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Publications

Thong Teck Tan, Ruenn Chai Lai, Jayanthi Padmanabhan, Wei Kian Sim, Andre Boon Hwa Choo and Sai Kiang Lim (2021) Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV). Pharmaceuticals 14: 345
Xiaohui Wang, Xiang Lin, Zihan Zheng, Bingtai Lu, Jun Wang, Andy Hee-Meng Tan, Meng Zhao, Jia Tong Loh, Sze Wai Ng, Qian Chen, Fan Xiao, Enyu Huang, King-Hung Ko, Zhong Huang, Jingyi Li, Kin-Hang Kok, Gen Lu, Xiaohui Liu, Kong-Peng Lam, Wanli Liu, Yuxia Zhang, Kwok-Yung Yuen, Tak Wah Mak & Liwei Lu (2021) Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection. Nature Communications 12: 1914
Eun Myoung Shin, Vinh Thang Huynh, Sultan Abda Neja, Chia Yi Liu, Anandhkumar Raju, Kelly Tan, Nguan Soon Tan, Jayantha Gunaratne, Xuezhi Bi, Lakshminarayan M. Iyer, L. Aravind and Vinay Tergaonkar (2021) GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer. Science Advances 7(12): eabe2470
Alan Tin-Lun Lam, Alison P. Lee, Premkumar Jayaraman, Kah Yong Tan, Deepak Raghothaman, Hsueh Lee Lim, He Cheng, Lihan Zhou, Andy Hee-Meng Tan, Shaul Reuveny and Steve Oh (2021) Multiomics analyses of cytokines, gene, miRNA, and pathway regulatory networks in human mesenchymal stem cells expanded in stirred microcarrier-spinner cultures. Stem Cell Research (Published Online)
Zixi Wang, Di Guan, Jianxin Huo, Subhra K Biswas, Yuhan Huang, Yuansheng Yang, Shengli Xu and Kong-Peng Lam (2021) IL-10 enhances human natural killer cell effector function via metabolic reprogramming regulated by mTOR signaling. Frontiers in Immunology (Published Online)
Genetics of Exfoliation Syndrome Partnership; Zheng Li, Zhenxun Wang, Mei Chin Lee, Matthias Zenkel, Esther Peh, Mineo Ozaki, Fotis Topouzis, Satoko Nakano, Anita Chan, Shuwen Chen, Susan E I Williams, Andrew Orr, Masakazu Nakano, Nino Kobakhidze, Tomasz Zarnowski, Alina Popa-Cherecheanu, Takanori Mizoguchi, Shin-Ichi Manabe, Ken Hayashi, Shigeyasu Kazama, Kenji Inoue, Yosai Mori, Kazunori Miyata, Kazuhisa Sugiyama, Tomomi Higashide, Etsuo Chihara, Ryuichi Ideta, Satoshi Ishiko, Akitoshi Yoshida, Kana Tokumo, Yoshiaki Kiuchi, Tsutomu Ohashi, Toshiya Sakurai, Takako Sugimoto, Hideki Chuman, Makoto Aihara, Masaru Inatani, Kazuhiko Mori, Yoko Ikeda, Morio Ueno, Daniel Gaston, Paul Rafuse, Lesya Shuba, Joseph Saunders, Marcelo Nicolela, George Chichua, Sergo Tabagari, Panayiota Founti, Kar Seng Sim, Wee Yang Meah, Hui Meng Soo, Xiao Yin Chen, Anthi Chatzikyriakidou, Christina Keskini, Theofanis Pappas, Eleftherios Anastasopoulos, Alexandros Lambropoulos, Evangelia S Panagiotou, Dimitrios G Mikropoulos, Ewa Kosior-Jarecka, Augustine Cheong, Yuanhan Li, Urszula Lukasik, Monisha E Nongpiur, Rahat Husain, Shamira A Perera, Lydia Álvarez, Montserrat García, Héctor González-Iglesias, Andrés F V Cueto, Luis F V Cueto, Federico Martinón-Torres, Antonio Salas, Çilingir Oguz, Nevbahar Tamcelik, Eray Atalay, Bilge Batu, Murat Irkec, Dilek Aktas, Burcu Kasim, Yury S Astakhov, Sergei Y Astakhov, Eugeny L Akopov, Andreas Giessl, Christian Mardin, Claus Hellerbrand, Jessica N Cooke Bailey, Robert P Igo Jr, Jonathan L Haines, Deepak P Edward, Steffen Heegaard, Sonia Davila, Patrick Tan, Jae H Kang, Louis R Pasquale, Friedrich E Kruse, André Reis, Trevor R Carmichael, Michael Hauser, Michele Ramsay, Georg Mossböck, Nilgun Yildirim, Kei Tashiro, Anastasios G P Konstas, Miguel Coca-Prados, Jia Nee Foo, Shigeru Kinoshita, Chie Sotozono, Toshiaki Kubota, Michael Dubina, Robert Ritch, Janey L Wiggs, Francesca Pasutto, Ursula Schlötzer-Schrehardt, Ying Swan Ho, Tin Aung, Wai Leong Tam, Chiea Chuen Khor (2021) Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 325(8): 753-764
Fang Yu, Nivasini Selva Kumar, Satnam Singh, Walter Hunziker, Sum Huan Ng and Deepak Choudhury (2021) Isolation of primary brain endothelial cells, pericytes and astrocytes on a microfluidic immunopanning chip (MIC). Microfluidics and Nanofluidics 25:25
Pei Kun Richie Tay, Pei Yu Lim and Dave Siak-Wei Ow (2021) A SH3_5 cell anchoring domain for non-recombinant surface display on lactic acid bacteria. Frontiers in Biotechnology and Bioengineering 8: 614498
Weichao Zhai, Jerome Tan, Tobias Russell, Sixun Chen, Dennis McGonagle, May Win Naing, Derrick Yong and Elena Jones (2021) Multi-pronged Approach to Human Mesenchymal Stromal Cells Senescence Quantification with a Focus on Label Free Methods. Scientific Reports 11(1): 1054
Bin Zhang, Ruenn Chai Lai, Wei Kian Sim, Andre Boon Hwa Choo, Ellen Birgit Lane and Sai Kiang Lim (2021) Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation. International Journal of Molecular Sciences 22(2): 720

Jaichandran Sivalingam, Yu SuE, Zhong Ri Lim, Alan T.L. Lam, Alison P. Lee, Hsueh Lee Lim, Hong Yu Chen, Hong Kee Tan, Tushar Warrier, Jing Wen Hang, Nazmi B. Nazir, Andy H.M. Tan, Laurent Renia, Yuin Han Loh, Shaul Reuveny, Benoit Malleret and Steve K.W. Oh (2020) A Scalable Suspension Platform for Generating High-Density Cultures of Universal Red Blood Cells from Human Induced Pluripotent Stem Cells. Stem Cell Reports 16(1): 182-197
Liu Dan, Chen Sixun and May Win Naing (2020) A review of manufacturing capabilities of cell spheroid generation technologies and future development. Biotechnology and Bioengineering 118(2): 542-554
Andy Hee-Meng Tan, Gloria Hoi Wan Tso, Biyan Zhang, Pei-Yun Teo, Xijun Ou, Sze-Wai Ng, Alex Xing Fah Wong, Sean Jing Xiang Tan, Arleen Sanny, Susana Soo-Yeon Kim, Alison P. Lee, Shengli Xu, and Kong-Peng Lam (2020) TACI constrains TH17 pathogenicity and protects against gut inflammation. iScience 23(11): 101707
Edward G. Pallister, Matthew S. F. Choo, Ian Walsh, Jien-Nee Tai, Shi-Jie Tay, Yuansheng Yang, Say-Kong Ng, Pauline M. Rudd, Sabine L. Flitsch and Terry Nguyen-Khuong (2020) Utility of Ion-Mobility Spectrometry for Deducing Branching of Multiply Charged Glycans and Glycopeptides in a High-Throughput Positive ion LC-FLR-IMS-MS Workflow. Analytical Chemistry 92(23):15323-15335
Deepak Choudhury, Satnam Singh, Jasmine Si Han Seah, David Chen Loong Yeo and Lay Poh Tan (2020) Commercialization of Plant-Based Meat Alternatives. Trends in Plant Science 25(11): 1055-1058
Yu Yang Fredik Liu, Yin Lu, Steve Oh, Gareth J. Conduit (2020) Machine learning to predict mesenchymal stem cell efficacy for cartilage repair. PLOS Computational Biology (Published Online)
Katrina Adlerz, Divya Patel, Jon Rowley, Kelvin Ng, Tabassum Ahsan (2020) Strategies for Scalable Manufacturing and Translation of MSC-Derived Extracellular Vesicles. Stem Cell Research 48: 101978
Jia Tong Loh, Joey Kay Hui Teo, Hong-Hwa Lim and Kong-Peng Lam (2020) Emerging Roles of Downstream of Kinase 3 in Cell Signaling. Frontiers in Immunology 11: 566192
Deepak Choudhury, Marcus Yee, Zach Lee Jia Sheng, Ahmad Amirul and May Win Naing (2020) Decellularization systems and devices: State-of-the-art. Acta Biomaterialia (Review Paper) 115: 51–59
Harish K. Handral , Shi Hua Tay, Weng Wan Chan and Deepak Choudhury (2020) 3D printing of cultured meat products. Critical Reviews in Food Science and Nutrition (Published Online)
Kae Hwan Sim, Lillian Chia-Yi Liu, Hwee Tong Tan, Kelly Tan, Daniel Ng, Wei Zhang, Yuansheng Yang, Stephen Tate and Xuezhi Bi (2020) A comprehensive CHO SWATH-MS spectral library for robust quantitative profiling of 10,000 proteins. Scientific Data 7(1): 263
Youshan Melissa Lin, Alan Tin Lun Lam, Jialing Lee, Teo Kim Leng, Eileen Sim, Li Jian, Jessica Pei Wen Toh, Xiafei Ren, Barry WL Tan, Mahesh Choolani, Jerry Kok Yen Chan, Shaul Reuveny, James Hoi Po Hui, William R. Birch and Steve Kah Weng Oh (2020) Human early mesenchymal stromal cells delivered on porous lightweight biodegradable polycaprolactone-based microcarriers result in improved cartilage formation. Materialia 13: 100851
Julian L. Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V. Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W. L. Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K. Luthra, William D. Shingleton, Steve K. W. Oh, Li Zeng and Edward G. Robins (2020) Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease. Stem Cell Research & Therapy 11: 347
Weng Wan Chan, David Chen Loong Yeo, Vernice Tan, Satnam Singh, Deepak Choudhury and May Win Naing (2020) Additive Biomanufacturing with Collagen Inks. Bioengineering 7: 66
Saeideh Kholgh Eshkalak, Erfan Rezvani Ghomi, Yunqian Dai, Deepak Choudhury and Seeram Ramakrishna (2020) The role of three-dimensional printing in healthcare and medicine. Materials and Design 194: 108940
Hock Chuan Yeo, Jongkwang Hong, Meiyappan Lakshmanan and Dong-Yup Lee (2020) Enzyme capacity-based genome scale modelling of CHO cells. Metabolic Engineering 60: 138-147
Chaminda Jayampath Seneviratne, Preethi Balan, Tanujaa Suriyanarayanan, Meiyappan Lakshmanan, Dong-Yup Lee, Mina Rho, Nicholas Jakubovics, Bernd Brandt, Wim Crielaard and Egija Zaura (2020) Oral microbiome-systemic link studies: perspectives on current limitations and future artificial intelligence-based approaches. Critical Reviews in Microbiology 46(3): 288-299
Candice Qiu Xia Yam, David Boy Chia, Idina Shi, Hong Hwa Lim and Uttam SURANA (2020) Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling. Nucleic Acid Research 48(11): 6092-6107
Lokanand Koduru, Hyang Yeon Kim, Meiyappan Lakshmanan, Bijayalaxmi Mohanty, Yi Qing Lee, Choong Hwan Lee and Dong-Yup Lee (2020) Genome-scale metabolic reconstruction and in silico analysis of rice leaf blight pathogen, Xanthomonas oryzae. Molecular Plant Pathology 21(4):527-540
Serene W Chen, Darryl Tan, Yuan Sheng Yang and Wei Zhang (2020) Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies. mAbs 12(1): 1718440
Leonard Leong, Heng Liang Tan, Simeon Cua, Kylie Su Mei Yong, Qingfeng Chen and Andre Choo (2020) Preclinical Activity of Embryonic Annexin A2-Specific Chimeric Antigen Receptor T Cells Against Ovarian Cancer. International Journal of Molecular Sciences 21(2): 381
Filip Laco, Alan Tin-Lun Lam, Tsung-Liang Woo, Gerine Tong, Valerie Ho, Poh-Loong Soong, Elina Grishina, Kun-Han Lin, Shaul Reuveny and Steve Kah-Weng Oh (2020) Selection of human induced pluripotent stem cells lines optimization of cardiomyocytes differentiation in an integrated suspension microcarrier bioreactor. Stem Cell Research and Therapy 11: 118
Christian Lieven, Moritz E. Beber, Brett G. Olivier, Frank T. Bergmann, Meric Ataman, Parizad Babaei, Jennifer A. Bartell, Lars M. Blank, Siddharth Chauhan, Kevin Correia, Christian Diener, Andreas Dräger, Birgitta E. Ebert, Janaka N. Edirisinghe, José P. Faria, Adam M. Feist, Georgios Fengos, Ronan M. T. Fleming, Beatriz García-Jiménez, Vassily Hatzimanikatis, Wout van Helvoirt, Christopher S. Henry, Henning Hermjakob, Markus J. Herrgård, Ali Kaafarani, Hyun Uk Kim, Zachary King, Steffen Klamt, Edda Klipp, Jasper J. Koehorst, Matthias König, Meiyappan Lakshmanan, Dong-Yup Lee, Sang Yup Lee, Sunjae Lee, Nathan E. Lewis, Filipe Liu, Hongwu Ma, Daniel Machado, Radhakrishnan Mahadevan, Paulo Maia, Adil Mardinoglu, Gregory L. Medlock, Jonathan M. Monk, Jens Nielsen, Lars Keld Nielsen, Juan Nogales, Intawat Nookaew, Bernhard O. Palsson, Jason A. Papin, Kiran R. Patil, Mark Poolman, Nathan D. Price, Osbaldo Resendis-Antonio, Anne Richelle, Isabel Rocha, Benjamín J. Sánchez, Peter J. Schaap, Rahuman S. Malik Sheriff, Saeed Shoaie, Nikolaus Sonnenschein, Bas Teusink, Paulo Vilaça, Jon Olav Vik, Judith A. H. Wodke, Joana C. Xavier, Qianqian Yuan, Maksim Zakhartsev & Cheng Zhang (2020) MEMOTE for standardized genome-scale metabolic model testing. Nature Biotechnology (Correspondence)
Jianxin Huo, Shengli Xu and Kong-Peng Lam (2020) ASK1 mediates Nur77 expression in T-cell receptor mediated thymocyte apoptosis. Cells 9(3): 585
Zixi Wang, Di Guan, Shu Wang, Louis Yi Ann Chai, Shengli Xu and Kong-Peng Lam (2020) Glycolysis and Oxidative Phosphorylation Play Critical Roles in Natural Killer Cell Receptor-Mediated Natural Killer Cell Functions. Frontiers in Immunology 11: 202
Alan T.L. Lam, Shaul Reuveny and Steve Kah-Weng Oh (2020) Human Mesenchymal Stem Cell Therapy for Cartilage Repair: Review on Isolation, Expansion, and Constructs. Stem Cell Research 44: 101738

Tan Heng Liang and Andre Choo (2019) Opportunities for Antibody Discovery Using Human Pluripotent Stem Cells: Conservation of Oncofetal Targets. International Journal of Molecular Sciences 20: 5752
Christine Lin Chin, Justin Bryan Goh, Harini Srinivasan, Kaiwen Ivy Liu, Ali Gowher, Raghuvaran Shanmugam, Hsueh Lee Lim, Matthew Choo, Wen Qin Tang, Andy Hee-Meng Tan, Terry Nguyen-Khuong, Meng How Tan and Say Kong Ng (2019) A human expression system based on HEK293 for the stable production of recombinant erythropoietin. Scientific Reports 9: 16768
Edward G. Pallister, Matthew S. F. Choo, Jien-Nee Tai, Dawn S. Z. Leong, Wen-Qin Tang, Say-Kong Ng, Kun Huang, Andrea Marchesi, Peter Both, Christopher Gray, Pauline M. Rudd, Sabine L. Flitsch and Terry Nguyen-Khuong (2019) Exploiting the Disialyl Galactose Activity of α2,6-Sialyltransferase from Photobacterium damselae To Generate a Highly Sialylated Recombinant α-1-Antitrypsin. Biochemistry (Published Online)
Jong Kwang Hong, Hong-Yeol Choi, Hae-Rim Park, Dong-Il Kim and Dong-Yup Lee (2019) Inhibition of autolysosome formation improves rrhGAA production driven by RAmy3D promoter in transgenic rice cell culture. Biotechnology and Bioprocess Engineering 24: 568-578
Seow Theng Ong, Aik Seng Ng, Xuan Rui Ng, Zhong Zhuang, Brandon Han Siang Wong, Praseetha Prasannan, Yee Jiun Kok, Xuezhi Bi, Heesung Shim, Heike Wulff, Kanianthara George Chandy and Navin Kumar Verma (2019) Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment. BIOELECTRICITY 1(3)
Heng Liang Tan, Bao Zhu Tan, Winfred Xi Tai Goh, Simeon Cua and Andre Choo (2019) In vivo surveillance and elimination of teratoma‐forming human embryonic stem cells with monoclonal antibody 2448 targeting annexin A2. Biotechnology and Bioengineering (Published Online)
Katherine Wongtrakul-Kish, Ian Walsh, Lyn Chiin Sim, Amelia Mak, Brian Liau, Vanessa Ding, Noor Hayati, Han Wang, Andre Choo, Pauline M. Rudd and Terry Nguyen-Khuong (2019) Combining Glucose Units, m/z, and Collision Cross Section Values: Multiattribute Data for Increased Accuracy in Automated Glycosphingolipid Glycan Identifications and Its Application in Triple Negative Breast Cancer. Analytical Chemistry 91(14): 9078-9085
Shengli Xu, Jianxin Huo, Yuhan Huang, Melissa Aw, Shuwen Chen, Shiya Mak, Lian Yee Yip, Ying Swan Ho, Sze Wai Ng, Andy Hee-Meng Tan, Alison Lee, Xijun Ou and Kong-Peng Lam (2019) von Hippel-Lindau Protein Maintains Metabolic Balance to Regulate the Survival of Naive B Lymphocytes. iSCIENCE 17: 379-392
Joshur Ang, Yong‐An Lee, Deepak Raghothaman, Premkumar Jayaraman, Kim L. Teo, Fahima J. Khan, Shaul Reuveny, Young‐Tae Chang, Nam‐Young Kang and Steve Oh (2019) Rapid Detection of Senescent Mesenchymal Stromal Cells by a Fluorescent Probe. Biotechnology Journal (Published Online)
Pao-Chun Lin, Kah Fai Chan, Irene A. Kiess, Joselyn Tan, Wahyu Shahreel, Sze-Yue Wong and Zhiwei Song (2019) Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics. mAbs 11(5): 965-976
Jia Tong Loh, Shengli Xu, Jian Xin Huo, Susana Soo-Yeon Kim, Yue Wang and Kong-Peng Lam (2019) Dok3–protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. Journal of Clinical Investigation 129(8): 2717-2729
Jianxin Huo, Shengli Xu and Kong-Peng Lam (2019) FAIM: An antagonist of Fas-killing and beyond. Cells 8(6). pii: E541
Peiqing Zhang, Carole Burel, Carole Plasson, Marie-Christine Kiefer-Meyer, Clément Ovide, Bruno Gügi, Corrine Wan, Gavin Teo, Amelia Mak, Zhiwei Song, Azeddine Driouich, Patrice Lerouge and Muriel Bardor (2019) Characterization of a GDP-Fucose Transporter and a Fucosyltransferase Involved in the Fucosylation of Glycoproteins in the Diatom Phaeodactylum tricornutum. Frontiers in Plant Science 10: 610
Meiyappan Lakshmanan, Yee Jiun Kok, Alison P. Lee, Sarantos Kyriakopoulos, Hsueh Lee Lim, Gavin Teo, Swan Li Poh, Wen Qin Tang, Jongkwang Hong, Andy Hee‐Meng Tan, Xuezhi Bi, Ying Swan Ho, Peiqing Zhang, Say Kong Ng and Dong‐Yup Lee (2019) Multi‐omics profiling of CHO parental hosts reveals cellline‐specific variations in bioprocessing traits. Biotechnology and Bioengineering 116(9): 2117-2129
Matthew S. Choo, Corrine Wan, Ce Huang Poo, Pauline M. Rudd and Terry Nguyen- Khuong (2019) GlycopeptideGraphMS: Improved Glycopeptide Detection and Identification by Exploiting Graph Theoretical Patterns in Mass and Retention Time. Analytical Chemistry 91(11):7236-7244
Alan Tin-Lun Lam, Eileen Jia-Hui Sim, Asha Shekaran, Jian Li, Kim-Leng Teo, Julian L. Goggi, Shaul Reuveny, William R. Birch & Steve Kah-Weng Oh (2019) Sub-confluent culture of human mesenchymal stromal cells on biodegradable polycaprolactone microcarriers enhances bone healing of rat calvarial defect. Cytotherapy 21(6): 631-642
Kenneth W. Witwer, Bas W.M. van Balkom, Stefania Bruno, Andre Choo, Massimo Dominici, Mario Gimona, Andrew F. Hill, Dominique de Kleijn, Mickey Koh, Ruenn Chai Lai, S. Alex Mitsialis, Luis A. Ortiz, Eva Rohde, Takashi Asada, Wei Seong Toh, Daniel J. Weiss, Lei Zheng, Bernd Giebel and Sai Kiang Lim (2019) Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. Journal of Extracellular Vesicles 8(1): 1609206
Zhigang Xie, Jing Yuan Chooi, Sabrina Hui Min Toh, Dongxiao Yang, Nurhidayah Binte Basri, Ying Swan Ho and Wee Joo Chn (2019) MMSET I acts as an oncoprotein and regulates GLO1 expression in t (4;14) multiple myeloma cells. Leukemia 33: 739–748
Zhenxun Wang, Lian Yee Yip, Jia Hui Jane Lee, Zhengwei Wu, Hui Yi Chew, Pooi Kiat William Chong, Chin Chye Teo, Heather Yin-Kuan Ang, Kai Lay Esther Peh, Ju Yuan, Siming Ma, Li Shi Kimberly Choo, Nurhidayah Basri, Xia Jiang, Qiang Yu, Axel M. Hillmer, Wan Teck Lim, Tony Kiat Hon Lim, Angela Takano, Eng Huat Tan, Daniel Shao Weng Tan, Ying Swan Ho, Bing Lim and Wai Leong Tam (2019) Methionine is a metabolic dependency of tumor-initiating cells. Nature Medicine 25: 825-837
Jaichandran Sivalingam and Steve Kah-Weng Oh (2019) Bioprocessing and biological challenges to large-scale red blood cell production from pluripotent stem cells: important factors to consider. Cell & Gene Therapy Insights 5(3): 483–504
Zhenxing Huang, Jianhe Wang, Xiaoli Xu, Haishan Wang, Yuan Qiao, Wern Cui Chu, Shengli Xu, Louis Chai, Fabien Cottier, Norman Pavelka, Marije Oosting, Leo A. B. Joosten, Mihai Netea, Carol Yee Leng Ng, Khai Pang Leong, Parag Kundu, Kong-Peng Lam, Sven Pettersson and Yue Wang (2019) Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nature Microbiology 4(5): 766-773
Susana Soo-Yeon Kim, Lynette Sze and Kong-Peng Lam (2019) The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance IFN-β response. Journal of Biological Chemistry 294(16): 6430-6438
Kian Ping Chan, Sheng-Hao Chao and James Chen Yong Kah (2019) Exploiting Protein Corona around Gold Nanoparticles Conjugated to p53 Activating Peptides To Increase the Level of Stable p53 Proteins in Cells. Bioconjugate Chemistry 30(3): 920-930
Reza Moloudi, Steve Oh, Chun Yang, Kim Leng Teo, Alan Tin-Lun Lam, Majid Ebrahimi Warkiani and May Win Naing (2019) Scaled-up Inertial Microfluidics: Retention System for Microcarrier-based Suspension Cultures. Biotechnology Journal 14(5): e1800674
Ningning Xu, Jianfa Ou, Yingnan Si, Kah Yong Goh, Daniel D. Flanigan, Xiaosi Han, Yuansheng Yang, Shang-Tian Yang, Lufang Zhou and Xiaoguang (Margaret) Liu (2019) Proteomics insight into the production of monoclonal antibody. Biochemical Engineering Journal 145: 177–185
Pooi Leng Ho, Han Kee Ong, Jeanette Teo, Dave Siak-Wei Ow and Sheng-Hao Chao (2019) HEXIM1 Peptide Exhibits Antimicrobial Activity Against Antibiotic Resistant Bacteria Through Guidance of Cell Penetrating Peptide. Frontiers in Microbiology (Published Online)
Kian Ping Chan, Sheng-Hao Chao and James Chen Yong Kah (2019) Enhanced Secretion of Functional Insulin with DNA-Functionalized Gold Nanoparticles in Cells. ACS Biomaterials Science & Engineering (Published Online)

Cai Tong Ng, Li Deng, Chen Chen, Hong Hwa Lim, Jian Shi, Uttam Surana, and Lu Gan (2018) Electron cryotomography analysis of Dam1C/DASH at the kinetochore–spindle interface in situ. Journal of Cell Biology 218(2): 455-473
Yee Jiun Kok, Lijuan Ye, Jeroen Muller, Dave Siak-Wei Ow and Xuezhi Bi (2018) Brewing with malted barley or raw barley: what makes the difference in the processes?, Applied Microbiology and Biotechnology 103(3): 1059-1067
Yee Hwee Lim, Fong Tian Wong, Wan Lin Yeo, Kuan Chieh Ching, Yi Wee Lim, Elena Heng, Shuwen Chen, De-Juin Tsai, Tsai-Ling Lauderdale, Kak-Shan Shia, Ying Swan Ho, Shawn Hoon, Ee Lui Ang, Mingzi M. Zhang, and Huimin Zhao (2018) Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR-Cas9 Activation. ChemBioChem 19: 1716–1719
Hock Chuan Yeo, Shuwen Chen, Ying Swan Ho and Dong‑Yup Lee (2018) An LC–MS-based lipidomics pre-processing framework underpins rapid hypothesis generation towards CHO systems biotechnology. Bioinformatics 14: 98
Jong Kwang Hong, Meiyappan Lakshmanan, Chetan Goudar and Dong-Yup Lee (2018) Towards next generation CHO cell line development and engineering by systems approaches. Current Opinion in Chemical Engineering 22: 1–10
Hong-Yeol Choi, Heajin Park, Jong Kwang Hong, Sun-Dal Kim, Jun-Young Kwon, SeungKwan You, Jonghye Do, Dong-Yup Lee, Ha Hyung Kim & Dong-Il Kim (2018) N-glycan Remodeling Using Mannosidase Inhibitors to Increase High-mannose Glycans on Acid α-Glucosidase in Transgenic Rice Cell Cultures. Scientific Reports 8: 16130
Jong Kwang Hong, Shilpa Nargund, Meiyappan Lakshmanan, Sarantos Kyriakopoulos, Do Yun Kim, Kok Siong Ang, Dawn Leong, Yuansheng Yang and Dong-Yup Lee (2018) Comparative phenotypic analysis of CHO clones and culture media for lactate shift. Journal of Biotechnology 283: 97–104
Jia Tong Loh, Thomas Jun Feng Lim, Kyoko Ikumi, Takuma Matoba, Baptiste Janela, Merry Gunawan, Tatsuya Toyama, Maegan Bunjamin, Lai Guan Ng, Michael Poidinger, Akimichi Morita, Florent Ginhoux, Sayuri Yamazaki, Kong-Peng Lam, and I-hsin Su (2018) Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells. CellPress (Published Online)
Hossein Tavassoli, Sanaz Naghavi Alhosseini, Andy Tay, Peggy P.Y. Chan, Steve Kah Weng Oh and Majid Ebrahimi Warkiani (2018) Large-scale production of stem cells utilizing microcarriers: A biomaterials engineering perspective from academic research to commercialized products. Biomaterials 181: 333-346
Qixing Zhong, Filip Laco, Mei-Chih Liao, Tsung Liang Woo, Steve Kah Weng Oh and Christina Li Lin Chai (2018) Influencing the fate of cardiac and neural stem cell differentiation using small molecule inhibitors of ALK5. STEM CELLS Translational Medicine 7(10): 709-720
R. Kumar, L. Coronel, B. Somalanka, A. Raju, O.A. Aning, O. An, Y.S. Ho, S. Chen, S.Y. Mak, P.Y. Hor, H. Yang, M. Lakshmanan, H. Itoh, S.Y. Tan, Y.K. Lim, A.P.C. Wong, S.H. Chew, T.H. Huynh, B.C. Goh, C.Y. Lim, V. Tergaonkar & C.F. Cheok (2018) Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nature Communications 9: 3931
Jessna H. M. Yeo, Mariati and Yuansheng Yang (2018) An IRES-Mediated Tricistronic Vector for Efficient Generation of Stable, High-Level Monoclonal Antibody Producing CHO DG44 Cell Lines. Anitbody Engineering 1827: 335-349 (Book Chapter)
Esmond Lee, Jaichandran Sivalingam, Zhong Ri Lim, Gloryn Chia, Low Gin Shi, Mackenna Roberts, Yuin-Han Loh, Shaul Reuveny and Steve Kah Weng Oh (2018) Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges. Biotechnology Advances 36: 2118–2128
Ian Walsh, Terry Nguyen-Khuong, Katherine Wongtrakul-Kish, Shi Jie Tay, Daniel Chew, Tasha Jose, Christopher H. Taron and Pauline M Rudd (2018) GlycanAnalyzer: Software for Automated Interpretation of N-Glycan Profiles after Exoglycosidase Digestions. Bioinformatics (Published Online)
Sherwin Ting, Alan Lam, Gerine Tong, Allen Chen, Heming Wei, JianJun Wu, Yue Ning Lam, Shaul Reuveny and Steve Oh (2018) Meticulous optimization of cardiomyocyte yields in a 3-stage continuous integrated agitation bioprocess. Stem Cell Research 31: 161-173
Jennifer Alagu, Yoko Itahana, Faizal Sim, Sheng-Hao Chao, Xuezhi Bi and Koji Itahana (2018) Tumor Suppressor p14ARF Enhances IFN-γ-Activated Immune Response by Inhibiting PIAS1 via SUMOylation. Journal of Immunology 201(2): 451-464
Reza Moloudi, Steve Oh, Chun Yang, Kim Leng Teo, Alan Tin-Lun Lam, Majid Ebrahimi Warkiani and May Win Naing (2018) Inertial-Based Filtration Method for Removal of Microcarriers from Mesenchymal Stem Cell Suspensions. Scientific Reports 8: 12481
Tan Heng Liang, Charlene Yong, Tan Bao Zhu, Fong Wey Jia, Jayanthi Padmanabhan, Angela Chin, Vanessa Ding, Ally Lau, Zheng Lu, Bi Xuezhi, Yang Yuansheng, Andre Choo (2018) Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer. Scientific Reports 8: 11608
Natasha A. Pereira, Kah Fai Chan, Pao Chun Lin and Zhiwei Song (2018) The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer mAbs for enhanced ADCC. mAbs 10(5): 693-711
Filip Laco, Tsung Liang Woo, Qixing Zhong, Radoslaw Szmyd, Sherwin Ting, Fahima Jaleel Khan, Christina L. L. Chai, Shaul Reuveny, Allen Chen and Steve Oh (2018) Unraveling the Inconsistencies of Cardiac Differentiation Efficiency Induced by the GSK3β Inhibitor CHIR99021 in Human Pluripotent Stem Cells. Stem Cell Reports 10(6): 1851-1866
Thomas Allison, Peter Andrews, Yishai Avior, Ivana Barbaric, Nissim Benvenisty, Christoph Bock, Jennifer Brehm, Oliver Brüstle, Ivan Damjanov, Andrew Elefanty, Daniel Felkner, Paul Gokhale, Florian Halbritter, Lyn Healy, Tim Xiaoming Hu, Barbara Knowles, Jeanne Loring, Tenneille Ludwig, Robyn Mayberry, Jameelah S. Mohamed, Suzanne Miacallef, Franz-Josef Müller, Christine Mummery, Norio Nakatsuji, Elizabeth Ng, Steve K. W. Oh, Orla O'Shea, Martin Pera, Benjamin Reubinoff, Paul Robson, Janet Rossant, Bernhard Schuldt, Davor Solter, Koula Sourris, Glyn Stacey, Edouard Stanley, Hirofumi Suemori, Kazutoshi Takahashi, and Shinya Yamanaka (2018) Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. Nature Communications 9(1): 1925
Reza Moloudi, Steve Oh, Chun Yang, Majid Ebrahimi Warkiani, and May Win Naing (2018) Inertial particle focusing dynamics in a trapezoidal straight microchannel: application to particle filtration. Microfluidics and Nanofluidics 22:33
Esmond Lee, Zhong Ri Lim, Hong Yu-Chen, Bin Xia Yang, Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jaichandran Sivalingam, Shaul Reuveny, Yuin-Han Loh and Steve Kah-Weng Oh (2018) Defined serum free medium for bioreactor culture of an immortalized human erythroblast cell line. Biotechnology Journal 13(4): e1700567
K P Myu Mai Ja, Kee Pah Lim, Allen Chen, Sherwin Ting, Shi Qi Li, Nicole Tee, Chrishan Ramachandra, Ashish Mehta, Philip Wong, Steve Oh & Winston Shim (2018) Construction of a Vascularized Hydrogel for Cardiac Tissue Formation in a Porcine Model. Journal of Tissue Engineering and Regenerative Medicine 12(4): e2029-e2038
Na Gao, Ming Xia, Jingcheng Dai, Dianzhen Yu, Weixing An, Shuyang Li, Shuangyuan Liu, Penghui He, Liping Zhang, Zhenbin Wu, Xuezhi Bi, Shouwen Chen, Daniel H. Haft and Dongru Qiu (2018) Both widespread PEP-CTERM proteins and exopolysaccharides are required for floc formation of Zoogloea resiniphila and other activated sludge bacteria. Environmental Microbiology 20(5): 1677-1692
Xuezhi Bi, Lijuan Ye, Ally Lau, Yee Jiun Kok, Lu Zheng, Daniel Ng, Kelly Tan, Dave Ow, Edwin Ananta, Christina Vafiadi and Jeroen Muller (2018) Proteomic Profiling of Barley Spent Grains Guides Enzymatic Solubilization of the Remaining Proteins. Applied Microbiology and Biotechnology 102(9): 4159-4170
Andy Hee-Meng Tan, Arleen Sanny, Sze-Wai Ng, Ying-Swan Ho, Nurhidayah Basri, Alison Ping Lee & Kong-Peng Lam (2018) Excessive interferon-a signaling in autoimmunity alters glycosphingolipid processing in B cells. Journal of Autoimmunity 89: 53-62
Sarantos Kyriakopoulos, Kok Siong Ang, Meiyappan Lakshmanan, Zhuangrong Huang, Seongkyu Yoon, Rudiyanto Gunawan and Dong-Yup Lee (2018) Kinetic modelling of mammalian cell culture bioprocessing: the quest to advance biomanufacturing. Biotechnology Journal 13(3): e1700229
Shuai He, Yi Mon Ei Kyaw, Eddie Khay Ming Tan, Laurent Bekale, Malvin Wei Cherng Kang, Susana Soo-Yeon Kim, Ivan Tan, Kong-Peng Lam, and James Chen Yong Kah (2018) Quantitative and Label-Free Detection of Protein Kinase A Activity Based on Surface-Enhanced Raman Spectroscopy with Gold Nanostars. Analytical Chemistry 90(10): 6071-6080
Dawn Sow Zong Leong, Brian Kah Hui Teo, Janice Gek Ling Tan, Hayati Kamari, Yuan Sheng Yang, Peiqing Zhang and Say Kong Ng (2018) Application of maltose as energy source in protein-free CHO-K1 culture to improve the production of recombinant monoclonal antibody. Scientific Reports 8(1): 4037
Xijun Ou, Jianxin Huo, Yanfeng Li, Shengli Xu and Kong-Peng Lam (2018) Transcription factor YY1 is essential for iNKT cell development. Cellular & Molecular Immunology (Published Online)
Pranjul Mishra, Na-Rae Lee, Meiyappan Lakshmanan, Minsuk Kim, Byung-Gee Kim and Dong-Yup Lee (2018) Genome-scale model-driven strain design for dicarboxylic acid production in Yarrowia lipolytica. BMC Systems Biology 12(Suppl 2): 12
Kian Ping Chan, Sheng-Hao Chao, and James Chen Yong Kah (2018) Universal mRNA Translation Enhancement with Gold Nanoparticles Conjugated to Oligonucleotides with a Poly(T) Sequence. ACS Applied Materials & Interfaces 10(6): 5203-5212
David Hutchinson, Judith Müller, Joseph E McCarthy, Yurii K Gun’ko, Navin Kumar Verma, Xuezhi Bi, Luisana Di Cristo, Laura Kickham, Dania Movia, Adriele Prina-Mello & Yuri Volkov (2018) Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 13: 441–449
Sung Kyu Jang, Sookyung Kim, Muhammad Saad Salman, Ji-ryang Jang, Yu Mi Um, Lihan Tan, Jin-Hong Park, Woo-Seok Choe, and Sungjoo Lee (2018) Harnessing Recombinant DnaJ Protein as Reversible Metal Chelator for a High-Performance Resistive Switching Device. Chemistry of Materials 30(3): 781–788
Justin Bryan Goh and Ng Say Kong (2018) Impact of host cell line choice on glycan profile. Critical Reviews in Biotechnology (Published Online)
Congqiang Zhang, Xixian Chen, Nic D. Lindley, Heng-Phon Too (2018) A "plug-n-play" modular metabolic system for the production of apocarotenoids. Biotechnology and Bioengineering 115(1): 174-183

Muhammad Saad Salman, A Reum Park, Min Jin Cha, Youngjin Choi, Sung Kyu Jang, Lihan Tan, Pil J. Yoo and Woo-Seok Choe (2017) Lysozyme-templated Meso-macroporous Hollow TiO2 for Lithium-ion Battery Anode. ACS Applied Nano Materials 1(2): 698–710
TingDong Yan, Wen Fong Ooi, Aditi Qamra, Alice Cheung, DongLiang Ma, Gopinath Meenakshi Sundaram, Chang Xu, Manjie Xing, LaiFong Poon, Jing Wang, Yan Ping Loh, Jess Hui Jie Ho, Joscelyn Jun Quan Ng, Muhammad Khairul Ramlee, Luay Aswad, Steve G. Rozen, Sujoy Ghosh, Frederic A. Bard, Prabha Sampath, Vinay Tergaonkar, James O.J. Davies, Jim R. Hughes, Eyleen Goh, Xuezhi Bi, Melissa Jane Fullwood, Patrick Tan & Shang Li (2017) HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis. Nature Communication 9(1): 100
Pei-Yu Lim, Lee Ling Tan, Dave Siak-Wei Ow and Fong T. Wong (2017) A propeptide toolbox for secretion optimization of Flavobacterium meningosepticum endopeptidase in Lactococcus lactis. Microbial Cell Factories 16(1): 221
Shu Hui Neo, Ka Yan Chung, Jia Min Quek & Heng-Phon Too (2017) Trehalose significantly enhances the recovery of serum and serum exosomal miRNA from a paperbased matrix. Scientific Reports 7(1): 16686
Miran Rada, Mohammad Althubiti, Akang E. Ekpenyong-Akiba, Koon-Guan Lee, Kong Peng Lam, Olga Fedorova, Nickolai A. Barlev and Salvador Macip (2017) BTK blocks the inhibitory effects of MDM2 on p53 activity. Oncotarget 8(63): 106639-106647
Jung-Hyun Kim, Andreas Kurtz, Bao-Zhu Yuan, Fanyi Zeng, Geoff Lomax, Jeanne F. Loring, Jeremy Crook, Ji Hyeon Ju, Laura Clarke, Maneesha S. Inamdar, Martin Pera, Meri T. Firpo, Michael Sheldon, Nafees Rahman, Orla O’Shea, Patricia Pranke, Qi Zhou, Rosario Isasi, Ruttachuk Rungsiwiwut, Shin Kawamata, Steve Oh, Tenneille Ludwig, Tohru Masui, Thomas J. Novak, Tsuneo Takahashi, Wataru Fujibuchi, Soo Kyung Koo, Glyn N. Stacey (2017) Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. STEM CELLS Translational Medicine (Published Online)
Zhuangrong Huang, Dong-Yup Lee and Seongkyu Yoon (2017) Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures. Biotechnology and Bioengineering 114 (12): 2717-2728
Eun Sung Jung, Hye Min Park, Seung Min Hyun, Jong Cheol Shon, Meiyappan Lakshmanan, Minsoo Noh, Hock Chuan Yeo, Kwang‑Hyeon Liu, Dong‑Yup Lee, Jae Sung Hwang and Choong Hwan Lee (2017) Integrative metabolomic analysis reveals diet supplementation with green tea alleviates UVB-damaged mouse skin correlated with ascorbate metabolism and urea cycle. Metabolomics 13(7): 82
Lokanand Koduru, Yujin Kim, Jeongsu Bang, Meiyappan Lakshmanan, Nam Soo Han & Dong-Yup Lee (2017) Genome-scale modeling and transcriptome analysis of Leuconostoc mesenteroides unravel the redox governed metabolic states in obligate heterofermentative lactic acid bacteria. Scientific Reports 7(1): 15721
Congqiang Zhang, Xixian Chen, Nic D. Lindley, Heng-Phon Too (2018) A "plug-n-play" modular metabolic system for the production of apocarotenoids. Biotechnology and Bioengineering 115(1): 174-183
Asja T. Moerkamp, Hau Wan Leung, Noortje A.M. Bax, Stephanie Holst, Kirsten Lodder, Thijs Berends, Calinda K.E. Dingenouts, Andre Choo, Anke M. Smits and Marie‐Jose Goumans (2017) Glycosylated cell surface markers for the isolation of human cardiac progenitors. Stem Cells and Development 26(21): 1552-1565
Liau B, Tan B, Teo G, Zhang P, Choo A, Rudd P.M (2017) Shotgun Glycomics Identifies Tumor-Associated Glycan Ligands Bound by an Ovarian Carcinoma-Specific Monoclonal Antibody. Scientific Reports 7(1): 14489
Lynn Y. W. Yap, Sadasivam Murali, Gajadhar Bhakta, Drew M. Titmarsh, Allen Kuan-Liang Chen, Lyn Chiin Sim, Muriel Bardor, Yu Ming Lim, James C.H. Goh, Steve K.W. Oh, Andre B.H. Choo, Andre J. van Wijnen, David E. Robinson, Jason D. Whittle, William R. Birch, Robert D. Short, Victor Nurcombe, Simon M. Cool (2017) Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells. Journal of Biomedical Materials Research Part B: Applied Biomaterials (Published Online)
Han Kee Ong, Benjamin P.C. Soo, Kai Ling Chu, and Sheng-Hao Chao (2017) XBP-1, a cellular target for the development of novel anti-viral strategies. Current Protein & Peptide Science (Published Online)
Woei-Yuh Saw, Erwin Tantoso, Husna Begum, Lihan Zhou, Ruiyang Zou, Cheng He, Sze Ling Chan, Linda Wei-Lin Tan, Lai-Ping Wong, Wenting Xu, Don Kyin Nwe Moong, Yenly Lim, Bowen Li, Nisha Esakimuthu Pillai, Trevor A. Peterson, Tomasz Bielawny, Peter J. Meikle, Piyushkumar A. Mundra, Wei-Yen Lim, Ma Luo, Kee-Seng Chia, Rick Twee-Hee Ong, Liam R. Brunham, Chiea-Chuen Khor, Heng Phon Too, Richie Soong, Markus R. Wenk, Peter Little & Yik-Ying Teo (2017) Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study. Nature Communications 8(1): 653
Jessna H.M. Yeo, Steven C.L. Ho, Susanto Woen, Mariati, Esther Koh, Tay Shi Jie, Peiqing Zhang, Yuansheng Yang (2017) Optimized selection marker and CHO host cell combinations for generating high monoclonal producing cell lines. Biotechnology Journal (Published Online)
Jian'er Lin, Shu Hui Neo, Steven C. L. Ho, Jessna H. M. Yeo, Tianhua Wang, Wei Zhang, Xuezhi Bi, Sheng-Hao Chao and Yuansheng Yang (2017) Impact of Signal Peptides on Furin-2A Mediated Monoclonal Antibody Secretion in CHO Cells. Biotechnology Journal 12: 9
Benjamin P.C. Soo, Julian Tay, Shirelle Ng, Steven C.L. Ho, Yuansheng Yang, and Sheng-Hao Chao (2017) Correlation between expression of recombinant proteins and abundance of H3K4Me3 on the enhancer of human cytomegalovirus major immediate-early promoter. Molecular Biotechnology 59(8): 315-322
Sally S. L. Yap, Terry Nguyen-Khuong, Pauline M. Rudd and Sylvie Alonso (2017) Dengue Virus Glycosylation: What Do We Know?. Frontiers in Microbiology 8: 1415
Damiano Piovesan, Ian Walsh, Giovanni Minervini and Silvio C. E. Tosatto (2017) FELLS: fast estimator of latent local structure. Bioinformatics 33(12): 1889-1891
Jianxin Huo, Yuhan Huang, Shengli Xu and Kong-Peng Lam (2017) Analysis of signaling events in B-1a cells. Methods in Molecular Biology 1643: 75-83
Lifeng Qiu, Mei-Chih Liao, Allen K. Chen, Shunhui Wei, Shaoping Xie, Shaul Reuveny, Zhi Dong Zhou, Walter Hunziker, Eng King Tan, Steve K.W. Oh and Li Zeng (2017) Immature Midbrain Dopaminergic Neurons Derived from Floor-Plate Method Improve Cell Transplantation Therapy Efficacy for Parkinson’s Disease. Stem Cells Translational Medicine (Published Online)
Faraaz Noor Khan Yusufi, Meiyappan Lakshmanan, Ying Swan Ho, Bernard Liat Wen Loo, Pramila Ariyaratne, Yuansheng Yang, Say Kong Ng, Tessa Rui Min Tan, Hock Chuan Yeo, Hsueh Lee Lim, Sze Wai Ng, Ai Ping Hiu, Chung Ping Chow, Corrine Wan, Chen Shuwen, Gavin Teo, Gao Song, Ju Xin Chin, Xiaoan Ruan, Ken Wing Kin Sung, Wei-Shou Hu, Miranda Gek Sim Yap, Muriel Bardor, Niranjan Nagarajan and Dong-Yup Lee (2017) Mammalian systems biotechnology reveals global cellular adaptations in a recombinant CHO cell line. Cell Systems 4(5): 530-542.e6
Youshan Melissa Lin, Jialing Lee, Jessica Fang Yan Lim, Mahesh Choolani, Jerry Kok Yen Chan, Shaul Reuveny and Steve Kah Weng Oh (2017) Critical attributes of human early mesenchymal stromal cells-laden microcarrier constructs for improved chondrogenic differentiation. Stem Cell Research & Therapy 8: 93
Matthew S. F. Choo, Vanessa Ding, Heng Liang Tan, Brian Liau, Lauren Hartley-Tassell, Roberto Castangia, Omar Belgacem, Stuart M. Haslam, Anne Dell and Andre B. H. Choo (2017) Characterization of H Type 1 and Type 1 N-acetyllactosamine glycan epitopes on ovarian cancer specifically recognized by the anti-glycan monoclonal antibody mAb-A4. Journal of Biological Chemistry 292(15): 6163-6176
Yiu-Wing Kam, Cheryl Yi-Pin Lee, Teck-Hui Teo, Shanshan W. Howland, Siti Naqiah Amrun, Fok-Moon Lum, Peter See, Nicholas Qing-Rong Kng, Roland G. Huber, Mei-Hui Xu, Heng-Liang Tan, Andre Choo, Sebastian Maurer-Stroh, Florent Ginhoux, Katja Fink, Cheng-I Wang, Lisa F.P. Ng, and Laurent Rénia (2017) Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections. JCI Insight 2(8): e92428
Yoon Khei Ho, Li Han Zhou, Kam C. Tam, Heng Phon Too (2017) Enhanced non-viral gene delivery by coordinated endosomal release and inhibition of β-tubulin deactylase. Nucleic Acids Research (Published Online)
Kian Ping Chan, Yang Gao, Jeremy Xianwei Goh, Dewi Susanti, Eugenia Li Ling Yeo, Sheng-Hao Chao and James Chen Yong Kah (2017) Exploiting the Protein Corona on DNA Functionalized Gold Nanoparticles for Enhanced mRNA Translation. ACS Applied Materials & Interfaces 9(12): 10408-10417
Dawn Sow Zong Leong, Janice Gek Ling Tan, Christine Lin Chin, Shi Ya Mak, Ying Swan Ho and Say Kong Ng (2017) Evaluation and use of disaccharides as energy source in protein-free mammalian cell cultures. Scientific Reports Scientific Reports 7: 45216
Jian Li, Alan Tin-Lun Lam, Jessica Pei Wen Toh, Shaul Reuveny, Steve Kah-Weng Oh and William R. Birch (2017) Tunable Volumetric Density and Porous Structure of Spherical Poly-ɛ-caprolactone Microcarriers, as Applied in Human Mesenchymal Stem Cell Expansion. Langmuir 33(12): 3068–3079
Alan Tin-Lun Lam, Jian Li, Jessica Pei-Wen Toh, Eileen Jia-Hui Sim, Allen Kuan-Liang Chen, Jerry Kok-Yen Chan, Mahesh Choolani, Shaul Reuveny, William R. Birch and Steve Kah-Weng Oh (2017) Biodegradable poly-ε-caprolactone microcarriers for efficient production of human mesenchymal stem cells and secreted cytokines in stirred bioreactors. Cytotherapy 19(3): 419-432
Han Bin Pek, Pei Yu Lim, Chengcheng Liu, Dong-Yup Lee, Xuezhi Bi, Fong Tian Wong, Dave Siak-Wei Ow (2017) Cytoplasmic expression of a thermostable invertase from Thermotoga maritima in Lactococcus lactis. Biotechnology Letters (Published Online)
Ying Swan Ho, Lian Yee Yip, Nurhidayah Basri, Vivian Su Hui Chong, Chin Chye Teo, Eddy Tan, Kah Ling Lim, Gek San Tan, Xulei Yang, Si Yong Yeo, Mariko Si Yue Koh, Anantham Devenand, Angela Takano, Daniel Shao Weng Tan and Tony Kiat Hon Lim (2017) Lipidomic Profiling of Lung Pleural Effusion Identifies Unique Metabotype for EFGR-Mutants in Non-Small Cell Lung Cancer. Scientific Reports 6: 35110
Jinjia Wang, Xiaolong Wang, Lei Shi, Fei Qi, Ping Zhang, Yuanxing Zhang, Xiangshan Zhou, Zhiwei Song & Menghao Cai (2017) Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris. Scientific Reports 7: 41850
Janice H.C. Plani-Lam, Neli S. Slavova-Azmanova, Nicole Kucera, Alison Louw, Jiulia Satiaputraa, Peter Singer, Kong-Peng Lam, Margaret L. Hibbs, and Evan Ingley (2017) Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity. Experimental Hematology 46: 70-82.e10
Jiyun Zheng, Tan Heng Liang, Paul Matsudaira and Andre Choo (2017) Excess reactive oxygen species production mediates monoclonal antibody-induced human embryonic stem cell death via oncosis. Cell Death and Differentiation 1–13
Yun Sun Lee, Hyun-Seung Park, Dong-Kyu Lee, Murukarthick Jayakodi, Nam-Hoon Kim, Sang-Choon Lee, Atreyee Kundu, Dong-Yup Lee, Young Chang Kim, Jun Gyo In, Sung Won Kwon and Tae-Jin Yang (2017) Comparative analysis of the transcriptomes and primary metabolite profiles of adventitious roots of five Panax ginseng cultivars. Journal of Ginseng Research 41(1): 60-68
Maximilian Klement, Jiyun Zheng, Chengcheng Liu, Victor Vai-Tak Wong, Andre Boon-Hwa Choo, Dong-Yup Lee, and Dave Siak-Wei Ow (2017) Antibody engineering of a cytotoxic monoclonal antibody 84 against human embryonic stem cells: Investigating the effects of multivalency on cytotoxicity. Journal of Biotechnology 243: 29–37
Yan-Feng Li, Shengli Xu, Yuhan Huang, Xijun Ou & Kong-Peng Lam (2016) Tyrosine kinase c-Abl regulates the survival of plasma cells. Scientific Reports 7: 40133

Katrin Weinhandl, Melanie Ballach, Margit Winkler, Mudassar Ahmad, Anton Glieder, Ruth Birner-Gruenberger, Ian Fotheringham, Franck Escalettes, Andrea Camattari (2017) Pichia pastoris mutants as host strains for efficient secretion of recombinant branched chain aminotransferase (BCAT). Journal of Biotechnology 235: 84-91
Ian Walsh, Sophie Zhao, Matthew Campbell, Christopher H Taron, Pauline M Rudd (2016) Quantitative profiling of glycans and glycopeptides: an informatics' perspective. Current Opinion in Structural Biology 40: 70-80
Quan Chen, Phyllicia Toh, Aina Hoi, Mo Xian, Xinying Peng, Yuansheng Yang, Haibo Zhang, Rui Nian, and Wei Zhang (2016) Improved protein-A chromatography for monoclonal antibody purification. Chinese Journal of Biotechnology 32(6): 1−12
Meiyappan Lakshmanan, C. Y. Maurice Cheung, Bijayalaxmi Mohanty and Dong-Yup Lee (2016) Modeling rice metabolism: from elucidating environmental effects on cellular phenotype to guiding crop improvement. Frontiers in Plant Science 7: 1795
Hooman Hefz, Kok Siong Ang, Michael Hanscho, Aarash Bordbar, David Ruckerbauer, Meiyappan Lakshmanan, Camila A. Orellana, Deniz Baycin-Hizal, Yingxiang Huang, Daniel Ley, Veronica S. Martinez, Sarantos Kyriakopoulos, Natalia E. Jime´nez, Daniel C. Zielinski, Lake-Ee Quek, Tune Wulff, Johnny Arnsdorf, Shangzhong Li, Jae Seong Lee, Giuseppe Paglia, Nicolas Loira, Philipp N. Spahn, Lasse E. Pedersen, Jahir M. Gutierrez, Zachary A. King, Anne Mathilde Lund, Harish Nagarajan, Alex Thomas, Alyaa M. Abdel-Haleem, Juergen Zanghellini, Helene F. Kildegaard, Bjørn G. Voldborg, Ziomara P. Gerdtzen, Michael J. Betenbaugh, Bernhard O. Palsson, Mikael R. Andersen, Lars K. Nielsen, Nicole Borth, Dong-Yup Lee, and Nathan E. Lewis (2016) A consensus genome-scale reconstruction of CHO cell metabolism for improved biotherapeutic protein production. Cell Systems 3(5): 434-443
Steven C. L. Ho, Esther Y. C. Koh, Benjamin P. C. Soo, Mariati, Sheng-Hao Chao and Yuansheng Yang (2016) Evaluating the use of a CpG free promoter for long-term recombinant protein expression stability in Chinese hamster ovary cells. BMC Biotechnology 16: 71
Asha Shekaran, Alan Lam, Eileen Sim, Lee Jialing, Li Jian, Jessica Toh Pei Wen, Jerry Kok Yen Chan, Mahesh Choolani, Shaul Reuveny, William Birch and Steve Oh (2016) Biodegradable ECM-Coated PCL Microcarriers Support Scalable Human Early MSC Expansion and in vivo Bone Formation. Cytotherapy 18(10): 1332-1344
Steven C.L. Ho, Rui Nian, Susanto Woen, Jake Chng, Peiqing Zhang and Yuansheng Yang (2016) Impact of hydrolysates on monoclonal antibody productivity, purification and quality in Chinese hamster ovary cells. Journal of Bioscience and Bioengineering 122(4): 499–506
Minsuk Kim, Gwanggyu Sun, Dong-Yup Lee and Byung-Gee Kim (2016) BeReTa: a systematic method for identifying target transcriptional regulators to enhance microbial production of chemicals. Bioinformatics (Published Online)
Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb, Koon-Guan Lee, Kong-Peng Lam, George D.D. Jones, Nickolai A. Barlev, and Salvador Macip (2016) BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses. Cancer Research 76(18): 5405-5414
Quan Chen, Phyllicia Toh, Yue Sun, Sarah Maria Abdul Latiff,Aina Hoi, Mo Xian, Haibo Zhang, Rui Nian, Wei Zhang and Pete Gagnon (2016) Histone-dependent IgG conservation in octanoic acid precipitation and its mechanism. Applied Microbiology and Biotechnology (Published Online)
Andrea Camattari, Amelia Goh, Lian Yee Yip, Gaowen Liu, Ivan Liachko, Maitreya J. Dunham and Giulia Rancati (2016) Characterization of a panARS-based episomal vector in the methylotrophic yeast Pichia pastoris for recombinant protein production and synthetic biology applications. Microbial Cell Factories 15(1): 139
Jaichandran Sivalingam, Alan Tin-Lun Lam, Hong Yu Chen, Bin Xia Yang, Allen Kuan-Liang Chen, Shaul Reuveny, Yuin-Han Loh and Steve Kah-Weng Oh (2016) Superior red blood cell generation from human pluripotent stem cells via a novel microcarrier based embryoid body platform. Tissue Engineering Part C: Methods 22(8): 765-780
Beate Hintersteiner, Nico Lingg, Peiqing Zhang, Susanto Woen, Kong Meng Hoi, Stefan Stranner, Susanne Wiederkum, Oliver Mutschlechner, Manfred Schuster, Hans Loibner and Alois Jungbauer (2016) Charge heterogeneity: basic antibody charge variants with increased binding to Fc receptors. mAbs 8(8): 1548-1560
Nan Yu, Jin-Su Kang, Chung-Chuan Chang, Tai-Yong Lee and Dong-Yup Lee (2016) Robust economic optimization and environmental policy analysis for microgrid planning: An application to Taichung Industrial Park, Taiwan. Energy 113: 671-682
Quan Chen, Sarah Maria Abdul Latiff, Phyllicia Toh, Xinying Peng, Aina Hoi, Mo Xian, Haibo Zhang, Rui Nian, Wei Zhang and Pete Gagnon (2016) A simple and efficient purification platform for monoclonal antibody production based on chromatin-directed cell culture clarification integrated with precipitation and void-exclusion anion exchange chromatography. Journal of Biotechnology 236: 128–140
Hock Chuan Yeo, Sherwin Ting, Romulo Martin Brena, Geoffrey Koh, Allen Chen, Siew Qi Toh, Yu Ming Lim, Steve Kah Weng Oh and Dong-Yup Lee (2016) Genome-Wide Transcriptome and Binding Sites Analyses Identify Early FOX Expressions for Enhancing Cardiomyogenesis Efficiency of hESC Cultures. Scientific Reports 6: 31068
Chang-Yien Chan, Isaac Desheng Liu, Lourdes Paula Resontoc, Kar-Hui Ng, Yiong-Huak Chan, Perry Yew-Weng Lau, Mya Than, Stanley C. Jordan, Kong-Peng Lam, Wee-Song Yeo, and Hui-Kim Yap (2016) T-lymphocyte activation markers as predictors of responsiveness to Rituximab among patients with FSGS. Clinical Journal of the American Society of Nephrology 11(8): 1360-1368
Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani, Wei Hseun Yeap, Peter See Chi Ee, Boris San Luis, Bernett Lee, Terence Lee, Shi Ya Mak, Ying Swan Ho, Kong Peng Lam, Choon Kiat Ong, Ruby Y. J. Huang, Florent Ginhoux, Olaf Rotzschke, Roger D. Kamm, and Siew Cheng Wong (2016) Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology 5(8): e1191731
Rui Nian and Pete Gagnon (2016) Advance chromatin extraction enhances performance and productivity of cation exchange chromatography-based capture of Immunoglobulin G monoclonal antibodies. Journal of Chromatography A 1453: 54–61
Yan-Feng Li, Xijun Ou, Shengli Xu, Zi-Bing Jin, Naoharu Iwai, and Kong-Peng Lam (2016) Loss of miR-182 affects B-cell extrafollicular antibody response. Immunology 148(2): 140-149
Bijayalaxmi Mohanty, Meiyappan Lakshmanan, Sun-Hyung Lim, Jae Kwang Kim, Sun-Hwa Ha, and Dong-Yup Lee (2016) Light-specific transcriptional regulation of the accumulation of carotenoids and phenolic compounds in rice leaves. Plant Signalling & Behavior 11(6): e1184808
Neil Swainston, Kieran Smallbone, Hooman Hefzi, Paul D. Dobson, Judy Brewer, Michael Hanscho, Daniel C. Zielinski, Kok Siong Ang, Natalie J. Gardiner, Jahir M. Gutierrez, Sarantos Kyriakopoulos, Meiyappan Lakshmanan, Shangzhong Li, Joanne K. Liu, Veronica S. Martınez, Camila A. Orellana, Lake-Ee Quek, Alex Thomas, Juergen Zanghellini, Nicole Borth, Dong-Yup Lee, Lars K. Nielsen, Douglas B. Kell, Nathan E. Lewis and Pedro Mendes (2016) Recon 2.2: from reconstruction to model of human metabolism. Metabolomics 12(7): 109
Kok Siong Ang, Sarantos Kyriakopoulos, Wei Li and Dong-Yup Lee (2016) Multi-omics data driven analysis establishes reference codon biases for synthetic gene design in microbial and mammalian cells. Methods 102: 26-35
Pranjul Mishra, Gyu-Yeon Park, Meiyappan Lakshmanan, Hee-Seok Lee, Hongweon Lee, Matthew Wook Chang, Chi Bun Ching, Jungoh Ahn, Dong-Yup Lee (2016) Genome-scale metabolic modeling and in silico analysis of lipid accumulating yeast Candida tropicalis for dicarboxylic acid production. Biotechnology and Bioengineering (Published Online)
Youshan Melissa Lin, Jessica Fang Yan Lim, Jialing Lee, Mahesh Choolani, Jerry Kok Yen Chan, Shaul Reuveny, Steve Kah Weng Oh (2016) Expansion in microcarrier-spinner cultures improves the chondrogenic potential of human early mesenchymal stem cells. Cytotherapy 18: 740-753
Tomoya Fukawa, Benjamin Chua Yan-Jiang, Jason Chua Min-Wen, Elwin Tan Jun-Hao, Dan Huang, Chao-Nan Qian, Pauline Ong, Zhimei Li, Shuwen Chen, Shi Ya Mak, Wan Jun Lim, Hiro-omi Kanayama, Rosmin Elsa Mohan, Ruiqi Rachel Wang, Jiunn Herng Lai, Clarinda Chua, Hock Soo Ong, Ker-Kan Tan, Ying Swan Ho, Iain Beehuat Tan, Bin Tean Teh & Ng Shyh-Chang (2016) Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nature Medicine 22(6): 666-671
Chen Chen, Graziella El Khoury, Peiqing Zhang, Pauline M. Rudd, Christopher R. Lowe (2016) A carbohydrate-binding affinity ligand for the specific enrichment of glycoproteins. Journal of Chromatography A 1444: 8-20
Bijayalaxmi Mohanty, Ai Kitazumi, C.Y. Maurice Cheung, Meiyappan Lakshmanan, Benildo G. de los Reyes, In-Cheol Jang and Dong-Yup Lee (2016) Identification of candidate network hubs involved in metabolic adjustments of rice under drought stress by integrating transcriptome data and genome-scale metabolic network. Plant Science 242: 224-239
Minsuk Kim, Jeong Sang Yi, Meiyappan Lakshmanan, Dong-Yup Lee and Byung-Gee Kim (2016) Transcriptomics-based strain optimization tool for designing secondary metabolite overproducing strains of Streptomyces coelicolor. Biotechnology and Bioengineering 113(3): 651-660
Wee Siang Lim, Kevin Kai Siang Phang, Andy Hee-Meng Tan, Sam Fong-Yau Li, Dave Siak-Wei Ow (2016) Small colony variants and single nucleotide variations in Pf1 region of PB1 phage-resistant Pseudomonas aeruginosa. Frontiers in Microbiology 7: 282
Lifeng Qiu, Yu Ming Lim, Allen K Chen, Shaul Reuveny, Steve K.W. Oh, Eng King Tan, Li Zeng (2016) Microcarrier-expanded Neural Progenitor Cells can Survive, Differentiate, and Innervate Host Neurons Better when Transplanted as Aggregates. Cell Transplantation 25(7): 1343-1357
Jaichandran Sivalingam, Dimitar Kenanov, Hao Han, Ajit Johnson Nirmal, Wai Har Ng, Sze Sing Lee, Jeyakumar Masilamani, Toan Thang Phan, Sebastian Maurer-Stroh & Oi Lian Kon (2016) Multidimensional genome-wide analyses show accurate FVIII integration by ZFN in primary human cells. Molecular Therapy 24(3): 607-619
Tessa Rui Min Tan, Kong Meng Hoi, Peiqing Zhang, Say Kong Ng (2016) Characterization of a Polyethylene Glycol-Amphotericin B Conjugate Loaded with Free AMB for Improved Antifungal Efficacy. PLoS One 11(3): e0152112
Peiqing Zhang, Susanto Woen, Tianhua Wang, Brian Liau, Sophie Zhao, Chen Chen, Yuansheng Yang, Zhiwei Song, Mark R. Wormald, Chuanfei Yu and Pauline M. Rudd (2016) Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs. Drug Discovery Today 21(5): 740-765
Jianxin Huo, Yi Ma, Jian-Jun Liu, Ying Swan Ho, Sylvia Liu, Li Ying Soh, Shuwen Chen, Shengli Xu, Weiping Han, An Hong, Su Chi Lim, Kong-Peng Lam (2016) Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis. Cell Death and Disease 7: e2091
Pete Gagnon and Rui Nian (2016) Conformational plasticity of IgG during protein A affinity chromatography. Journal of Chromatography A 1433: 98-105
Shu Hui Neo, Qiao Jing Lew, Ser Mei Koh, Lu Zheng, Xuezhi Bi, and Sheng-Hao Chao (2016) Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. Oncotargets 7(5): 5483-5494
Rui Nian, Wei Zhang, Lihan Tan, Jeremy Lee, Xeuzhi Bi, Yuansheng Yang, Hui Theng Gan and Pete Gagnon (2016) Advance chromatin extraction improves capture performance of protein A affinity chromatography. Journal of Chromatography A 1431: 1-7

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