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Publications

2023

  • Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, and Yuansheng Yang (2023) Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies. mAbs 15(1): 2231129
  • Bryan Nicholas Chua, Wei Mei Guo, Han Teng Wong, Dave Siak-Wei Ow, Pooi Leng Ho, Winston Koh, Ann Koay and Fong Tian Wong (2023) A sweeter future: Using protein language models for exploring sweeter brazzein homologs. Food Chemistry 426: 136580
  • Xun Hui Yeo, Vignesh Sundararajan, Zhengwei Wu, Zi Jin Cheryl Phua, Yin Ying Ho, Kai Lay Esther Peh, Yi-Chia Chiu, Tuan Zea Tan, Dennis Kappei, Ying Swan Ho, David Shao Peng Tan, Wai Leong Tam and Ruby Yun-Ju Huang (2023) The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer. Communications Biology 6(1): 660
  • Kuin Tian Pang, Yuan Sheng Yang, Wei Zhang, Ying Swan Ho, Pietro Sormanni, Thomas C.T. Michaels, Ian Walsh and Sean Chia (2023) Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics. Biotechnology Advances 67: 108192
  • Jiayin Yu, Zhihao Guo, Jiachang Yan, Changxin Bu, Chang Peng, Cuie Li, Rui Mao, Jian Zhang, Zhi Wang, Shi Chen, Meicun Yao, Zhiyong Xie, Chuan Yang, Yi Yan Yang, Peiyan Yuan and Xin Ding (2023) Gastric Acid-Responsive ROS Nanogenerators for Effective Treatment of Helicobacter pylori Infection without Disrupting Homeostasis of Intestinal Flora. Advanced Science e2206957
  • Kuin Tian Pang † , Larry Sai Weng Loo †, Sean Chia, Francesca Yi Teng Ong, Hanry Yu and Ian Walsh (2023) Insight into muscle stem cell regeneration and mechanobiology. Stem Cell Research & Therapy 14: 129
  • Chengnan Li #, Yingying Gan #, Zongshao Li #, Mengjing Fu, Yuzhen Li, Xinran Peng, Yongqiang Yang, Guo-Bao Tian, Yi Yan Yang, Peiyan Yuan and Xin Ding (2023) Neutrophil-inspired photothermo-responsive drug delivery system for targeted treatment of bacterial infection and endotoxins neutralization. Biomaterials Research 27(1): 30
  • Jiayu Leong, Joyce Tay, Shengcai Yang, Chuan Yang, Eddy Wei Ping Tan, Yanming Wang, Bing Qian Tan, Sherwin Hor, Yau Hong Chua, Jeremy Pang Kern Tan, Qingfeng Chen, James L Hedrick and Yi Yan Yang (2023) Nanocomplexes of Biodegradable Anticancer Macromolecules: Prolonged Plasma Half-life, Reduced Toxicity, and Increased Tumor Targeting. Advanced Healthcare Materials e2201560
  • Sean Chia, Shi Jie Tay, Zhiwei Song, Yuansheng Yang, Ian Walsh and Kuin Tian Pang (2023) Enhancing pharmacokinetic and pharmacodynamic properties of recombinant therapeutic proteins by manipulation of sialic acid content. Biomedicine & Pharmacotherapy 163: 114757
  • Sophia Beng Hui Lim, Shang Wei, Andy Hee‑Meng Tan, Maurice A. M. van Steensel and Xinhong Lim (2023) Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche. Scientific Reports 13: 4027
  • Harish K. Handral, Tom Adam Wyrobnik and Alan Tin-Lun Lam (2023) Emerging Trends in Biodegradable Microcarriers for Therapeutic Applications. Polymers 15: 1487
  • Lin Zhao, Ming-Hsu Chen, Xuezhi Bi and Juan Du (2023) Physicochemical properties, structural characteristics and in vitro digestion of brown rice–pea protein isolate blend treated by microbial transglutaminase. Food Hydrocolloids 141: 108673
  • An Eng Lim and Shireen Goh (2023) Effect of Microchannel Diameter on Electroosmotic Flow Hysteresis. Energies 16: 2154
  • Serene W Chen, Zi Ying Zheng, Farouq Bin Mahfut, Yuansheng Yang, Masahiro Ogino, Kazuo Okada, Kohei Sato and Wei Zhang (2023) Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step. PLOS One 18(1): e0280760
  • Yangyang Zhan, Haixia Xu, Hween Tong Tan, Ying Swan Ho, Dongxiao Yang, Shuwen Chen, Dave Siak-Wei Ow, Xin Lv, Fang Wei, Xuezhi Bi and Shouwen Chen (2023) Systematic Adaptation of Bacillus licheniformis to 2-Phenylethanol Stress. Applied and Environmental Microbiology 89(2): e0156822
  • Ming Xia, Dianzhen Yu, Han Chen, Jingcheng Dai, Na Gao, Shuyang Li, Xuezhi Bi and Dongru Qiu (2023) An RpoN-dependent PEP-CTERM gene is involved in floc formation of an Aquincola tertiaricarbonis strain. BMC Microbiology 23: 20
  • Wee Swan Yap, Deepak Choudhury and Ratima Suntornnond (2023) Towards Biomanufacturing of Cultured Meat. Trends in Biotechnology 41(3): 292-294

2022

  • Lokanand Koduru, Meiyappan Lakshmanan, Yi Qing Lee, Pooi-Leng Ho, Pei-Yu Lim, Wei Xuan Ler, Say Kong Ng, Dongseok Kim, Doo-Sang Park, Mazlina Banu, Dave Siak-Wei Ow and Dong-Yup Lee (2022) Systematic evaluation of genome-wide metabolic landscapes in lactic acid bacteria reveals diet-induced and strain-specific probiotic idiosyncrasies. Cell Reports 41(10): 111735
  • Sie Huey Lee, Wei Xuan Yap, Chloe Qiu Zhen Jiang, Wei Xuan Ler, Jeanette Woon Pei Teo, Say Kong Ng, Desmond Heng (2022) Designing a ‘Plug-and-Play’ Powder Formulation Platform for the Inhaled Protein Therapeutics. Journal of Drug Delivery Science and Technology 76: 103820
  • Serene Chen, Hoi Kong Meng, Farouq Bin Mahfut, Yang Yuansheng and Zhang Wei (2022) Effective flow-through polishing strategies for knob-into-hole bispecific antibodies. Bioresources and Bioprocessing 9: 98
  • Andy Hee-Meng Tan, Alice Man Sze Cheung and Dieter Kabelitz (2022) Next generation gamma delta T cell-based tumor immunotherapy. Frontiers in Immunology 13: 1041362
  • Chee Fan Tan, Soon Hong Kwan, Chun Shing Lee, Yan Ni Annie Soh , Ying Swan Ho and Xuezhi Bi (2022) Cottonseed Meal Protein Isolate as a New Source of Alternative Proteins: A Proteomics Perspective. International Journal of Molecular Sciences 23: 10105
  • Tram Anh Nguyen, Jia Wei Joel Heng , Pornchai Kaewsapsak, Eng Piew Louis Kok, Dominik Stanojević, Hao Liu, Angelysia Cardilla, Albert Praditya, Zirong Yi, Mingwan Lin, Jong Ghut Ashley Aw, Yin Ying Ho, Kai Lay Esther Peh, Yuanming Wang, Qixing Zhong, Jacki Heraud-Farlow, Shifeng Xue, Bruno Reversade, Carl Walkley, Ying Swan Ho, Mile Šikić, Yue Wan and Meng How Tan (2022) Direct identification of A-to-I editing sites with nanopore native RNA sequencing. Nature Methods 19: 833-844
  • Sean Chia, Gavin Teo, Shi Jie Tay, Larry Loo Sai Weng, Corrine Wan, Sim Lyn Chiin, Hanry Yu, Ian Walsh and Kuin Tian Pang (2022) An Integrative Glycomic Approach for Quantitative Meat Species Profiling. Foods 11(13): 1952
  • Serene Chen, Hoi Kong Meng, Yang Yuansheng and Zhang Wei (2022) Excellent removal of knob‑into‑hole bispecific antibody byproducts and impurities in a single‑capture chromatography. Bioresources and Bioprocessing 9: 72
  • Jianxin Huo, Yuhan Huang, Ziying Zheng, Xin Ni Tay, Farouq Bin Mahfut, Wei Zhang, Kong-Peng Lam, Yuansheng Yang and Shengli Xu (2022) Development of a T cell-redirecting bispecific antibody targeting B-cell maturation antigen for suppressing multiple myeloma cell growth. Antibody Therapeutics 5(2): 138-149
  • John Fink, Michael Scott, Sebastian Rieck, Robert Jones, Jean Sebastian Parisse, Heidi Hagen, Yonatan Lipsitz, Steve Oh, Dominic Clarke (2022) Impact Considerations of Post-Production Processes on Cell and Gene Drug Products. Cytotherapy 24(6): 583-589
  • Amrita M. Nargund, Chang Xu, Amit Mandoli, Atsushi Okabe, Gao Bin Chen, Kie Kyon Huang, Taotao Sheng, Xiaosai Yao, Jia Ming Nickolas Teo, Raghav Sundar, Yee Jiun Kok, Yi Xiang See Manjie Xing, Zhimei Li, Chern Han Yong, Aparna Anand,Zul Fazreen A.I., Lai Fong. Poon, Michelle Shu Wen. Ng, Javier Yu Peng Koh, Wen Fong Ooi, Su Ting Tay, Xuewen Ong, Angie Lay Keng Tan, Heike I. Grabsch, Melissa Jane. Fullwood, Tean Bin Teh, Xuezhi Bi, Atsushi Kaneda, Shang Li and Patrick Tan (2022) Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer. Cancer Research 82(14): 2538-2551
  • Akshaya Srinivasan, Padmapriya Sathiyanathan, Lu Yin, Tong Ming Liu, Alan Lam, Maanasa Ravikumar, Raymond Alexander Alfred Smith, Han Ping Loh, Ying Zhang, Ling Ling, Say Kong Ng, Yuan Sheng Yang, Alexander Lezhava, James Hui, Steve Oh, Simon M. Cool (2022) Strategies to enhance immunomodulatory properties and reduce heterogenity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy 24(5): 456-472
  • Alan Lam, Valerie Ho, Svetlan Vassilev, Shaul Reuveny and Steve Oh (2022) An Allied Reprogramming, Selection, Expansion and Differentiation platform for creating hiPSC on Microcarriers. Cell Proliferation (Published Online)
  • Tom A. Wyrobnik, Steve Oh, Andrea Ducci, Martina Micheletti (2022) Engineering characterization of the novel Bach impeller for bioprocessing applications requiring low power inputs. Chemical Engineering Science 252: 117263
  • Sixun Chen, Ahmad Amirul Bin Abdul Rahim, Who‑Whong Wang, Rachael Cheong, Akshaya V. Prabhu, Jerome Zu Yao Tan, May Win Naing, Han Chong Toh & Dan Liu (2022) In‑situ scalable manufacturing of Epstein–Barr virus‑specific T‑cells using bioreactor with an expandable culture area (BECA). Scientific Reports 12: 7045
  • Lokanand Koduru, Meiyappan Lakshmanan, Shawn Hoon, Dong-Yup Lee, Yuan Kun Lee and Dave Siak-Wei Ow (2022) Systems biology of gut microbiota-human receptor interactions: Toward anti-inflammatory probiotics. Frontiers in Microbiology 13: 846555
  • SuE Yu, Svetlan Vassilev, Zhong Ri Lim, Jaichandran Sivalingam, Alan Tin Lun Lam, Valerie Ho, Laurent Renia, Benoit Malleret, Shaul Reuveny and Steve Kah Weng Oh (2022) Selection of O-negative induced pluripotent stem cell clones for high-density red blood cell production in a scalable perfusion bioreactor system. Cell Proliferation 55(8): e13218
  • Ying Ying Wu, Jia Sheng Zach Lee, Sixun Chen and Dan Liu (2022) Sterile Fluid Transfer for Cell Therapy Manufacturing—The Value of Multiple-Use Aseptic Connector. Frontiers in Bioengineering and Biotechnology-Biomaterials 9: 806677
  • Satnam Singh, Wee Swan Yap, Xiao Yu Ge, Veronica Lee Xi Min and Deepak Choudhury (2022) Cultured Meat production fueled by fermentation . Trends in Food Science & Technology 120: 48-58
  • Svetlan Vassilev and Steve Kah Weng Oh (2022) Manufacturing human pluripotent stem cells and differentiated progenitors. Cell Culture Engineering and Technology (Book Chapter)
  • Jia Tong Loh, Bin Zhang, Joey Kay Hui Teo, Ruenn Chai Lai, Andre Boon Hwa Choo, Kong-Peng Lam and Sai Kiang Lim (2022) Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes. Cytotherapy 24(7): 711-719
  • Valerie Ho, Gerine Tong, Alan Lam, Shaul Reuveny, and Steve Oh (2022) Integrating Human Induced Pluripotent Stem Cell Expansion Capability and Cardiomyocyte Differentiation Potential in a Microcarrier Suspension Culture. Methods in Molecular Biology 2436: 67-81
  • Zhenzhong Chen, Seokgyu Han, Arleen Sanny, Dorothy Leung‑Kwan Chan, Danny van Noort, Wanyoung Lim, Andy Hee‑Meng Tan and Sungsu Park (2022) 3D hanging spheroid plate for high-throughput CAR T cell cytotoxicity assay. Journal of Nanobiotechnology 20:30
  • Shipin Zhang, Keng Lin Wong, Xiafei Ren, Kristeen Ye Wen Teo, Hassan Afizah, Andre Boon Hwa Choo, Ruenn Chai Lai, Sai Kiang Lim, James Hoi Po Hui and Wei Seong Toh (2022) Mesenchymal stem cell exosomes promote functional osteochondral repair in a clinically relevant porcine model. American Journal of Sports Medicine 50(3): 788-800
  • Ian Walsh, Matthew Myint, Terry Nguyen-Khuong, Ying Swan Ho, Say Kong Ng and Meiyappan Lakshmanan (2022) Harnessing the potential of machine learning for advancing “Quality by Design” in biomanufacturing. mAbs 14(1)
  • Chelsia Wang Qiuxia and Andy Tan Hee Meng (2022) Driving CARs on the biomanufacturing road to clinical success. Cell & Gene Therapy Insights 7(11): 1613–1621

2021

  • Nana Y D Ankrah, David B Bernstein, Matthew Biggs, Maureen Carey, Melinda Engevik, Beatriz García-Jiménez, Meiyappan Lakshmanan, Alan R Pacheco, Snorre Sulheim and Gregory L Medlock (2021) Enhancing Microbiome Research through Genome-Scale Metabolic Modeling mSystems 6(6): e0059921
  • Evan Tan, Cara Sze Hui Chin, Zhi Feng Sherman Lim, Say Kong Ng (2021) HEK293 Cell Line as a Platform to Produce Recombinant Proteins and Viral Vectors. Frontiers in Bioengineering and Biotechnology 9: 796991
  • Yin Yin Siew, Amrita Rai, Han Bin Pek, Dave Siak-Wei Ow and Wei Zhang (2021) New and Efficient Purification Process for Recombinant Human Insulin Produced in Escherichia coli. Applied Microbiology and Biotechnology 105(24): 9137-9151
  • Sishir K Kamalapuram, Harish Handral and Deepak Choudhury (2021) Cultured Meat Prospects for a Billion! Foods 10: 2922
  • Weng Wan Chan, Fang Yu, Quang Bach Le, Sixun Chen, Marcus Yee and Deepak Choudhury (2021) Towards Biomanufacturing of Cell-derived matrices. International Journal of Molecular Sciences 22(21): 11929
  • Yusuke Mimura, Radka Saldova, Yuka Mimura-Kimura, Pauline M. Rudd and Roy Jefferis (2021) Importance and Monitoring of Therapeutic Immunoglobulin G Glycosylation. Antibody Glycosylation (Book Chapter)
  • Yusuke Mimura, Radka Saldova, Yuka Mimura-Kimura, Pauline M. Rudd and Roy Jefferis (2021) Micro-Heterogeneity of Antibody Molecules. Antibody Glycosylation (Book Chapter)
  • Ee Theng Ng, Satnam Singh, Wee Swan Yap, Shi Hua Tay and Deepak Choudhury (2021) Cultured Meat – A Patentometric Analysis. Critical Reviews in Food Science and Nutrition (Published Online)
  • Ser Yue Loo, Li Ping Toh, William Haowei Xie, Elina Pathak, Wilson Tan, Siming Ma, May Yin Lee, S. Shatishwaran, Joanna Zhen Zhen Yeo, Ju Yuan, Yin Ying Ho, Esther Kai Lay Peh, Magendran Muniandy, Federico Torta, Jack Chan, Tira J. Tan, Yirong Sim, Veronique Tan, Benita Tan, Preetha Madhukumar, Wei Sean Yong, Kong Wee Ong, Chow Yin Wong, Puay Hoon Tan, Yoon Sim Yap, Lih-Wen Deng, Rebecca Dent, Roger Foo, Markus R. Wenk, Soo Chin Lee, Ying Swan Ho, Elaine Hsuen Lim and Wai Leong Tam (2021) Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Science Advances 7(41): eabh2443
  • Georg von Massow, Steve Oh, Alan Lam and Kenth Gustafsson (2021) Gamma Delta T Cells and Their Involvement in COVID-19 Virus Infections. Frontiers in Immunology (Published Online)
  • Ian Walsh, Sophie Zhao, Katherine Wongtrakul-Kish, Matthew Choo, Shi Jie Tay, Christopher H. Taron, Pauline M. Rudd, and Terry Nguyen-Khuong (2021) Glycoinformatics tools for comprehensive characterization of glycans enzymatically released from proteins. Methods in Molecular Biology (Book Chapter)
  • Tsz Wai Ngai, Gamal Ahmed Elfar, Pearlyn Yeo, Nicholas Phua, Jin Hui Hor, Shuwen Chen, Ying Swan Ho and Chit Fang Cheok (2021) Nitro-Deficient Niclosamide Confers Reduced Genotoxicity and Retains Mitochondrial Uncoupling Activity for Cancer Therapy. International Journal of Molecular Sciences 22(19): 10420
  • Zhong Ri Lim, Svetlan Vassilev, Yew Wai Leong, Jing Wen Hang, Laurent Rénia, Benoit Malleret and Steve Kah-Weng Oh (2021) "Industrially Compatible Transfusable iPSC-Derived RBCs: Progress, Challenges and Prospective Solutions". International Journal of Molecular Sciences 22(18): 9808
  • Yin Ying Ho, Hao Kim Lu, Zhi Feng Sherman Lim, Hao Wei Lim, Ying Swan Ho, Say Kong Ng (2021) Applications and Analysis of Hydrolysates in Animal Cell Culture. Bioresources and Bioprocessing 18(1): 93
  • Laura Sutarlie, Dave Siak-Wie Ow, Say Kong Ng, Yuansheng Yang and Xiaodi Su (2021) Gold Nanoparticle-based “Mix and Measure” Fluorimetric Assays to Quantify Antibody Titer. Chemistry – An Asian Journal 16: 1-7
  • Alison P. Lee, Yee Jiun Kok, Meiyappan Lakshmanan, Dawn Leong, Lu Zheng, Hsueh Lee Lim, Shuwen Chen, Shi Ya Mak, Kok Siong Ang, Neil Templeton, Taha Salim, Xiaona Wei, Eric Gifford, Andy Hee‐Meng Tan, Xuezhi Bi, Say Kong Ng, Dong‐Yup Lee, Wai Lam W. Ling and Ying Swan Ho (2021) Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality. Biotechnology and Bioengineering (Published Online)
  • Ian Walsh, Dmytro Fishman, Dario Garcia-Gasulla, Tiina Titma, Gianluca Pollastri, ELIXIR Machine Learning focus group, Jennifer Harrow, Fotis E. Psomopoulos & Silvio C.E. Tosatto (2021) DOME: Recommendations for supervised machine learning validation in biology. Nature Methods 18: 1122–1127
  • Dave Siak-Wei Ow, Min-Kyu Oh, Chung-Jen Chiang and Yun-Peng Chao (2021) Technological Advances Improving Recombinant Protein Production in Bacteria. Frontiers in Microbiology 12: 729472
  • Siew Yin Yin and Zhang Wei (2021) Downstream processing of recombinant human insulin and its analogues production from E. coli inclusion bodies. Bioresources and Bioprocessing 8: 65
  • Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-Ok Lee, Vineeth T. Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J. Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A. Luftig, Dennis Kappei, Warren D. Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen and Patrick Tan (2021) Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation. Genome Biology 22(1):167
  • Christophe Lay, Collins Wenhan Chu, Rikky Wenang Purbojati, Enzo Acerbi, Daniela I. Drautz-Moses, Paola Florez de Sessions, Song Jie, Eliza Ho, Yee Jiun Kok, Xuezhi Bi, Shuwen Chen, Shi Ya Mak, Mei Chien Chua, Anne E. N. Goh, Wen Chin Chiang, Rajeshwar Rao, Surasith Chaithongwongwatthana, Nipon Khemapech, Voranush Chongsrisawat, Rocio Martin, the JULIUS Study Group, Guus Roeselers, Ying Swan Ho, Martin L. Hibberd, Stephan C. Schuster and Jan Knol (2021) A synbiotic intervention modulates metaomics signatures of gut redox potential and acidity in elective caesarean born infants. BMC Microbiology 21(1): 191
  • Ngan T. B. Nguyen, Jianer Lin, Shi JieTay, Mariati, Jessna Yeo, Terry Nguyen‑Khuong & Yuansheng Yang (2021) Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans. Scientific Reports 11(1): 12969
  • Jasmine Si Han Seah, Satnam Singh, Lay Poh Tan and Deepak Choudhury (2021) Scaffolds for the manufacture of cultured meat. Critical Reviews in Biotechnology 1-13
  • Mario Gimona, Maria Felice Brizzi, Andre Boon Hwa Choo, Massimo Dominici, Sean M. Davidson, Johannes Grillari, Dirk M. Hermann, Andrew F. Hill, Dominique devv Kleijn, Ruenn Chai Lai, Charles Lai, Rebecca Lim, Marta Monguió-Tortajada, Maurizio Muraca, Takahiro Ochiya, Luis A. Ortiz, Wei Seong Toh, Yong Weon Yi, Kenneth W. Witwer, Bernd Giebel and Sai Kiang Lim (2021) Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell (MSC)-derived small extracellular vesicles. Cytotherapy 23(5): 373-380
  • Satnam Singh, Sachin Mishra, Song Juha, Manojit Pramanik, Parasuraman Padmanabhan and Balázs Gulyás (2021) Nanotechnology Facilitated Cultured Neuronal Network and Its Applications. International Journal of Molecular Sciences 22(11): 5552
  • Serene W Chen, Wei Zhang (2021) Current trends and challenges in the downstream purification of bispecific antibodies. Antibody Therapeutics 4(2): 73–88
  • Man Mohan Shrestha, Chun-Yan Lim, Xuezhi Bi, Robert C. Robinson and Weiping Han (2021) Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts. Frontiers in Endocrinology 12: 653557
  • Kuin Tian Pang, Shi Jie Tay, Corrine Wan, Ian Walsh, Matthew S.F. Choo, Yuan Sheng Yang, Andre Choo, Ying Swan Ho and Terry Nguyen-Khuong (2021) Semi-automated Glycoproteomic Data Analysis of LC-MS data using GlycopeptideGraphMS in Process Development of Monoclonal Antibody Biologics. Frontiers in Chemistry-Analytical Chemistry (Published Online)
  • Duy Tien Ta, Kai Ling Chu, Nur Izzati Bte Soonaan, Christine Chin, Say Kong Ng and Wei Zhang (2021) A new and simplified anion exchange chromatographic process for the purification of cell-grown influenza A H1N1 virus. Separation and Purification Technology 263: 118412
  • Thong Teck Tan, Ruenn Chai Lai, Jayanthi Padmanabhan, Wei Kian Sim, Andre Boon Hwa Choo and Sai Kiang Lim (2021) Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV). Pharmaceuticals 14: 345
  • Xiaohui Wang, Xiang Lin, Zihan Zheng, Bingtai Lu, Jun Wang, Andy Hee-Meng Tan, Meng Zhao, Jia Tong Loh, Sze Wai Ng, Qian Chen, Fan Xiao, Enyu Huang, King-Hung Ko, Zhong Huang, Jingyi Li, Kin-Hang Kok, Gen Lu, Xiaohui Liu, Kong-Peng Lam, Wanli Liu, Yuxia Zhang, Kwok-Yung Yuen, Tak Wah Mak & Liwei Lu (2021) Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection. Nature Communications 12: 1914
  • Eun Myoung Shin, Vinh Thang Huynh, Sultan Abda Neja, Chia Yi Liu, Anandhkumar Raju, Kelly Tan, Nguan Soon Tan, Jayantha Gunaratne, Xuezhi Bi, Lakshminarayan M. Iyer, L. Aravind and Vinay Tergaonkar (2021) GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer. Science Advances 7(12): eabe2470
  • Alan Tin-Lun Lam, Alison P. Lee, Premkumar Jayaraman, Kah Yong Tan, Deepak Raghothaman, Hsueh Lee Lim, He Cheng, Lihan Zhou, Andy Hee-Meng Tan, Shaul Reuveny and Steve Oh (2021) Multiomics analyses of cytokines, gene, miRNA, and pathway regulatory networks in human mesenchymal stem cells expanded in stirred microcarrier-spinner cultures. Stem Cell Research 53:102272
  • Zixi Wang, Di Guan, Jianxin Huo, Subhra K Biswas, Yuhan Huang, Yuansheng Yang, Shengli Xu and Kong-Peng Lam (2021) IL-10 enhances human natural killer cell effector function via metabolic reprogramming regulated by mTOR signaling. Frontiers in Immunology 12:619195
  • Genetics of Exfoliation Syndrome Partnership; Zheng Li, Zhenxun Wang, Mei Chin Lee, Matthias Zenkel, Esther Peh, Mineo Ozaki, Fotis Topouzis, Satoko Nakano, Anita Chan, Shuwen Chen, Susan E I Williams, Andrew Orr, Masakazu Nakano, Nino Kobakhidze, Tomasz Zarnowski, Alina Popa-Cherecheanu, Takanori Mizoguchi, Shin-Ichi Manabe, Ken Hayashi, Shigeyasu Kazama, Kenji Inoue, Yosai Mori, Kazunori Miyata, Kazuhisa Sugiyama, Tomomi Higashide, Etsuo Chihara, Ryuichi Ideta, Satoshi Ishiko, Akitoshi Yoshida, Kana Tokumo, Yoshiaki Kiuchi, Tsutomu Ohashi, Toshiya Sakurai, Takako Sugimoto, Hideki Chuman, Makoto Aihara, Masaru Inatani, Kazuhiko Mori, Yoko Ikeda, Morio Ueno, Daniel Gaston, Paul Rafuse, Lesya Shuba, Joseph Saunders, Marcelo Nicolela, George Chichua, Sergo Tabagari, Panayiota Founti, Kar Seng Sim, Wee Yang Meah, Hui Meng Soo, Xiao Yin Chen, Anthi Chatzikyriakidou, Christina Keskini, Theofanis Pappas, Eleftherios Anastasopoulos, Alexandros Lambropoulos, Evangelia S Panagiotou, Dimitrios G Mikropoulos, Ewa Kosior-Jarecka, Augustine Cheong, Yuanhan Li, Urszula Lukasik, Monisha E Nongpiur, Rahat Husain, Shamira A Perera, Lydia Álvarez, Montserrat García, Héctor González-Iglesias, Andrés F V Cueto, Luis F V Cueto, Federico Martinón-Torres, Antonio Salas, Çilingir Oguz, Nevbahar Tamcelik, Eray Atalay, Bilge Batu, Murat Irkec, Dilek Aktas, Burcu Kasim, Yury S Astakhov, Sergei Y Astakhov, Eugeny L Akopov, Andreas Giessl, Christian Mardin, Claus Hellerbrand, Jessica N Cooke Bailey, Robert P Igo Jr, Jonathan L Haines, Deepak P Edward, Steffen Heegaard, Sonia Davila, Patrick Tan, Jae H Kang, Louis R Pasquale, Friedrich E Kruse, André Reis, Trevor R Carmichael, Michael Hauser, Michele Ramsay, Georg Mossböck, Nilgun Yildirim, Kei Tashiro, Anastasios G P Konstas, Miguel Coca-Prados, Jia Nee Foo, Shigeru Kinoshita, Chie Sotozono, Toshiaki Kubota, Michael Dubina, Robert Ritch, Janey L Wiggs, Francesca Pasutto, Ursula Schlötzer-Schrehardt, Ying Swan Ho, Tin Aung, Wai Leong Tam, Chiea Chuen Khor (2021) Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 325(8): 753-764
  • Fang Yu, Nivasini Selva Kumar, Satnam Singh, Walter Hunziker, Sum Huan Ng and Deepak Choudhury (2021) Isolation of primary brain endothelial cells, pericytes and astrocytes on a microfluidic immunopanning chip (MIC). Microfluidics and Nanofluidics 25:25
  • Pei Kun Richie Tay, Pei Yu Lim and Dave Siak-Wei Ow (2021) A SH3_5 cell anchoring domain for non-recombinant surface display on lactic acid bacteria. Frontiers in Biotechnology and Bioengineering 8: 614498
  • Weichao Zhai, Jerome Tan, Tobias Russell, Sixun Chen, Dennis McGonagle, May Win Naing, Derrick Yong and Elena Jones (2021) Multi-pronged Approach to Human Mesenchymal Stromal Cells Senescence Quantification with a Focus on Label Free Methods. Scientific Reports 11(1): 1054
  • Bin Zhang, Ruenn Chai Lai, Wei Kian Sim, Andre Boon Hwa Choo, Ellen Birgit Lane and Sai Kiang Lim (2021) Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation. International Journal of Molecular Sciences 22(2): 720

2020

  • Jaichandran Sivalingam, Yu SuE, Zhong Ri Lim, Alan T.L. Lam, Alison P. Lee, Hsueh Lee Lim, Hong Yu Chen, Hong Kee Tan, Tushar Warrier, Jing Wen Hang, Nazmi B. Nazir, Andy H.M. Tan, Laurent Renia, Yuin Han Loh, Shaul Reuveny, Benoit Malleret and Steve K.W. Oh (2020) A Scalable Suspension Platform for Generating High-Density Cultures of Universal Red Blood Cells from Human Induced Pluripotent Stem Cells. Stem Cell Reports 16(1): 182-197
  • Liu Dan, Chen Sixun and May Win Naing (2020) A review of manufacturing capabilities of cell spheroid generation technologies and future development. Biotechnology and Bioengineering 118(2): 542-554
  • Andy Hee-Meng Tan, Gloria Hoi Wan Tso, Biyan Zhang, Pei-Yun Teo, Xijun Ou, Sze-Wai Ng, Alex Xing Fah Wong, Sean Jing Xiang Tan, Arleen Sanny, Susana Soo-Yeon Kim, Alison P. Lee, Shengli Xu, and Kong-Peng Lam (2020) TACI constrains TH17 pathogenicity and protects against gut inflammation. iScience 23(11): 101707
  • Edward G. Pallister, Matthew S. F. Choo, Ian Walsh, Jien-Nee Tai, Shi-Jie Tay, Yuansheng Yang, Say-Kong Ng, Pauline M. Rudd, Sabine L. Flitsch and Terry Nguyen-Khuong (2020) Utility of Ion-Mobility Spectrometry for Deducing Branching of Multiply Charged Glycans and Glycopeptides in a High-Throughput Positive ion LC-FLR-IMS-MS Workflow. Analytical Chemistry 92(23):15323-15335
  • Deepak Choudhury, Satnam Singh, Jasmine Si Han Seah, David Chen Loong Yeo and Lay Poh Tan (2020) Commercialization of Plant-Based Meat Alternatives. Trends in Plant Science 25(11): 1055-1058
  • Yu Yang Fredik Liu, Yin Lu, Steve Oh, Gareth J. Conduit (2020) Machine learning to predict mesenchymal stem cell efficacy for cartilage repair. PLOS Computational Biology (Published Online)
  • Katrina Adlerz, Divya Patel, Jon Rowley, Kelvin Ng, Tabassum Ahsan (2020) Strategies for Scalable Manufacturing and Translation of MSC-Derived Extracellular Vesicles. Stem Cell Research 48: 101978
  • Jia Tong Loh, Joey Kay Hui Teo, Hong-Hwa Lim and Kong-Peng Lam (2020) Emerging Roles of Downstream of Kinase 3 in Cell Signaling. Frontiers in Immunology 11: 566192
  • Deepak Choudhury, Marcus Yee, Zach Lee Jia Sheng, Ahmad Amirul and May Win Naing (2020) Decellularization systems and devices: State-of-the-art. Acta Biomaterialia (Review Paper) 115: 51–59
  • Harish K. Handral , Shi Hua Tay, Weng Wan Chan and Deepak Choudhury (2020) 3D printing of cultured meat products. Critical Reviews in Food Science and Nutrition (Published Online)
  • Kae Hwan Sim, Lillian Chia-Yi Liu, Hwee Tong Tan, Kelly Tan, Daniel Ng, Wei Zhang, Yuansheng Yang, Stephen Tate and Xuezhi Bi (2020) A comprehensive CHO SWATH-MS spectral library for robust quantitative profiling of 10,000 proteins. Scientific Data 7(1): 263
  • Youshan Melissa Lin, Alan Tin Lun Lam, Jialing Lee, Teo Kim Leng, Eileen Sim, Li Jian, Jessica Pei Wen Toh, Xiafei Ren, Barry WL Tan, Mahesh Choolani, Jerry Kok Yen Chan, Shaul Reuveny, James Hoi Po Hui, William R. Birch and Steve Kah Weng Oh (2020) Human early mesenchymal stromal cells delivered on porous lightweight biodegradable polycaprolactone-based microcarriers result in improved cartilage formation. Materialia 13: 100851
  • Julian L. Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V. Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W. L. Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K. Luthra, William D. Shingleton, Steve K. W. Oh, Li Zeng and Edward G. Robins (2020) Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease. Stem Cell Research & Therapy 11: 347
  • Weng Wan Chan, David Chen Loong Yeo, Vernice Tan, Satnam Singh, Deepak Choudhury and May Win Naing (2020) Additive Biomanufacturing with Collagen Inks. Bioengineering 7: 66
  • Saeideh Kholgh Eshkalak, Erfan Rezvani Ghomi, Yunqian Dai, Deepak Choudhury and Seeram Ramakrishna (2020) The role of three-dimensional printing in healthcare and medicine. Materials and Design 194: 108940
  • Hock Chuan Yeo, Jongkwang Hong, Meiyappan Lakshmanan and Dong-Yup Lee (2020) Enzyme capacity-based genome scale modelling of CHO cells. Metabolic Engineering 60: 138-147
  • Chaminda Jayampath Seneviratne, Preethi Balan, Tanujaa Suriyanarayanan, Meiyappan Lakshmanan, Dong-Yup Lee, Mina Rho, Nicholas Jakubovics, Bernd Brandt, Wim Crielaard and Egija Zaura (2020) Oral microbiome-systemic link studies: perspectives on current limitations and future artificial intelligence-based approaches. Critical Reviews in Microbiology 46(3): 288-299
  • Candice Qiu Xia Yam, David Boy Chia, Idina Shi, Hong Hwa Lim and Uttam SURANA (2020) Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling. Nucleic Acid Research 48(11): 6092-6107
  • Lokanand Koduru, Hyang Yeon Kim, Meiyappan Lakshmanan, Bijayalaxmi Mohanty, Yi Qing Lee, Choong Hwan Lee and Dong-Yup Lee (2020) Genome-scale metabolic reconstruction and in silico analysis of rice leaf blight pathogen, Xanthomonas oryzae. Molecular Plant Pathology 21(4):527-540
  • Serene W Chen, Darryl Tan, Yuan Sheng Yang and Wei Zhang (2020) Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies. mAbs 12(1): 1718440
  • Leonard Leong, Heng Liang Tan, Simeon Cua, Kylie Su Mei Yong, Qingfeng Chen and Andre Choo (2020) Preclinical Activity of Embryonic Annexin A2-Specific Chimeric Antigen Receptor T Cells Against Ovarian Cancer. International Journal of Molecular Sciences 21(2): 381
  • Filip Laco, Alan Tin-Lun Lam, Tsung-Liang Woo, Gerine Tong, Valerie Ho, Poh-Loong Soong, Elina Grishina, Kun-Han Lin, Shaul Reuveny and Steve Kah-Weng Oh (2020) Selection of human induced pluripotent stem cells lines optimization of cardiomyocytes differentiation in an integrated suspension microcarrier bioreactor. Stem Cell Research and Therapy 11: 118
  • Christian Lieven, Moritz E. Beber, Brett G. Olivier, Frank T. Bergmann, Meric Ataman, Parizad Babaei, Jennifer A. Bartell, Lars M. Blank, Siddharth Chauhan, Kevin Correia, Christian Diener, Andreas Dräger, Birgitta E. Ebert, Janaka N. Edirisinghe, José P. Faria, Adam M. Feist, Georgios Fengos, Ronan M. T. Fleming, Beatriz García-Jiménez, Vassily Hatzimanikatis, Wout van Helvoirt, Christopher S. Henry, Henning Hermjakob, Markus J. Herrgård, Ali Kaafarani, Hyun Uk Kim, Zachary King, Steffen Klamt, Edda Klipp, Jasper J. Koehorst, Matthias König, Meiyappan Lakshmanan, Dong-Yup Lee, Sang Yup Lee, Sunjae Lee, Nathan E. Lewis, Filipe Liu, Hongwu Ma, Daniel Machado, Radhakrishnan Mahadevan, Paulo Maia, Adil Mardinoglu, Gregory L. Medlock, Jonathan M. Monk, Jens Nielsen, Lars Keld Nielsen, Juan Nogales, Intawat Nookaew, Bernhard O. Palsson, Jason A. Papin, Kiran R. Patil, Mark Poolman, Nathan D. Price, Osbaldo Resendis-Antonio, Anne Richelle, Isabel Rocha, Benjamín J. Sánchez, Peter J. Schaap, Rahuman S. Malik Sheriff, Saeed Shoaie, Nikolaus Sonnenschein, Bas Teusink, Paulo Vilaça, Jon Olav Vik, Judith A. H. Wodke, Joana C. Xavier, Qianqian Yuan, Maksim Zakhartsev & Cheng Zhang (2020) MEMOTE for standardized genome-scale metabolic model testing. Nature Biotechnology (Correspondence)
  • Jianxin Huo, Shengli Xu and Kong-Peng Lam (2020) ASK1 mediates Nur77 expression in T-cell receptor mediated thymocyte apoptosis. Cells 9(3): 585
  • Zixi Wang, Di Guan, Shu Wang, Louis Yi Ann Chai, Shengli Xu and Kong-Peng Lam (2020) Glycolysis and Oxidative Phosphorylation Play Critical Roles in Natural Killer Cell Receptor-Mediated Natural Killer Cell Functions. Frontiers in Immunology 11: 202
  • Alan T.L. Lam, Shaul Reuveny and Steve Kah-Weng Oh (2020) Human Mesenchymal Stem Cell Therapy for Cartilage Repair: Review on Isolation, Expansion, and Constructs. Stem Cell Research 44: 101738

2019

  • Tan Heng Liang and Andre Choo (2019) Opportunities for Antibody Discovery Using Human Pluripotent Stem Cells: Conservation of Oncofetal Targets. International Journal of Molecular Sciences 20: 5752
  • Christine Lin Chin, Justin Bryan Goh, Harini Srinivasan, Kaiwen Ivy Liu, Ali Gowher, Raghuvaran Shanmugam, Hsueh Lee Lim, Matthew Choo, Wen Qin Tang, Andy Hee-Meng Tan, Terry Nguyen-Khuong, Meng How Tan and Say Kong Ng (2019) A human expression system based on HEK293 for the stable production of recombinant erythropoietin. Scientific Reports 9: 16768
  • Edward G. Pallister, Matthew S. F. Choo, Jien-Nee Tai, Dawn S. Z. Leong, Wen-Qin Tang, Say-Kong Ng, Kun Huang, Andrea Marchesi, Peter Both, Christopher Gray, Pauline M. Rudd, Sabine L. Flitsch and Terry Nguyen-Khuong (2019) Exploiting the Disialyl Galactose Activity of α2,6-Sialyltransferase from Photobacterium damselae To Generate a Highly Sialylated Recombinant α-1-Antitrypsin. Biochemistry (Published Online)
  • Jong Kwang Hong, Hong-Yeol Choi, Hae-Rim Park, Dong-Il Kim and Dong-Yup Lee (2019) Inhibition of autolysosome formation improves rrhGAA production driven by RAmy3D promoter in transgenic rice cell culture. Biotechnology and Bioprocess Engineering 24: 568-578
  • Seow Theng Ong, Aik Seng Ng, Xuan Rui Ng, Zhong Zhuang, Brandon Han Siang Wong, Praseetha Prasannan, Yee Jiun Kok, Xuezhi Bi, Heesung Shim, Heike Wulff, Kanianthara George Chandy and Navin Kumar Verma (2019) Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment. BIOELECTRICITY 1(3)
  • Heng Liang Tan, Bao Zhu Tan, Winfred Xi Tai Goh, Simeon Cua and Andre Choo (2019) In vivo surveillance and elimination of teratoma‐forming human embryonic stem cells with monoclonal antibody 2448 targeting annexin A2. Biotechnology and Bioengineering (Published Online)
  • Katherine Wongtrakul-Kish, Ian Walsh, Lyn Chiin Sim, Amelia Mak, Brian Liau, Vanessa Ding, Noor Hayati, Han Wang, Andre Choo, Pauline M. Rudd and Terry Nguyen-Khuong (2019) Combining Glucose Units, m/z, and Collision Cross Section Values: Multiattribute Data for Increased Accuracy in Automated Glycosphingolipid Glycan Identifications and Its Application in Triple Negative Breast Cancer. Analytical Chemistry 91(14): 9078-9085
  • Shengli Xu, Jianxin Huo, Yuhan Huang, Melissa Aw, Shuwen Chen, Shiya Mak, Lian Yee Yip, Ying Swan Ho, Sze Wai Ng, Andy Hee-Meng Tan, Alison Lee, Xijun Ou and Kong-Peng Lam (2019) von Hippel-Lindau Protein Maintains Metabolic Balance to Regulate the Survival of Naive B Lymphocytes. iSCIENCE 17: 379-392
  • Joshur Ang, Yong‐An Lee, Deepak Raghothaman, Premkumar Jayaraman, Kim L. Teo, Fahima J. Khan, Shaul Reuveny, Young‐Tae Chang, Nam‐Young Kang and Steve Oh (2019) Rapid Detection of Senescent Mesenchymal Stromal Cells by a Fluorescent Probe. Biotechnology Journal (Published Online)
  • Pao-Chun Lin, Kah Fai Chan, Irene A. Kiess, Joselyn Tan, Wahyu Shahreel, Sze-Yue Wong and Zhiwei Song (2019) Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics. mAbs 11(5): 965-976
  • Jia Tong Loh, Shengli Xu, Jian Xin Huo, Susana Soo-Yeon Kim, Yue Wang and Kong-Peng Lam (2019) Dok3–protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. Journal of Clinical Investigation 129(8): 2717-2729
  • Jianxin Huo, Shengli Xu and Kong-Peng Lam (2019) FAIM: An antagonist of Fas-killing and beyond. Cells 8(6). pii: E541
  • Peiqing Zhang, Carole Burel, Carole Plasson, Marie-Christine Kiefer-Meyer, Clément Ovide, Bruno Gügi, Corrine Wan, Gavin Teo, Amelia Mak, Zhiwei Song, Azeddine Driouich, Patrice Lerouge and Muriel Bardor (2019) Characterization of a GDP-Fucose Transporter and a Fucosyltransferase Involved in the Fucosylation of Glycoproteins in the Diatom Phaeodactylum tricornutum. Frontiers in Plant Science 10: 610
  • Meiyappan Lakshmanan, Yee Jiun Kok, Alison P. Lee, Sarantos Kyriakopoulos, Hsueh Lee Lim, Gavin Teo, Swan Li Poh, Wen Qin Tang, Jongkwang Hong, Andy Hee‐Meng Tan, Xuezhi Bi, Ying Swan Ho, Peiqing Zhang, Say Kong Ng and Dong‐Yup Lee (2019) Multi‐omics profiling of CHO parental hosts reveals cellline‐specific variations in bioprocessing traits. Biotechnology and Bioengineering 116(9): 2117-2129
  • Matthew S. Choo, Corrine Wan, Ce Huang Poo, Pauline M. Rudd and Terry Nguyen- Khuong (2019) GlycopeptideGraphMS: Improved Glycopeptide Detection and Identification by Exploiting Graph Theoretical Patterns in Mass and Retention Time. Analytical Chemistry 91(11):7236-7244
  • Alan Tin-Lun Lam, Eileen Jia-Hui Sim, Asha Shekaran, Jian Li, Kim-Leng Teo, Julian L. Goggi, Shaul Reuveny, William R. Birch & Steve Kah-Weng Oh (2019) Sub-confluent culture of human mesenchymal stromal cells on biodegradable polycaprolactone microcarriers enhances bone healing of rat calvarial defect. Cytotherapy 21(6): 631-642
  • Kenneth W. Witwer, Bas W.M. van Balkom, Stefania Bruno, Andre Choo, Massimo Dominici, Mario Gimona, Andrew F. Hill, Dominique de Kleijn, Mickey Koh, Ruenn Chai Lai, S. Alex Mitsialis, Luis A. Ortiz, Eva Rohde, Takashi Asada, Wei Seong Toh, Daniel J. Weiss, Lei Zheng, Bernd Giebel and Sai Kiang Lim (2019) Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. Journal of Extracellular Vesicles 8(1): 1609206
  • Zhigang Xie, Jing Yuan Chooi, Sabrina Hui Min Toh, Dongxiao Yang, Nurhidayah Binte Basri, Ying Swan Ho and Wee Joo Chn (2019) MMSET I acts as an oncoprotein and regulates GLO1 expression in t (4;14) multiple myeloma cells. Leukemia 33: 739–748
  • Zhenxun Wang, Lian Yee Yip, Jia Hui Jane Lee, Zhengwei Wu, Hui Yi Chew, Pooi Kiat William Chong, Chin Chye Teo, Heather Yin-Kuan Ang, Kai Lay Esther Peh, Ju Yuan, Siming Ma, Li Shi Kimberly Choo, Nurhidayah Basri, Xia Jiang, Qiang Yu, Axel M. Hillmer, Wan Teck Lim, Tony Kiat Hon Lim, Angela Takano, Eng Huat Tan, Daniel Shao Weng Tan, Ying Swan Ho, Bing Lim and Wai Leong Tam (2019) Methionine is a metabolic dependency of tumor-initiating cells. Nature Medicine 25: 825-837
  • Jaichandran Sivalingam and Steve Kah-Weng Oh (2019) Bioprocessing and biological challenges to large-scale red blood cell production from pluripotent stem cells: important factors to consider. Cell & Gene Therapy Insights 5(3): 483–504
  • Zhenxing Huang, Jianhe Wang, Xiaoli Xu, Haishan Wang, Yuan Qiao, Wern Cui Chu, Shengli Xu, Louis Chai, Fabien Cottier, Norman Pavelka, Marije Oosting, Leo A. B. Joosten, Mihai Netea, Carol Yee Leng Ng, Khai Pang Leong, Parag Kundu, Kong-Peng Lam, Sven Pettersson and Yue Wang (2019) Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nature Microbiology 4(5): 766-773
  • Susana Soo-Yeon Kim, Lynette Sze and Kong-Peng Lam (2019) The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance IFN-β response. Journal of Biological Chemistry 294(16): 6430-6438
  • Kian Ping Chan, Sheng-Hao Chao and James Chen Yong Kah (2019) Exploiting Protein Corona around Gold Nanoparticles Conjugated to p53 Activating Peptides To Increase the Level of Stable p53 Proteins in Cells. Bioconjugate Chemistry 30(3): 920-930
  • Reza Moloudi, Steve Oh, Chun Yang, Kim Leng Teo, Alan Tin-Lun Lam, Majid Ebrahimi Warkiani and May Win Naing (2019) Scaled-up Inertial Microfluidics: Retention System for Microcarrier-based Suspension Cultures. Biotechnology Journal 14(5): e1800674
  • Ningning Xu, Jianfa Ou, Yingnan Si, Kah Yong Goh, Daniel D. Flanigan, Xiaosi Han, Yuansheng Yang, Shang-Tian Yang, Lufang Zhou and Xiaoguang (Margaret) Liu (2019) Proteomics insight into the production of monoclonal antibody. Biochemical Engineering Journal 145: 177–185
  • Pooi Leng Ho, Han Kee Ong, Jeanette Teo, Dave Siak-Wei Ow and Sheng-Hao Chao (2019) HEXIM1 Peptide Exhibits Antimicrobial Activity Against Antibiotic Resistant Bacteria Through Guidance of Cell Penetrating Peptide. Frontiers in Microbiology (Published Online)
  • Kian Ping Chan, Sheng-Hao Chao and James Chen Yong Kah (2019) Enhanced Secretion of Functional Insulin with DNA-Functionalized Gold Nanoparticles in Cells. ACS Biomaterials Science & Engineering (Published Online)

2018

  • Cai Tong Ng, Li Deng, Chen Chen, Hong Hwa Lim, Jian Shi, Uttam Surana, and Lu Gan (2018) Electron cryotomography analysis of Dam1C/DASH at the kinetochore–spindle interface in situ. Journal of Cell Biology 218(2): 455-473
  • Yee Jiun Kok, Lijuan Ye, Jeroen Muller, Dave Siak-Wei Ow and Xuezhi Bi (2018) Brewing with malted barley or raw barley: what makes the difference in the processes?, Applied Microbiology and Biotechnology 103(3): 1059-1067
  • Yee Hwee Lim, Fong Tian Wong, Wan Lin Yeo, Kuan Chieh Ching, Yi Wee Lim, Elena Heng, Shuwen Chen, De-Juin Tsai, Tsai-Ling Lauderdale, Kak-Shan Shia, Ying Swan Ho, Shawn Hoon, Ee Lui Ang, Mingzi M. Zhang, and Huimin Zhao (2018) Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR-Cas9 Activation. ChemBioChem 19: 1716–1719
  • Hock Chuan Yeo, Shuwen Chen, Ying Swan Ho and Dong‑Yup Lee (2018) An LC–MS-based lipidomics pre-processing framework underpins rapid hypothesis generation towards CHO systems biotechnology. Bioinformatics 14: 98
  • Jong Kwang Hong, Meiyappan Lakshmanan, Chetan Goudar and Dong-Yup Lee (2018) Towards next generation CHO cell line development and engineering by systems approaches. Current Opinion in Chemical Engineering 22: 1–10
  • Hong-Yeol Choi, Heajin Park, Jong Kwang Hong, Sun-Dal Kim, Jun-Young Kwon, SeungKwan You, Jonghye Do, Dong-Yup Lee, Ha Hyung Kim & Dong-Il Kim (2018) N-glycan Remodeling Using Mannosidase Inhibitors to Increase High-mannose Glycans on Acid α-Glucosidase in Transgenic Rice Cell Cultures. Scientific Reports 8: 16130
  • Jong Kwang Hong, Shilpa Nargund, Meiyappan Lakshmanan, Sarantos Kyriakopoulos, Do Yun Kim, Kok Siong Ang, Dawn Leong, Yuansheng Yang and Dong-Yup Lee (2018) Comparative phenotypic analysis of CHO clones and culture media for lactate shift. Journal of Biotechnology 283: 97–104
  • Jia Tong Loh, Thomas Jun Feng Lim, Kyoko Ikumi, Takuma Matoba, Baptiste Janela, Merry Gunawan, Tatsuya Toyama, Maegan Bunjamin, Lai Guan Ng, Michael Poidinger, Akimichi Morita, Florent Ginhoux, Sayuri Yamazaki, Kong-Peng Lam, and I-hsin Su (2018) Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells. CellPress (Published Online)
  • Hossein Tavassoli, Sanaz Naghavi Alhosseini, Andy Tay, Peggy P.Y. Chan, Steve Kah Weng Oh and Majid Ebrahimi Warkiani (2018) Large-scale production of stem cells utilizing microcarriers: A biomaterials engineering perspective from academic research to commercialized products. Biomaterials 181: 333-346
  • Qixing Zhong, Filip Laco, Mei-Chih Liao, Tsung Liang Woo, Steve Kah Weng Oh and Christina Li Lin Chai (2018) Influencing the fate of cardiac and neural stem cell differentiation using small molecule inhibitors of ALK5. STEM CELLS Translational Medicine 7(10): 709-720
  • R. Kumar, L. Coronel, B. Somalanka, A. Raju, O.A. Aning, O. An, Y.S. Ho, S. Chen, S.Y. Mak, P.Y. Hor, H. Yang, M. Lakshmanan, H. Itoh, S.Y. Tan, Y.K. Lim, A.P.C. Wong, S.H. Chew, T.H. Huynh, B.C. Goh, C.Y. Lim, V. Tergaonkar & C.F. Cheok (2018) Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nature Communications 9: 3931
  • Jessna H. M. Yeo, Mariati and Yuansheng Yang (2018) An IRES-Mediated Tricistronic Vector for Efficient Generation of Stable, High-Level Monoclonal Antibody Producing CHO DG44 Cell Lines. Anitbody Engineering 1827: 335-349 (Book Chapter)
  • Esmond Lee, Jaichandran Sivalingam, Zhong Ri Lim, Gloryn Chia, Low Gin Shi, Mackenna Roberts, Yuin-Han Loh, Shaul Reuveny and Steve Kah Weng Oh (2018) Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges. Biotechnology Advances 36: 2118–2128
  • Ian Walsh, Terry Nguyen-Khuong, Katherine Wongtrakul-Kish, Shi Jie Tay, Daniel Chew, Tasha Jose, Christopher H. Taron and Pauline M Rudd (2018) GlycanAnalyzer: Software for Automated Interpretation of N-Glycan Profiles after Exoglycosidase Digestions. Bioinformatics (Published Online)
  • Sherwin Ting, Alan Lam, Gerine Tong, Allen Chen, Heming Wei, JianJun Wu, Yue Ning Lam, Shaul Reuveny and Steve Oh (2018) Meticulous optimization of cardiomyocyte yields in a 3-stage continuous integrated agitation bioprocess. Stem Cell Research 31: 161-173
  • Jennifer Alagu, Yoko Itahana, Faizal Sim, Sheng-Hao Chao, Xuezhi Bi and Koji Itahana (2018) Tumor Suppressor p14ARF Enhances IFN-γ-Activated Immune Response by Inhibiting PIAS1 via SUMOylation. Journal of Immunology 201(2): 451-464
  • Reza Moloudi, Steve Oh, Chun Yang, Kim Leng Teo, Alan Tin-Lun Lam, Majid Ebrahimi Warkiani and May Win Naing (2018) Inertial-Based Filtration Method for Removal of Microcarriers from Mesenchymal Stem Cell Suspensions. Scientific Reports 8: 12481
  • Tan Heng Liang, Charlene Yong, Tan Bao Zhu, Fong Wey Jia, Jayanthi Padmanabhan, Angela Chin, Vanessa Ding, Ally Lau, Zheng Lu, Bi Xuezhi, Yang Yuansheng, Andre Choo (2018) Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer. Scientific Reports 8: 11608
  • Natasha A. Pereira, Kah Fai Chan, Pao Chun Lin and Zhiwei Song (2018) The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer mAbs for enhanced ADCC. mAbs 10(5): 693-711
  • Filip Laco, Tsung Liang Woo, Qixing Zhong, Radoslaw Szmyd, Sherwin Ting, Fahima Jaleel Khan, Christina L. L. Chai, Shaul Reuveny, Allen Chen and Steve Oh (2018) Unraveling the Inconsistencies of Cardiac Differentiation Efficiency Induced by the GSK3β Inhibitor CHIR99021 in Human Pluripotent Stem Cells. Stem Cell Reports 10(6): 1851-1866
  • Thomas Allison, Peter Andrews, Yishai Avior, Ivana Barbaric, Nissim Benvenisty, Christoph Bock, Jennifer Brehm, Oliver Brüstle, Ivan Damjanov, Andrew Elefanty, Daniel Felkner, Paul Gokhale, Florian Halbritter, Lyn Healy, Tim Xiaoming Hu, Barbara Knowles, Jeanne Loring, Tenneille Ludwig, Robyn Mayberry, Jameelah S. Mohamed, Suzanne Miacallef, Franz-Josef Müller, Christine Mummery, Norio Nakatsuji, Elizabeth Ng, Steve K. W. Oh, Orla O'Shea, Martin Pera, Benjamin Reubinoff, Paul Robson, Janet Rossant, Bernhard Schuldt, Davor Solter, Koula Sourris, Glyn Stacey, Edouard Stanley, Hirofumi Suemori, Kazutoshi Takahashi, and Shinya Yamanaka (2018) Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. Nature Communications 9(1): 1925
  • Reza Moloudi, Steve Oh, Chun Yang, Majid Ebrahimi Warkiani, and May Win Naing (2018) Inertial particle focusing dynamics in a trapezoidal straight microchannel: application to particle filtration. Microfluidics and Nanofluidics 22:33
  • Esmond Lee, Zhong Ri Lim, Hong Yu-Chen, Bin Xia Yang, Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jaichandran Sivalingam, Shaul Reuveny, Yuin-Han Loh and Steve Kah-Weng Oh (2018) Defined serum free medium for bioreactor culture of an immortalized human erythroblast cell line. Biotechnology Journal 13(4): e1700567
  • K P Myu Mai Ja, Kee Pah Lim, Allen Chen, Sherwin Ting, Shi Qi Li, Nicole Tee, Chrishan Ramachandra, Ashish Mehta, Philip Wong, Steve Oh & Winston Shim (2018) Construction of a Vascularized Hydrogel for Cardiac Tissue Formation in a Porcine Model. Journal of Tissue Engineering and Regenerative Medicine 12(4): e2029-e2038
  • Na Gao, Ming Xia, Jingcheng Dai, Dianzhen Yu, Weixing An, Shuyang Li, Shuangyuan Liu, Penghui He, Liping Zhang, Zhenbin Wu, Xuezhi Bi, Shouwen Chen, Daniel H. Haft and Dongru Qiu (2018) Both widespread PEP-CTERM proteins and exopolysaccharides are required for floc formation of Zoogloea resiniphila and other activated sludge bacteria. Environmental Microbiology 20(5): 1677-1692
  • Xuezhi Bi, Lijuan Ye, Ally Lau, Yee Jiun Kok, Lu Zheng, Daniel Ng, Kelly Tan, Dave Ow, Edwin Ananta, Christina Vafiadi and Jeroen Muller (2018) Proteomic Profiling of Barley Spent Grains Guides Enzymatic Solubilization of the Remaining Proteins. Applied Microbiology and Biotechnology 102(9): 4159-4170
  • Andy Hee-Meng Tan, Arleen Sanny, Sze-Wai Ng, Ying-Swan Ho, Nurhidayah Basri, Alison Ping Lee & Kong-Peng Lam (2018) Excessive interferon-a signaling in autoimmunity alters glycosphingolipid processing in B cells. Journal of Autoimmunity 89: 53-62
  • Sarantos Kyriakopoulos, Kok Siong Ang, Meiyappan Lakshmanan, Zhuangrong Huang, Seongkyu Yoon, Rudiyanto Gunawan and Dong-Yup Lee (2018) Kinetic modelling of mammalian cell culture bioprocessing: the quest to advance biomanufacturing. Biotechnology Journal 13(3): e1700229
  • Shuai He, Yi Mon Ei Kyaw, Eddie Khay Ming Tan, Laurent Bekale, Malvin Wei Cherng Kang, Susana Soo-Yeon Kim, Ivan Tan, Kong-Peng Lam, and James Chen Yong Kah (2018) Quantitative and Label-Free Detection of Protein Kinase A Activity Based on Surface-Enhanced Raman Spectroscopy with Gold Nanostars. Analytical Chemistry 90(10): 6071-6080
  • Dawn Sow Zong Leong, Brian Kah Hui Teo, Janice Gek Ling Tan, Hayati Kamari, Yuan Sheng Yang, Peiqing Zhang and Say Kong Ng (2018) Application of maltose as energy source in protein-free CHO-K1 culture to improve the production of recombinant monoclonal antibody. Scientific Reports 8(1): 4037
  • Xijun Ou, Jianxin Huo, Yanfeng Li, Shengli Xu and Kong-Peng Lam (2018) Transcription factor YY1 is essential for iNKT cell development. Cellular & Molecular Immunology (Published Online)
  • Pranjul Mishra, Na-Rae Lee, Meiyappan Lakshmanan, Minsuk Kim, Byung-Gee Kim and Dong-Yup Lee (2018) Genome-scale model-driven strain design for dicarboxylic acid production in Yarrowia lipolytica. BMC Systems Biology 12(Suppl 2): 12
  • Kian Ping Chan, Sheng-Hao Chao, and James Chen Yong Kah (2018) Universal mRNA Translation Enhancement with Gold Nanoparticles Conjugated to Oligonucleotides with a Poly(T) Sequence. ACS Applied Materials & Interfaces 10(6): 5203-5212
  • David Hutchinson, Judith Müller, Joseph E McCarthy, Yurii K Gun’ko, Navin Kumar Verma, Xuezhi Bi, Luisana Di Cristo, Laura Kickham, Dania Movia, Adriele Prina-Mello & Yuri Volkov (2018) Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 13: 441–449
  • Sung Kyu Jang, Sookyung Kim, Muhammad Saad Salman, Ji-ryang Jang, Yu Mi Um, Lihan Tan, Jin-Hong Park, Woo-Seok Choe, and Sungjoo Lee (2018) Harnessing Recombinant DnaJ Protein as Reversible Metal Chelator for a High-Performance Resistive Switching Device. Chemistry of Materials 30(3): 781–788
  • Justin Bryan Goh and Ng Say Kong (2018) Impact of host cell line choice on glycan profile. Critical Reviews in Biotechnology (Published Online)
  • Congqiang Zhang, Xixian Chen, Nic D. Lindley, Heng-Phon Too (2018) A "plug-n-play" modular metabolic system for the production of apocarotenoids. Biotechnology and Bioengineering 115(1): 174-183

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