2024
- Elaine GY Chew, Zhehao Liu, Zheng Li, Sun Ju Chung, Michelle M Lian, Moses Tandiono, Yue Jing Heng, Ebonne Y Ng, Louis CS Tan, Wee Ling Chng, Tiak Ju Tan, Esther KL Peh, Ying Swan Ho, Xiao Yin Chen, Erin YT Lim, Chu Hua Chang, Jonavan J Leong, Ting Xuan Peh, Ling Ling Chan, Yinxia Chao, Wing-Lok Au, Kumar M Prakash, Jia Lun Lim, Yi Wen Tay, Vincent Mok, Anne YY Chan, Juei-Jueng Lin, Beom S Jeon, Kyuyoung Song, Clement C Tham, Chi Pui Pang, Jeeyun Ahn, Kyu Hyung Park, Janey L Wiggs, Tin Aung, Ai Huey Tan, Azlina Ahmad Annuar, Mary B Makarious, Cornelis Blauwendraat, Mike A Nalls, Laurie A Robak, Roy N Alcalay, Ziv Gan-Or, Richard Reynolds, Shen-Yang Lim, Yun Xia, Chiea Chuen Khor, Eng-King Tan, Zhenxun Wang, Jia Nee Foo (2024) Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson’s disease risk. Nature Aging (Published Online)
- Kuin Tian Pang, Yi Fan Hong, Fumi Shozui, Shunpei Furomitsu, Matthew Myint, Ying Swan Ho, Yaron R Silberberg, Ian Walsh and Meiyappan Lakshmanan (2024) Genome-scale modeling of CHO cells unravel the critical role of asparagine in cell culture feed media. Biotechnology Journal 19(11): e202400072
- Sixun Chen and Dan Liu (2024) Rapid Manufacturing of CAR-T Therapy: Strategies and Impact. Trends in Biotechnology S0167-7799(24): 00271-3
- Sixun Chen, Akshaya V Prabhu, Ahmad Amirul Bin Abdul Rahim, Kang-Zheng Lee and Dan Liu (2024) Enriching central memory T cells using novel bioreactor design for T cell manufacturing. Cytotherapy S1465-3249(24): 00891-0
- Viknesvaran Selvarajan, Samuel Ken-En Gan and Yuen Ling Ng (2024) Editorial: Unlocking the potential of cell therapy: exploring cell types, induction methods, and culture techniques. Frontiers in Cell and Developmental Biology 12: 1515978
- Hoi Kong Meng, Kuin Tian Pang, Corrine Wan, Zi Ying Zheng, Qiu Beiying, Yuansheng Yang, Wei Zhang, Ying Swan Ho, Ian Walsh and Sean Chia (2024) Thermal and pH stress dictate distinct mechanisms of monoclonal antibody aggregation. International Journal of Biological Macromolecules 282: 136601
- Jia Qian Tor, Quang Bach Le, Hariharan Ezhilarasu, Weng Wan Chan and Deepak Choudhury (2024) Advancements and regulations of biomanufacturing cell-based cartilage repair therapies. Trends in Biotechnology S0167-7799(24): 00277-4
- Ryan Haryadi, Kah Fai Chan, Pao Chun Lin, Yun Lei Tan, Corrine Wan, Wahyu Shahreel, Shi Jie Tay, Terry Nguyen-Khuong, Ian Walsh and Zhiwei Song (2024) Generating and characterizing a comprehensive panel of CHO cells glycosylation mutants for advancing glycobiology and biotechnology research. Scientific Reports 14: 23068
- Piyush Agarwal, Chris McCready, Say Kong Ng, Jake Chng Ng, Jeroen van de Laar, Maarten Penning and Gerben Zijlstra (2024) Hybrid Modeling for In-silico Optimization of a Dynamic Perfusion Cell Culture Process. Biotechnology Progress (Published Online)
- Xuan Dong, Xuezhi Bi and Siew Young Quek (2024) Integrative approach to assessing bioactivity from hempseed protein isolate extracted and dehydrated by different methods: Synergising in silico prediction and in vitro validation. Food Chemistry 463: 141459
- Sixun Chen, Tan Dai Nguyen, Kang-Zheng Lee and Dan Liu (2024) Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: critical process parameters and analytical technologies. Biotechnology Advances 77: 108434
- Nattha Ingavat, Nuruljannah Dzulkiflie, Jia Min Liew, Xinhui Wang, Eunice Leong, Han Ping Loh, Say Kong Ng, Yuansheng Yang and Wei Zhang (2024) Investigation on Environmental Factors Contributing to Bispecific Antibody Stability and the Reversal of Self-Associated Aggregates. Bioresources and Bioprocessing 11: 82
- Xinhui Wang, Nattha Ingavat, Jia Min Liew, Nuruljannah Dzulkiflie, Han Ping Loh, Yee Jiun Kok, Xuezhi Bi, Yuansheng Yang and Wei Zhang (2024) Effects of molecule hydrophobicity and structural flexibility of appended bispecific antibody on Protein A chromatography. Journal of Chromatography A 1731: 465206
- Jiayu Leong †, Wen Qin Tang †, Jake Chng †, Wei Xuan Ler, Norhaizat Abdul Manan, Lyn Chiin Sim, Zi Ying Zheng, Wei Zhang, Ian Walsh, Gerben Zijlstra, Maarten Pennings and Say Kong Ng (2024) Biomass specific perfusion rate as a control lever for the continuous manufacturing of biosimilar monoclonal antibodies from CHO cell cultures. Biotechnology Journal 19(7): e2400092
- Koki Mandai, Mark Jun Hao Tan, Suman Padhi and Kuin Tian Pang (2024) A Cross-Era Discourse on ChatGPT's Influence in Higher Education Through the Lens of John Dewey and Benjamin Bloom. Education Sciences 14(6): 614
- Meiyappan Lakshmanan, Sean Chia, Kuin Tian Pang, Lyn Chiin Sim, Gavin Teo, Shi Ya Mak, Shuwen Chen, Hsueh Lee Lim, Alison P. Lee, Farouq Bin Mahfut, Say Kong Ng, Yuansheng Yang, Annie Soh, Andy Hee-Meng Tan, Andre Choo, Ying Swan Ho, Terry Nguyen-Khuong and Ian Walsh (2024) Antibody Glycan Quality Predicted from CHO Cell Culture Media Markers and Machine Learning. Computational and Structural Biotechnology Journal 23: 2497-2506
- Alok Tanala Patra, Evan Tan, Yee Jiun Kok, Say Kong Ng and Xuezhi Bi (2024) Temporal Insights into Molecular and Cellular Responses during rAAV Production in HEK293T Cells. Molecular Therapy: Methods & Clinical Development 32(3): 101278
- Vivian V T Nguyen, Joshua A Welsh, Tobias Tertel, Andre Choo, Simonides I van de Wakker, Kyra A Y Defourny, Bernd Giebel, Pieter Vader, Jayanthi Padmanabhan, Sai Kiang Lim, Esther N M Nolte-'t Hoen, Marianne C Verhaar, R Beklem Bostancioglu, Antje M Zickler, Jia Mei Hong, Jennifer C Jones, Samir El Andaloussi, Bas W M van Balkom and André Görgens (2024) Inter-laboratory multiplex bead-based surface protein profiling of MSC-derived EV preparations identifies MSC-EV surface marker signatures. Journal of Extracellular Vesicles 13(6): e12463
- Brian Liau †, Li Zhang †, Melgious Jin Yan Ang, Jian Yao Ng, Suresh Babu, Sonja Schneider, Ravindra Gudihal, Ki Hyun Bae and Yi Yan Yang (2024) Quantitative analysis of mRNA-lipid nanoparticle stability in human plasma and serum by size-exclusion chromatography coupled with dual-angle light scattering. Nanomedicine: Nanotechnology, Biology, and Medicine 58: 102745
- Jun Wei Ng, Tong Mei Teh, Chee Fan Tan, Xuezhi Bi, Zhi En Low and Md. Mahabubur Rahman Talukder (2024) Alkaline solubilization of microalgal protein and its impact on the functional properties of protein extract. Future Foods 9: 100368
- Boon Min Poh, Lee Chuen Liew, Yan Ni Annie Soh, Ruenn Chai Lai, Sai Kiang Lim, Ying Swan Ho and Boon Seng So (2024) MSC-Derived Small Extracellular Vesicles Exert Cardioprotective Effect Through Reducing VLCFAs and Apoptosis in Human Cardiac Organoid IRI Model. Stem Cells 42(5): 416-429
- Shi Ya Mak, Shuwen Chen, Wey Jia Fong, Andre Choo and Ying Swan Ho (2024) A simple and highly sensitive LC–MS workflow for characterization and quantification of ADC cleavable payloads. Scientific Reports 14: 11018
- Priyatharshini Murugan, Wee Swan Yap, Hariharan Ezhilarasu, Ratima Suntornnond, Quang Bach Le, Satnam Singh, Jasmine Si Han Seah, Pei Leng Tan, Weibiao Zhou, Lay Poh Tan and Deepak Choudhury (2024) Decellularised plant scaffolds facilitate porcine skeletal muscle tissue engineering for cultivated meat biomanufacturing. npj Science of Food 8(1): 25
- Xinran Peng, Jiaoyu Chen, Yingying Gan, Li Yang, Yuanjing Luo, Changxin Bu, Yi Huang, Xinhai Chen, Jeremy Tan, Yi Yan Yang, Peiyan Yuan and Xin Ding (2024) Biofunctional lipid nanoparticles for precision treatment and prophylaxis of bacterial infections. Science Advances 10(14): eadk9754
- Sie Huey Lee, Dave Siak-Wei Ow, Pei Kun Richie Tay, Dai Chen, Pui Shan Chow, Yi Yan Yang, Shao Quan Liu and Desmond Heng (2024) A Formulation Platform for Incorporating Live Probiotics into Different Food Matrices. Journal of Food Engineering 378: 112113
- Ayça Altay Benetti, Eugene Yang Zhi Tan, Zi Wei Chang, Ki Hyun Bae, Ma Thinzar Thwin, Ram Pravin Kumar Muthuramalingam, Kuo-Chieh Liao, Yue Wan, Lisa F. P. Ng, Laurent Renia, Jianping Liu, Xiaoyuan Chen, Yi Yan Yang, Kevin P. White and Giorgia Pastorin (2024) Design and Characterization of a New Formulation for the Delivery of COVID-19-mRNA Vaccine to the Nasal Mucosa. Vaccines 12(4):409
- Ratima Suntornnond, Wee Swan Yap, Pei Ying Lim and Deepak Choudhury (2024) Redefining the Plate: Biofabrication in Cultivated Meat for Sustainability, Cost-Efficiency, Nutrient Enrichment, and Enhanced Organoleptic Experiences. Current Opinion in Food Science 57: 101164
- Sishir K. Kamalapuram and Deepak Choudhury (2024) Industry 4.0 technologies for cultivated meat manufacturing. Food Bioengineering 3: 14–28
- Ki Hyun Bae †, Bhuvaneshwari Shunmuganathan †, Li Zhang †, Andrew Lim, Rashi Gupta, Yanming Wang, Boon Lin Chua, Yang Wang, Yue Gu, Xinlei Qian, Isabelle Siang Ling Tan, Kiren Purushotorman, Paul A. MacAry, Kevin P. White and Yi Yan Yang (2024) Durable cross-protective neutralizing antibody responses elicited by lipid nanoparticle-formulated SARS-CoV-2 mRNA vaccines. npj Vaccines 9(1): 43
- Valériane Malika Keita, Yi Qing Lee, Meiyappan Lakshmanan, Dave Siak Wei Ow, Paul Staniland, Jessica Staniland, Ian Savill, Kang Lan Tee, Tuck Seng Wong and Dong Yup Lee (2024) Evaluating oleaginous yeasts for enhanced microbial lipid production using sweetwater as a sustainable feedstock. Microbial Cell Factories 23: 63
- Rachel Sim, Chuan Yang and Yi Yan Yang (2024) Chemical Proteomics and Morphological Profiling Revealing MYDGF as a Target for Synthetic Anticancer Macromolecules. Biomacromolecules 25(2): 1047-1057
- Dorothy Leung-Kwan Chan, Pei-Yu Lim, Arleen Sanny, Danai Georgiadou, Alison P. Lee and Andy Hee-Meng Tan (2024) Technical, commercial, and regulatory challenges of cellular agriculture for seafood production. Trends in Food Science and Technology 144: 104341
- Nattha Ingavat, Xinhui Wang, Jia Min Liew, Farouq Bin Mahfut, Ka Pui But, Yee Jiun Kok, Xuezhi Bi, Yuansheng Yang, Kobayashi Shintaro, Maria Tsoumpra and Wei Zhang (2024) Harnessing ceramic hydroxyapatite as an effective polishing strategy to remove product and process related impurities in bispecific antibody purification. Bioresources and Bioprocessing 10: 93
- Ki Hyun Bae, Fritz Lai, Qingfeng Chen and Motoichi Kurisawa (2024) Potentiating Gilteritinib Efficacy Using Nanocomplexation with a Hyaluronic Acid–Epigallocatechin Gallate Conjugate. Polymers 16(2): 225
- Chelsia Qiuxia Wang †, Pei Yu Lim † and Andy Hee-Meng Tan (2024) Gamma/delta T cells as cellular vehicles for anti-tumor immunity. Frontiers in Immunology 14: 1282758
† Authors contributed equally to this work.
2023
- Ang Jin, Rachel Z. Bennie, Olivia J. Ogilvie, Hamish J. F. Trlin, Ng Say Kong, Hanry Yu, Renwick C. J. Dobson and Laura J. Domigan (2023) Sculpting the future of meat: Biomaterial approaches and structural engineering for large-scale cell-based production. Sustainable Food Proteins 1–18
- Jason Tan, Yunhui Fang, Chuan Yang, Joyce Tay, Nathanael Tan, Nithiyaa D/O Bala Krishnan, Boon Lin Chua, Yanli Zhao, Yunbo Chen, James L Hedrick and Yi Yan Yang (2023) pH-Responsive Polymeric Micelle Dynamic Complexes for Selective Killing of Helicobacter pylori. Biomacromolecules 24(12): 5551-5562
- Guisheng Zeng, Xiaoli Xu, Yee Jiun Kok, Fu-Sheng Deng, Eve Wai Ling Chow, Jiaxin Gao, Xuezhi Bi and Yue Wang (2023) Cytochrome c regulates hyphal morphogenesis by interfering with cAMP-PKA signaling in Candida albicans. Cell Reports 42: 113473
- Sarah E Sandler, Robert I Horne, Sara Rocchetti, Robert Novak, Nai-Shu Hsu, Marta Castellana Cruz, Z Faidon Brotzakis, Rebecca C Gregory, Sean Chia, Gonçalo J L Bernardes, Ulrich F Keyser and Michele Vendruscolo (2023) Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores. Journal of the American Chemical Society 145(47): 25776-25788
- Jong Huat Tee, Udhaya Vijayakumar, Mahalakshmi Shanmugasundaram, Terence Y W Lam, Wupeng Liao, Yuansheng Yang, W S Fred Wong and Ruowen Ge (2023) Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice. Respiratory Research 24(1): 269
- Wee Swan Yap, Priyatharshini Murugan, Ratima Suntornnond and Deepak Choudhury (2023) Commercial opportunities, future directions, and novel approaches to fermentation. Cellular Agriculture (Technology, Society, Sustainability and Science) 22: 343-357 (Book Chapter)
- Weng Wan Chan, Quang Bach Le, May Win Naing and Deepak Choudhury (2023) Commercialization of skin substitutes for third-degree burn wounds. Trends in Biotechnology S0167-7799 (23): 00296-2
- Hei Man Wong, Cheok Hong Mun, Weng Keong Loke, Wei Qi Lim, Geraldine Wei Yen Chee, Sook Lan Tan, Jye Yng Teo, Yi Yan Yang, Hendrix Tanoto, Xian Jun Loh, Chen Ee Lee, Chuanwen Tiang, Wei Yee Wan, Charlene Cheong, Kue Bien How, Moi Lin Ling and Ban Hock Tan (2023) Moist heat as a promising method to decontaminate N95 masks – a large scale clinical study comparing four decontamination modalities: moist heat, steam, ultraviolet-C irradiation and hydrogen peroxide plasma. International Journal of Infectious Diseases 136: 151-157
- Pooja Jain, Ruby Yu-Tong Lin, Keerti Mishra, Harish Handral and Nileshkumar Dubey (2023) Three-dimensional eco-friendly bacterial nanocellulose (BNC) scaffold for regenerative dentistry: Characterization, cytocompatibility and differentiation potential. Dental Materials 40(1): 151-157
- Lin Ding, Steve Oh, Jesus Shrestha, Alan Lam, Yaqing Wang, Payar Radfar and Majid Ebrahimi Warkiani (2023) Scaling up stem cell production: harnessing the potential of microfluidic devices. Biotechnology Advances 69: 108271
- Ashlynn Ling Zhi Lee, Nithiyaa Balakrishnan, Jian Yao Ng, Shaoqiong Liu, Zhan Yuin Ong, Yanming Wang, Shujun Gao and Yi Yan Yang (2023) Injectable Hydrogels Prepared Using Novel Synthetic Short Peptides with Defined Structure and Gelatin as Scaffolds to Support Cell and Tissue Growth. Advanced Healthcare Materials e2302786
- Zeyuan Cao, Peiyi Li, Yuzhen Li, Manjin Zhang, Meng Hao, Wenwen Li, Xueli Mao, Lijie Mo, Chuan Yang, Xin Ding, Yi Yan Yang, Peiyan Yuan, Songtao Shi and Xiaoxing Kou (2023) Encapsulation of Nano-Bortezomib in Apoptotic Stem Cell-Derived Vesicles for the Treatment of Multiple Myeloma. Small 19(40): e2301748
- Lin Ding, Steve Oh, Jesus Shrestha, Alan Lam, Yaqing Wang, Payar Radfar and Majid Ebrahimi Warkiani (2023) Scaling up stem cell production: harnessing the potential of microfluidic devices. Biotechnology Advances 69: 108271
- Ngan T B Nguyen, Hau Wan Leung, Kuin Tian Pang, Shi Jie Tay, Ian Walsh, Andre B H Choo and Yuansheng Yang (2023) Optimizing effector functions of monoclonal antibodies via tailored N-glycan engineering using a dual landing pad CHO targeted integration platform. Scientific Reports 13(1): 15620
- Chengyuan Qin, Ning Tang, Yingying Gan, Huimin Zhao, Yuzhen Li, Guo-Bao Tian, Yi Yan Yang, Peiyan Yuan and Xin Ding (2023) Liposomes Co-Delivering Curcumin and Colistin to Overcome Colistin Resistance in Bacterial Infections. Advanced Healthcare Materials 12(24): e2202903
- Nicholas Tan Kwan Zen #, Kerwin Kwek Zeming #, Teo Kim Leng, Mavis Loberas, Jialing Lee, Goh Chin Ren, Yang Da Hou, Steve Oh, James Hui Hoi Po, Simon M. Cool, Han Wei Hou and Jongyoon Han (2023) Scalable Mesenchymal Stem Cells Enrichment from Bone Marrow Aspirate using Deterministic Lateral Displacement (DLD) Microfluidics Sorting. Lab on a Chip 23(19): 4313-4323
- Robert I Horne, Michael A Metrick 2nd, Wing Man, Dillon J Rinauro, Z Faidon Brotzakis, Sean Chia, Georg Meisl and Michele Vendruscolo (2023) Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts. ACS Chemical Neuroscience 14(17): 3125-3131
- Sixun Chen #, Ahmad Amirul Bin Abdul Rahim #, Pamela Mok and Dan Liu (2023) An effective device to enable consistent scratches for in vitro scratch assays. BMC Biotechnology 23(1): 32
- Huimin Zhao #, Lan-lan Zhong #, Chuan Yang #, Ning Tang, Yanwei He, Wan He, Zihan Zhao, Changbu Wu, Peiyan Yuan, Yi Yan Yang, Guo-bao Tian and Xin Ding (2023) Antibiotic-Polymer Self-Assembled Nanocomplex to Reverse Phenotypic Resistance of Bacteria towards Last-Resort Antibiotic Colistin. ACS Nano 17(16): 15411-15423
- Jin Hao Tan †, Anqi Chen †, Jiawu Bi †, Yee Hwee Lim, Fong Tian Wong and Dave Siak-Wei Ow (2023) The Engineering, Expression, and Immobilization of Epimerases for D-Allulose Production.International Journal of Molecular Sciences 24(16): 12703
- Xiaoman Luo #, Chau Sang Lau #, Bach Quang Le, Tuan Chun Tan, Jian Hui Too, Raymond Alexander Alfred Smith, Na Yu and Simon M Cool (2023) Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis. Scientific Reports 13(1): 11774
- Agnès Kuroki, Douglas Jie Wen Tay, Adeline C. Y. Chua, Bernice Siu Yan Tan, Ning Li, Jiayu Leong, Kai Sen Tan, Yanming Wang, Eddy Wei PingTan, Laurent Rénia, James L. Hedrick, Yi Yan Yang and Guan Huei Lee (2023) Amphiphilic Sulfonated Polycarbonates Inactivate SARS-CoV-2 in Seconds. Macromolecules 56(15): 6003–6009
- Yoon-Mi Choi, Dong-Hyuk Choi, Yi Qing Lee, Lokanand Koduru, Nathan E Lewis, Meiyappan Lakshmanan and Dong-Yup Lee (2023) Mitigating biomass composition uncertainties in flux balance analysis using ensemble representations. Computational and Structural Biotechnology Journal 21: 3736-3745
- Robert I Horne, Mhd Hussein Murtada, Donghui Huo, Z Faidon Brotzakis, Rebecca C Gregory, Andrea Possenti, Sean Chia and Michele Vendruscolo (2023) Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation. Journal of Chemical Theory and Computation 19(14): 4701-4710
- Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, and Yuansheng Yang (2023) Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies. mAbs 15(1): 2231129
- Adrielle Xianwen Chen, Huan Yi Lau, Jye Yng Teo, Yanming Wang, Darryl Zhi Yong Choong, Yue Wang, He-Kuan Luo, Yi Yan Yang and Ning Li (2023) Water-Mediated In Situ Fabrication of CuI Nanoparticles on Flexible Cotton Fabrics as a Sustainable and Skin-Compatible Coating with Broad-Spectrum Antimicrobial Efficacy. ACS Applied Nano Materials 6(14): 13238–13249
- Agnès Kuroki, Douglas Jie Wen Tay, Adeline C. Y. Chua, Bernice Siu Yan Tan, Ning Li, Jiayu Leong,, Kai Sen Tan, Yanming Wang, Eddy Wei Ping Tan, Laurent Rénia, James L. Hedrick, Yi Yan Yang and Guan Huei Lee (2023) Amphiphilic Sulfonated Polycarbonates Inactivate SARS-CoV-2 in Seconds. Macromolecules 56(15): 6003–6009
- Bryan Nicholas Chua, Wei Mei Guo, Han Teng Wong, Dave Siak-Wei Ow, Pooi Leng Ho, Winston Koh, Ann Koay and Fong Tian Wong (2023) A sweeter future: Using protein language models for exploring sweeter brazzein homologs. Food Chemistry 426: 136580
- Xun Hui Yeo, Vignesh Sundararajan, Zhengwei Wu, Zi Jin Cheryl Phua, Yin Ying Ho, Kai Lay Esther Peh, Yi-Chia Chiu, Tuan Zea Tan, Dennis Kappei, Ying Swan Ho, David Shao Peng Tan, Wai Leong Tam and Ruby Yun-Ju Huang (2023) The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer. Communications Biology 6(1): 660
- Kuin Tian Pang, Yuan Sheng Yang, Wei Zhang, Ying Swan Ho, Pietro Sormanni, Thomas C.T. Michaels, Ian Walsh and Sean Chia (2023) Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics. Biotechnology Advances 67: 108192
- Jiayin Yu, Zhihao Guo, Jiachang Yan, Changxin Bu, Chang Peng, Cuie Li, Rui Mao, Jian Zhang, Zhi Wang, Shi Chen, Meicun Yao, Zhiyong Xie, Chuan Yang, Yi Yan Yang, Peiyan Yuan and Xin Ding (2023) Gastric Acid-Responsive ROS Nanogenerators for Effective Treatment of Helicobacter pylori Infection without Disrupting Homeostasis of Intestinal Flora. Advanced Science e2206957
- Kuin Tian Pang † , Larry Sai Weng Loo †, Sean Chia, Francesca Yi Teng Ong, Hanry Yu and Ian Walsh (2023) Insight into muscle stem cell regeneration and mechanobiology. Stem Cell Research & Therapy 14: 129
- Chengnan Li #, Yingying Gan #, Zongshao Li #, Mengjing Fu, Yuzhen Li, Xinran Peng, Yongqiang Yang, Guo-Bao Tian, Yi Yan Yang, Peiyan Yuan and Xin Ding (2023) Neutrophil-inspired photothermo-responsive drug delivery system for targeted treatment of bacterial infection and endotoxins neutralization. Biomaterials Research 27(1): 30
- Jiayu Leong, Joyce Tay, Shengcai Yang, Chuan Yang, Eddy Wei Ping Tan, Yanming Wang, Bing Qian Tan, Sherwin Hor, Yau Hong Chua, Jeremy Pang Kern Tan, Qingfeng Chen, James L Hedrick and Yi Yan Yang (2023) Nanocomplexes of Biodegradable Anticancer Macromolecules: Prolonged Plasma Half-life, Reduced Toxicity, and Increased Tumor Targeting. Advanced Healthcare Materials e2201560
- Sean Chia, Shi Jie Tay, Zhiwei Song, Yuansheng Yang, Ian Walsh and Kuin Tian Pang (2023) Enhancing pharmacokinetic and pharmacodynamic properties of recombinant therapeutic proteins by manipulation of sialic acid content. Biomedicine & Pharmacotherapy 163: 114757
- Sophia Beng Hui Lim, Shang Wei, Andy Hee Meng Tan, Maurice A. M. van Steensel and Xinhong Lim (2023) Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche. Scientific Reports 13: 4027
- Harish K. Handral, Tom Adam Wyrobnik and Alan Tin-Lun Lam (2023) Emerging Trends in Biodegradable Microcarriers for Therapeutic Applications. Polymers 15: 1487
- Lin Zhao, Ming-Hsu Chen, Xuezhi Bi and Juan Du (2023) Physicochemical properties, structural characteristics and in vitro digestion of brown rice–pea protein isolate blend treated by microbial transglutaminase. Food Hydrocolloids 141: 108673
- An Eng Lim and Shireen Goh (2023) Effect of Microchannel Diameter on Electroosmotic Flow Hysteresis. Energies 16: 2154
- Serene W Chen, Zi Ying Zheng, Farouq Bin Mahfut, Yuansheng Yang, Masahiro Ogino, Kazuo Okada, Kohei Sato and Wei Zhang (2023) Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step. PLOS One 18(1): e0280760
- Yangyang Zhan, Haixia Xu, Hween Tong Tan, Ying Swan Ho, Dongxiao Yang, Shuwen Chen, Dave Siak-Wei Ow, Xin Lv, Fang Wei, Xuezhi Bi and Shouwen Chen (2023) Systematic Adaptation of Bacillus licheniformis to 2-Phenylethanol Stress. Applied and Environmental Microbiology 89(2): e0156822
- Ming Xia, Dianzhen Yu, Han Chen, Jingcheng Dai, Na Gao, Shuyang Li, Xuezhi Bi and Dongru Qiu (2023) An RpoN-dependent PEP-CTERM gene is involved in floc formation of an Aquincola tertiaricarbonis strain. BMC Microbiology 23: 20
- Wee Swan Yap, Deepak Choudhury and Ratima Suntornnond (2023) Towards Biomanufacturing of Cultured Meat. Trends in Biotechnology 41(3): 292-294
# Authors contributed equally to this work.
2022
- Lokanand Koduru, Meiyappan Lakshmanan, Yi Qing Lee, Pooi-Leng Ho, Pei-Yu Lim, Wei Xuan Ler, Say Kong Ng, Dongseok Kim, Doo-Sang Park, Mazlina Banu, Dave Siak-Wei Ow and Dong-Yup Lee (2022) Systematic evaluation of genome-wide metabolic landscapes in lactic acid bacteria reveals diet-induced and strain-specific probiotic idiosyncrasies. Cell Reports 41(10): 111735
- Han Kee Ong, Ngan T B Nguyen, Jiawu Bi and Yuansheng Yang (2022) Vector design for enhancing expression level and assembly of knob-into-hole based FabscFv-Fc bispecific antibodies in CHO cells. Antibody Therapeutics 5(4): 288-300
- Sie Huey Lee, Wei Xuan Yap, Chloe Qiu Zhen Jiang, Wei Xuan Ler, Jeanette Woon Pei Teo, Say Kong Ng, Desmond Heng (2022) Designing a ‘Plug-and-Play’ Powder Formulation Platform for the Inhaled Protein Therapeutics. Journal of Drug Delivery Science and Technology 76: 103820
- Serene Chen, Hoi Kong Meng, Farouq Bin Mahfut, Yang Yuansheng and Zhang Wei (2022) Effective flow-through polishing strategies for knob-into-hole bispecific antibodies. Bioresources and Bioprocessing 9: 98
- Andy Hee-Meng Tan, Alice Man Sze Cheung and Dieter Kabelitz (2022) Next generation gamma delta T cell-based tumor immunotherapy. Frontiers in Immunology 13: 1041362
- Chee Fan Tan, Soon Hong Kwan, Chun Shing Lee, Yan Ni Annie Soh , Ying Swan Ho and Xuezhi Bi (2022) Cottonseed Meal Protein Isolate as a New Source of Alternative Proteins: A Proteomics Perspective. International Journal of Molecular Sciences 23: 10105
- Tram Anh Nguyen, Jia Wei Joel Heng , Pornchai Kaewsapsak, Eng Piew Louis Kok, Dominik Stanojević, Hao Liu, Angelysia Cardilla, Albert Praditya, Zirong Yi, Mingwan Lin, Jong Ghut Ashley Aw, Yin Ying Ho, Kai Lay Esther Peh, Yuanming Wang, Qixing Zhong, Jacki Heraud-Farlow, Shifeng Xue, Bruno Reversade, Carl Walkley, Ying Swan Ho, Mile Šikić, Yue Wan and Meng How Tan (2022) Direct identification of A-to-I editing sites with nanopore native RNA sequencing. Nature Methods 19: 833-844
- Sean Chia, Gavin Teo, Shi Jie Tay, Larry Loo Sai Weng, Corrine Wan, Sim Lyn Chiin, Hanry Yu, Ian Walsh and Kuin Tian Pang (2022) An Integrative Glycomic Approach for Quantitative Meat Species Profiling. Foods 11(13): 1952
- Serene Chen, Hoi Kong Meng, Yang Yuansheng and Zhang Wei (2022) Excellent removal of knob‑into‑hole bispecific antibody byproducts and impurities in a single‑capture chromatography. Bioresources and Bioprocessing 9: 72
- Jianxin Huo, Yuhan Huang, Ziying Zheng, Xin Ni Tay, Farouq Bin Mahfut, Wei Zhang, Kong-Peng Lam, Yuansheng Yang and Shengli Xu (2022) Development of a T cell-redirecting bispecific antibody targeting B-cell maturation antigen for suppressing multiple myeloma cell growth. Antibody Therapeutics 5(2): 138-149
- John Fink, Michael Scott, Sebastian Rieck, Robert Jones, Jean Sebastian Parisse, Heidi Hagen, Yonatan Lipsitz, Steve Oh, Dominic Clarke (2022) Impact Considerations of Post-Production Processes on Cell and Gene Drug Products. Cytotherapy 24(6): 583-589
- Amrita M. Nargund, Chang Xu, Amit Mandoli, Atsushi Okabe, Gao Bin Chen, Kie Kyon Huang, Taotao Sheng, Xiaosai Yao, Jia Ming Nickolas Teo, Raghav Sundar, Yee Jiun Kok, Yi Xiang See Manjie Xing, Zhimei Li, Chern Han Yong, Aparna Anand,Zul Fazreen A.I., Lai Fong. Poon, Michelle Shu Wen. Ng, Javier Yu Peng Koh, Wen Fong Ooi, Su Ting Tay, Xuewen Ong, Angie Lay Keng Tan, Heike I. Grabsch, Melissa Jane. Fullwood, Tean Bin Teh, Xuezhi Bi, Atsushi Kaneda, Shang Li and Patrick Tan (2022) Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer. Cancer Research 82(14): 2538-2551
- Akshaya Srinivasan, Padmapriya Sathiyanathan, Lu Yin, Tong Ming Liu, Alan Lam, Maanasa Ravikumar, Raymond Alexander Alfred Smith, Han Ping Loh, Ying Zhang, Ling Ling, Say Kong Ng, Yuan Sheng Yang, Alexander Lezhava, James Hui, Steve Oh, Simon M. Cool (2022) Strategies to enhance immunomodulatory properties and reduce heterogenity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy 24(5): 456-472
- Alan Lam, Valerie Ho, Svetlan Vassilev, Shaul Reuveny and Steve Oh (2022) An Allied Reprogramming, Selection, Expansion and Differentiation platform for creating hiPSC on Microcarriers. Cell Proliferation (Published Online)
- Tom A. Wyrobnik, Steve Oh, Andrea Ducci, Martina Micheletti (2022) Engineering characterization of the novel Bach impeller for bioprocessing applications requiring low power inputs. Chemical Engineering Science 252: 117263
- Sixun Chen, Ahmad Amirul Bin Abdul Rahim, Who‑Whong Wang, Rachael Cheong, Akshaya V. Prabhu, Jerome Zu Yao Tan, May Win Naing, Han Chong Toh & Dan Liu (2022) In‑situ scalable manufacturing of Epstein–Barr virus‑specific T‑cells using bioreactor with an expandable culture area (BECA). Scientific Reports 12: 7045
- Lokanand Koduru, Meiyappan Lakshmanan, Shawn Hoon, Dong-Yup Lee, Yuan Kun Lee and Dave Siak-Wei Ow (2022) Systems biology of gut microbiota-human receptor interactions: Toward anti-inflammatory probiotics. Frontiers in Microbiology 13: 846555
- SuE Yu, Svetlan Vassilev, Zhong Ri Lim, Jaichandran Sivalingam, Alan Tin Lun Lam, Valerie Ho, Laurent Renia, Benoit Malleret, Shaul Reuveny and Steve Kah Weng Oh (2022) Selection of O-negative induced pluripotent stem cell clones for high-density red blood cell production in a scalable perfusion bioreactor system. Cell Proliferation 55(8): e13218
- Ying Ying Wu, Jia Sheng Zach Lee, Sixun Chen and Dan Liu (2022) Sterile Fluid Transfer for Cell Therapy Manufacturing—The Value of Multiple-Use Aseptic Connector. Frontiers in Bioengineering and Biotechnology-Biomaterials 9: 806677
- Satnam Singh, Wee Swan Yap, Xiao Yu Ge, Veronica Lee Xi Min and Deepak Choudhury (2022) Cultured Meat production fueled by fermentation . Trends in Food Science & Technology 120: 48-58
- Svetlan Vassilev and Steve Kah Weng Oh (2022) Manufacturing human pluripotent stem cells and differentiated progenitors. Cell Culture Engineering and Technology (Book Chapter)
- Jia Tong Loh, Bin Zhang, Joey Kay Hui Teo, Ruenn Chai Lai, Andre Boon Hwa Choo, Kong-Peng Lam and Sai Kiang Lim (2022) Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes. Cytotherapy 24(7): 711-719
- Valerie Ho, Gerine Tong, Alan Lam, Shaul Reuveny, and Steve Oh (2022) Integrating Human Induced Pluripotent Stem Cell Expansion Capability and Cardiomyocyte Differentiation Potential in a Microcarrier Suspension Culture. Methods in Molecular Biology 2436: 67-81
- Zhenzhong Chen, Seokgyu Han, Arleen Sanny, Dorothy Leung‑Kwan Chan, Danny van Noort, Wanyoung Lim, Andy Hee‑Meng Tan and Sungsu Park (2022) 3D hanging spheroid plate for high-throughput CAR T cell cytotoxicity assay. Journal of Nanobiotechnology 20:30
- Shipin Zhang, Keng Lin Wong, Xiafei Ren, Kristeen Ye Wen Teo, Hassan Afizah, Andre Boon Hwa Choo, Ruenn Chai Lai, Sai Kiang Lim, James Hoi Po Hui and Wei Seong Toh (2022) Mesenchymal stem cell exosomes promote functional osteochondral repair in a clinically relevant porcine model. American Journal of Sports Medicine 50(3): 788-800
- Ian Walsh, Matthew Myint, Terry Nguyen-Khuong, Ying Swan Ho, Say Kong Ng and Meiyappan Lakshmanan (2022) Harnessing the potential of machine learning for advancing “Quality by Design” in biomanufacturing. mAbs 14(1)
- Chelsia Wang Qiuxia and Andy Tan Hee Meng (2022) Driving CARs on the biomanufacturing road to clinical success. Cell & Gene Therapy Insights 7(11): 1613–1621
2021
- Nana Y D Ankrah, David B Bernstein, Matthew Biggs, Maureen Carey, Melinda Engevik, Beatriz García-Jiménez, Meiyappan Lakshmanan, Alan R Pacheco, Snorre Sulheim and Gregory L Medlock (2021) Enhancing Microbiome Research through Genome-Scale Metabolic Modeling mSystems 6(6): e0059921
- Evan Tan, Cara Sze Hui Chin, Zhi Feng Sherman Lim, Say Kong Ng (2021) HEK293 Cell Line as a Platform to Produce Recombinant Proteins and Viral Vectors. Frontiers in Bioengineering and Biotechnology 9: 796991
- Yin Yin Siew, Amrita Rai, Han Bin Pek, Dave Siak-Wei Ow and Wei Zhang (2021) New and Efficient Purification Process for Recombinant Human Insulin Produced in Escherichia coli. Applied Microbiology and Biotechnology 105(24): 9137-9151
- Sishir K Kamalapuram, Harish Handral and Deepak Choudhury (2021) Cultured Meat Prospects for a Billion! Foods 10: 2922
- Weng Wan Chan, Fang Yu, Quang Bach Le, Sixun Chen, Marcus Yee and Deepak Choudhury (2021) Towards Biomanufacturing of Cell-derived matrices. International Journal of Molecular Sciences 22(21): 11929
- Yusuke Mimura, Radka Saldova, Yuka Mimura-Kimura, Pauline M. Rudd and Roy Jefferis (2021) Importance and Monitoring of Therapeutic Immunoglobulin G Glycosylation. Antibody Glycosylation (Book Chapter)
- Yusuke Mimura, Radka Saldova, Yuka Mimura-Kimura, Pauline M. Rudd and Roy Jefferis (2021) Micro-Heterogeneity of Antibody Molecules. Antibody Glycosylation (Book Chapter)
- Ee Theng Ng, Satnam Singh, Wee Swan Yap, Shi Hua Tay and Deepak Choudhury (2021) Cultured Meat – A Patentometric Analysis. Critical Reviews in Food Science and Nutrition (Published Online)
- Ser Yue Loo, Li Ping Toh, William Haowei Xie, Elina Pathak, Wilson Tan, Siming Ma, May Yin Lee, S. Shatishwaran, Joanna Zhen Zhen Yeo, Ju Yuan, Yin Ying Ho, Esther Kai Lay Peh, Magendran Muniandy, Federico Torta, Jack Chan, Tira J. Tan, Yirong Sim, Veronique Tan, Benita Tan, Preetha Madhukumar, Wei Sean Yong, Kong Wee Ong, Chow Yin Wong, Puay Hoon Tan, Yoon Sim Yap, Lih-Wen Deng, Rebecca Dent, Roger Foo, Markus R. Wenk, Soo Chin Lee, Ying Swan Ho, Elaine Hsuen Lim and Wai Leong Tam (2021) Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Science Advances 7(41): eabh2443
- Georg von Massow, Steve Oh, Alan Lam and Kenth Gustafsson (2021) Gamma Delta T Cells and Their Involvement in COVID-19 Virus Infections. Frontiers in Immunology (Published Online)
- Ian Walsh, Sophie Zhao, Katherine Wongtrakul-Kish, Matthew Choo, Shi Jie Tay, Christopher H. Taron, Pauline M. Rudd, and Terry Nguyen-Khuong (2021) Glycoinformatics tools for comprehensive characterization of glycans enzymatically released from proteins. Methods in Molecular Biology (Book Chapter)
- Tsz Wai Ngai, Gamal Ahmed Elfar, Pearlyn Yeo, Nicholas Phua, Jin Hui Hor, Shuwen Chen, Ying Swan Ho and Chit Fang Cheok (2021) Nitro-Deficient Niclosamide Confers Reduced Genotoxicity and Retains Mitochondrial Uncoupling Activity for Cancer Therapy. International Journal of Molecular Sciences 22(19): 10420
- Zhong Ri Lim, Svetlan Vassilev, Yew Wai Leong, Jing Wen Hang, Laurent Rénia, Benoit Malleret and Steve Kah-Weng Oh (2021) "Industrially Compatible Transfusable iPSC-Derived RBCs: Progress, Challenges and Prospective Solutions". International Journal of Molecular Sciences 22(18): 9808
- Yin Ying Ho, Hao Kim Lu, Zhi Feng Sherman Lim, Hao Wei Lim, Ying Swan Ho, Say Kong Ng (2021) Applications and Analysis of Hydrolysates in Animal Cell Culture. Bioresources and Bioprocessing 18(1): 93
- Laura Sutarlie, Dave Siak-Wie Ow, Say Kong Ng, Yuansheng Yang and Xiaodi Su (2021) Gold Nanoparticle-based “Mix and Measure” Fluorimetric Assays to Quantify Antibody Titer. Chemistry – An Asian Journal 16: 1-7
- Alison P. Lee, Yee Jiun Kok, Meiyappan Lakshmanan, Dawn Leong, Lu Zheng, Hsueh Lee Lim, Shuwen Chen, Shi Ya Mak, Kok Siong Ang, Neil Templeton, Taha Salim, Xiaona Wei, Eric Gifford, Andy Hee‐Meng Tan, Xuezhi Bi, Say Kong Ng, Dong‐Yup Lee, Wai Lam W. Ling and Ying Swan Ho (2021) Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality. Biotechnology and Bioengineering (Published Online)
- Ian Walsh, Dmytro Fishman, Dario Garcia-Gasulla, Tiina Titma, Gianluca Pollastri, ELIXIR Machine Learning focus group, Jennifer Harrow, Fotis E. Psomopoulos & Silvio C.E. Tosatto (2021) DOME: Recommendations for supervised machine learning validation in biology. Nature Methods 18: 1122–1127
- Dave Siak-Wei Ow, Min-Kyu Oh, Chung-Jen Chiang and Yun-Peng Chao (2021) Technological Advances Improving Recombinant Protein Production in Bacteria. Frontiers in Microbiology 12: 729472
- Siew Yin Yin and Zhang Wei (2021) Downstream processing of recombinant human insulin and its analogues production from E. coli inclusion bodies. Bioresources and Bioprocessing 8: 65
- Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-Ok Lee, Vineeth T. Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J. Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A. Luftig, Dennis Kappei, Warren D. Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen and Patrick Tan (2021) Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation. Genome Biology 22(1):167
- Christophe Lay, Collins Wenhan Chu, Rikky Wenang Purbojati, Enzo Acerbi, Daniela I. Drautz-Moses, Paola Florez de Sessions, Song Jie, Eliza Ho, Yee Jiun Kok, Xuezhi Bi, Shuwen Chen, Shi Ya Mak, Mei Chien Chua, Anne E. N. Goh, Wen Chin Chiang, Rajeshwar Rao, Surasith Chaithongwongwatthana, Nipon Khemapech, Voranush Chongsrisawat, Rocio Martin, the JULIUS Study Group, Guus Roeselers, Ying Swan Ho, Martin L. Hibberd, Stephan C. Schuster and Jan Knol (2021) A synbiotic intervention modulates metaomics signatures of gut redox potential and acidity in elective caesarean born infants. BMC Microbiology 21(1): 191
- Ngan T. B. Nguyen, Jianer Lin, Shi JieTay, Mariati, Jessna Yeo, Terry Nguyen‑Khuong & Yuansheng Yang (2021) Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans. Scientific Reports 11(1): 12969
- Jasmine Si Han Seah, Satnam Singh, Lay Poh Tan and Deepak Choudhury (2021) Scaffolds for the manufacture of cultured meat. Critical Reviews in Biotechnology 1-13
- Mario Gimona, Maria Felice Brizzi, Andre Boon Hwa Choo, Massimo Dominici, Sean M. Davidson, Johannes Grillari, Dirk M. Hermann, Andrew F. Hill, Dominique devv Kleijn, Ruenn Chai Lai, Charles Lai, Rebecca Lim, Marta Monguió-Tortajada, Maurizio Muraca, Takahiro Ochiya, Luis A. Ortiz, Wei Seong Toh, Yong Weon Yi, Kenneth W. Witwer, Bernd Giebel and Sai Kiang Lim (2021) Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell (MSC)-derived small extracellular vesicles. Cytotherapy 23(5): 373-380
- Satnam Singh, Sachin Mishra, Song Juha, Manojit Pramanik, Parasuraman Padmanabhan and Balázs Gulyás (2021) Nanotechnology Facilitated Cultured Neuronal Network and Its Applications. International Journal of Molecular Sciences 22(11): 5552
- Serene W Chen, Wei Zhang (2021) Current trends and challenges in the downstream purification of bispecific antibodies. Antibody Therapeutics 4(2): 73–88
- Man Mohan Shrestha, Chun-Yan Lim, Xuezhi Bi, Robert C. Robinson and Weiping Han (2021) Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts. Frontiers in Endocrinology 12: 653557
- Kuin Tian Pang, Shi Jie Tay, Corrine Wan, Ian Walsh, Matthew S.F. Choo, Yuan Sheng Yang, Andre Choo, Ying Swan Ho and Terry Nguyen-Khuong (2021) Semi-automated Glycoproteomic Data Analysis of LC-MS data using GlycopeptideGraphMS in Process Development of Monoclonal Antibody Biologics. Frontiers in Chemistry-Analytical Chemistry (Published Online)
- Duy Tien Ta, Kai Ling Chu, Nur Izzati Bte Soonaan, Christine Chin, Say Kong Ng and Wei Zhang (2021) A new and simplified anion exchange chromatographic process for the purification of cell-grown influenza A H1N1 virus. Separation and Purification Technology 263: 118412
- Thong Teck Tan, Ruenn Chai Lai, Jayanthi Padmanabhan, Wei Kian Sim, Andre Boon Hwa Choo and Sai Kiang Lim (2021) Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV). Pharmaceuticals 14: 345
- Xiaohui Wang, Xiang Lin, Zihan Zheng, Bingtai Lu, Jun Wang, Andy Hee-Meng Tan, Meng Zhao, Jia Tong Loh, Sze Wai Ng, Qian Chen, Fan Xiao, Enyu Huang, King-Hung Ko, Zhong Huang, Jingyi Li, Kin-Hang Kok, Gen Lu, Xiaohui Liu, Kong-Peng Lam, Wanli Liu, Yuxia Zhang, Kwok-Yung Yuen, Tak Wah Mak & Liwei Lu (2021) Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection. Nature Communications 12: 1914
- Eun Myoung Shin, Vinh Thang Huynh, Sultan Abda Neja, Chia Yi Liu, Anandhkumar Raju, Kelly Tan, Nguan Soon Tan, Jayantha Gunaratne, Xuezhi Bi, Lakshminarayan M. Iyer, L. Aravind and Vinay Tergaonkar (2021) GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer. Science Advances 7(12): eabe2470
- Alan Tin-Lun Lam, Alison P. Lee, Premkumar Jayaraman, Kah Yong Tan, Deepak Raghothaman, Hsueh Lee Lim, He Cheng, Lihan Zhou, Andy Hee-Meng Tan, Shaul Reuveny and Steve Oh (2021) Multiomics analyses of cytokines, gene, miRNA, and pathway regulatory networks in human mesenchymal stem cells expanded in stirred microcarrier-spinner cultures. Stem Cell Research 53:102272
- Zixi Wang, Di Guan, Jianxin Huo, Subhra K Biswas, Yuhan Huang, Yuansheng Yang, Shengli Xu and Kong-Peng Lam (2021) IL-10 enhances human natural killer cell effector function via metabolic reprogramming regulated by mTOR signaling. Frontiers in Immunology 12:619195
- Genetics of Exfoliation Syndrome Partnership; Zheng Li, Zhenxun Wang, Mei Chin Lee, Matthias Zenkel, Esther Peh, Mineo Ozaki, Fotis Topouzis, Satoko Nakano, Anita Chan, Shuwen Chen, Susan E I Williams, Andrew Orr, Masakazu Nakano, Nino Kobakhidze, Tomasz Zarnowski, Alina Popa-Cherecheanu, Takanori Mizoguchi, Shin-Ichi Manabe, Ken Hayashi, Shigeyasu Kazama, Kenji Inoue, Yosai Mori, Kazunori Miyata, Kazuhisa Sugiyama, Tomomi Higashide, Etsuo Chihara, Ryuichi Ideta, Satoshi Ishiko, Akitoshi Yoshida, Kana Tokumo, Yoshiaki Kiuchi, Tsutomu Ohashi, Toshiya Sakurai, Takako Sugimoto, Hideki Chuman, Makoto Aihara, Masaru Inatani, Kazuhiko Mori, Yoko Ikeda, Morio Ueno, Daniel Gaston, Paul Rafuse, Lesya Shuba, Joseph Saunders, Marcelo Nicolela, George Chichua, Sergo Tabagari, Panayiota Founti, Kar Seng Sim, Wee Yang Meah, Hui Meng Soo, Xiao Yin Chen, Anthi Chatzikyriakidou, Christina Keskini, Theofanis Pappas, Eleftherios Anastasopoulos, Alexandros Lambropoulos, Evangelia S Panagiotou, Dimitrios G Mikropoulos, Ewa Kosior-Jarecka, Augustine Cheong, Yuanhan Li, Urszula Lukasik, Monisha E Nongpiur, Rahat Husain, Shamira A Perera, Lydia Álvarez, Montserrat García, Héctor González-Iglesias, Andrés F V Cueto, Luis F V Cueto, Federico Martinón-Torres, Antonio Salas, Çilingir Oguz, Nevbahar Tamcelik, Eray Atalay, Bilge Batu, Murat Irkec, Dilek Aktas, Burcu Kasim, Yury S Astakhov, Sergei Y Astakhov, Eugeny L Akopov, Andreas Giessl, Christian Mardin, Claus Hellerbrand, Jessica N Cooke Bailey, Robert P Igo Jr, Jonathan L Haines, Deepak P Edward, Steffen Heegaard, Sonia Davila, Patrick Tan, Jae H Kang, Louis R Pasquale, Friedrich E Kruse, André Reis, Trevor R Carmichael, Michael Hauser, Michele Ramsay, Georg Mossböck, Nilgun Yildirim, Kei Tashiro, Anastasios G P Konstas, Miguel Coca-Prados, Jia Nee Foo, Shigeru Kinoshita, Chie Sotozono, Toshiaki Kubota, Michael Dubina, Robert Ritch, Janey L Wiggs, Francesca Pasutto, Ursula Schlötzer-Schrehardt, Ying Swan Ho, Tin Aung, Wai Leong Tam, Chiea Chuen Khor (2021) Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 325(8): 753-764
- Fang Yu, Nivasini Selva Kumar, Satnam Singh, Walter Hunziker, Sum Huan Ng and Deepak Choudhury (2021) Isolation of primary brain endothelial cells, pericytes and astrocytes on a microfluidic immunopanning chip (MIC). Microfluidics and Nanofluidics 25:25
- Pei Kun Richie Tay, Pei Yu Lim and Dave Siak-Wei Ow (2021) A SH3_5 cell anchoring domain for non-recombinant surface display on lactic acid bacteria. Frontiers in Biotechnology and Bioengineering 8: 614498
- Weichao Zhai, Jerome Tan, Tobias Russell, Sixun Chen, Dennis McGonagle, May Win Naing, Derrick Yong and Elena Jones (2021) Multi-pronged Approach to Human Mesenchymal Stromal Cells Senescence Quantification with a Focus on Label Free Methods. Scientific Reports 11(1): 1054
- Bin Zhang, Ruenn Chai Lai, Wei Kian Sim, Andre Boon Hwa Choo, Ellen Birgit Lane and Sai Kiang Lim (2021) Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation. International Journal of Molecular Sciences 22(2): 720
2020
- Jaichandran Sivalingam, Yu SuE, Zhong Ri Lim, Alan T.L. Lam, Alison P. Lee, Hsueh Lee Lim, Hong Yu Chen, Hong Kee Tan, Tushar Warrier, Jing Wen Hang, Nazmi B. Nazir, Andy H.M. Tan, Laurent Renia, Yuin Han Loh, Shaul Reuveny, Benoit Malleret and Steve K.W. Oh (2020) A Scalable Suspension Platform for Generating High-Density Cultures of Universal Red Blood Cells from Human Induced Pluripotent Stem Cells. Stem Cell Reports 16(1): 182-197
- Liu Dan, Chen Sixun and May Win Naing (2020) A review of manufacturing capabilities of cell spheroid generation technologies and future development. Biotechnology and Bioengineering 118(2): 542-554
- Andy Hee-Meng Tan, Gloria Hoi Wan Tso, Biyan Zhang, Pei-Yun Teo, Xijun Ou, Sze-Wai Ng, Alex Xing Fah Wong, Sean Jing Xiang Tan, Arleen Sanny, Susana Soo-Yeon Kim, Alison P. Lee, Shengli Xu, and Kong-Peng Lam (2020) TACI constrains TH17 pathogenicity and protects against gut inflammation. iScience 23(11): 101707
- Edward G. Pallister, Matthew S. F. Choo, Ian Walsh, Jien-Nee Tai, Shi-Jie Tay, Yuansheng Yang, Say-Kong Ng, Pauline M. Rudd, Sabine L. Flitsch and Terry Nguyen-Khuong (2020) Utility of Ion-Mobility Spectrometry for Deducing Branching of Multiply Charged Glycans and Glycopeptides in a High-Throughput Positive ion LC-FLR-IMS-MS Workflow. Analytical Chemistry 92(23):15323-15335
- Deepak Choudhury, Satnam Singh, Jasmine Si Han Seah, David Chen Loong Yeo and Lay Poh Tan (2020) Commercialization of Plant-Based Meat Alternatives. Trends in Plant Science 25(11): 1055-1058
- Yu Yang Fredik Liu, Yin Lu, Steve Oh, Gareth J. Conduit (2020) Machine learning to predict mesenchymal stem cell efficacy for cartilage repair. PLOS Computational Biology (Published Online)
- Katrina Adlerz, Divya Patel, Jon Rowley, Kelvin Ng, Tabassum Ahsan (2020) Strategies for Scalable Manufacturing and Translation of MSC-Derived Extracellular Vesicles. Stem Cell Research 48: 101978
- Jia Tong Loh, Joey Kay Hui Teo, Hong-Hwa Lim and Kong-Peng Lam (2020) Emerging Roles of Downstream of Kinase 3 in Cell Signaling. Frontiers in Immunology 11: 566192
- Deepak Choudhury, Marcus Yee, Zach Lee Jia Sheng, Ahmad Amirul and May Win Naing (2020) Decellularization systems and devices: State-of-the-art. Acta Biomaterialia (Review Paper) 115: 51–59
- Harish K. Handral , Shi Hua Tay, Weng Wan Chan and Deepak Choudhury (2020) 3D printing of cultured meat products. Critical Reviews in Food Science and Nutrition (Published Online)
- Kae Hwan Sim, Lillian Chia-Yi Liu, Hwee Tong Tan, Kelly Tan, Daniel Ng, Wei Zhang, Yuansheng Yang, Stephen Tate and Xuezhi Bi (2020) A comprehensive CHO SWATH-MS spectral library for robust quantitative profiling of 10,000 proteins. Scientific Data 7(1): 263
- Youshan Melissa Lin, Alan Tin Lun Lam, Jialing Lee, Teo Kim Leng, Eileen Sim, Li Jian, Jessica Pei Wen Toh, Xiafei Ren, Barry WL Tan, Mahesh Choolani, Jerry Kok Yen Chan, Shaul Reuveny, James Hoi Po Hui, William R. Birch and Steve Kah Weng Oh (2020) Human early mesenchymal stromal cells delivered on porous lightweight biodegradable polycaprolactone-based microcarriers result in improved cartilage formation. Materialia 13: 100851
- Julian L. Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V. Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W. L. Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K. Luthra, William D. Shingleton, Steve K. W. Oh, Li Zeng and Edward G. Robins (2020) Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease. Stem Cell Research & Therapy 11: 347
- Weng Wan Chan, David Chen Loong Yeo, Vernice Tan, Satnam Singh, Deepak Choudhury and May Win Naing (2020) Additive Biomanufacturing with Collagen Inks. Bioengineering 7: 66
- Saeideh Kholgh Eshkalak, Erfan Rezvani Ghomi, Yunqian Dai, Deepak Choudhury and Seeram Ramakrishna (2020) The role of three-dimensional printing in healthcare and medicine. Materials and Design 194: 108940
- Hock Chuan Yeo, Jongkwang Hong, Meiyappan Lakshmanan and Dong-Yup Lee (2020) Enzyme capacity-based genome scale modelling of CHO cells. Metabolic Engineering 60: 138-147
- Chaminda Jayampath Seneviratne, Preethi Balan, Tanujaa Suriyanarayanan, Meiyappan Lakshmanan, Dong-Yup Lee, Mina Rho, Nicholas Jakubovics, Bernd Brandt, Wim Crielaard and Egija Zaura (2020) Oral microbiome-systemic link studies: perspectives on current limitations and future artificial intelligence-based approaches. Critical Reviews in Microbiology 46(3): 288-299
- Candice Qiu Xia Yam, David Boy Chia, Idina Shi, Hong Hwa Lim and Uttam SURANA (2020) Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling. Nucleic Acid Research 48(11): 6092-6107
- Lokanand Koduru, Hyang Yeon Kim, Meiyappan Lakshmanan, Bijayalaxmi Mohanty, Yi Qing Lee, Choong Hwan Lee and Dong-Yup Lee (2020) Genome-scale metabolic reconstruction and in silico analysis of rice leaf blight pathogen, Xanthomonas oryzae. Molecular Plant Pathology 21(4):527-540
- Serene W Chen, Darryl Tan, Yuan Sheng Yang and Wei Zhang (2020) Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies. mAbs 12(1): 1718440
- Leonard Leong, Heng Liang Tan, Simeon Cua, Kylie Su Mei Yong, Qingfeng Chen and Andre Choo (2020) Preclinical Activity of Embryonic Annexin A2-Specific Chimeric Antigen Receptor T Cells Against Ovarian Cancer. International Journal of Molecular Sciences 21(2): 381
- Filip Laco, Alan Tin-Lun Lam, Tsung-Liang Woo, Gerine Tong, Valerie Ho, Poh-Loong Soong, Elina Grishina, Kun-Han Lin, Shaul Reuveny and Steve Kah-Weng Oh (2020) Selection of human induced pluripotent stem cells lines optimization of cardiomyocytes differentiation in an integrated suspension microcarrier bioreactor. Stem Cell Research and Therapy 11: 118
- Christian Lieven, Moritz E. Beber, Brett G. Olivier, Frank T. Bergmann, Meric Ataman, Parizad Babaei, Jennifer A. Bartell, Lars M. Blank, Siddharth Chauhan, Kevin Correia, Christian Diener, Andreas Dräger, Birgitta E. Ebert, Janaka N. Edirisinghe, José P. Faria, Adam M. Feist, Georgios Fengos, Ronan M. T. Fleming, Beatriz García-Jiménez, Vassily Hatzimanikatis, Wout van Helvoirt, Christopher S. Henry, Henning Hermjakob, Markus J. Herrgård, Ali Kaafarani, Hyun Uk Kim, Zachary King, Steffen Klamt, Edda Klipp, Jasper J. Koehorst, Matthias König, Meiyappan Lakshmanan, Dong-Yup Lee, Sang Yup Lee, Sunjae Lee, Nathan E. Lewis, Filipe Liu, Hongwu Ma, Daniel Machado, Radhakrishnan Mahadevan, Paulo Maia, Adil Mardinoglu, Gregory L. Medlock, Jonathan M. Monk, Jens Nielsen, Lars Keld Nielsen, Juan Nogales, Intawat Nookaew, Bernhard O. Palsson, Jason A. Papin, Kiran R. Patil, Mark Poolman, Nathan D. Price, Osbaldo Resendis-Antonio, Anne Richelle, Isabel Rocha, Benjamín J. Sánchez, Peter J. Schaap, Rahuman S. Malik Sheriff, Saeed Shoaie, Nikolaus Sonnenschein, Bas Teusink, Paulo Vilaça, Jon Olav Vik, Judith A. H. Wodke, Joana C. Xavier, Qianqian Yuan, Maksim Zakhartsev & Cheng Zhang (2020) MEMOTE for standardized genome-scale metabolic model testing. Nature Biotechnology (Correspondence)
- Jianxin Huo, Shengli Xu and Kong-Peng Lam (2020) ASK1 mediates Nur77 expression in T-cell receptor mediated thymocyte apoptosis. Cells 9(3): 585
- Zixi Wang, Di Guan, Shu Wang, Louis Yi Ann Chai, Shengli Xu and Kong-Peng Lam (2020) Glycolysis and Oxidative Phosphorylation Play Critical Roles in Natural Killer Cell Receptor-Mediated Natural Killer Cell Functions. Frontiers in Immunology 11: 202
- Alan T.L. Lam, Shaul Reuveny and Steve Kah-Weng Oh (2020) Human Mesenchymal Stem Cell Therapy for Cartilage Repair: Review on Isolation, Expansion, and Constructs. Stem Cell Research 44: 101738