Centre for Genome Diagnostics (CDG)
The Centre for Genome Diagnostics (CDG) was established to co-develop genomic technologies for the nucleic acid-based therapeutics and diagnostics markets in collaboration with local enterprises.
Combining scientific expertise with state-of-the-art platforms, we provide end-to-end solutions from assay development and validation to commercialisation, accelerating the translation of research into real-world healthcare impact.
Key Services
- High-throughput transcriptome sequencing (designed for Drug-Seq and large-scale gene expression profiling)
- Viral Whole Genome Sequencing (WGS)
- Whole Genome Sequencing (WGS)
- Whole Exome Sequencing (WES)
- Whole Transcriptome Sequencing
- Exosomal RNA Sequencing
- High-quality lysate preparation with superior Ribosome-protected mRNA fragments (RPFs)
- High-quality DNA/RNA extraction for a wide range of biological samples (blood, tissues, FFPE tissues and organoids etc.)
- Custom assay development for qPCR (including multiplex) and LAMP Isothermal amplification, along with high-accuracy genotyping services
Key Applications
- Molecular Diagnostics
- Gene expression profiling
- Biomarker discovery
- Cell type characterisation
- Drug response studies
- Oncology companion diagnostics
- Pharmacogenomics testing
Key Equipment
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Image 1. NextSeq 550 System
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Image 2. MiSeq Platform
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Image 3. abSEQ
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Image 4. SeqStudio Genetic Analyzer
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Image 5.MGI SP-960 (fully automated sample preparation system with a 96-channel pipette, supporting WES, WGS and RNS library workflows)
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Image 6. QIAcuity One (digital PCR)
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Image 7. CFX96 Real-time PCR
Our People
Team Image for Centre for Genome Diagnostics (CGD)
Dr Alexander Lezhave (middle) is a leader in translational diagnostics, molecular genomics and precision medicine at the Genome Institute of Singapore (GIS). As the head of the Centre for Genome Diagnostics (CGD), he drives the translation of cutting-edge scientific discoveries into impactful clinical solutions, advancing personalised healthcare across Singapore and the region. Through his leadership, innovative diagnostic technologies move seamlessly from research to real-world application, improving patient care and disease management.