Dr Ng completed his Bachelor of Medical Science (Honours) degree from University of New South Wales, Australia in 2000. He was then awarded an International Postgraduate Research Scholarship to conduct his PhD work at the Garvan Institute of Medical Research in Sydney, Australia. After completing his PhD in 2004, he joined Institute of Molecular and Cell Biology in Singapore for his postdoctoral training under the supervision of Professor Lam Kong Peng. In 2006, Dr Ng joined Professor Wolfgang Weninger’s laboratory at the Wistar Institute in Philadelphia USA. Following his postdoctoral training, Dr Ng joined Singapore Immunology Network (SIgN) to establish his own laboratory in 2009. He is also an adjunct Assistant Professor at the National University of Singapore and Nanyang Technological University in Singapore. Dr Ng has also been appointed as a adjunct Scientist at KK Women’s and Children’s Hospital (KKH), Singapore. The primary research focus of his group is to study how immune cells exert their function in the context of intact organs by intravital multiphoton microscopy. Using a combination of functional and in vivo imaging studies, his group aims to determine the sequence of cellular and molecular events involved in the regulation of immune cell homeostasis. Dr Ng’s laboratory has established several intravital imaging approaches for direct visualization of immune cell behaviour in the skin, bone marrow, lung, brain and muscle. Dr Ng’s contributions to the field of immunology research is best exemplified by his multiple publications in leading journals such as Journal of Experimental Medicine, Advanced Materials, Nature Protocols and Journal of Investigative Dermatology. He is also a review editor of Frontiers in Immunotherapies and Vaccines and an academic editor for PloS One. Dr. Ng also recently joined the editorial board of Cellular Immunology and Journal of Dermatological Research.

Adjunct Positions

  • Adjunct Assistant Professor, NUS, Singapore
  • Adjunct Assistant Professor, NTU, Singapore
  • Joint Scientist, KKH, Singapore
  • Adjunct Associate Professor, University of Sydney Medical School, Australia

Research Focus

The immune system consists of an extensive network of immune cells distributed among various body compartments, including lymphoid and non-lymphoid organs. A major characteristic of leukocytes is that they rely on their migratory behavior to execute their effector functions in a temporal and anatomical defined manner, and to return to a state of homeostasis after the response. To attain a comprehensive understanding of the cellular and molecular mechanisms of leukocyte function, ideally, the trafficking/migratory activities of leukocytes should be investigated within their native microenvironment in a dynamic manner. The primary goal of our laboratory is to understand how the local micro-milieu impacts on the cellular activities and function of myeloid cells. Specially, we aim to investigate the behavior of neutrophils and monocytes in a compartmentalized manner, i.e. by deciphering their interactive behavior in the bone marrow (BM), within the circulatory system and peripheral tissue/organ. To achieve this, we will make use of a combination of intravital imaging techniques, conventional cellular and molecular approaches, as well as in vivo models.

Intravital Imaging Models established in the lab

Lab Members

SIgN Fellow Postdocs (Ph.D) Research Officers PhD Students
Shu Zhen CHONG De Hua LIU Keith LEONG Nazihah Husna ABDUL AZIZ
Changming SHI Ka Hang LIONG Leonard TAN
Melissa NG Ye Chean TEH
Immanuel KWOK Ming Yao CHOOI
 Jackson LI  
 Yingrou TAN (Visiting Scientist)  



 2021 HCR2020 HCR

Lai Guan Ng's SIgN affiliated publications (last updated 30 November 2022)