Jonathan Yuin-Han LOH

Lab Location: #8-01   Email:   Tel: 65869592

Jonathan studied Biology and graduated with B.Sc. 1st Class honours from the National University of Singapore (NUS). He then did his Ph.D. research as an A*STAR Scholar at the Stem Cell and Developmental Biology group, Genome Institute of Singapore under the mentorship of Dr Ng Huck Hui. There, he mapped the transcriptional network of Nanog and Oct4 in Embryonic Stem Cells (ESCs), and identified several novel transcription factors and histone demethylases, such as Esrrb, Rif1, Zic3, Kdm3a and Kdm4c, which play essential roles in maintaining the self-renewal and pluripotency of ESCs. During his postdoctoral fellowship at the Division of Pediatric Hematology and Oncology, Boston Children’s Hospital, Harvard Medical School, he was trained under the tutelage of Dr George Daley. There, he pioneered the use of human blood cells for reprogramming to induced pluripotent stem cells (iPSCs), and the modelling of congenital and somatic Hematologic diseases using iPSCs. Jon is now a Senior Principal Investigator at the Institute of Molecular and Cell Biology where he also serves as the Programme Coordinator for the Stem cell, Regenerative Medicine and Ageing research. Concurrently, he is an Associate Professor (Adjunct) at the NUS Yong Loo Lin School of Medicine Department of Physiology, NUS Faculty of Science Department of Biological Sciences, as well as a Faculty member of the NUS Graduate School of Integrative Sciences and Engineering. His laboratory is interested in dissecting the mechanisms regulating cell fate changes, and developing novel tools in deriving reprogrammed and differentiated cell types. His research work has earned him several prestigious national and international accolades including the Quest Technology Award, Philip Yeo Prize, Singapore Young Scientist Award, Singapore Youth Award, A*STAR Investigatorship Award, World Technology Network Fellowship, MIT TR35 Asia Pacific Award, SCSS Susan Lim’s Award and the NRF Investigatorship Award. He serves on the International Committee at the International Society for Stem Cell Research (ISSCR), the Executive Committee of the Stem Cell Society Singapore (SCSS) and the Executive Council for the Singapore Association for the Advancement of Science (SAAS).