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Press Releases

1. Found: Molecule that stops heart from healing (The Straits Times, 22 Aug 2017)

2. New way to detect heart failure that's hard to diagnose (The Straits Times, 21 July 2017)

3. Multinational heart failure study shows high prevalence of coronary artery disease, hypertension and diabetes in Asian patients (Media Release, 16 June 2016)

4. 11 local institutes team up for study on heart failure (The Straits Times, 13 July 2015)

5. Bayer, EDB to fund S$30m regional disease research (The Business Times, 9 July 2015)

6. AstraZeneca to collaborate with key Singapore research organisations in heart failure (11 Mar 2015)

7. Doctors hail LCZ696, a new drug for heart failure (The Straits Times, 4 September 2014)


Publications
2018

1. Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling
Circulation. 2018 Jun 5;137(23):2497-2513

2. Mortality Associated With Heart Failure With Preserved Versus Reduced Ejection Fraction In A Prospective International Multi-Ethnic Cohort Study
Eur Heart J. 2018 May 21;39(20):1770-1780

3. Prevalence, clinical correlates and outcomes of anaemia in multiethnic Asian patients with heart failure with reduced ejection fraction
ESC Heart Failure 2018 Mar 31. doi: 10.1002/ehf2.12279. [Epub ahead of print]

4. Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
JACC: Basic to translational science; Vol 3, Issue 2, April 2018

5. Distinctive Molecular Signature and Activated Signaling Pathways in Aortic Smooth Muscle Cells of the Patients with Myocardial Infarction
Atherosclerosis 2018 Apr; 271:237-244

6. MicroRNA-143 modulates the expression of Natriuretic Peptide Receptor 3 in cardiac cells
Scientific Reports; Volume 8, Article number: 7055 (2018) 

7. Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry
PLoS Med 15(3)

8. N-terminal pro-B-type Natriuretic Peptide and Prognosis in Caucasian versus Asian Patients with Heart Failure
ESC Heart Failure 2018 Apr; 5(2):279-287

9. Chronic obstructive pulmonary disease and β-blocker treatment in Asian patients with heart failure
ESC Heart Fail. 2018 Apr;5(2):297-305

10. A risk assessment score and initial high-sensitivity troponin combine to identify low-risk of acute myocardial infarction in the emergency department
Academic Emergency Medicine Journal; 2018 Apr; 25(4):434-443 

11. Daily Home BNP Monitoring in HF for prediction of impending clinical deterioration: Results from the HOME HF study

12. Prognostic Implications of Dual Platelet Reactivity Testing in Acute Coronary Syndrome
Thrombosis and Haemostasis 2018 Feb; 118(2): 415-426

13. Transapical cardioscopic mitral annuloplasty: a short-term survival study in a porcine model

Interactive CardioVascular and Thoracic Surgery 2018 Jan 1; 26(1):131-138

14. Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Cell Reports 2 Jan 2018; 22: 299–312

15. ICare-ACS (Improving Care Processes for Patients With Suspected Acute Coronary Syndrome): A Study of Cross-System Implementation of a National Clinical Pathway
Circulation. 2018 Jan 23;137(4):354-363

16. N-terminal B-type Natriuretic Peptide in Heart Failure

Heart Failure Clinics. 2018 Jan;14(1):27-39 

17. Single-dose Intravenous Iron in Southeast Asian Heart Failure Patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF)
ESC Heart Failure; 18 Jan 2018; Vol 5 (2): 344–353


2017
1. The heart regulates the endocrine response to heart failure: cardiac contribution to circulating neprilysin

Eur Heart J 2017 Dec 13; doi:10.1093/eurheartj/ehx679 [Epub ahead of print]; 21;39(20):1794-1798

2. The Prognostic Value of Highly Sensitive Cardiac Troponin Assays for Adverse Events in Men and Women with Stable Heart Failure and a preserved versus a reduced Ejection Fraction

Eur J Heart Fail. 2017 Dec;19(12):1638-1647

3. MicroRNA-31 Promotes Adverse Cardiac Remodeling and Dysfunction in Ischemic Heart Disease

J Mol Cell Cardiol 2017 Nov; 112:27-39 

4. Variability in Microplate Surface Properties and Its Impact on ELISA

J Appl Lab Medicine 2017 Oct; Vol. 2, Issue 6 

5. Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure
Am Heart J. 2017 Sep; 191:75-81

6. The Association of Heart Failure-related microRNAs with Neurohormonal Signaling

Biochim Biophys Acta (Mol Basis of Disease) 2017 Aug; 1863(8): 2031-2040 

7. Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
Nature communications (published online 9 Aug 2017); doi:10.1038/s41467-017-00319-8

8. Identification of novel microRNAs in the sheep heart and their regulation in heart failure

Scientific Reports 2017 Aug 15;7(1):8250

9. Disparity Between Indications for and Utilization of Implantable Cardioverter Defibrillators in Asian Patients With Heart Failure

10. Metabolic and Blood Pressure Effects of Walnut Supplementation in a Mouse Model of the Metabolic Syndrome

Nutrients 2017 Jul 7;9(7)

11. Characterization and Standardization of Cultured Cardiac Fibroblasts for Ex Vivo Models of Heart Fibrosis and Heart Ischemia

Tissue Eng Part C Methods. 2017 Jul;23(7):422-433 

12. Mortality and acute exacerbated COPD: a pilot study on the influence of myocardial injury

Eur Respir J. 2017 Jun 29;49(6)

13. Ankyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential

Int J Mol Sci; 2017 Jun 26;18(7) 

14. Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction

J Am Heart Assoc. 2017 Jun 13;6(6)

15. Risk Stratification Model for 30-day Heart Failure Readmission in a Multi-ethnic South East Asian Community

Am J Cardiol. 2017 May 1;119(9):1428-1432 

16. Risk stratification of Asian patients with Heart Failure and Reduced Ejection Fraction:The effectiveness of the "Echo Heart Failure Score"
Eur J Heart Failure 2017 May; Vol 19; 12:1732-1735

17. Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction

18. A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: results from the New Zealand acute coronary syndrome (NZACS) audit group national audits of 2002, 2007 and 2012

19. Transitioning from Usual Care to Biomarker-Based Personalized and Precision Medicine in Heart Failure: Call for Action

Eur Heart J . 2017 Feb 15. doi: 10.1093/eurheartj/ehx027. [Epub ahead of print] 

20. Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure

JACC Heart Fail. 2017 Jan;5(1):14-24

21. A landscape of circular RNA expression in the human heart

22. HEART score performance in Asian and Caucasian patients presenting to the emergency department with suspected acute coronary syndrome

Eur Heart J Acute Cardiovasc Care. 2017 Mar 1:2048872617700870. doi: 10.1177/2048872617700870. [Epub ahead of print]

23. Superior performance of NT-proBNP for diagnosis of Acute Decompensated Heart Failure in an Asian compared with a Western setting

Eur J Heart Fail 2017 Feb; 19 (2), 209-217

24. Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction


2016
1. Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research

Eur Heart J. 2016 Dec 23. 0:1-5

2. Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and meta-analysis

Eur J Heart Fail. 2016 Dec; 18(12):1472-1487

3. Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Association With Exercise Capacity, Left Ventricular Filling Pressures, Natriuretic Peptides, and Left Atrial Volume
JACC Heart Fail. 2016 Dec. 5(2):92-98

4. Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure
JACC Heart Fail. 2016 Nov 30; S2213-1779(16):30501-7

5. The International Human Epigenome Consortium: A blueprint for scientific collaboration and discovery

Cell. 2016 Nov 17; 167(5):1145-1149

6. Heart Failure With Preserved Ejection Fraction and Atrial Fibrillation: Vicious Twins

J Am Coll Cardiol. 2016 Nov 15; 68(20):2217-2228

7. Serum ferritin and risk for new-onset heart failure and cardiovascular events in the community

Eur J Heart Fail. 2016 Oct 19; 19(3):348-356  

8. Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy

Sci Rep. 2016 Oct 12; 6, article number:35247

9. Influence of Ethnicity, Age, and Time on Sex Disparities in Long-Term Cause-Specific Mortality After Acute Myocardial Infarction
J Am Heart Assoc. 2016 Oct 6; 5(10)  

10. Random Plasma Glucose Levels and Cardiovascular Risk

JAMA Cardiol. 2016 Oct 1;1(7):823-824  

11. A simplified, Landendorff-free method for concomitant isolation of viable cardiac myocytes and non-myocytes from the adult mouse heart

Circ Res 2016 Sep 30;119(8):909-20

12. Ethnic differences in the association of QRS duration with ejection fraction and outcome in heart failure
Heart. 2016 Sep 15;102(18):1464-71

13. A Test in Context: Neprilysin: Function, Inhibition, and Biomarker

J Am Coll Cardiol. 2016 Aug 9; 68(6):639-53

14. Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry

Eur Heart J (2016) Aug 7; 37(41):3141-3153

15. A genomic and epigenomic comparison of fetal and adult human cardiac fibroblasts reveal novel key transcription factors in adult cardiac fibroblasts

JACC Bas Trans Sci. July 2016; 1(7):590-602 

16. Three-Dimensional Tricuspid Annular Motion Analysis from Cardiac Magnetic Resonance Feature-Tracking

Ann Biomed Eng. 2016 Jul 19; 44(12):3522-3538

17. AAV9 delivery of shRNA to the mouse heart

Curr Protoc Mol Biol. 2016 Jul 1; 115:23.16.1-9 

18. Heart Failure with Preserved Ejection Fraction in Hypertension

Current Opinion in Cardiology, Jul 2016, 31(4):410-416 

19. High-Sensitivity Sandwich ELISA for PlasmaNT-proUcn2: Plasma Concentrations and Relationship to Mortality in Heart Failure
Clinical Chemistry 2016 Jun; 62(6):856-865

20. Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps

JACC Heart Failure 2016 June; 4(6):419-427 

21. Association of Age, Sex, Body Size and Ethnicity with Electrocardiographic Values in Community-based Older Asian Adults

Heart Lung and Circulation 2016 Jul; 25(7):705-11

22. Understanding Heart Failure With Mid-Range Ejection Fraction
JACC Heart Failure 2016 Jun; 4(6):473-476

23. Paradoxical Low Gradient Aortic Stenosis: The HFpEF of Aortic Stenosis

Journal of the American College of Cardiology 2016 May; 67(20):2447-2448

24. Intra-Left Ventricular Flow Velocity Distributions, Based on Color Doppler Echo Vector Flow Mapping of Normal Subjects and Heart Failure Patients

Cardiology Science and Technology 2016 May, Chapter 14, 391-411

25. Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways
Biochem Biophys Res Commun. 2016 May 20; 474(1):168-74

26. Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis
Int J Mol Sci. 2016 May 18;17(5)

27. Discovery of Potential Therapeutic miRNA Targets in Cardiac Ischemia-Reperfusion Injury
J Cardiovasc Pharmacol Ther. 2016 May;21(3):296-309

28. Cardiac MRI based numerical modeling of left ventricular fluid dynamics with mitral valve incorporated

J Biomech. 2016 May 3;49(7):1199-205

29. Longitudinal Community-Based Study of QT Interval and Mortality in Southeast Asians

PLoS One. 2016 May 5;11(5) 

30. MicroRNA and Heart Failure
Int J Mol Sci. 2016 Apr 6; 17(4):502

31. The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease

Neth Heart J. 2016 Mar; 24(3):188-98

32. Racial Differences in Electrocardiographic Characteristics and Prognostic Significance in Whites Versus Asians

J Am Heart Assoc. 2016 Mar 25;5(3) 

33. Incidentalome from Genomic Sequencing: A barrier to personalized medicine?

EBioMedicine. 2016 Feb 4; 5:211-216

34. Microvascular endothelial dysfunction in heart failure with preserved ejection fraction

Heart. 2016 Feb 15; 102(4):257-9 

35. Connecting Heart Failure with Preserved Ejection Fraction and Renal Dysfunction – The Role of Endothelial Dysfunction and Inflammation

European Journal of Heart Failure 2016 Feb 10; 18(6):588-98

36. Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort

PLOS ONE, 2016 Jan 28

37. Breakthrough in heart failure with preserved ejection fraction: are we there yet?
The Korean Journal of Internal Medicine 2016 Jan; 31(1):1-14


2015 and beyond

1. Automated quantitative assessment of cardiovascular magnetic resonance-derived atrioventricular junction velocities
Am J Physiol Heart Circ Physiol. 2015 Dec 1; 309(11):H1923-35

2. Minding the Gap in Heart Failure: Understanding the Pulse Pressure in Reduced Versus Preserved Ejection Fraction
JACC: Heart Failure Epub 2015 Dec 2

3. Variational Reconstruction of Left Cardiac Structure from CMR Images
PLoS One. Dec 2015;10(12):e0145570

4. Rationale and Design of a Pilot Randomized Controlled Trial to Assess the Role of Intravenous Ferric Carboxymaltose in Asian Patients with Heart Failure (PRACTICE-ASIA-HF)
ESC Heart Failure Epub 2015 Dec 16

5. Vascular Health Indices and Cognitive Domain Function: Singapore Longitudinal Ageing Studies
Journal of Alzheimer's Disease 2015 Nov 26; 50(1):27-40

6. The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease
Expert Review of Molecular Diagnostic, 2015 Nov 04; 15(12):1577-1588

7. Hematological Parameters Improve Prediction of Mortality and Secondary Adverse Events in Coronary Angiography Patients: A Longitudinal Cohort Study
Medicine (Baltimore); 2015 Nov; 94(45)

8. Growth Differentiation Factor 15 in Heart Failure with Preserved versus Reduced Ejection Fraction
Eur J Heart Fail Epub 2015 Oct 25

9. FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy
Int J Cardiol 2015 Sep 15; 195:85-94

 

10. Women Undergoing Coronary Angiography for Myocardial Infarction or Who Present With Multivessel Disease Have a Poorer Prognosis Than Men
Angiology 2015 Sep 7

11. Electrocardiographic Criteria for Left Ventricular Hypertrophy in Asians Differs From Criteria Derived From Western Populations—Community-based Data from an Asian Population.
Ann Acad Med Singapore 2015 Aug; 44(8):274-283

12. Cardiac Endothelium-Myocyte Interaction: Clinical Opportunities for New Heart Failure Therapies Regardless of Ejection Fraction
Eur Heart J 2015 Aug 14; 36(31):2050-2060

13. Diabetic Cardiomyopathy: An Expression Of Stage B Heart Failure With Preserved Ejection Fraction
Diabetes & Vascular Disease Research Jul 2015, Vol. 12(4):234–238

14. The Relationship among Carotid Artery Remodeling, Cardiac Geometry, and Serum N-terminal Pro-B-type Natriuretic Peptide Level in Asymptomatic Asians: Sex-differences and Longitudinal GEE study.
PLOS ONE 2015 Jul 1; 10(7)

15. Inter-Ethnic Differences in Quantified Coronary Artery Disease Severity and All-Cause Mortality among Dutch and Singaporean Percutaneous Coronary Intervention Patients
PLOS ONE 2015 Jul 6; 10(7)

16. Heart Failure In Southeast Asia: Facts And Figures (Invited Editorial)
ESC-Heart Failure June 2015, Issue 2, Volume 2:46-49

17. Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B
J Mol Cell Cardiol 2015 May; 82:174-83

18. Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100
J Mol Cell Cardiol 2015 May; 82:13-21

19. Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction
Eur J Heart Fail. 2015 Apr;17(4):393-404

20. Patient Selection in Heart Failure With Preserved Ejection Fraction Clinical Trials
J Am Coll Cardiol 2015, 65(16):1668–1682

21. Heart failure with preserved ejection fraction in women: the Dutch Queen of Hearts program
Neth Heart J. 2015 Feb; 23(2):89-93

22. Iron deficiency in a multi-ethnic Asian population with and without heart failure: prevalence, clinical correlates, functional significance and prognosis
Eur J Heart Fail. 2014 Oct; 16(10):1125-32

23. Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry
Eur J Heart Fail., Aug 2013, 15(8):928–936

24. The Singapore Heart Failure Outcomes and Phenotypes (SHOP) Study and Prospective Evaluation of Outcome in Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PEOPLE) Study: Rationale and Design
J Card Fail. 2013 Mar;19(3):156-62

25. Growth differentiation factor 15, ST2, high-sensitivity troponin T, and N- terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection fraction
Eur J Heart Fail. 2012 Dec; 14(12):1338-47


Posters

1. Left atrial strain by cardiac magnetic resonance feature tracking is a novel diagnostic biomarker of heart failure with preserved ejection fraction

ESC 2017

2. Myocardial T1 and extracellular measurement in heart failure with preserved ejection: Reproducibility at 3T and comparison with heart failure with reduced ejection fraction

EuroCMR 2017

3. Role of Chronic Inflammation in Driving Progression of Heart Failure
CYTO Asia 2017

4. SG10K: Insights into the genetic architecture of Singaporeans
ASHG 2017

5. Dynamic Metabolomic Profiling Reveals Evidence for Metabolic Inflexibility in the Failing Heart

American Heart Association 2017 

6. Introducing "SG10K": Cataloging genetic diversity and population structures in 10,000 South Asians

ASHG 2016 Annual Meeting; Poster ID:1613T

7. Extracellular volume fraction mapping at 3T with non-rigid image co-registration

SCMR 19th Annual Scientific Sessions; Poster ID: P032; Control ID#:2359524

8. Novel method for atrioventricular motion assessment from three-dimensional cine magnetic resonance imaging