Enabling Discoveries Through Shared Scientific Infrastructure
Article Title: A*STAR Study Reveals New Insights into Autism and Early Brain Development
Researchers from the ASTAR Genome Institute of Singapore (GIS) and ASTAR Bioinformatics Institute (BII) have uncovered how spatial differences in early brain development may contribute to the diversity of autism spectrum disorder (ASD). Published in Nature Communications, the study used brain organoids, single-cell analysis and computational modelling to show that developmental changes associated with autism can occur in distinct regions of the developing brain rather than uniformly across the tissue.
Acknowledgement of iCORE Microscopy & iCORE Genomics
We are pleased to share that iCORE Microscopy and iCORE Genomics were acknowledged in this publication for their contributions to the research. iCORE Microscopy provided access to advanced microscopy instrumentation, while iCORE Genomics supported the study through whole-exome sequencing and single-cell RNA sequencing services. Together, these capabilities enabled researchers to investigate complex biological questions and advance scientific discovery.
This acknowledgement reflects the continued commitment of iCORE Microscopy and iCORE Genomics to supporting cutting-edge research by providing researchers with access to state-of-the-art technologies, scientific expertise and shared research infrastructure.
Read more about the study here: https://www.nature.com/articles/s41467-026-74320-5