6):1167-81.

Chotivanich K, Udomsangpetch R, Suwanarusk R, Pukrittayakamee S, Wilairatana P, Beeson JG, Day NP, White NJ. Plasmodium vivax Adherence to Placental Glycosaminoglycans. PLoS One. 2012;7(4):e34509.

Vaulont S, Rénia L, Labie D. [Malaria: is there a role for the iron-hepcidin axis?].[Article in French] Med Sci (Paris). 2012 May;28(5):462-4.

Kosaisavee V, Lek-Uthai U, Suwanarusk R, Grüner AC, Russell B, Nosten F, Rénia L, Snounou G. Genetic Diversity in New Members of the Reticulocyte Binding Protein Family in Thai Plasmodium vivax Isolates. PLoS One. 2012;7(3):e32105.

Kam YW, Lum FM, Teo TH, Lee WW, Simarmata D, Harjanto S, Chua CL, Chan YF, Wee JK, Chow A, Lin RT, Leo YS, Le Grand R, Sam IC, Tong JC, Roques P, Wiesmüller KH, Rénia L, Rötzschke O, Ng LF. Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein. EMBO Mol Med. 2012 Apr;4(4):330-43.

Kam YW, Simarmata D, Chow A, Her Z, Teng TS, Ong EK, Rénia L, Leo YS, Ng LF. Early appearance of neutralizing immunoglobulin G3 antibodies is associated With Chikungunya virus clearance and long-term clinical protection. J Infect Dis. 2012 Apr;205(7):1147-54.

Renia L, Wu Howland S, Claser C, Charlotte Gruner A, Suwanarusk R, Hui Teo T, Russell B, Ng L. Cerebral malaria: Mysteries at the blood-brain barrier. Virulence. 2012 Mar 1;3(2):193-201. 

Hafalla JCR, Claser C, Couper KN, Grau GE, Renia L, de Souza B, Riley EM. The CTLA-4 and PD-1/PD-L1 Inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. PLoS Pathog. 2012; 8(2):e1002504.

Borlon C, Russell B, Sriprawat K, Suwanarusk R, Erhart A, Renia L, Nosten F, D'Alessandro U. Cryopreserved Plasmodium vivax and cord blood reticulocytes can be used for invasion and short term culture. Int J Parasitol. 2012 Feb;42(2):155-60.

2011

Lee CY, Kam YW, Fric J, Malleret B, Koh EG, Prakash C, Huang W, Lee WW, Lin C, Lin RT, Renia L, Wang CI, Ng LF, Warter L. Chikungunya Virus Neutralization Antigens and Direct Cell-to-Cell Transmission Are Revealed by Human Antibody-Escape Mutants. PLoS Pathog. 2011 Dec;7(12):e1002390. Epub 2011 Dec 1.

Phyo AP, Lwin KM, Price RN, Ashley EA, Russell B, Sriprawat K, Lindegardh N, Singhasivanon P, White NJ, Nosten F. Dihydroartemisinin-Piperaquine Versus Chloroquine in the Treatment of Plasmodium vivax Malaria in Thailand: A Randomized Controlled Trial. Clin Infect Dis. 2011 Nov;53(10):977-84.

Proux S, Suwanarusk R, Barends M, Zwang J, Price RN, Leimanis M, Kiricharoen L, Laochan N, Russell B, Nosten F, Snounou G. Considerations on the use of nucleic acid-based amplification for malaria parasite detection. Malar J. 2011 Oct 28;10(1):323. [Epub ahead of print]

Russell B, Suwanarusk R, Borlon C, Costa FT, Chu CS, Rijken MJ, Sriprawat K, Warter L, Koh EG, Malleret B, Colin Y, Bertrand O, Adams JH, D'Alessandro U, Snounou G, Nosten F, Rénia L. A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. Blood. Sep 29 2011; 118(13):e74-81. 

Malleret B, Claser C, Ong ASM, Suwanarusk R, Sriprawat K, Howland SW, Russell B, Nosten F, Renia L. A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development. Sci. Rep. 2011;1:118.

Bouillet LE, Dias MO, Dorigo NA, Moura AD, Russell B, Nosten F, Renia L, Braga EM, Gazzinelli RT, Rodrigues MM, Soares IS, Bruna-Romero O. Long-term humoral and cellular immune responses elicited by a heterologous Plasmodium vivax Apical Membrane Antigen 1 protein-prime/adenovirus-boost immunization protocol. Infect Immun. Sep 2011; 79(9):3642-3652.

Russell B, Li A, Lim CT. Atomic Force Microscopy as a Nanotool to Investigate Malaria-Infected Erythrocytes. Bionanotechnology II: Global Prospects. 2011, CRC Press: 287-295. [Book Chapter]

Dhorda M, Nyehangane D, Renia L, Piola P, Guerin PJ, Snounou G. Transmission of Plasmodium vivax in South-Western Uganda: Report of Three Cases in Pregnant Women. PLoS One. 2011; 6(5):e19801.

Howland SW, Poh CM, Rénia L. Directional, seamless, and restriction enzyme-free construction of random-primed complementary DNA libraries using phosphorothioate-modified primers. Anal Biochem. 2011 Sep 1;416(1):141-3.

Mok S, Imwong M, Mackinnon MJ, Sim J, Ramaodoss R, Yi P, Mayxay M, Chotivanich K, Liong KY, Russel B, Socheat D, Newton PN, Day NP, White NJ, Preiser PR, Nosten F, Dondorp AM, Bozdech Z. Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics. 2011 Aug 3;12(1):391.

Rijken MJ, Boel ME, Russell B, Imwong M, Leimanis ML, Pyae Phyo A, Muehlenbachs A, Lindegardh N, McGready R, Renia L, Snounou G, Singhasivanon P, Nosten F. Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand. Malar J. 2011 May 5;10:113.

Kaewpongsri S, Sriprawat K, Suwanarusk R, Kyle DE, Lek-Uthai U, Leimanis M, Lwin KM, Phyo AP, Zwang J, Russell B, Nosten F, Renia L. The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Mar;55(3):1300-4.

Siswantoro H, Russell B, Ratcliff A, Prasetyorini B, Chalfein F, Marfurt J, Kenangalem E, Wuwung M, Piera KA, Ebsworth EP, Anstey NM, Tjitra E, Price RN. In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. Antimicrob Agents Chemother. 2011 Jan;55(1):197-202.

Claser C, Malleret B, Gun SY, Wong AY, Chang ZW, Teo P, See PC, Howland SW, Ginhoux F, Renia L. CD8 T Cells and IFN-gamma Mediate the Time-Dependent Accumulation of Infected Red Blood Cells in Deep Organs during Experimental Cerebral Malaria. PLoS One. 2011; 6(4):e18720.

Depinay N, Franetich JF, Gruner AC, Mauduit M, Chavatte JM, Luty AJ, van Gemert GJ, Sauerwein RW, Siksik JM, Hannoun L, Mazier D, Snounou G, Renia L. Inhibitory effect of TNF-alpha on malaria pre-erythrocytic stage development: influence of host hepatocyte/parasite combinations. PLoS One. 2011; 6(3):e17464.

Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF. Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating Factor. J Infect Dis. 2011 Jan;203(2):149-57.

Imwong M, Russell B, Suwanarusk R, Nzila A, Leimanis ML, Sriprawat K, Kaewpongsri S, Phyo AP, Snounou G, Nosten F, Renia L. Methotrexate Is Highly Potent Against Pyrimethamine-Resistant Plasmodium vivax. J Infect Dis. 2011 Jan;203(2):207-10.

2010

Price RN, Marfurt J, Chalfein F, Kenangalem E, Piera KA, Tjitra E, Anstey NM, Russell B. In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax. Antimicrob Agents Chemother. 2010 Dec;54(12):5146-50.

Li A, Russell B, Renia L, Lek-Uthai U, Nosten F, Lim CT. High density of 'spiky' excrescences covering the surface of an erythrocyte infected with Plasmodium malariae. Br J Haematol. Oct 2010; 151(1):1.

Rottmann M, McNamara C, Yeung BKS, Lee MCS, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Thierry T, Diagana TT. Spiroindolones, a Potent Compound Class for the Treatment of Malaria. Science. Sep 3 2010; 329(5996):1175-1180.

Carvalho BO, Lopes SC, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite JA, Rodrigues MM, Soares IS, Oliveira TR, Wunderlich G, Lacerda MV, del Portillo HA, Araujo MO, Russell B, Suwanarusk R, Snounou G, Renia L, Costa FT. On the cytoadhesion of Plasmodium vivax-infected erythrocytes. J Infect Dis. Aug 15 2010; 202(4):638-647.

Rénia L, Grüner AC, Snounou G. Cerebral malaria: in praise of epistemes. Trends Parasitol. 2010 Jun;26(6):275-7.

Matheoud D, Perié L, Hoeffel G, Vimeux L, Parent I, Marañón C, Bourdoncle P, Renia L, Prevost-Blondel A, Lucas B, Feuillet V, Hosmalin A. Crosspresentation by dendritic cells from live cells induces protective immune responses in vivo. Blood. 2010 Jun 3;115(22):4412-20. 

Her Z, Malleret B, Chan M, Ong EK, Wong SC, Kwek DJ, Tolou H, Lin RT, Tambyah PA, Rénia L, Ng LF. Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response. J Immunol. 2010, 184 (10), 5903-5913.

Leimanis ML, Jaidee A, Sriprawat K, Kaewpongsri S, Suwanarusk R, Barends M, Phyo AP, Russell B, Renia L, Nosten F. Plasmodium vivax Susceptibility to Ferroquine. Antimicrob Agents Chemother. 2010 May;54(5):2228-30.

Mauduit M, Tewari R, Depinay N, Kayibanda M, Lallemand E, Chavatte JM, Snounou G, Rénia L, Grüner AC. A minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites. Infect Immun. 2010 May;78(5):2182-8.

Jiménez JN, Snounou G, Letourneur F, Rénia L, Vélez ID, Muskus CE. Near-fixation of a Pfmsp1 block 2 allelic variant in genetically diverse Plasmodium falciparum populations across Western Colombia. Acta Trop. 2010 Apr;114(1):67-70.

Tong JC, Simarmata D, Lin RTP, Rénia L, Ng LFP. HLA class I restriction as a possible driving force for Chikungunya evolution. PLoS One. 2010 Feb 26;5(2): e9291.

Krief S, Escalante AA, Pacheco MA, Mugisha L, Andre C, Halbwaz M, Fischer A, Krief JM, Kasenene J, Cranfield M, Cornejo O, Chavatte JM, Lim C, Letourneur F, Gruner AC, McCutchan TF, Rénia L, Snounou G. On the Diversity of Malaria Parasites in African Apes and the Origin of Plasmodium falciparum from Bonobos. PLoS Pathog. 2010, Feb 12; 6, e100765.

Wang Y, Ait-Oufella H, Herbin O, Bonnin P, Ramkhelawon B, Taleb S, Huang J, Offenstadt G, Combadière C, Rénia L, Johnson JL, Tharaux PL, Tedgui A, Mallat Z. TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest. 2010 Feb 1;120(2):422-32.

2009

Sponaas AM, Freitas do Rosario AP, Voisine C, Mastelic B, Thompson J, Koernig S, Jarra W, Rénia L, Mauduit M, Potocnik AJ, Langhorne J. Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria. Blood. 2009 Dec 24; 114(27):5522-31.

Kam YW, Ong EK, Rénia L, Tong JC, Ng LF. Immuno-biology of Chikungunya and implications for disease intervention. Microbes Infect. 2009. Dec; 11(14-15):1186-96.

Mauduit M, Grüner AC, Tewari R, Depinay N, Kayibanda M, Chavatte JM, Franetich JF, Crisanti A, Mazier D, Snounou G, Rénia L. A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites. PLoS One. 2009 Nov 5; 4(11):e7717.

Mazier D, Rénia L, Snounou G. A pre-emptive strike against malaria's stealthy hepatic forms. Nat Rev Drug Discov. 2009 Nov; 8(11):854-64.

Manéglier B, Malleret B, Guillemin GJ, Spreux-Varoquaux O, Devillier P, Rogez-Kreuz C, Porcheray F, Thérond P, Dormont D, Clayette P. Modulation of indoleamine-2,3-dioxygenase expression and activity by HIV-1 in human macrophages. Fundam Clin Pharmacol. 2009 Oct; 23(5):573-81.

Roestenberg M, McCall M, Hopman J, Wiersma J, Luty AJ, van Gemert GJ, van de Vegte-Bolmer M, van Schaijk B, Teelen K, Arens T, Spaarman L, de Mast Q, Roeffen W, Snounou G, Rénia L, van der Ven A, Hermsen CC, Sauerwein R. Protection against a malaria challenge by sporozoite inoculation. N Engl J Med. 2009 Jul 30; 361(5):468-77.

Sriprawat K, Kaewpongsri S, Suwanarusk R, Leimanis ML, Lek-Uthai U, Phyo AP,Snounou G, Russell B, Renia L, Nosten F. Effective and cheap removal of leukocytes and platelets from Plasmodium vivax infected blood. Malar J. 2009 Jun 2; 8:115

Mitchell C, Couton D, Couty JP, Anson M, Crain AM, Bizet V, Rénia L, Pol S, Mallet V, Gilgenkrantz H. Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. Am J Pathol. 2009 May; 174(5):1766-75.

Anstey NM, Russell B, Yeo TW, Price RN. The pathophysiology of vivax malaria. Trends Parasitol. 2009 May; 25(5):220-7.

Handayani S, Chiu DT, Tjitra E, Kuo JS, Lampah D, Kenangalem E, Renia L, Snounou G, Price RN, Anstey NM, Russell B. High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. J Infect Dis. 2009 Feb 1; 199(3):445-50.

2008

Belnoue E, Voza T, Costa FT, Grüner AC, Mauduit M, Rosa DS, Depinay N, Kayibanda M, Vigário AM, Mazier D, Snounou G, Sinnis P, Rénia L. Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage. J Immunol. 2008 Dec15; 181(12):8552-8.

Buffet PA, Briand V, Rénia L, Thellier M, Danis M, Mazier D. Intermittent preventive antimalarial treatment to children (IPTc): firebreak or fire trap? Trends Parasitol. 2008 Nov; 24(11):48

Bozdech Z, Mok S, Hu G, Imwong M, Jaidee A, Russell B, Ginsburg H, Nosten F, Day NP, White NJ, Carlton JM, Preiser PR. The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proc Natl Acad Sci USA. 2008 Oct 21; 105(42):16290-5.

Belnoue E, Potter SM, Rosa DS, Mauduit M, Grüner AC, Kayibanda M, Mitchell AJ, Hunt NH, Rénia L. Control of pathogenic CD8+ T cell migration to the brain by IFN-gamma during experimental cerebral malaria. Parasite Immunol. 2008 Oct; 30(10):544-53.

Rénia L. Protective immunity against malaria liver stage after vaccination with live parasites. Parasite. 2008 Sep; 15(3):379-83.

Lek-Uthai U, Suwanarusk R, Ruengweerayut R, Skinner-Adams TS, Nosten F, Gardiner DL, Boonma P, Piera KA, Andrews KT, Machunter B, McCarthy JS, Anstey NM, Price RN, Russell B. Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum. Antimicrob Agents Chemother. Jul 2008; 52(7):2435-2441.

Togbe D, de Sousa PL, Fauconnier M, Boissay V, Fick L, Scheu S, Pfeffer K, Menard R, Grau GE, Doan BT, Beloeil JC, Renia L, Hansen AM, Ball HJ, Hunt NH, Ryffel B, Quesniaux VF. Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One. 2008 Jul 9; 3(7):e2608.

Sharrock WW, Suwanarusk R, Lek-Uthai U, Edstein MD, Kosaisavee V, Travers T, Jaidee A, Sriprawat K, Price RN, Nosten F, Russell B. Plasmodium vivax trophozoites insensitive to chloroquine. Malar J. 2008 May 27;7:94.

Suksumek N, Leelawat K, Leelawat S, Russell BM, Lek-Uthai U. TaqMan real-time PCR assay for specific detection of Opisthorchis viverrini DNA in Thai patients with hepatocellular carcinoma and cholangiocarcinoma. Exp Parasitol. 2008; 199:217-224.

Rottman M, Soudais C, Vogt G, Renia L, Emile JF, Decaluwe H, Gaillard JL, Casanova JL. IFN-gamma mediates the rejection of hematopoietic stem cells in IFN-gammaR1-deficient hosts. PLoS Med. 2008 Jan 29; 5(1):e26.

2007

Grüner AC, Mauduit M, Tewari R, Romero JF, Depinay N, Kayibanda M, Lallemand E, Chavatte JM, Crisanti A, Sinnis P, Mazier D, Corradin G, Snounou G, Rénia L. Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS One. 2007 Dec 26; 2(12):e1371.

CV

Research Activities

June 2007-2006: DR2 INSERM, Head of Malaria Immunobiology group, director of Department of Immunology, Institut Cochin (Dir: Pr Axel Kahn), INSERM U567, CNRS 8204, Hôpital Cochin,

2005-2002 : DR2 INSERM, head of Immunohepatology group, co-director of Department of Immunology, Institut Cochin (Dir: Pr Axel Kahn), INSERM U567, CNRS 8204, Hôpital Cochin

2001-1997, head of group Analysis of anti-malaria immune response
INSERM U445 (head: Dr. JG Guillet), ICGM, Hôpital Cochin, Paris.

1997-1993: permanent position, CR2 INSERM (Dr D. Mazier’s group). INSERM U313 (head: Pr. M. Gentilini). Project: Cellular Immunity against malaria liver stages.

1993-1993: Research associate (Dr D. Mazier’s group), Stanley Foundation fellowship. INSERM U313. Project: Processing of plasmodial antigens in malaria-infected hepatocytes.

1992-1991: Post doctoral position, Mac Arthur Foundation fellowship. Division of Immunology (head: Pr. V Nussenzweig), Department of Pathology, New York University School of Medicine. New York. Project: Transgenic mice expressing plasmodial antigens and models of protection induced by the malaria hepatic stages

1991-1988: Ph. D. student in INSERM U313 (Dr D. Mazier’s group), Ministère de la Recherche et de la Technologie fellowship. Project: Humoral and cellular mechanisms against malaria liver stage.

1988-1987: part-time (Dr D. Mazier’s group) INSERM U313 (dir: Pr. M. Gentilini), Dept. de Parasitologie, CHU Pitié-Salpêtrière, Paris. Project: Analysis of antibody responses against plasmodium sporozoites


Diplomas

1998
Habilitation to Supervise Research, Université Paris V, René Descartes.

1991
Ph. D. in Public Health

1988
DEA: Biologie de la Cellule normale et Pathologique (Université Paris V)
Maîtrise de Biologie Cellulaire, mention: Immunologie (Université Paris VI)

1987
Maîtrise de Biochimie (Université Paris VI)
Licence de Biochimie (Université Paris VI)
Licence de Biologie et de Physiologie Cellulaire (Université Paris VI)
Certificat d'Immunologie et Pathologie Parasitaire (Université Paris VI)


License for Animal Experiment


France : N° 007270 from « Ministère de l’Agriculture et de la Pêche » September, 13, 1996 (Paris)
Singapore: RCULAC certificate, Numéro BRC/ACUC/135/2007, August 2007


Direction


I have supervised of 7 post-doctoral fellows, 6 Ph D. students, 9 graduate students, and of 9 training summer students and 5 training technicians.


Teaching

Many lectures in Ph.D. Master and undergraduate programs in France, Portugal, Brazil and Colombia


Ad Hoc Referee

For Ph. D. defence
Referee for 8 Ph. D. defence in France and abroad (Switzerland, Colombia).


For Journals

Nature Medicine, Nature, Science, Journal of Immunology, Infection and Immunity, European Cytokine Network, Journal of Infectious Diseases, Microbes and Infection, Parasite Immunology, Parasite, Journal of Immunological Methods, Experimental Parasitology, Laboratory Investigations, Vaccine, Cytometry, American Journal of Tropical Medicine and Hygiene


For Instituitions

Members over the last 15 years of committees in Infectious Diseases in France, and expert for institutions such as European Union, INSERM (France) CNPq (Brazil), for the German agency Deustsche Forschungsgemeinschaft (DFG, Germany), NWO ( Holland), Wellcome Trust (UK)


Organisation Of Scientific Meetings

Co-organizer of the ICMAT 2009 (International Conference on Materials for Advanced Technologies) sponsored by GEM4 (Global Enterprise for Micro-Mechanics and Molecular Medicine), June 28-July 3 2009
Co-organizer of the Singapore Malaria Network Meeting 2008. Current Topics to Malaria, Nanyang Technological University, Singapore, January 31-February 1 2008
Co-organize of the “Day of Infectious Diseases of the Institut cochin”, 31 Mars 2005


Grants

Received 12 grants from the French government and charities and from the European Union


Scientific Production

79 original articles and 15 review articles in peer-reviewed journals, and 11 reviews and book chapters.


Seminars

Given 39 seminars nationally and internationally.


Conference Presentation

Given 23 oral presentations (14 on invitations) and 66 poster presentations in national and international conferences.

Lab

Scientific production of Laurent Rénia

2016

Lee WW, Teo TH, Lum FM, Andiappan AK, Amrun SN, Rénia L, Rötzschke O, Ng LF. Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice. Sci Rep. 2016 Nov 25;6:37603.

Rénia L, Goh YS. Malaria Parasites: The Great Escape. Front Immunol. 2016 Nov 7;7:463.

Her Z, Kam YW, Gan VC, Lee B, Thein TL, Tan JJ, SIgN Immunomonitoring Platform, Lee LK, Fink K, Lye DC, Renia L, Leo YS, Ng LF. Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection. J Infect Dis. 2017 Jan 1;215(1):42-51

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 Oct 17;213(11):2293-2314.

Lim MY, LaMonte G, Lee MC, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A, Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GM, Ho PC, Yeung BK, Chow ED, Lim L, Fidock DA, Diagana TT, Winzeler EA, Bifani P. UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nat Microbiol. 2016 Sep 19;1:16166.

Chang ZW, Malleret B, Russell B, Renia L, Claser C. An ex-vivo maturation assay for testing antimalarial sensitivity of rodent malaria parasites. Antimicrob Agents Chemother. 2016 Sep 6. [Epub ahead of print]

Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, Yarski M, Poh CM, Lee JS, Cooper MA, Rénia L, Richard D, McCarthy JS, Sharpe AH, Wykes MN. Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity. Immunity. 2016 Aug 16;45(2):333-45.

Zhang R, Lee WC, Lau YL, Albrecht L, Lopes SC, Costa FT, Suwanarusk R, Nosten F, Cooke BM, Rénia L, Russell B. Rheopathologic Consequence of Plasmodium vivax Rosette Formation. PLoS Negl Trop Dis. 2016 Aug 10;10(8):e0004912.

Gupta P, Lai SM, Sheng J, Tetlak P, Balachander A, Claser C, Renia L, Karjalainen K, Ruedl C. Tissue-Resident CD169(+) Macrophages Form a Crucial Front Line against Plasmodium Infection. Cell Rep. 2016 Aug 9;16(6):1749-61.

Goh YS, Peng K, Chia WN, Siau A, Chotivanich K, Gruner AC, Preiser P, Mayxay M, Pukrittayakamee S, Sriprawat K, Nosten F, White NJ, Renia L. Neutralizing Antibodies against Plasmodium falciparum Associated with Successful Cure after Drug Therapy. PLoS One. 2016 Jul 18;11(7):e0159347.

Horne-Debets JM, Karunarathne DS, Faleiro RJ, Poh CM, Renia L, Wykes MN. Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria. Sci Rep. 2016 May 24;6:26210.

Peng K, Goh YS, Siau A, Franetich JF, Chia WN, Ong AS, Malleret B, Wu YY, Snounou G, Hermsen CC, Adams JH, Mazier D, Preiser PR, Sauerwein RW, Grüner AC, Rénia L. Breadth of humoral response and antigenic targets of sporozoite-inhibitory antibodies associated with sterile protection induced by controlled human malaria infection. Cell Microbiol. 2016 Dec;18(12):1739-1750.

Russell B, Rénia L, Malleret B. Reply to "Flow Cytometry for Antimalarial Drug Testing: More than Meets the Eye". J Clin Microbiol. 2016 Mar;54(3):818-9.

Li JL, Lim CH, Tay FW, Goh CC, Devi S, Malleret B, Lee B, Bakocevic N, Chong SZ, Evrard M, Tanizaki H, Lim HY, Russell B, Renia L, Zolezzi F, Poidinger M, Angeli V, John AL, Harris JE, Tey HL, Tan SM, Kabashima K, Weninger W, Larbi A, Ng LG. Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation Through CXCL2. J Invest Dermatol. 2016 Feb;136(2):416-24.

Cho JS, Russell B, Kosasaivee V, Zhang R, Colin Y, Bertrand O, Chandramohanadas R, Chu CS, Nosten F, Renia L, Malleret B. Unambiguous determination of Plasmodium vivax reticulocyte invasion by flow cytometry. Int J Parasitol. 2016 Jan;46(1):31-9.

Zhang R, Suwanarusk R, Malleret B, Cooke BM, Nosten F, Ling LY, Dao M, Lim CT, Renia L, Tan KS, Russell B. A basis for rapid clearance of circulating ring-stage malaria parasites by the spiroindolone KAE609. J Infect Dis. 2016 Jan 1;213(1):100-4.

2015

Howland SW, Gun SY, Claser C, Poh CM, Rénia L. Measuring antigen presentation in mouse brain endothelial cells ex vivo and in vitro. Nat Protoc. 2015 Dec;10(12):2016-2026. 

Howland SW, Ng GX, Chia SK, Rénia L. Investigating proteasome inhibitors as potential adjunct therapies for experimental cerebral malaria. Parasite Immunol. 2015 Nov;37(11):599-604.

Woodrow CJ, Wangsing C, Sriprawat K, Christensen P, Nosten F, Rénia L, Russell B, Malleret B. A comparison between flow cytometry, microscopy and lactate dehydrogenase ELISA for Plasmodium falciparum drug-susceptibility testing under field conditions. J Clin Microbiol. 2015 Oct;53(10):3296-303.

Leite JA, Bargieri DY, Carvalho BO, Albrecht L, Lopes SC, Kayano AC, Farias AS, Chia WN, Claser C, Malleret B, Russell B, Castiñeiras C, Santos LM, Brocchi M, Wunderlich G, Soares IS, Rodrigues MM, Rénia L, Costa FT. Immunization with the MAEBL M2 domain protects against lethal Plasmodium yoelii infection. Infect Immun. 2015 Oct;83(10):3781-92.

Imwong M, Nguyen TN, Tripura R, Peto TJ, Lee SJ, Lwin KM, Suangkanarat P, Jeeyapant A, Vihokhern B, Wongsaen K, Van Hue D, Dong le T, Nguyen TU, Lubell Y, von Seidlein L, Dhorda M, Promnarate C, Snounou G, Malleret B, Rénia L, Keereecharoen L, Singhasivanon P, Sirithiranont P, Chalk J, Nguon C, Hien TT, Day N, White NJ, Dondorp A, Nosten F. The epidemiology of subclinical malaria infections in South-East Asia: findings from cross-sectional surveys in Thailand-Myanmar border areas, Cambodia, and Vietnam. Malar J. 2015 Sep 30;14(1):381.

Andolina C, Landier J, Carrara V, Chu CS, Franetich JF, Roth A, Rénia L, Roucher C, White NJ, Snounou G, Nosten F. The suitability of laboratory-bred Anopheles cracens for the production of Plasmodium vivax sporozoites. Malar J. 2015 Aug 12;14:312. 

Teo TH, Her Z, Tan JJ, Lum FM, Lee WW, Chan YH, Ong RY, Kam YW, Leparc-Goffart I, Gallian P, Rénia L, de Lamballerie X, Ng LF. Caribbean and La Réunion Chikungunya virus isolates differ in their capacity to induce pro-inflammatory Th1 and NK cell responses and acute joint pathology. J Virol. 2015 Aug 1;89(15):7955-69. 

de Cassan SC, Shakri AR, Llewellyn D, Elias SC, Cho JS, Goodman AL, Jin J, Douglas AD, Suwanarusk R, Nosten FH, Rénia L, Russell B, Chitnis CE, Draper SJ. Preclinical Assessment of Viral Vectored and Protein Vaccines Targeting the Duffy-Binding Protein Region II of Plasmodium Vivax. Front Immunol. 2015 Jul 8;6:348. 

Schlitzer A, Sivakamasundari V, Chen J, Sumatoh HR, Schreuder J, Lum J, Malleret B, Zhang SQ, Larbi A, Zolezzi F, Renia L, Poidinger M, Naik S, Newell EW, Robson P, Ginhoux F. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat Immunol. 2015 Jul;16(7):718-28.

Howland SW, Poh CM, Rénia L. Activated Brain Endothelial Cells Cross-Present Malaria Antigen. PLoS Pathog. 2015 Jun 5;11(6):e1004963. 

Lee WW, Teo TH, Her Z, Lum FM, Kam YW, Haase D, Rénia L, Rötzschke O, Ng LF. Expanding regulatory T cells alleviates chikungunya virus-induced pathology in mice. J Virol. 2015 May 20. [Epub ahead of print] 

Howland SW, Claser C, Poh CM, Gun SY, Rénia L. Pathogenic CD8+ T cells in experimental cerebral malaria. Semin Immunopathol. 2015 May;37(3):221-31.

Lee KG, Kim SS, Kui L, Voon DC, Mauduit M, Bist P, Bi X, Pereira NA, Liu C, Sukumaran B, Rénia L, Ito Y, Lam KP. Bruton's Tyrosine Kinase Phosphorylates DDX41 and Activates Its Binding of dsDNA and STING to Initiate Type 1 Interferon Response. Cell Rep. 2015 Feb 24;10(7):1055-65.

Teng Y, Suwanarusk R, Ngai MH, Srinivasan R, Ong AS, Ho B, Rénia L, Chai CL. An amidation/cyclization approach to the synthesis of N-hydroxyquinolinones and their biological evaluation as potential anti-plasmodial, anti-bacterial, and iron(II)-chelating agents. Bioorg Med Chem Lett. 2015 Feb 1;25(3):607-10.

Malmquist NA, Sundriyal S, Caron J, Chen P, Witkowski B, Menard D, Suwanarusk R, Renia L, Nosten F, Jiménez-Díaz MB, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Wittlin S, Duffy S, Avery VM, Ruecker A, Delves MJ, Sinden RE, Fuchter MJ, Scherf A. Histone methyltransferase inhibitors: orally bioavailable, fast acting molecules with activity against different human malaria species. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9.

Malleret B, Li A, Zhang R, Tan KS, Suwanarusk R, Claser C, Cho JS, Koh EG, Chu CS, Pukrittayakamee S, Ng ML, Ginhoux F, Ng LG, Lim CT, Nosten F, Snounou G8, Rénia L, Russell B. Plasmodium vivax: restricted tropism and rapid remodelling of CD71 positive reticulocytes. Blood. 2015 Feb 19;125(8):1314-24.

Edwards CL, Best SE, Gun SY, Claser C, James KR, de Oca MM, Sebina I, de Labastida Rivera F, Amante FH, Hertzog PJ, Engwerda CR, Renia L, Haque A. Spatio-temporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection. Eur J Immunol. 2015 Jan;45(1):130-41.

Suwanarusk R, Russell B, Ong A, Sriprawat K, Chu SC, PyaePhyo A, Malleret B, Nosten F, Renia L. Methylene blue inhibits the asexual development of vivax malaria parasites from a region of increasing chloroquine resistance. J Antimicrob Chemoth. 2015 Jan;70(1):124-9.

Her Z, Teng TS, Tan JJ, Teo TH, Kam YW, Lum FM, Lee WW, Gabriel C, Melchiotti R, Andiappan AK, Lulla V, Lulla A, Win MK, Chow A, Biswas SK, Leo YS, Lecuit M, Merits A, Rénia L, Ng LF. Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response. EMBO Mol Med. 2014 Dec 1;7(1):24-41.

2014

Chia WN, Goh YS, Renia L. Novel approaches to identify protective malaria vaccine candidates. Front Microbiol. 2014 Nov 17;5:586.

Poh CM, Howland SW, Grotenbreg GM, Rénia L. Damage to the blood-brain barrier during experimental cerebral malaria results from the synergistic effects of CD8+ T cells with different specificities. Infect Immun. 2014 Nov;82(11):4854-64.

Chandramohanadas R, Basappa, Russell B, Liew K, Yau YH, Chong A, Min L, Gunalan K, Raman R, Renia L, Nosten F, Geifman Shochat S, Dao M, Sasisekharan R, Suresh S, Preiser P. Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevent Host Invasion of Divergent Plasmodial Species. J Infect Dis. 2014 Nov 15;210(10):1616-26.

Loh CC, Suwanarusk R, Lee YQ, Chan KW, Choy KY, Rénia L, Russell B, Lear MJ, Nosten FH, Tan KS, Chow LM. Characterization of the Commercially-Available Fluorescent Chloroquine-BODIPY Conjugate, LynxTag-CQGREEN, as a Marker for Chloroquine Resistance and Uptake in a 96-Well Plate Assay. PLoS One. 2014 Oct 24;9(10):e110800. 

Gun SY, Claser C, Tan K, Renia L. Interferons and Interferon Regulatory Factors in Malaria. Mediat Inflamm. 2014;2014:243713.

Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, Vd Vegte-Bolmer M, V Gemert GJ, Wirjanata G, Sebayang B, Marfurt J, Russell B, Suwanarusk R, Price RN, Nosten F, Tungtaeng A, Gettayacamin M, Sattabongkot J, Taylor J, Walker JR, Tully D, Patra KP, Flannery EL, Vinetz JM, Renia L, Sauerwein RW, Winzeler EA, Glynne RJ, Diagana TT. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission. Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7

Imwong M, Hanchana S, Malleret B, Rénia L, Day NP, Dondorp A, Nosten F, Snounou G, White NJ. High throughput ultra-sensitive molecular techniques to quantify low density malaria parasitaemias. J Clin Microbiol. 2014 Sep;52(9):3303-9.

Rénia L, Howland SW. Targeting the olfactory bulb during experimental cerebral malaria. Trends Parasitol. 2014 Aug;30(8):375-6.

Tan JJ, Capozzoli M, Sato M, Watthanaworawit W, Ling CL, Mauduit M, Malleret B, Grüner AC, Tan R, Nosten FH, Snounou G, Rénia L, Ng LF. An integrated lab-on-chip for rapid identification and simultaneous differentiation of tropical pathogens. PLoS Negl Trop Dis. 2014 Jul 31;8(7):e3043. 

Ch'ng JH, Lee YQ, Gun SY, Chia WN, Chang ZW, Wong LK, Batty KT, Russell B, Nosten F, Renia L, Tan KS. Validation of a chloroquine-induced cell death mechanism for clinical use against malaria. Cell Death Dis. 2014 Jun 26;5:e1305.

Haque A, Best SE, Montes de Oca M, James KR, Ammerdorffer A, Edwards CL, de Labastida Rivera F, Amante FH, Bunn PT, Sheel M, Sebina I, Koyama M, Varelias A, Hertzog PJ, Kalinke U, Gun SY, Rénia L, Ruedl C, Macdonald KP, Hill GR, Engwerda CR. Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity. J Clin Invest. 2014 Jun 2;124(6):2483-96.

Bakocevic N, Claser C, Yoshikawa S, Jones LA, Chew S, Goh CC, Malleret B, Larbi A, Ginhoux F, de Lafaille MC, Karasuyama H, Renia L, Ng LG. CD41 is a reliable identification and activation marker for murine basophils in the steady-state and during helminth and malarial infections. Eur J Immunol. 2014 Jun;44(6):1823-34.

Lee WC, Malleret B, Lau YL, Mauduit M, Fong MY, Cho JS, Suwanarusk R, Zhang R, Albrecht L, Costa FT, Preiser P, McGready R, Renia L, Nosten F, Russell B. Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes. Blood. 2014 May 1;123(18):e100-9.

Siau A, Huang X, Yam XY, Bob NS, Sun H, Rajapakse JC, Renia L, Preiser PR. Identification of a new export signal in Plasmodium Yoelii: identification of a new exportome. Cell Microbiol. 2014 May;16(5):673-86.  

Lopes SC, Albrecht L, Carvalho BO, Siqueira AM, Thomson-Luque R, Nogueira PA, Fernandez-Becerra C, Del Portillo HA, Russell BM, Rénia L, Lacerda MV, Costa FT. Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential. J Infect Dis. 2014 May 1;209(9):1403-7.

Vicentin EC, Françoso KS, Rocha MV, Iourtov D, Dos Santos FL, Kubrusly FS, Sakauchi MA, Raw I, Nosten F, Rénia L, Rodrigues MM, Russell B, Soares IS. Invasion-Inhibitory Antibodies Elicited by Immunization with Plasmodium vivax Apical Membrane Antigen-1 Expressed in Pichia pastoris Yeast. Infect Immun. 2014 Mar;82(3):1296-307.

Claser C, Malleret B, Peng K, Bakocevic N, Gun SY, Russell B, Ng LG, Rénia L. Rodent Plasmodium-infected red blood cells: Imaging their fates and interactions within their hosts. Parasitol Int. 2014 Feb;63(1):187-94. 

2013

Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, Macdonald KP, Good MF, Renia L, Ahmed R, Sharpe AH, Wykes MN. PD-1 Dependent Exhaustion of CD8(+) T Cells Drives Chronic Malaria. Cell Rep. 2013 Dec 12;5(5):1204-13.

McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Nagle A, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman A-M, Dechering KJ, Kumar TR, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013 Dec 12;504(7479):248-53.

Malleret B, Xu F, Mohandas N, Suwanarusk R, Chu C, Leite JA, Low K, Turner C, Sriprawat K, Zhang R, Bertrand O, Colin Y, Costa FT, Ong CN, Ng ML, Lim CT, Nosten F, Rénia L, Russell B. Significant Biochemical, Biophysical and Metabolic Diversity in Circulating Human Cord Blood Reticulocytes. PLoS One. 2013 Oct 8;8(10):e76062.

Devi S, Wang Y, Chew WK, Lima R, A-González N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S, Keeble JL, Goh CC, Li JL, Evrard M, Malleret B, Larbi A, Renia L, Haniffa M, Tan SM, Chan JK, Balabanian K, Nagasawa T, Bachelerie F, Hidalgo A, Ginhoux F, Kubes P, Ng LG. Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med. 2013 Oct 21;210(11):2321-36.

Russell B, Malleret B, Suwanarusk R, Anthony C, Kanlaya S, Lau YL, Woodrow CJ, Nosten F, Renia L. Field-based flow cytometry for ex vivo characterization of Plasmodium vivax and P. falciparum antimalarial sensitivity. Antimicrob Agents Chemother. 2013 Oct;57(10):5170-4.

Koh S, Shimasaki N, Suwanarusk R, Ho ZZ, Chia A, Banu N, Wu Howland S, Ong AS, Gehring AJ, Stauss H, Renia L, Sällberg M, Campana D, Bertoletti A. A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus. Mol Ther Nucleic Acids. 2013 Aug 13;2:e114.

Howland SW, Poh CM, Gun SY, Claser C, Malleret B, Shastri N, Ginhoux F, Grotenbreg GM, Rénia L. Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria. EMBO Mol Med. 2013 Jul;5(7):984-99.

Lum FM, Teo TH, Lee WW, Kam YW, Rénia L, Ng LF. An Essential Role of Antibodies in the Control of Chikungunya Virus Infection. J Immunol. 2013 Jun 15;190(12):6295-302.

Guermonprez P, Helft J, Claser C, Deroubaix S, Karanje H, Gazumyan A, Darasse-Jèze G, Telerman SB, Breton G, Schreiber HA, Frias-Staheli N, Billerbeck E, Dorner M, Rice CM, Ploss A, Klein F, Swiecki M, Colonna M, Kamphorst AO, Meredith M, Niec R, Takacs C, Mikhail F, Hari A, Bosque D, Eisenreich T, Merad M, Shi Y, Ginhoux F, Rénia L, Urban BC, Nussenzweig MC. Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat Med. 2013 Jun;19(6):730-8.

SchlitzerA, McGovern N, Teo P, Zelante T, Atarashi K, Low D, Ho AW, See P, Shin A, Wasan PS, Hoeffel G,  Malleret B, Heiseke A, Chew S, Jardine L, Purvis HA, Hilkens CM, John Tam J, Poidinger M, Stanley RE, Krug AB, Renia L, Sivasankar B, Ng LG, Collin M, Ricciardi-Castagnoli P, Honda K, Haniffa M, Ginhoux F. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity. 2013 May 23;38(5):970-983. 

Lee WC, Russell B, Lau YL, Fong MY, Chu C, Sriprawat K, Suwanarusk R, Nosten F, Renia L. Giemsa-stained wet mount based method for reticulocyte quantification: a viable alternative in resource limited or malaria endemic settings. PLoS One. 2013;8(4):e60303.

Bittencourt AR, Vicentin EC, Jimenez MC, Ricci R, Leite JA, Costa FT, Ferreira LC, Russell B, Nosten F, Rénia L, Galinski MR, Barnwell JW, Rodrigues MM, Soares IS. Antigenicity and Immunogenicity of Plasmodium vivax Merozoite Surface Protein-3. PLoS One. 2013;8(2):e56061.

Rénia L, Grüner AC, Mauduit M, Snounou G. Vaccination using normal live sporozoites under drug treatment. Methods Mol Biol. 2013;923:567-76.

Li A, Rénia L, Lim CT, Russell B. Atomic force microscopy of Plasmodium-infected red blood cells: detecting and localizing single molecular recognition events. Methods Mol Biol. 2013;923:299-305.

2012

Teo TH, Lum FM, Claser C, Lulla V, Lulla A, Merits A, Rénia L, Ng LF. A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice. J Immunol. 2012 Dec 3. [Epub ahead of print]

Kam YW, Lee WW, Simarmata D, Harjanto S, Teng TS, Tolou H, Chow A, Lin RT, Leo YS, Rénia L, Ng LF. Longitudinal analysis of the human antibody response to chikungunya virus infection: implications for sero-diagnosis assays and vaccine development. J Virol. 2012 Dec;86(23):13005-15.

Russell B, Suwanarusk R, Malleret B, Costa FT, Snounou G, Kevin Baird J, Nosten F, Rénia L. Human ex vivo studies on asexual Plasmodium vivax: the best way forward. Int J Parasitol. 2012 Nov;42(12):1063-70.

Costa FT, Lopes SC, Albrecht L, Ataíde R, Siqueira AM, Souza RM, Russell B, Renia L, Marinho CR, Lacerda MV. On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field. Int J Parasitol. 2012 Nov;42(12):1099-105.

Snounou G, Escalante A, Kasenene J, Rénia L, Grüner AC, Krief S. [Malaria in hominids]. (Article in French) Bull Acad Natl Med. 2012 Nov;195(8):1945-54.

Phanpoowong T, Lek-Uthai U, Thongrungkiat S, Komalamisra N, Srisawat R, Russell B, Renia L. Dengue-2 Virus Carrying Capacity of Thai Aedes Aegypti Strains with Different Susceptibility to Deltamethrin. Southeast Asian J Trop Med Public Health 2012;43(3):634-40.

Mauduit M, See P, Peng K, Rénia L, Ginhoux F. Dendritic cells and the malaria pre-erythrocytic stage. Immunol Res. 2012 Sep;53(1-3):115-26.

Piva L, Tetlak P, Claser C, Karjalainen K, Renia L, Ruedl C. Cutting Edge: Clec9A+ Dendritic Cells Mediate the Development of Experimental Cerebral Malaria. J Immunol. 2012 Aug 1;189(3):1128-32.

Her Z, Lum FM, Chow A, Leo YS, Rénia L, Chiocchia G, Ng LF. Reply - Involvement of RANKL and Osteoprotegerin in Chikungunya Fever. J Infect Dis. 2012 Aug;206(3):457-9.

Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, Wasan PS, Wang XN, Malinarich F, Malleret B, Larbi A, Tan P, Zhao H, Poidinger M, Pagan S, Cookson S, Dickinson R, Dimmick I, Jarrett RF, Renia L, Tam J, Song C, Connolly J, Chan JK, Gehring A, Bertoletti A, Collin M, Ginhoux F. Human Tissues Contain CD141(hi) Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103(+) Nonlymphoid Dendritic Cells. Immunity. 2012 Jul 27;37(1):60-73.

Chan CL, Rénia L, Tan KS. A Simplified, Sensitive Phagocytic Assay for Malaria Cultures Facilitated by Flow Cytometry of Differentially-Stained Cell Populations. PLoS ONE. 2012; 7(6):e38523.

Ch'ng JH, Renia L, Nosten F, Tan KS. Can we teach an old drug new tricks? Trends Parasitol. 2012 2012 Jun;28(6):220-4.

Hoeffel G, Wang Y, Greter M, See P, Teo P, Malleret B, Leboeuf M, Low D, Oller G, Almeida F, Choy SH, Grisotto M, Renia L, Conway SJ, Stanley ER, Chan JK, Ng LG, Samokhvalov IM, Merad M, Ginhoux F. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages. J Exp Med. 2012 Jun 4;209(6):1167-81.

Chotivanich K, Udomsangpetch R, Suwanarusk R, Pukrittayakamee S, Wilairatana P, Beeson JG, Day NP, White NJ. Plasmodium vivax Adherence to Placental Glycosaminoglycans. PLoS One. 2012;7(4):e34509.

Vaulont S, Rénia L, Labie D. [Malaria: is there a role for the iron-hepcidin axis?].[Article in French] Med Sci (Paris). 2012 May;28(5):462-4.

Kosaisavee V, Lek-Uthai U, Suwanarusk R, Grüner AC, Russell B, Nosten F, Rénia L, Snounou G. Genetic Diversity in New Members of the Reticulocyte Binding Protein Family in Thai Plasmodium vivax Isolates. PLoS One. 2012;7(3):e32105.

Kam YW, Lum FM, Teo TH, Lee WW, Simarmata D, Harjanto S, Chua CL, Chan YF, Wee JK, Chow A, Lin RT, Leo YS, Le Grand R, Sam IC, Tong JC, Roques P, Wiesmüller KH, Rénia L, Rötzschke O, Ng LF. Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein. EMBO Mol Med. 2012 Apr;4(4):330-43.

Kam YW, Simarmata D, Chow A, Her Z, Teng TS, Ong EK, Rénia L, Leo YS, Ng LF. Early appearance of neutralizing immunoglobulin G3 antibodies is associated With Chikungunya virus clearance and long-term clinical protection. J Infect Dis. 2012 Apr;205(7):1147-54.

Renia L, Wu Howland S, Claser C, Charlotte Gruner A, Suwanarusk R, Hui Teo T, Russell B, Ng L. Cerebral malaria: Mysteries at the blood-brain barrier. Virulence. 2012 Mar 1;3(2):193-201. 

Hafalla JCR, Claser C, Couper KN, Grau GE, Renia L, de Souza B, Riley EM. The CTLA-4 and PD-1/PD-L1 Inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. PLoS Pathog. 2012; 8(2):e1002504.

Borlon C, Russell B, Sriprawat K, Suwanarusk R, Erhart A, Renia L, Nosten F, D'Alessandro U. Cryopreserved Plasmodium vivax and cord blood reticulocytes can be used for invasion and short term culture. Int J Parasitol. 2012 Feb;42(2):155-60.

2011

Lee CY, Kam YW, Fric J, Malleret B, Koh EG, Prakash C, Huang W, Lee WW, Lin C, Lin RT, Renia L, Wang CI, Ng LF, Warter L. Chikungunya Virus Neutralization Antigens and Direct Cell-to-Cell Transmission Are Revealed by Human Antibody-Escape Mutants. PLoS Pathog. 2011 Dec;7(12):e1002390. Epub 2011 Dec 1.

Phyo AP, Lwin KM, Price RN, Ashley EA, Russell B, Sriprawat K, Lindegardh N, Singhasivanon P, White NJ, Nosten F. Dihydroartemisinin-Piperaquine Versus Chloroquine in the Treatment of Plasmodium vivax Malaria in Thailand: A Randomized Controlled Trial. Clin Infect Dis. 2011 Nov;53(10):977-84.

Proux S, Suwanarusk R, Barends M, Zwang J, Price RN, Leimanis M, Kiricharoen L, Laochan N, Russell B, Nosten F, Snounou G. Considerations on the use of nucleic acid-based amplification for malaria parasite detection. Malar J. 2011 Oct 28;10(1):323. [Epub ahead of print]

Russell B, Suwanarusk R, Borlon C, Costa FT, Chu CS, Rijken MJ, Sriprawat K, Warter L, Koh EG, Malleret B, Colin Y, Bertrand O, Adams JH, D'Alessandro U, Snounou G, Nosten F, Rénia L. A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. Blood. Sep 29 2011; 118(13):e74-81. 

Malleret B, Claser C, Ong ASM, Suwanarusk R, Sriprawat K, Howland SW, Russell B, Nosten F, Renia L. A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development. Sci. Rep. 2011;1:118.

Bouillet LE, Dias MO, Dorigo NA, Moura AD, Russell B, Nosten F, Renia L, Braga EM, Gazzinelli RT, Rodrigues MM, Soares IS, Bruna-Romero O. Long-term humoral and cellular immune responses elicited by a heterologous Plasmodium vivax Apical Membrane Antigen 1 protein-prime/adenovirus-boost immunization protocol. Infect Immun. Sep 2011; 79(9):3642-3652.

Russell B, Li A, Lim CT. Atomic Force Microscopy as a Nanotool to Investigate Malaria-Infected Erythrocytes. Bionanotechnology II: Global Prospects. 2011, CRC Press: 287-295. [Book Chapter]

Dhorda M, Nyehangane D, Renia L, Piola P, Guerin PJ, Snounou G. Transmission of Plasmodium vivax in South-Western Uganda: Report of Three Cases in Pregnant Women. PLoS One. 2011; 6(5):e19801.

Howland SW, Poh CM, Rénia L. Directional, seamless, and restriction enzyme-free construction of random-primed complementary DNA libraries using phosphorothioate-modified primers. Anal Biochem. 2011 Sep 1;416(1):141-3.

Mok S, Imwong M, Mackinnon MJ, Sim J, Ramaodoss R, Yi P, Mayxay M, Chotivanich K, Liong KY, Russel B, Socheat D, Newton PN, Day NP, White NJ, Preiser PR, Nosten F, Dondorp AM, Bozdech Z. Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics. 2011 Aug 3;12(1):391.

Rijken MJ, Boel ME, Russell B, Imwong M, Leimanis ML, Pyae Phyo A, Muehlenbachs A, Lindegardh N, McGready R, Renia L, Snounou G, Singhasivanon P, Nosten F. Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand. Malar J. 2011 May 5;10:113.

Kaewpongsri S, Sriprawat K, Suwanarusk R, Kyle DE, Lek-Uthai U, Leimanis M, Lwin KM, Phyo AP, Zwang J, Russell B, Nosten F, Renia L. The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Mar;55(3):1300-4.

Siswantoro H, Russell B, Ratcliff A, Prasetyorini B, Chalfein F, Marfurt J, Kenangalem E, Wuwung M, Piera KA, Ebsworth EP, Anstey NM, Tjitra E, Price RN. In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. Antimicrob Agents Chemother. 2011 Jan;55(1):197-202.

Claser C, Malleret B, Gun SY, Wong AY, Chang ZW, Teo P, See PC, Howland SW, Ginhoux F, Renia L. CD8 T Cells and IFN-gamma Mediate the Time-Dependent Accumulation of Infected Red Blood Cells in Deep Organs during Experimental Cerebral Malaria. PLoS One. 2011; 6(4):e18720.

Depinay N, Franetich JF, Gruner AC, Mauduit M, Chavatte JM, Luty AJ, van Gemert GJ, Sauerwein RW, Siksik JM, Hannoun L, Mazier D, Snounou G, Renia L. Inhibitory effect of TNF-alpha on malaria pre-erythrocytic stage development: influence of host hepatocyte/parasite combinations. PLoS One. 2011; 6(3):e17464.

Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF. Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating Factor. J Infect Dis. 2011 Jan;203(2):149-57.

Imwong M, Russell B, Suwanarusk R, Nzila A, Leimanis ML, Sriprawat K, Kaewpongsri S, Phyo AP, Snounou G, Nosten F, Renia L. Methotrexate Is Highly Potent Against Pyrimethamine-Resistant Plasmodium vivax. J Infect Dis. 2011 Jan;203(2):207-10.

2010

Price RN, Marfurt J, Chalfein F, Kenangalem E, Piera KA, Tjitra E, Anstey NM, Russell B. In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax. Antimicrob Agents Chemother. 2010 Dec;54(12):5146-50.

Li A, Russell B, Renia L, Lek-Uthai U, Nosten F, Lim CT. High density of 'spiky' excrescences covering the surface of an erythrocyte infected with Plasmodium malariae. Br J Haematol. Oct 2010; 151(1):1.

Rottmann M, McNamara C, Yeung BKS, Lee MCS, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Thierry T, Diagana TT. Spiroindolones, a Potent Compound Class for the Treatment of Malaria. Science. Sep 3 2010; 329(5996):1175-1180.

Carvalho BO, Lopes SC, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite JA, Rodrigues MM, Soares IS, Oliveira TR, Wunderlich G, Lacerda MV, del Portillo HA, Araujo MO, Russell B, Suwanarusk R, Snounou G, Renia L, Costa FT. On the cytoadhesion of Plasmodium vivax-infected erythrocytes. J Infect Dis. Aug 15 2010; 202(4):638-647.

Rénia L, Grüner AC, Snounou G. Cerebral malaria: in praise of epistemes. Trends Parasitol. 2010 Jun;26(6):275-7.

Matheoud D, Perié L, Hoeffel G, Vimeux L, Parent I, Marañón C, Bourdoncle P, Renia L, Prevost-Blondel A, Lucas B, Feuillet V, Hosmalin A. Crosspresentation by dendritic cells from live cells induces protective immune responses in vivo. Blood. 2010 Jun 3;115(22):4412-20. 

Her Z, Malleret B, Chan M, Ong EK, Wong SC, Kwek DJ, Tolou H, Lin RT, Tambyah PA, Rénia L, Ng LF. Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response. J Immunol. 2010, 184 (10), 5903-5913.

Leimanis ML, Jaidee A, Sriprawat K, Kaewpongsri S, Suwanarusk R, Barends M, Phyo AP, Russell B, Renia L, Nosten F. Plasmodium vivax Susceptibility to Ferroquine. Antimicrob Agents Chemother. 2010 May;54(5):2228-30.

Mauduit M, Tewari R, Depinay N, Kayibanda M, Lallemand E, Chavatte JM, Snounou G, Rénia L, Grüner AC. A minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites. Infect Immun. 2010 May;78(5):2182-8.

Jiménez JN, Snounou G, Letourneur F, Rénia L, Vélez ID, Muskus CE. Near-fixation of a Pfmsp1 block 2 allelic variant in genetically diverse Plasmodium falciparum populations across Western Colombia. Acta Trop. 2010 Apr;114(1):67-70.

Tong JC, Simarmata D, Lin RTP, Rénia L, Ng LFP. HLA class I restriction as a possible driving force for Chikungunya evolution. PLoS One. 2010 Feb 26;5(2): e9291.

Krief S, Escalante AA, Pacheco MA, Mugisha L, Andre C, Halbwaz M, Fischer A, Krief JM, Kasenene J, Cranfield M, Cornejo O, Chavatte JM, Lim C, Letourneur F, Gruner AC, McCutchan TF, Rénia L, Snounou G. On the Diversity of Malaria Parasites in African Apes and the Origin of Plasmodium falciparum from Bonobos. PLoS Pathog. 2010, Feb 12; 6, e100765.

Wang Y, Ait-Oufella H, Herbin O, Bonnin P, Ramkhelawon B, Taleb S, Huang J, Offenstadt G, Combadière C, Rénia L, Johnson JL, Tharaux PL, Tedgui A, Mallat Z. TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest. 2010 Feb 1;120(2):422-32.

2009

Sponaas AM, Freitas do Rosario AP, Voisine C, Mastelic B, Thompson J, Koernig S, Jarra W, Rénia L, Mauduit M, Potocnik AJ, Langhorne J. Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria. Blood. 2009 Dec 24; 114(27):5522-31.

Kam YW, Ong EK, Rénia L, Tong JC, Ng LF. Immuno-biology of Chikungunya and implications for disease intervention. Microbes Infect. 2009. Dec; 11(14-15):1186-96.

Mauduit M, Grüner AC, Tewari R, Depinay N, Kayibanda M, Chavatte JM, Franetich JF, Crisanti A, Mazier D, Snounou G, Rénia L. A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites. PLoS One. 2009 Nov 5; 4(11):e7717.

Mazier D, Rénia L, Snounou G. A pre-emptive strike against malaria's stealthy hepatic forms. Nat Rev Drug Discov. 2009 Nov; 8(11):854-64.

Manéglier B, Malleret B, Guillemin GJ, Spreux-Varoquaux O, Devillier P, Rogez-Kreuz C, Porcheray F, Thérond P, Dormont D, Clayette P. Modulation of indoleamine-2,3-dioxygenase expression and activity by HIV-1 in human macrophages. Fundam Clin Pharmacol. 2009 Oct; 23(5):573-81.

Roestenberg M, McCall M, Hopman J, Wiersma J, Luty AJ, van Gemert GJ, van de Vegte-Bolmer M, van Schaijk B, Teelen K, Arens T, Spaarman L, de Mast Q, Roeffen W, Snounou G, Rénia L, van der Ven A, Hermsen CC, Sauerwein R. Protection against a malaria challenge by sporozoite inoculation. N Engl J Med. 2009 Jul 30; 361(5):468-77.

Sriprawat K, Kaewpongsri S, Suwanarusk R, Leimanis ML, Lek-Uthai U, Phyo AP,Snounou G, Russell B, Renia L, Nosten F. Effective and cheap removal of leukocytes and platelets from Plasmodium vivax infected blood. Malar J. 2009 Jun 2; 8:115

Mitchell C, Couton D, Couty JP, Anson M, Crain AM, Bizet V, Rénia L, Pol S, Mallet V, Gilgenkrantz H. Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. Am J Pathol. 2009 May; 174(5):1766-75.

Anstey NM, Russell B, Yeo TW, Price RN. The pathophysiology of vivax malaria. Trends Parasitol. 2009 May; 25(5):220-7.

Handayani S, Chiu DT, Tjitra E, Kuo JS, Lampah D, Kenangalem E, Renia L, Snounou G, Price RN, Anstey NM, Russell B. High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. J Infect Dis. 2009 Feb 1; 199(3):445-50.

2008

Belnoue E, Voza T, Costa FT, Grüner AC, Mauduit M, Rosa DS, Depinay N, Kayibanda M, Vigário AM, Mazier D, Snounou G, Sinnis P, Rénia L. Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage. J Immunol. 2008 Dec15; 181(12):8552-8.

Buffet PA, Briand V, Rénia L, Thellier M, Danis M, Mazier D. Intermittent preventive antimalarial treatment to children (IPTc): firebreak or fire trap? Trends Parasitol. 2008 Nov; 24(11):48

Bozdech Z, Mok S, Hu G, Imwong M, Jaidee A, Russell B, Ginsburg H, Nosten F, Day NP, White NJ, Carlton JM, Preiser PR. The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proc Natl Acad Sci USA. 2008 Oct 21; 105(42):16290-5.

Belnoue E, Potter SM, Rosa DS, Mauduit M, Grüner AC, Kayibanda M, Mitchell AJ, Hunt NH, Rénia L. Control of pathogenic CD8+ T cell migration to the brain by IFN-gamma during experimental cerebral malaria. Parasite Immunol. 2008 Oct; 30(10):544-53.

Rénia L. Protective immunity against malaria liver stage after vaccination with live parasites. Parasite. 2008 Sep; 15(3):379-83.

Lek-Uthai U, Suwanarusk R, Ruengweerayut R, Skinner-Adams TS, Nosten F, Gardiner DL, Boonma P, Piera KA, Andrews KT, Machunter B, McCarthy JS, Anstey NM, Price RN, Russell B. Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum. Antimicrob Agents Chemother. Jul 2008; 52(7):2435-2441.

Togbe D, de Sousa PL, Fauconnier M, Boissay V, Fick L, Scheu S, Pfeffer K, Menard R, Grau GE, Doan BT, Beloeil JC, Renia L, Hansen AM, Ball HJ, Hunt NH, Ryffel B, Quesniaux VF. Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One. 2008 Jul 9; 3(7):e2608.

Sharrock WW, Suwanarusk R, Lek-Uthai U, Edstein MD, Kosaisavee V, Travers T, Jaidee A, Sriprawat K, Price RN, Nosten F, Russell B. Plasmodium vivax trophozoites insensitive to chloroquine. Malar J. 2008 May 27;7:94.

Suksumek N, Leelawat K, Leelawat S, Russell BM, Lek-Uthai U. TaqMan real-time PCR assay for specific detection of Opisthorchis viverrini DNA in Thai patients with hepatocellular carcinoma and cholangiocarcinoma. Exp Parasitol. 2008; 199:217-224.

Rottman M, Soudais C, Vogt G, Renia L, Emile JF, Decaluwe H, Gaillard JL, Casanova JL. IFN-gamma mediates the rejection of hematopoietic stem cells in IFN-gammaR1-deficient hosts. PLoS Med. 2008 Jan 29; 5(1):e26.


2007

Grüner AC, Mauduit M, Tewari R, Romero JF, Depinay N, Kayibanda M, Lallemand E, Chavatte JM, Crisanti A, Sinnis P, Mazier D, Corradin G, Snounou G, Rénia L. Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS One. 2007 Dec 26; 2(12):e1371.

Lengagne R, Graff-Dubois S, Garcette M, Renia L, Kato M, Guillet JG, Engelhard VH, Avril MF, Abastado JP, Prévost-Blondel A. Distinct role for CD8 T cells toward cutaneous tumors and visceral metastases. J Immunol. 2008 Jan 1; 180(1):130-7.

Iyer J, Grüner AC, Rénia L, Snounou G, Preiser PR. Invasion of host cells by malaria parasites: a tale of two protein families. Mol Microbiol. 2007 Jul; 65(2):231-49.

Bongfen SE, Torgler R, Romero JF, Renia L, Corradin G. Plasmodium berghei-infected primary hepatocytes process and present the circumsporozoite protein to specific CD8+ T cells in vitro. J Immunol. 2007 Jun 1; 178(11):7054-63.

Vigário AM, Belnoue E, Grüner AC, Mauduit M, Kayibanda M, Deschemin JC, Marussig M, Snounou G, Mazier D, Gresser I, Rénia L. Recombinant human IFN-alpha inhibits cerebral malaria and reduces parasite burden in mice. J Immunol. 2007 May 15; 178(10):6416-25.

Soulard V, Roland J, Sellier C, Gruner AC, Leite-de-Moraes M, Franetich JF, Rénia L, Cazenave PA, Pied S. Primary infection of C57BL/6 mice with Plasmodium yoelii induces a heterogeneous response of NKT cells. Infect Immun. 2007 May; 75(5):2511-22.

Snounou G, Rénia L. The vaccine is dead--long live the vaccine. Trends Parasitol. 2007 Apr; 23(4):129-32.

2006

Rénia L, Potter SM. Co-infection of malaria with HIV: an immunological perspective. Parasite Immunol. 2006 Nov; 28(11):589-95.

Rénia L, Grüner AC, Mauduit M, Snounou G. Vaccination against malaria with live parasites. Expert Rev Vaccines. 2006 Aug; 5(4):473-81.

Lena G, Lallemand E, Gruner AC, Boeglin J, Roussel S, Schaffner AP, Aubry A, Franetich JF, Mazier D, Landau I, Briand JP, Didierjean C, Rénia L, Guichard G. 1,3,5-Triazepane-2,6-diones as structurally diverse and conformationally constrained dipeptide mimetics: identification of malaria liver stage inhibitors
from a small pilot library. Chemistry. 2006 Nov 15; 12(33):8498-512.

Babayan SA, Attout T, Harris A, Taylor MD, Le Goff L, Vuong PN, Rénia L, Allen JE, Bain O. Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. Int J Parasitol. 2006 Jul; 36(8):903-14.

Rénia L, Potter SM, Mauduit M, Rosa DS, Kayibanda M, Deschemin JC, Snounou G, Grüner AC. Pathogenic T cells in cerebral malaria. Int J Parasitol. 2006 May 1; 36(5):547-54. .

Morosan S, Hez-Deroubaix S, Lunel F, Renia L, Giannini C, Van Rooijen N, Battaglia S, Blanc C, Eling W, Sauerwein R, Hannoun L, Belghiti J, Brechot C, Kremsdorf D, Druilhe P. Liver-stage development of Plasmodium falciparum, in a humanized mouse model. J Infect Dis. 2006 Apr 1; 193(7):996-1004.

Renia L, Maranon C, Hosmalin A, Gruner AC, Silvie O, Snounou G. Do apoptotic Plasmodium-infected hepatocytes initiate protective immune responses? J Infect Dis. 2006 Jan 1; 193(1):163-4.

2005

Engwerda C, Belnoue E, Grüner AC, Rénia L. Experimental models of cerebral malaria. Curr Top Microbiol Immunol. 2005; 297:103-43.

Kumkhaek C, Phra-Ek K, Rénia L, Singhasivanon P, Looareesuwan S, Hirunpetcharat C, White NJ, Brockman A, Grüner AC, Lebrun N, Alloueche A, Nosten F, Khusmith S, Snounou G. Are extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressure? J Immunol. 2005 Sep 15; 175(6):3935-9.

Snounou G, Grüner AC, Müller-Graf CD, Mazier D, Rénia L. The Plasmodium sporozoite survives RTS,S vaccination. Trends Parasitol. 2005 Oct;21(10):456-61.

Voza T, Vigário AM, Belnoue E, Grüner AC, Deschemin JC, Kayibanda M, Delmas F, Janse CJ, Franke-Fayard B, Waters AP, Landau I, Snounou G, Rénia L. Species-specific inhibition of cerebral malaria in mice co-infected with Plasmodium spp. Infect Immun. 2005 Aug;73(8):4777-86.

Reynaud D, Ravet E, Titeux M, Mazurier F, Rénia L, Dubart-Kupperschmitt A, Roméo PH, Pflumio F. SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. Blood. 2005 Oct 1; 106(7):2318-28.

Imwong M, Pukrittayakamee S, Grüner AC, Rénia L, Letourneur F, Looareesuwan S, White NJ, Snounou G. Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. Malar J. 2005 Apr 27;4(1):20.

Lou DQ, Lesbordes JC, Nicolas G, Viatte L, Bennoun M, Van Rooijen N, Kahn A, Renia L, Vaulont S. Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo. Hepatology. 2005 May;41(5):1056-64.

Babayan S, Attout T, Specht S, Hoerauf A, Snounou G, Rénia L, Korenaga M, Bain O, Martin C. Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filarial Litomosoides sigmodontis. Med Microbiol Immunol. 2005 May; 194(3):151-62. Epub 2004 Aug 26.

2004

Kumkhaek C, Phra-ek K, Singhasivanon P, Looareesuwan S, Hirunpetcharat C, Brockman A, Grüner AC, Lebrun N, Rénia L, Nosten F, Snounou G, Khusmith S. A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of Plasmodium falciparum parasites from western Thailand. Southeast Asian J Trop Med Public Health. 2004 Jun; 35(2):281-7.

McRobert L, Preiser P, Sharp S, Jarra W, Kaviratne M, Taylor MC, Renia L, Sutherland CJ. Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle. Infect Immun. 2004 Nov; 72(11):6597-602.

Belnoue E, Guettier C, Kayibanda M, Le Rond S, Crain-Denoyelle AM, Marchiol C, Ziol M, Fradelizi D, Rénia L, Viguier M. Regression of established liver tumor induced by monoepitopic peptide-based immunotherapy. J Immunol. 2004 Oct 15; 173(8):4882-8.

Grüner AC, Snounou G, Fuller K, Jarra W, Rénia L, Preiser PR. The Py235 proteins: glimpses into the versatility of a malaria multigene family. Microbes Infect. 2004 Jul; 6(9):864-73.

Singh N, Preiser P*, Rénia L*, Balu B, Barnwell J, Blair P, Jarra W, Voza T, Landau I, Adams JH. Conservation and developmental control of alternative splicing in maebl among malaria parasites. J Mol Biol. 2004 Oct 22; 343(3):589-99. *Co-second author

Preiser P*, Rénia L*, Singh N, Balu B, Jarra W, Voza T, Kaneko O, Blair P, Torii M, Landau I, Adams JH. Antibodies against MAEBL ligand domains M1 and M2 inhibit sporozoite development in vitro. Infect Immun. 2004 Jun; 72(6):3604-8. *Co-first author

Silvie O, Franetich JF, Rénia L, Mazier D. Malaria sporozoite: migrating for a living. Trends Mol Med. 2004 Mar; 10(3):97-100;

Lengagne R, Le Gal FA, Garcette M, Fiette L, Ave P, Kato M, Briand JP, Massot C, Nakashima I, Rénia L, Guillet JG, Prévost-Blondel A. Spontaneous vitiligo in an animal model for human melanoma: role of tumor-specific CD8+ T cells. Cancer Res. 2004 Feb 15; 64(4):1496-501.

Belnoue E, Costa FT, Frankenberg T, Vigário AM, Voza T, Leroy N, Rodrigues MM, Landau I, Snounou G, Rénia L. Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment. J Immunol. 2004 Feb 15; 172(4):2487-95

2003

Babayan S, Ungeheuer MN, Martin C, Attout T, Belnoue E, Snounou G, Rénia L, Korenaga M, Bain O. Resistance and susceptibility to filarial infection with Litomosoides sigmodontis are associated with early differences in parasite development and in localized immune reactions. Infect Immun. 2003 Dec; 71(12):6820-9.

Belnoue E, Costa FT, Vigário AM, Voza T, Gonnet F, Landau I, Van Rooijen N, Mack M, Kuziel WA, Rénia L. Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria. Infect Immun. 2003 Jun; 71(6):3648-51.

Tourneur L, Mistou S, Michiels FM, Devauchelle V, Renia L, Feunteun J, Chiocchia G. Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells. Oncogene. 2003 May 8; 22(18):2795-804.

Imwong M, Pukrittayakamee S, Rénia L, Letourneur F, Charlieu JP, Leartsakulpanich U, Looareesuwan S, White NJ, Snounou G. Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure. Antimicrob Agents Chemother. 2003 May;47(5):1514-21.

Grüner AC, Snounou G, Brahimi K, Letourneur F, Rénia L, Druilhe P. Pre-erythrocytic antigens of Plasmodium falciparum: from rags to riches? Trends Parasitol. 2003 Feb; 19(2):74-8.

Belnoue E, Kayibanda M, Deschemin JC, Viguier M, Mack M, Kuziel WA, Rénia L. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood. 2003 Jun 1; 101(11):4253-9.

2002

Silvie O, Rubinstein E, Franetich JF, Prenant M, Belnoue E, Rénia L, Hannoun L, Eling W, Levy S, Boucheix C, Mazier D. Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Nat Med. 2003 Jan; 9(1):93-6.

Belnoue E, Kayibanda M, Vigario AM, Deschemin JC, van Rooijen N, Viguier M, Snounou G, Rénia L. On the pathogenic role of brain-sequestered alpha beta CD8+ T cells in experimental cerebral malaria. J Immunol. 2002 Dec 1; 169(11):6369-75.

Rénia L, Belnoue E, Vigário AM. T-cell mediated inhibition of liver-stage development assay. Methods Mol Med. 2002; 72:521-7.

Rénia L, Vigário AM, Belnoue E. Inhibition of sporozoite invasion. The double-staining assay. Methods Mol Med. 2002; 72:507-16.

Rénia L, Belnoue E, Landau I. Mouse models for pre-erythrocytic-stage malaria. Methods Mol Med. 2002; 72:41-55.

Voza T, Gautret P, Renia L, Gantier JC, Lombard MN, Chabaud AG, Landau I. Variation in murid Plasmodium desequestration and its modulation by stress and pentoxifylline. Parasitol Res. 2002 Apr;88(4):344-9.

Mallet VO, Mitchell C, Mezey E, Fabre M, Guidotti JE, Renia L, Coulombel L, Kahn A, Gilgenkrantz H. Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo. Hepatology. 2002 Apr; 35(4):799-804.

Preiser PR, Khan S, Costa FT, Jarra W, Belnoue E, Ogun S, Holder AA, Voza T, Landau I, Snounou G, Rénia L. Stage-specific transcription of distinct repertoires of a multigene family during Plasmodium life cycle. Science. 2002 Jan 11; 295(5553):342-5.

2001

Grüner AC, Brahimi K, Letourneur F, Rénia L, Eling W, Snounou G, Druilhe P. Expression of the erythrocyte-binding antigen 175 in sporozoites and in liver stages of Plasmodium falciparum. J Infect Dis. 2001 Oct 1; 184(7):892-7.

Vigário AM, Belnoue E, Cumano A, Marussig M, Miltgen F, Landau I, Mazier D, Gresser I, Rénia L. Inhibition of Plasmodium yoelii blood-stage malaria by interferon alpha through the inhibition of the production of its target cell, the reticulocyte. Blood. 2001 Jun 15; 97(12):3966-71.

Costa FT, Snounou G, Letourneur F, Lebrun N, Landau I, Rénia L. The primary structure of the circumsporozoite protein of Plasmodium atheruri, a malaria parasite of the African porcupine Atherurus africanus. Mol Biochem Parasitol. 2001 Apr 25; 114(1):125-7.

Baratin M, Ziol M, Romieu R, Kayibanda M, Gouilleux F, Briand P, Leroy P, Haddada H, Rénia L, Viguier M, Guillet JG. Regression of primary hepatocarcinoma in cancer-prone transgenic mice by local interferon-gamma delivery is associated with macrophages recruitment and nitric oxide production. Cancer Gene Ther. 2001 Mar; 8(3):193-202.

2000

Jung M, Drapier JC, Weidenbach H, Renia L, Oliveira L, Wang A, Beger HG, Nussler AK. Effects of hepatocellular iron imbalance on nitric oxide and reactive oxygen intermediates production in a model of sepsis. J Hepatol. 2000 Sep; 33(3):387-94.

Amani V, Vigário AM, Belnoue E, Marussig M, Fonseca L, Mazier D, Rénia L. Involvement of IFN-gamma receptor-medicated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection. Eur J Immunol. 2000 Jun; 30(6):1646-55.

Vuong PN, Richard F, Snounou G, Coquelin F, Rénia L, Gonnet F, Chabaud AG, Landau I. Development of irreversible lesions in the brain, heart and kidney following acute and chronic murine malaria infection. Parasitology. 1999 Dec; 119 (Pt 6):543-53.

Landau I, Chabaud AG, Mora-Silvera E, Coquelin F, Boulard Y, Rénia L, Snounou G. Survival of rodent malaria merozoites in the lymphatic network: potential role in chronicity of the infection. Parasite. 1999 Dec; 6(4):311-22

Ribeirão M, Pereira-Chioccola VL, Rénia L, Augusto Fragata Filho A, Schenkman S, Rodrigues MM. Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase. Parasite Immunol. 2000 Jan; 22(1):49-53.

1999

Rodrigues MM, Ribeirão M, Pereira-Chioccola V, Renia L, Costa F. Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene. Infect Immun. 1999 Aug; 67(8):3855-63.

André C, Couton D, Gaston J, Erraji L, Renia L, Varlet P, Briand P, Guillet JG. beta2-adrenergic receptor-selective agonist clenbuterol prevents Fas-induced liver apoptosis and death in mice. Am J Physiol. 1999 Mar; 276(3 Pt 1):G647-54.

1998

Druilhe P, Rénia L, Fidock D. Immunity to malaria liver stages. In: Malaria: Parasite Biology, Pathogenesis, and Protection. I.W. Sherman, editor. 1998. Chapter 34, pp 513-541,

Amani V, Boubou MI, Pied S, Marussig M, Walliker D, Mazier D, Rénia L. Cloned lines of Plasmodium berghei ANKA differ in their abilities to induce experimental cerebral malaria. Infect Immun. 1998 Sep; 66(9):4093-9.

1997

Marussig M, Nivez MP, Achbarou A, Rénia L, Mazier D. Interactions between malaria parasites and AIDS viruses: the TH1/TH2 cytokine balance. In Proceedings of the Indo-french Symposium on Immunomodulation. SN Upadhyay, editor. Narosa Publishing House, New Dehli, India. 1997, Chapter 13, pp 112-118.

Mazier D, Pied P, Petour P, Hulier E, Marussig M, Miltgen F, Landau L, Rénia L, Chauhan VS. Malaria peptides expressed on the surface of infected hepatocytes: isolation, synthesis and functional analysis. Ann Trop Med Parasitol.1997; 91:S21-S24.

Marussig M, Rénia L, Motard A, Miltgen F, Pétour P, Chauhan V, Corradin G, Mazier D. Linear and multiple antigen peptides containing defined T and B epitopes of the Plasmodium yoelii circumsporozoite protein: antibody-mediated protection and boosting by sporozoite infection. Int Immunol. 1997 Dec; 9(12):1817-24.

Rénia L, Ling IT, Marussig M, Miltgen F, Holder AA, Mazier D. Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge. Infect Immun. 1997 Nov; 65(11):4419-23.

Mora-Silvera E, Coquelin F, Vuong P, Deharo E, Gautret P, Renia L, Chabaud A, Landau I. Role of macrophages as possible transporters of Plasmodium yoelii nigeriensis merozoites through the lymphatic system. Parasite. 1997 Mar;4(1):83-5.

Pied S, Voegtle D, Marussig M, Rénia L, Miltgen F, Mazier D, Cazenave PA. Evidence for superantigenic activity during murine malaria infection. Int Immunol. 1997 Jan; 9(1):17-25

1996

Boulard Y, Coquelin F, Mora Silvera E, Renia L, Gautret P, Deharo E, Snounou G, Vuong PN, Chabaud A, Landau I. Dendritic leucocytes as possible carriers of murine Plasmodium merozoites. Parasite. 1996 Dec;3(4):383-6.

Achbarou A, Ombrouck C, Gneragbe T, Charlotte F, Rénia L, Desportes-Livage I, Mazier D. Experimental model for human intestinal microsporidiosis in interferon gamma receptor knockout mice infected by Encephalitozoon intestinalis. Parasite Immunol. 1996 Aug;18(8):387-92.

Hulier E, Pétour P, Marussig M, Nivez MP, Mazier D, Rénia L. Quantitative assessment of murine retrovirus LP-BM5 infection in MAIDS by PCR and anion exchange HPLC. J Virol Methods. 1996 Jul; 60(2):109-17.

Hulier E, Pétour P, Snounou G, Nivez MP, Miltgen F, Mazier D, Rénia L. A method for the quantitative assessment of malaria parasite development in organs of the mammalian host. Mol Biochem Parasitol. 1996 May; 77(2):127-35.

Marussig M, Rénia L, Mazier D. Interactions between AIDS viruses and malaria parasites: a role for macrophages? Res Virol. 1996 Mar-Jun; 147(2-3):139-45.

Goma J, Rénia L, Miltgen F, Mazier D. Iron overload increases hepatic development of Plasmodium yoelii in mice. Parasitology. 1996 Feb; 112 (Pt 2):165-8.

1995

Goma J, Renia L, Miltgen F, Mazier D. Effects of iron deficiency on the hepatic development of Plasmodium yoelii. Parasite. 1995 Dec; 2(4):351-6.

Faure P, Hulier E, Miltgen F, Renia L, Mazier D. Protective immunity against malaria: cellular changes in the liver vary according to the method of immunization. Parasite Immunol. 1995 Sep; 17(9):469-77.

Motard A, Marussig M, Rénia L, Baccam D, Landau I, Mattei D, Targett G, Mazier D. Immunization with the malaria heat shock like protein hsp70-1 enhances transmission to the mosquito. Int Immunol. 1995 Jan; 7(1):147-50


1994

Mazier D, Pétour P, Pied P, Marussig M, Rénia L. The protective immunity induced by surface epitopes of intrahepatic malaria parasites. In Recombinant and synthetic vaccines, G.P. Talwar, K. V. S. Rao and V. S. Chauhan, editors. Narosa Publishing House, New Dehli.1994, pp108-116.

Eckwalanga M, Marussig M, Tavares MD, Bouanga JC, Hulier E, Pavlovitch JH, Minoprio P, Portnoï D, Rénia L, Mazier D. Murine AIDS protects mice against experimental cerebral malaria: down-regulation by interleukin 10 of a T-helper type 1 CD4+ cell-mediated pathology. Proc Natl Acad Sci USA. 1994 Aug 16; 91(17):8097-101.

Rénia L, Rodrigues MM, Nussenzweig V. Intrasplenic immunization with infected hepatocytes: a mouse model for studying protective immunity against malaria pre-erythrocytic stage. Immunology.1994 May; 82(1):164-8.

1993

Marussig M, Motard A, Rénia L, Baccam D, Lebras J, Charmot G, Mazier D. Activity of doxycycline against pre-erythrocytic malaria. J Infect Dis. 1993 Dec; 168(6):1603-4.

Mazier D, Rénia L, Pied S, Nussler A, Marussig M, Landau I, Miltgen F, Grillot D, Del Giudice G, Grau G, et al. Hepatic stages of malaria: specific and non-specific factors inhibiting the development. Parassitologia. 1993 Jul; 35 Suppl: 59-63.

Nussler AK, Rénia L, Pasquetto V, Miltgen F, Matile H, Mazier D. In vivo induction of the nitric oxide pathway in hepatocytes after injection with irradiated malaria sporozoites, malaria blood parasites or adjuvants. Eur J Immunol. 1993 Apr; 23(4):882-7.

Rénia L, Grillot D, Marussig M, Corradin G, Miltgen F, Lambert PH, Mazier D, Del Giudice G. Effector functions of circumsporozoite peptide-primed CD4+ T cell clones against Plasmodium yoelii liver stages. J Immunol. 1993 Feb 15; 150(4):1471-8.

Rénia L, Xia D, Samols D, Nussenzweig V. Transgenic mice expressing C-reactive protein are susceptible to infection with Plasmodium yoelii sporozoites. Infect Immun. 1993 Jan; 61(1):348-9.

1992

Pied S, Civas A, Berlot-Picard F, Renia L, Miltgen F, Gentilini M, Doly J, Mazier D. IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite. J Immunol. 1992 Jan 1; 148(1):197-201.

1991

Rénia L, Marussig MS, Grillot D, Pied S, Corradin G, Miltgen F, Del Giudice G, Mazier D. In vitro activity of CD4+ and CD8+ T lymphocytes from mice immunized with a synthetic malaria peptide. Proc Natl Acad Sci USA. 1991 Sep 15; 88(18):7963-7.

Del Giudice G, Tougne C, Renia L, Ponnudurai T, Corradin G, Pessi A, Verdini AS, Louis JA, Mazier D, Lambert PH. Characterization of murine monoclonal antibodies against a repetitive synthetic peptide from the circumsporozoite protein of the human malaria parasite, Plasmodium falciparum. Mol Immunol. 1991 Sep; 28(9):1003-9

Etlinger HM, Renia L, Matile H, Manneberg M, Mazier D, Trzeciak A, Gillessen D. Antibody responses to a synthetic peptide-based malaria vaccine candidate: influence of sequence variants of the peptide. Eur J Immunol. 1991 Jun; 21(6):1505-11. .

Nussler A, Pied S, Goma J, Rénia L, Miltgen F, Grau GE, Mazier D. TNF inhibits malaria hepatic stages in vitro via synthesis of IL-6. Int Immunol. 1991 Apr; 3(4):317-21.

Pied S, Rénia L, Nüssler A, Miltgen F, Mazier D. Inhibitory activity of IL-6 on malaria hepatic stages. Parasite Immunol. 1991 Mar; 13(2):211-7.

Nussler A, Pied S, Pontet M, Miltgen F, Renia L, Gentilini M, Mazier D. Inflammatory status and pre-erythrocytic stages of malaria: role of the C-reactive protein. Exp Parasitol. 1991 Jan; 72(1):1-7.

Nüssler A, Drapier JC, Rénia L, Pied S, Miltgen F, Gentilini M, Mazier D. L-argentine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation. Eur J Immunol. 1991 Jan; 21(1):227-30.

1990

Mazier D, Rénia L, Nussler A, Pied S, Marussig M, Goma J, Grillot D, Miltgen F, Drapier JC, Corradin G, et al. Hepatic phase of malaria is the target of cellular mechanisms induced by the previous and the subsequent stages. A crucial role for liver nonparenchymal cells. Immunol Lett. 1990 Aug; 25(1-3):65-70.

Del Giudice G, Grillot D, Rénia L, Müller I, Corradin G, Louis JA, Mazier D, Lambert PH. Peptide-primed CD4+ cells and malaria sporozoites. Immunol Lett. 1990 Aug; 25(1-3):59-63.

Rénia L, Mattei D, Goma J, Pied S, Dubois P, Miltgen F, Nüssler A, Matile H, Menégaux F, Gentilini M, et al. A malaria heat-shock-like determinant expressed on the infected hepatocyte surface is the target of antibody-dependent cell-mediated cytotoxic mechanisms by nonparenchymal liver cells. Eur J Immunol. 1990 Jul; 20(7):1445-9.

Grillot D, Michel M, Müller I, Tougne C, Rénia L, Mazier D, Corradin G, Lambert PH, Louis JA, Del Giudice G. Immune responses to defined epitopes of the circumsporozoite protein of the murine malaria parasite, Plasmodium yoelii. Eur J Immunol. 1990 Jun; 20(6):1215-22

Lussow AR, Del Giudice G, Rénia L, Mazier D, Verhave JP, Verdini AS, Pessi A, Louis JA, Lambert PH. Use of a tuberculin purified protein derivative--Asn-Ala-Asn-Pro conjugate in bacillus Calmette-Guérin primed mice overcomes H-2 restriction of the antibody response and avoids the need for adjuvants. Proc Natl Acad Sci USA. 1990 Apr; 87(8):2960-4.

Mazier D, Goma J, Pied S, Renia L, Nussler A, Miltgen F, Mattei D, Grau G. Hepatic phase of malaria: a crucial role as "go-between" with other stages. Bull World Health Organ. 1990; 68 Suppl: 126-31.

1989

Nudelman S, Rénia L, Charoenvit Y, Yuan L, Miltgen F, Beaudoin RL, Mazier D. Dual action of anti-sporozoite antibodies in vitro. J Immunol. 1989 Aug 1; 143(3):996-1000.

1988

Rénia L, Miltgen F, Charoenvit Y, Ponnudurai T, Verhave JP, Collins WE, Mazier D. Malaria sporozoite penetration. A new approach by double staining. J Immunol Methods. 1988 Sep 13; 112(2):201-5.

Mazier D, Miltgen F, Nudelman S, Nussler A, Renia L, Pied S, Goma J, Gentilini M. Pre-erythrocytic stages of plasmodia. Role of specific and nonspecific factors. Biol Cell. 1988; 64(2):165-72.

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