Stem cell-derived antimicrobial peptides and EVs for cosmeceutical applications

We found a robust anti-bacterial effect of adipose-derived stem cells (ASCs) that undergo adipogenic differentiation and priming. Both proteins and extracellular vesicles (EVs; a.k.a. exosomes) have potent effects; we further optimized short peptides and conditions of EVs suitable for clinical and cosmeceutical applications. These peptides are effective against broad spectrum microbial species including antibiotic resistant strains. The student will investigate molecular basis underlying the priming mechanism of secreting antimicrobial proteins and EVs. The student may develop culture / differentiation conditions of ASCs, perform various microbiology experiments and test for healing of wound associated infection models. Both in vitro and in vivo wound models will be developed and employed together with our collaborators.