Sudipto ROY

Sudipto Roy is a Senior Principal Investigator at  at the Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR). He is also an Adjunct Associate Professor with the Department of Paediatrics of the National University of Singapore.

Sudipto  was trained as a developmental geneticist during his graduate studies, working on muscle and neuronal development with the fruit fly, Drosophila melanogaster. During his postdoctoral work at University of Sheffield, UK, he pivoted to vertebrate development, using the zebrafish as a model to understand mechanisms of Hedgehog signaling, and how this pathway regulates skeletal muscle development.

Sudipto’s  lab at the IMCB investigates the biology of cilia and flagella and the wide spectrum of human disorders that arise from dysfunction of these organelles. He uses genetic and cellular biological analyses with zebrafish and mouse models, as well as human embryonic stem cell-derived organoids and tissues, to tackle these questions. His lab has made seminal contributions towards our understanding of the transcriptional regulation of ciliary biogenesis and how mutations in genes encoding ciliary components cause diseases like polycystic kidney disease, brain developmental defects, congenital heart malformations and infertility. The current focus of the lab includes the study of the regulatory pathway that directs that differentiation of multiciliated cells, the role of cilia in cerebrospinal fluid flow and spine morphogenesis, the ciliary regulation of stem cell activity, neural development and neuronal signaling, cilia in sense organs and therapeutics for ciliary disorders.