Advancing Precision Medicine in Oncology through Strategic Partnerships
Transforming Cancer Diagnostics and Therapeutics with A*STAR and STCC

The objectives
Building a Robust Real-World Data Infrastructure for Precision Oncology
Enhancing Access to Genomic Profiling and Personalised Treatments
Accelerating Clinical Adoption of Precision Oncology Models

The impact
This precision oncology initiative has significantly improved early cancer detection and personalised treatment options. By leveraging A*STAR spinoffs like MiRXES, innovative diagnostics using miRNA are now available for early detection of gastric cancer, allowing clinicians to tailor treatments based on individual patient profiles and support more effective interventions. Additionally, the initiative has expanded genomic profiling capabilities for various cancers, thanks to contributions from Lucence. This enables precise detection of actionable mutations across a range of solid tumours and haematological malignancies, leading to targeted therapies that align with each patient’s unique cancer profile.
Furthermore, Lion TCR has made strides in developing novel immunotherapies, particularly for Hepatitis B-associated liver cancer. This focus on virus-related cancers represents a breakthrough in the field of immunotherapy, offering new hope to patients with limited treatment options and showcasing A*STAR's pioneering role in cancer treatment. Beyond these advancements, the project has established a national clinico-genomic cancer database, laying a strong foundation for Singapore’s future in precision oncology. By integrating real-world data into clinical research, the initiative accelerates the clinical adoption of precision oncology models, creating a sustainable ecosystem that enhances cancer care and research nationwide.
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