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Translational Laboratory in Genetic Medicine (TLGM)

The Translational Laboratory in Genetic Medicine (TLGM) is a unique joint initiative between A*STAR and the National University of Singapore (NUS), founded in 2012 and housed at Biopolis, Asia’s biomedical sciences R&D hub. The mission of the TLGM is the application of clinical genetics-based biomedical research to the discovery and development of novel diagnostics and therapeutics.

The TLGM has three major research focus areas:

  • Cardiometabolic Disease
  • Neurodegenerative Diseases
  • Pharmacogenomics & Personalized Medicine
 
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Cardiometabolic Disease Program

Cardiometabolic diseases are a leading cause of morbidity and mortality in both the developing and developed countries. Led by Dr. Roshni Singaraja, our group is interested in translational research with a focus on identification and  functional characterization of pathways involved in cardiometabolic disease. Our aim is to identify novel genes, validate the novel genes utilising human genetic association studies, and bridge the gap between the human association studies and functional mechanisms utilizing human investigative medicine studies, animal models and in vitro studies relevant to the disease states of diabetes mellitus, atherogenic dyslipidemia and cardiovascular disease.

 
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Neurodegenerative Diseases Program

The neurodegenerative diseases (NDD) laboratory, led by Dr. Mahmoud Pouladi, focuses on understanding how discrete genetic factors contribute to the development of NDD. Our aim is to define key disease processes underlying neurodegenerative disorders and to develop novel therapeutic approaches for intervention

 
Pharmacogenomics

Pharmacogenomics & Personalized Medicine Program

Led by Dr. Folefac Aminkeng, the PGx laboratory focuses on understanding how genetic information can be used to predict, diagnosis and treat disease. We are particularly focused on identifying genetic variation that predicts response to medications and understanding molecular mechanisms of drug toxicity.


Contact us

Our address:
8A Biomedical Grove
Immunos, Level 5
Singapore 138648
Tel: (65) 6407-4384
Lab: (65) 6407-4383
Email:
nuramirah_mdyusof@tlgm.a-star.edu.sg  (Lab matters) 
 pauline_low@tlgm.a-star.edu.sg (Admin matters)