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Yu FU
Central-Peripheral Communication
PhD- Neuroscience from Stony Brook University
Email: fu_yu@imcb.a-star.edu.sg
Lab page: https://yufulab.org/
SUMMARY
Dr. Yu FU is currently a Senior Principal Investigator at IMCB. He received his PhD in Neuroscience from Stony Brook University, New York, followed by postdoctoral training at the University of California, San Francisco from 2011-2015. Before joining IMCB, he led a research group at the Singapore Bioimaging Consortium (SBIC) of A*STAR from 2015 to 2021.
Dr. Fu's research focuses on understanding the neural regulation of energy homeostasis and the mechanisms of plastic change in neural circuits in response to lifestyle changes. His laboratory uses cutting-edge technologies in systems neuroscience research to elucidate the neural circuits regulating energy homeostasis and their plastic changes in response to lifestyle changes.
- 2022: NRF Investigatorship
- 2019: EMBO Global Investigatorship
- 2014: A*STAR Investigatorship
RESEARCH
Brain Plasticity Group
The rise of modern lifestyles and abundant food sources has led to a mismatch between our evolved eating mechanisms and current environment, leading to a rise in obesity and metabolic diseases. Our research group seeks to understand the complex interplay between genetic and environmental factors that shape neural circuits, influencing behavioral outcomes, energy balance, and metabolic health. By elucidating these mechanisms, we aim to uncover new insights into the development of metabolic diseases and identify potential therapeutic targets for their prevention and treatment.
PUBLICATIONS
- Plastic and stimulus-specific coding of salient events in the central amygdala.
Yang T, Yu K, Zhang X, Xiao X, Chen X, Fu Y, Li B. (2023)
Nature, 616(7957):510-519 - A triple-network organization for the mouse brain.
Mandino F, Vrooman RM, Foo HE, Bolton TAW, Salvan P, Teoh CL, Lee CL, Beauchamp A, Luo S, Bi R, Zhang J, Lim GHT, Low H, Sallet J, Gigg J, Lerch JP, Mars RB, Olivo M, Fu Y, Grandjean J. (2021)
Molecular Psychiatry, 27(2):865-872 - An mPOA-ARCAgRP pathway modulates cold-evoked eating behavior.
Yang S, Tan YL, Wu X, Wang J, Sun J, Liu A, Gan L, Shen B, Zhang X, Fu Y, Huang J. (2021)
Cell Reports, 36(6):109502. - A neural circuit for excessive feeding driven by environmental context in mice.
Lim Mohammad H*, Senol E*, Graf M, Lee CY, Li Q, Liu Q, Yeo XY, Wang M, Laskaratos A, Xu F, Luo SX, Jung S, Augustine GJ, Fu Y. (2021)
Nature Neuroscience 24(8):1132-1141. (cover paper) - A distinct parabrachial to lateral hypothalamus circuit for motivational suppression of feeding by nociception.
Phua SC, Tan YL§, Kok AMY, Senol E, Lee CY, Chiam JHC, Peng Y, Mohammad H, Lim JX, Fu Y. (2021)
Science Advances (7(19):eabe4323. doi: 10.1126/sciadv.abe4323. - Regulation of feeding by somatostatin neurons in the tuberal nucleus (*, equal contribution; §, corresponding author)
Luo SX*, Huang J*, Li Q*, Mohammad H, Lee CY, Krishna K, Kok AM, Tan YL, Lim JY, Li H, Yeow LY, Sun J, He M, Grandjean J, Sajikumar S, Han W, Fu Y. (2018)
Science 361(6397):76-81.
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