Dr Nicolas Gaudenzio
Dr Nicolas Gaudenzio
Adjunct Senior Principal Scientist
Research Themes: Neuroimmunology, mast cell biology, fetal-maternal interface
Biography
Dr Nico Gaudenzio is Research Director at the French national institute of health (Inserm), Entrepreneur and Chief Scientific Officer (CSO) at the biotech Genoskin (Toulouse FRA, Salem MA USA). Nico received a Master’s in bioengineering and a PhD in Immunology at the University of Toulouse, France and completed his postdoctoral training at the University of Stanford (CA USA). His work has contributed substantially to identifying molecular and cellular targets involved in allergic and non-allergic inflammation. Nico currently leads a large research program to investigate the role of neuroimmune interactions in health and disease. He is three times Laureate of the European Research Council and has received international prizes such as the ACTERIA Early Career Research Prize by the European Federation of Immunological Societies (EFIS) and the Rising Star Award by the International Union of Immunological Societies (IUIS).
Research Interests
The skin and mucous membranes of the respiratory and gastrointestinal tracts are highly innervated by sensory neurons. The main symptoms of inflammatory allergic disorders include itching, sneezing, coughing, and bowel dysmotility, which are closely linked to sensory neurons activation. We wish to bridge basic science with translational applications to uncover novel therapeutic targets for allergic and inflammatory diseases. By dissecting neuro-immune interactions at the molecular and cellular levels, our scientific goal is to identify key pathways that drive disease progression. Combining single-cell sequencing, computational imaging, genetic models and bioinformatics, we aim to translate these discoveries into potential interventions. To do so, we collaborate with clinicians, industrial partners and venture capitals to develop new therapies, including small molecules and biotherapies. Our ultimate goal is to restore immune-neuronal balance, offering new, effective treatments for patients with chronic allergic and inflammatory conditions.
Selected Publications
Serhan N, Abdullah NS, Gheziel N, Loste A, Ekren R, Labit E, Gonzalez AA, Oliva G, Tarot P, Petitfils C, Payros G, D’Avino P, Voisin A, Tinsley HFG, Gentek R, Brosseau C, Bodinier M, Reber LL, Val P, Akdis CA, Mitamura Y, Andiappan AK, Chan JKY, Ginhoux F, François A, Cénac N, Basso L, Gaudenzio N. Maternal stress triggers early-life eczema through fetal mast cell programming. Nature. 2025 Oct;646(8083):161–170. doi: 10.1038/s41586-025-09419-8. Epub 2025 Aug 27.
Scholaert M, Peries M, Braun E, Martin J, Serhan N, Loste A, Bruner A, Basso L, Chaput B, Merle E, Descargues P, Pagès E, Gaudenzio N. Multimodal profiling of biostabilized human skin modules reveals a coordinated ecosystem response to injected mRNA-1273 COVID-19 vaccine. Allergy. 2024 Dec;79(12):3341-3359. doi: 10.1111/all.16273. Epub 2024 Aug 19.
Tauber M*, Basso L*, Martin J*, Bostan L, Pinto MM, Thierry GR, Houmadi R, Serhan N, Loste A, Blériot C, Kamphuis JBJ, Grujic M, Kjellén L, Pejler G, Paul C, Dong X, Galli SJ, Reber LL, Ginhoux F, Bajenoff M, Gentek R, Gaudenzio N. Landscape of mast cell populations across organs in mice and humans. J Exp Med. 2023 Oct 2;220(10):e20230570. doi: 10.1084/jem.20230570. Epub 2023 Jul 18. Erratum in: J Exp Med. 2024 Feb 5;221(2):e2023057001172024c. doi: 10.1084/jem.2023057001172024c.
Scholaert M*, Houmadi R*, Martin J*, Serhan N*, Tauber M, Braun E, Basso L, Merle E, Descargues P, Viguier M, Lesort C, Chaput B, Kanitakis J, Jullien D, Livideanu CB, Lamant L, Pagès E, Gaudenzio Nc. 3D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System. Sci Adv. 2023 Jun 9;9(23):eadf9491. doi: 10.1126/sciadv.adf9491. Epub 2023 Jun 7.
Serhan N*, Basso L*, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ*, Gaudenzio N*c. House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation. Nat Immunol. 2019 Nov;20(11):1435-1443. doi: 10.1038/s41590-019-0493-z. Epub 2019 Oct 7.