.png?sfvrsn=c3edc68e_6)
Qingfeng CHEN
Humanised mouse for disease modelling
PhD- Immunology, University of Science and Technology, China
Email: qchen@imcb.a-star.edu.sg
SUMMARY
Qingfeng Chen is a Senior Principal Investigator at the Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR) . He is also an Adjunct Associate Professor at the Department of Microbiology, Yong Loo Lin School of Medicine, NUS.
Qingfeng joined IMCB in 2012 to develop humanised mouse models for the study of human infectious diseases, cancers, autoimmune diseases and stem cells. In 2018, while at IMCB, he co-founded Invivocue, a bioscience company in Singapore, that aims to support medical and pharmaceutical research, from target discovery, validation to pre-clinical development, and eventually advancing to clinical trials, through its humanised rodent models.
Prior to his role at IMCB, Qingfeng joined the Singapore-MIT Alliance for Research and Technology (SMART) to pursue his postdoctoral research on developing humanised mouse models. In 2011, he was promoted as research scientist at SMART.
- 2021: Industry Alignment Fund - Industry Collaboration Projects (IAF-ICP)
- 2017: National Research Foundation (NRF) Fellowship
- 2014: A*STAR Joint Council Office Development Program
RESEARCH
- 2021 Industry Alignment Fund - Industry Collaboration Projects (IAF-ICP)
- 2017 National Research Foundation (NRF) Fellowship
- 2014 A*STAR Joint Council Office Development Program
PUBLICATIONS
- Towards a better preclinical cancer model – Human immune aging in humanized mice.
Tan JHL, Hwang YY, Chin HX, Liu M, Tan SY, Chen Q. (2023)
Immun Ageing. 2023 Sep 27;20(1):49. doi: 10.1186/s12979-023-00374-4. PMID: 37752597; PMCID: PMC10523735 - Successful targeting of PD-1/PD-L1 with chimeric antigen receptor-natural killer cells and nivolumab in a humanized mouse cancer model.
Liu WN, So WY, Harden SL, Fong SY, Wong MXY, Tan WWS, Tan SY, Ong JKL, Rajarethinam R, Liu M, Cheng JY, Suteja L, Yeong JPS, Iyer NG, Lim DW, Chen Q. (2022)
Sci Adv. 2022 Nov 25;8(47):eadd1187. doi: 10.1126/sciadv.add1187. Epub 2022 Nov 23. PMID: 36417514; PMCID: PMC9683725 - Analysis and validation of human targets and treatments using a hepatocellular carcinoma-immune humanized mouse model.
Zhao Y, Wang J, Liu WN, Fong SY, Shuen TWH, Liu M, Harden S, Tan SY, Cheng JY, Tan WWS, Chan JKY, Chee CE, Lee GH, Toh HC, Lim SG, Wan Y, Chen Q. (2021)
Hepatology. 2021 Sep;74(3):1395-1410. doi: 10.1002/hep.31812. PMID: 33738839; PMCID: PMC9540409 - Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy.
Zhao Y, Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y, Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE, Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q. (2018)
Gut. 2018 Oct;67(10):1845-1854. doi: 10.1136/gutjnl-2017-315201. Epub 2018 Mar 30. PMID: 29602780; PMCID: PMC6145285 - Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice.
Zhao Y, Liu M, Chan XY, Tan SY, Subramaniam S, Fan Y, Loh E, Chang KTE, Tan TC, Chen Q. (2017)
Blood. 2017 Nov 2;130(18):1995-2005. doi: 10.1182/blood-2017-04-778779. Epub 2017 Aug 29. PMID: 28851698 - Characterisation of liver pathogenesis, human immune responses and drug testing in a humanised mouse model of HCV infection.
Keng CT, Sze CW, Zheng D, Zheng Z, Yong KS, Tan SQ, Ong JJ, Tan SY, Loh E, Upadya MH, Kuick CH, Hotta H, Lim SG, Tan TC, Chang KT, Hong W, Chen J, Tan YJ, Chen Q. (2016)
Gut. 2016 Oct;65(10):1744-53. doi: 10.1136/gutjnl-2014-307856. Epub 2015 Jul 6. PMID: 26149491; PMCID: PMC5036242
A*STAR celebrates International Women's Day
From groundbreaking discoveries to cutting-edge research, our researchers are empowering the next generation of female science, technology, engineering and mathematics (STEM) leaders.
Get inspired by our #WomeninSTEM