Tech Platforms

Drug Delivery & Nanomedicine

Exosomes and Secreted Nano-vesicles

The current lab was established in 2007 with a research focus on extracellular vesicles (EVs) from stem cells and synthetic EVs for the development of therapeutics, diagnostics, drug delivery systems, nutriceuticals and cosmeticeuticals. It was the first to demonstrate that mesenchymal stem cells (MSCs) secrete therapeutic exosomes, a class of extracellular vesicles (EVs). Since then, many of the reported therapeutic efficacies of mesenchymal stem cells for a wide spectrum of diseases were found to be underpinned by EVs.

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Nanomedicine: Design and Engineering of Multifunctional Nanomaterials for simultaneous targeting, bio-imaging and drug delivery.

The research objective of this work is to apply nanotechnology to medicine. We have developed a new class of florescent-magnetic nanoparticles as probes and aim to demonstrate their application in both fluorescent microscopy and MRI. Subsequent work will be undertaken to introduce multifunctional organic, organometallic or biological groups into nanostructured materials to render them with biocompatibility, targeting, drug loading and delivery functions. The cytotoxicity of such nanomaterial will also be evaluated.

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Nanotechnology in Healthcare

The rapid advancement of nanotechnology in the past decades results in developments of individual units that can be assembled to form hyrarchical systems with varying complexity. Our lab focuses on the design, engineering, and development of hybrid nano/microscale devices from biological parts by utilizing protein engineering as assembly tool towards future healthcare and sustainable earth.

Current projects on skin research include: Fundamental Study on Protein Nanocages for Cutaneous Delivery, and Tunable Display of siRNA on Protein Nanocapsules for the Management of Hyperpigmentation Skin Condition.

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