Qi-Jing LI

Translational T Cell Biology and Therapeutics
PhD – University of California (UC) Riverside, USA

SUMMARY
Prof Li Qi-Jing is a Distinguished Principal Scientist and the Chief Innovation Office at the Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR). He concurrently holds a joint appointment as a Distinguished Principal Scientist at the Singapore Immunology Network (SIgN), A*STAR.

Prof Li Qi-Jing’s early research at Stanford focused on TCR antigen recognition and signaling sensitivity. He made a series of key contributions in defining the minimal subunit, rate-limiting step, and sensitivity controls of TCR activation. In 2008, he established his own lab at Duke University, expanding into cancer immunology and clinical immunotherapy. In 2022, he joined A*STAR Singapore as a Distinguished Principal Scientist at IMCB and SIgN. Beyond basic research, Qi-Jing has been continuously translating his expertise in molecular biology and T cell biology into cancer immunotherapy and clinical immune monitoring. As an applied immunologist, he has built immunogenomics profiling tools, developed AI-driven antigen-specific TCR discovery platforms, engineered T cell and NK cell-based therapeutics, and designed and aided more than twenty phase I/II therapeutical trials against various cancers. As a serial entrepreneur, he co-founded three clinical-stage companies advancing CAR-T, TCR-T, and TIL cell therapeutics.

AWARDS & GRANTS
  • 2024 National Research Foundation (NRF) Investigatorship
  • 2024 Industry Alignment Fund-Pre-Positioning (IAF-PP) – Panakeia
  • 2024 Industry Alignment Fund-Pre-Positioning (IAF-PP) – EVANTICA
  • 2024 Open Fund – Large Collaborative Grant 
  • 2023 NRF Competitive Research Programme (CRP) 

RESEARCH

Qi-Jing's research focuses on translational T cell biology and therapeutics, with an emphasis on understanding how tumors evade immune surveillance and developing innovative strategies to enhance T cell-mediated anti-tumor immunity. He investigates how tumors inhibit T and NK cell function both locally and systemically and explores the complex pathways of T cell differentiation and memory development in the tumor microenvironment. By dissecting key transcription factors, signaling pathways, immune checkpoints, and epigenetic programs governing T and NK cell function, his laboratory aims to develop clinically feasible strategies to counteract tumor-biased systemic immune suppression. Utilizing a combination of immunological, biochemical, and bioinformatics approaches, Qi-Jing works to enhance the efficacy of CAR-T, TCR-T, and NK cell therapies for tumors through genomic engineering and combination therapies, ultimately translating these findings into effective cancer treatments.


PUBLICATIONS