EDDC Academic Research Organisation (EARO)
EARO is a fee-for-service initiative by EDDC, Singapore's national drug discovery and development platform. EARO was established in 2020 with an objective of enabling partners in the ecosystem to accelerate innovation cost effectively through access to EDDC specialised technologies and expertise. Our ISO 9001 certified core platforms - High Throughput Screening, the Compound Hub, and High Throughput Phenomics - support seamless end-to-end service delivery. In addition, we leverage EDDC's broader cross functional expertise to provide tailored consulting services to our clients.
Key Services
- Compound Hub
- Compound library access and management
- Focused, diversity and fragment libraries
- Compound plate preparation and reformatting
- Compound analytical QC
- Automated compound cherry-picking and serial dilution
- Nanlitre-scale compound plating
- High-Throughput Screening (HTS)
- Assay development and optimisation
- High-throughput screening
- Target validation
- Hit identification and confirmation
- Cell-based, biochemical and biophysical assays
- Cytotoxicity/ viability assessment
- Dose-response and concentration-response studies
- High-Throughput Phenomics (HTP)
- High-content screening
- Phenotypic profiling screening
- Mechanism-of-Action (MoA) studies
- Cell Painting and morphological profiling
- Morphometric analysis
- 3D spheroid characterisation
- Multiparametric cellular analysis
- Image-based cellular profiling
- Cell-based assays
- Cytotoxicity/ viability assessment
- Dose-response and concentration-response studies
- Equipment Access
- Autonomous access to scientific equipment
- Training on equipment usage
- Staff-assisted equipment usage
- Consultation
- Drug discovery consultation by EDDC subject matter experts on a case-by-case basis
Key Applications
- Drug discovery and screening
- Target validation]
- Hit identification and confirmation
- Compound and phenotypic profiling
- Mechanism-of-action (MoA) studies
- Cellular pathway and functional analysis
- Cytotoxicity and viability assessment
- Dose-response and concentration-response studies
- Phenotypic and morphological profiling
- 3D spheroid characterisation
- Biochemical and biophysical screening
- High-throughput assay development and optimisation
Key Equipment
- Revvity Opera Phenix
- Revvity Operetta CLS
- Revvity Opera Phenix Plus
- Cytomat 5C
- Akoya PhenoImager HT
- Amnis ImageStreamX
- Tecan Spark Multimode Reader
- BioTek MultiFlo FX
- BioTek 405 TS
- Thermo Multidrop Combi
- Thermo Biosafety Cabinet
- Biotechne Protein Simple JESS System
- Labcyte Echo 550 (Assisted)
- Agilent Bravo-BenchCel (Assisted)
- PerkinElmer JANUS (Assisted)
- Integrated automated workstation with Opera Phenix Plus +/- Phenix (Assisted)
Our People
EARO brings together a multidisciplinary team of scientists with expertise spanning compound management, assay development, high-throughput screening, phenotypic profiling, cell biology, high-content imaging, automation and analytical technologies. The team works closely with clients to develop and deliver tailored solutions that address their drug discovery and research needs.