What is the POLARIS TGFBI Test?
The POLARISTMTGFBI (Transforming Growth Factor beta Induced) test is a genetic test designed to aid in the diagnosis and management of patients with Stromal Corneal Dystrophies (CDs) and to identify family members of TGFBI-mutated patients who may also be at risk for Corneal Dystrophy.
How Can it Benefit Me?
The test provides Stromal Corneal Dystrophy patients with a personalized diagnosis of TGFBI mutation status, facilitating downstream clinical care in order to improve future disease progression and selection of mutation-specific therapies.
Test results can also assist in genetic counseling of families with affected individuals, and pre-surgical risk assessment of these family members before any eye surgery.
The POLARISTMTGFBI genetic test is a product of the POLARIS program, a national initiative for introducing and embedding OMIC information into disease diagnosis and treatment in Singapore. Contributing parties to the POLARISTMTGFBI genetic test include the Singapore National Eye Centre (SNEC), Singapore Eye Research Institute (SERI), Singapore General Hospital (SGH), National University Hospital (NUHS) and the Genome Institute of Singapore (GIS). This test builds upon prior research performed at SNEC, investigating the genetic causes of CDs.