Joe Yeong Poh Sheng

Lab Location: #5-19   Email:   Tel: 65869527  
Service Platform: Multiplex IHC Immuno-Mapping

Dr. Joe Yeong Poh Sheng (MBBS, PhD) is a Group Leader in the Institute of Molecular and Cell Biology (IMCB, A*STAR) and holds a joint appointment in the Department of Anatomical Pathology, Singapore General Hospital (SGH). He has underwent multidisciplinary training for clinical (MBBS), immunology (PhD) and histopathology (British Royal College of Pathologist (RCPath), Associateship), and possess more than 10 years of translational research experience.

He is the pioneer and key opinion leader in automation of quantitative multiplex (fluorescence-) immunohistochemistry (m-IHC/IF), utilising clinical autostainers to study and quantitate tumour immune microenvironment. He has established an integrative m-IHC/IF pathology platform in the Department of Anatomical Pathology, SGH which is the first of its kind in Asia-Pacific (APAC) region; providing a one-stop solution for scientists, clinicians, immunologists and pathologists to synergise their expertise in biomarker discovery and translation for clinical practice. This approach displays the importance of the emerging new branch of diagnostic pathology – immunopathology.

His works on breast cancer, liver cancer and colorectal cancer are included in multiple National Medical Research Council (NMRC) funded studies as well as pharmaceutical industry sponsored projects. He is a member of the British RCPath (associateship), United States and Canadian Academy of Pathology (USCAP) and Society for Immunotherapy of Cancer (SITC). His key vision is to bridge between immunologists and pathologists to better harness the advances of immunotherapy and further beyond. He is one of the winners of the Best Mentor award of NUS Wong Hock Boon Research Society in 2017 for his dedication to mentor medical students on translational research. He also served as a committee member in the World Immunotherapy Council (WIC) and is one of the organizers for its 2019 WIC Young Investigator Symposium in National Harbour, USA.

In 2018, he has set up an automated quantitative m-IHC/IF Immuno-Mapping service platform in IMCB, A*STAR as an official service portal to provide solutions for academic collaborators and industry partners who are keen to understand immunology profile and landscape of cancers and other diseases. This service platform is across partnership with SGH, National University of Singapore (NUS), Nanyang Technological University (NTU) and National Cancer Centre (NCC) with multi-disciplinary expertise contributions to provide the best solution. Powered by the state-of-the-art autostainer, 9+ colour imaging system and analytic packages, this platform is envisioned and well-prepared to become the APAC hub for Immuno-Mapping domain. The experience, track records, know-how as well as proprietary protocols and solutions that his group has built in the past few years safeguard the standard, quality and robustness of the platform. Other immuno-profiling methods, such as multi-colour high-dimensional flow cytometry (up to 24 markers), mass cytometry, multi-analyte profiling and multi-photon imaging, that are available in the ecosystem complement the Immuno-Mapping platform and allow multi-modal integration and interpretation of data which would be essential in this era of immunotherapy.


His research works with outstanding multiplex images were featured in multiple platforms and medias including DUNES Symposium cover page, Singapore Straits Times (Beautiful Science), Singaporean Society for Immunology (SgSI) Image of the Year, as well as Singhealth Tomorrow Medicine; and have earned him several prestigious awards at events including Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE), Singhealth Pathology Academic Clinical Programme (ACP) Research Day, Chinese American Pathologists Association (CAPA) and USCAP.

As a winner for the Best Mentor award of NUS Wong Hock Boon Research Society (2017), he’d also dedicated significant time to supervise medical students on translational research to help seeding next generation of clinician scientists.

Throughout the years, under his supervision or co-supervision with Prof. Tan Puay Hoon and A/Prof. Tony Lim Kiat Hon from SGH, the students won several awards and prizes from conferences including Singhealth Pathology ACP Research Day, LKCMedicine Research Symposium, Farrer Park Hospital Annual Scientific Meeting, Singapore Health and Biomedical Congress, SingHealth Medical Student Talent Development Award, Singhealth Duke-NUS Scientific Congress, as well as RCPA Medical Students Scholarship Award for Research and Scholarship Award for Pathology Update.