Skin Disease

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Skin Disease affects nearly a quarter of the World’s population and ranks among the leading causes of disability, profoundly affecting quality of life. The Skin Disease Theme envisions transforming the lives of people with skin disease through mechanistic discoveries and research-driven therapeutics.

We generate deep biological insights grounded in patient samples, genetics and advanced skin models. Our mission is to elucidate pathophysiological mechanisms of skin disease and unlock novel pharmacological intervention points, enabling the development and translation of effective therapies that meaningfully improve patient outcomes.

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Inflammatory and Immune-Mediated Skin Diseases

We study chronic and relapsing inflammatory conditions driven by immune dysregulation, focusing on diseases such as atopic dermatitis, chronic hand eczema, contact hypersensitivity and delayed-type hypersensitivity. Our work aims to uncover immune pathways, epithelial-immune crosstalk and environmental triggers that contribute to disease persistence and treatment resistance.

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Skin Barrier, Repair and Regeneration

We investigate conditions where barrier integrity and tissue repair are compromised, including ichthyosis vulgaris and regenerative medicine. Research efforts focus on epidermal differentiation, stem cell dynamics and strategies to restore functional skin architecture.

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Fibrosis, Scarring and Matrix Disorders

We investigate diseases characterized by excessive extracellular matrix deposition and aberrant tissue remodelling, such as keloids, hypertrophic scars, scleroderma, morphea and cutaneous amyloidosis. By dissecting fibroblast biology, immune-stromal interactions and profibrotic signalling pathways, we aim to identify new antifibrotic targets and therapeutic approaches.

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Genetic, Rare and Metabolic Skin Diseases

Our research includes genodermatoses and metabolic skin disorders such as lipodystrophy, where genetic defects disrupt skin structure and systemic homeostasis. These rare diseases provide powerful models to understand fundamental skin biology and to develop targeted, mechanism-based interventions.

05 Skin Appendage Disorders Cancer

Skin Appendages Disorders and Cancer

We study disorders of skin appendages and malignancies, including hair loss, acne and skin cancers. Our research spans hair follicle biology, sebaceous gland function, tumour-microenvironment interactions and early disease detection, with the goal of enabling novel preventive and therapeutic strategies.