Events

Seminar on Titanium Alloys and Biomaterials Manufacturing Technologies for Medical Applications

Date: 09 Sep 2010 - 09 Sep 2010

Venue: SIMTech Auditorium, Tower Block, Level 3

Introduction
This seminar is co-organised by PE COI (MedTech) and sponsored by ITS Science & Medical, Dassault Systèmes and EOS Singapore. Participants will benefit from learning the scientific trends and state-of-the-art of Titanium processing particularly for implant applications.

Abstracts
The Dream Implant – A Surgeon’s Perspective by Dr Wilson Wang, NUH
Orthopaedic implants are widely used to treat a variety of clinical conditions, ranging from hip and knee replacements to fracture fixation implants to spinal fusion devices, amongst others. Such implants form the basis of a multi-billion dollar industry with health implications for many millions of patients each year. Successful treatment can restore function, alleviate pain and correct deformities; on the other hand implant failure can lead to disastrous consequences, with high morbidity and socio-economic costs to both patient and society. This talk will examine the various applications of biomaterial implants in orthopaedic practice and how they can help patients, and also explore the major problems that still face implant surgery and technology today. From the end-user’s point of view, Dr Wang will share his vision of the ideal implant for the future: Is it a dream or can it be a reality?     

Form, Material and Manufacture Follow Function by Mr Lukasz Pienkowski, 4T Technologies

With a wide range of forming techniques and grades, titanium is a versatile alloy that due to its biocompatibility is

ideal for use in implants. For successful implant development, the medical application and its functional requirements

have to be defined by both the engineer and the surgeon before a suitable grade can be chosen and the

manufacturing process defined. For defining the function clearly an effective research, communication

and development process can lead to a substantial reduction in costs of mass-produced implants and, in highly

complicated cases, of customised titanium implants. On the example of recent projects in Singapore and Germany

some of these techniques will be outlined to illustrate its effects on the manufacturing process.

FEA Simulation on Implant Technology by Mr Bhavesh Kumar, DS Simulia
The use of computational numerical modelling, such as Finite Element Analysis (FEA), has become well established as tool for helping engineers design a wide range of products and the processes used to manufacture them. The rapid development in compute power is enabling the techniques to become much more sophisticated so that today realistic simulation of complex systems is possible. In Bioengineering the ability to model the behavior of both natural human tissue combined with the well proven analysis of standard engineering materials, i.e. metals and plastics, etc opens up tremendous opportunities for those developing products for medical use to improve their performance, reduce costs and get products to market faster. A related benefit is that these tools can help surgeons and others in the medical field customise or tailor make products for patients. In this presentation we will review some of the modelling methods commonly used and provide examples of typical applications from medical devices to engineered endoprosthetics with a particular focus on titanium implants. The analysis of these as they will behave in the patient  (as opposed to within a laboratory) is allowing the medical profession to achieve much greater rates of clinical success and gives those manufacturers who have leveraged simulation a competitive edge.   

Forming Technology of Titanium Alloys for Biomedical Applications - Challenges and Possibility by Dr Danno Atsushi, SIMTech
The forming technology of titanium alloys is important for industries to reduce the material waste and cost, in the manufacturing of biomedical components, but the titanium alloys are generally difficult-to-form material due to its high flow stress and poor ductility. The challenges in SIMTech on forming technology will be shown mainly for two kinds of titanium alloys, i.e., low elastic modulus/high strength titanium alloy “Gum Metal” and Ti-6Al-4V alloy for biomedical applications. The topics will includes:
(i)Possibility of high precision forming by combining stamping and cold forging
(ii)Challenge to cold and warm forming of Ti-alloys (Formability and spin forming)

EOS e-Manufacturing Solutions for Biomedical Industry Using Ti by Mr Anand Prakasam, EOS
e-Manufacturing is defined as  the fast, flexible and cost effective production of complex parts directly from a CAD data within a short time using a technology called Laser Sintering /Melting. In the presentation we will cover 
(i) The process of Laser Sintering - the key towards e-Manufacturing 
(ii) The different materials / systems of EOS Laser Sintering 
(iii) Applications in Biomedical industry 
(iv) Brief introduction on EOS  

Forging Applied to Biomedical Metals and Alloys by Dr Margam Chandrasekaran, Bio-scaffold International
There has been growing emphasis on medical technology over the recent past and new technologies have been applied in processing of biomaterials for medical applications. A global investment on medical technology research has been over billion US$. Processing plays a vital role in the final properties achievable in an artificial implant. The properties that are critical to an artificial implant include comparable or higher strength and modulus to that of bone, high fatigue and wear resistance and fracture toughness and anisotropic elastic properties similar to that of bone/tissue. The talk reviews the process of forging applied to implant materials in particular and their advantages and disadvantages in terms of achieving the desired properties.  

Printing of Titanium Implant Prototype by Dr Florencia Wiria Edith, SIMTech
Dental implant plays an important role as a conduit of force and stress to flow from the tooth to the related bone. In the load sharing between an implant and its related bone, the amount of stress carried by each of them directly related to their stiffness or modulus. Hence, it is a crucial issue for the implant to have matching mechanical properties, in particular modulus, between the implant and its related bone. Titanium is a metallic material that has good biocompatibility and corrosion resistance. Whilst the modulus of the bulk material is still higher than that of bone, it is the lowest among all other commonly used metallic implant materials, such as stainless steel or cobalt alloy. Hence it is potential to further reduce the modulus of pure Titanium by engineering its processing method to obtain porous structure. In this project, porous Titanium implant prototype is fabricated using 3-dimensional printing. This technique allows the flexibility of design customisation, which is beneficial for implant fabrication as tailoring of implant size and shape helps to ensure the implant would fit nicely to the patient. The fabricated Titanium prototype had a modulus of 4.8—13.2 GPa, which is in the range of natural bone modulus. The compressive strength achieved was between 167 to 455 MPa. Subsequent cell culture study indicated that the porous Titanium prototype had good biocompatibility and is suitable for bone cell attachment and proliferation.  

About the Speakers
Dr Wilson Wang is a Senior Consultant Orthopaedic Surgeon at the National University Hospital, and the current Head of Hip and Knee Surgery in the Department of Orthopaedic Surgery. He completed his medical degree with distinctions at the University of London, and was awarded the Douglas Cree Prize in Medicine for his final MBBS Examinations. He was subsequently the Girdlestone Scholar at the University of Oxford for his doctorate (DPhil) degree, where he did research on implant wear and implant-related infection. His further surgical and orthopedic training was obtained in Singapore and the UK, where he did the Joint Replacement Fellowship at the Nuffield Orthopaedic Centre in Oxford. In his clinical practice, Dr Wang now specialises in knee and hip replacement surgery and as well as other forms of joint reconstruction. He leads an active research programme in orthopaedic implant biomaterials, and his work has been recognised locally and internationally, including the Singapore Orthopaedic Association & Bioengineering Society Prize, the Asia-Pacific Orthopedic Association Pfizer Prize in Orthopedic Infection, and 3rd Prize at the European Orthopaedic Research Society Meeting. He currently holds research grants as principal investigator from BMRC and NMRC totaling $1.2 million, and is a member of the Singapore Orthopaedic Association, European Orthopaedic Research Society, British Orthopedic Research Society, NUS Nanoscience and Nanotechnology Initiative, and NUH Bioethics Committee.

Mr Lukasz Pienkowski has worked on the development of titanium implants at 4T Technologies in Singapore since 2009. He advocates a holistic design process focused on strong communication between surgeons and engineers with fluent borders between the two professions. Mr Pienkowski received his Master degree in Design Strategy and Innovation from Brunel University in London and has worked in a variety of Product and Brand Development roles in the Medical, Environmental and Transport industries.

Mr Bhavesh Kumar has been a part of SIMULIA India for close to 7 years. He started his career as an Applications Engineer handling technical support and training for Abaqus FEA products. As a Technical Manager, he later led the Technical Services Team with a focus on providing technical support and services across various engineering domains, ranging from automotive and aerospace to defense. In this role, he was closely involved with customers working on biomedical applications to address their simulation requirements, and guided them on areas such as Nitinol material characterisation, stent deployment analysis, biological tissue modelling, and analysis of biomedical equipments. In his current role as a Principal Consultant to the SIMULIA Asia Industry Team, he closely interacts with key customers in the region and helps formulating and promoting the use of best practices for simulation workflows. Bhavesh has an MS in Mechanical Engineering from SUNY Stony Brook, New York, and a BE in Mechanical Engineering from National Institute of Technology, Trichy, India.

Mr Anand Prakasam has 5 years of Techno commercial sales in CAD/ CAM /CAE in software like Pro Engineer, Catia, Ansys, LSDyna, Adams, Mastercam. He has more than 11 years sales and operational experience with EOS laser Sintering systems in the field of automotive, aerospace, tooling, casting development and Medical. He had developed a software program to analyse and simulate the fatigue life cycle of a control plug of prototype fast breeder reactor using several scientific theories and made a comparison to predict the optimum life of this component under fatigue. 

Dr Danno Atsushi has been engaged in R&D work from 1964 to 2003 on the high precision bulk-metal forming technology for manufacturing automotive components in Toyota Central R & D Labs. in Japan. His R&D work includes Rotary forming (gears, stepped shafts), Forging lubrication (warm, cold), Forging CAE (FEM simulation, Knowledge based expert system) and some special metal forming processes. He authored or co-authored more than 50 original technical papers and took 25 patents on his R&D work. In 1981, he was granted a doctorate degree in Engineering. from Osaka University in Japan. He was appointed as Director and board member of Toyota Central R & D Labs. from 1995 to 2001. He is currently a Visiting Research Scientist in SIMTech and has been actively involved in R&D with special focus on metal forming technology since August 2003.

Dr Margam Chandrasekaran is currently the Chief Scientist of Bio-scaffold International Pte Ltd responsible for R&D on process, new product and regulatory approvals. He has more than 18 years of research experience in various fields of engineering including processing of bio-materials and published more than 100 papers in refereed International journals and conferences. He has also co-authored two books for Imperial College Press and Editor for series on bio-engineering and bio-materials by Imperial College Press. Prior to joining BSI, he was a Research Scientist with SIMTech. His research interests are in the areas of processing of biomaterials for scaffolds and medical applications, tribology, processing of Ti and intermetallics for Aerospace and biomedical applications.

Dr Florencia Edith Wiria received her B.Eng. and PhD degrees from Nanyang Technological University in 2003 and 2007 respectively. Her PhD topic is on selective laser sintering of polyvinylalcohol/hydroxyapatite biocomposite for tissue engineering application. Dr Wiria joined SIMTech in April 2007 and has worked on research projects in recycling process of advanced ceramic materials and printing of metallic and ceramic materials for implant prototypes. Her research interests are biomaterial processing through layer manufacturing and characterisation of these materials for medical implant applications.

Programme

8.45am

Registration & Breakfast Networking

9.25am

Welcome & Introduction

9.30am

The Dream Implant – A Surgeon’s Perspective
by Dr Wilson Wang, NUH

9.50am

Form, Material and Manufacture Follow Functionby Mr Lukasz Pienkowski, 4T Technologies

10.10am

FEA Simulation on Implant Technology by Mr Bhavesh Kumar, DS Simulia

10.40am

Intermissiont and Networking

11.00am

Forming Technology of Titanium Alloys for Biomedical Applications - Challenges and Possibility by Dr Danno Atsushi, SIMTech

11.20am

EOS e-Manufacturing Solutions for Biomedical Industry Using Ti by Mr Anand Prakasam, EOS

11.40am

Forging Applied to Biomedical Metals and Alloys by Dr Margam Chandrasekaran, Bio-scaffold International

12.00pm

Printing of Titanium Implant Prototype by Dr Wiria Florencia Edith, SIMTech

12.20pm

Q&A

12.30pm

Lunch and Networking

Registration
This is a non-chargeable seminar and pre-registration is required. Seats are available on a first-come, first-served basis. To reserve a place, please register online.

Who Should Attend 
R&D Managers, engineering and research staff from precision engineering industry, biomedical industry, clinicians and researchers from hospitals and research institutes; academics and research students from polytechnics and universities.

Enquiries
For technical enquiries: Dr Yu Poh Ching, Email: pcyu@SIMTech.a-star.edu.sg
For general enquiries: Alice Koh, Email: kohth@SCEI.a-star.edu.sg