A*STAR SIFBI × ScaleUp Bio

Scale with Confidence

The Fermentation Joint Lab helps companies develop scalable and economical bioprocesses—connecting bench-scale optimisation, pilot validation and commercial manufacturing through one integrated partnership.

A*STAR SIFBI × ScaleUp Bio
Bench to commercial
Develop · Validate · Scale
2 x 100 L
Pilot fermentation capacity
30+
Projects supported
10,000 L
Demonstrated industrial scale
70–90%
Operational utilisation

An Integrated Scale-Up Pathway

One process. Three connected scales.

 

Progress from early process development to industrial transfer with fewer handovers, clearer scale-up decisions and access to complementary SIFBI and ScaleUp Bio infrastructure.

01
Development scale
0.5–5 L

Bench development

→

Rapidly screen operating conditions, optimise media and generate the process understanding needed for successful scale-up.

A*STAR SIFBI
02
Pilot scale
Up to 200 L

Pilot validation

→

Validate aerobic, anaerobic and continuous fermentation processes under food-grade, industry-relevant operating conditions.

A*STAR SIFBI x ScaleUp Bio
03
Industrial scale
Up to 10,000 L

Industrial transfer

✓

Transfer a robust and validated process to ScaleUp Bio’s commercial facility for larger-scale demonstration and manufacturing.

ScaleUp Bio
Our Differentiator
One connected pathway
 

The same integrated partnership supports your process across development, pilot validation and commercial transfer—preserving process knowledge, reducing rework and preparing for manufacturing from the outset.

Core Capabilities

Optimise the whole bioprocess

 

Our teams connect fermentation development with downstream recovery, purification and drying so that performance is considered across the complete value chain.

Upstream
Fermentation development

Robust processes built for scale

Media and parameter optimisation, enzymatic bioprocess design, in-process analytics, solid-state fermentation and aerobic, anaerobic or continuous operation.

 
16 × 0.5 L parallel reactors
1.5 L and 5 L development systems
4 × 10 L and 2 × 100 L fermenters
Downstream
Recovery and purification

From culture to high-value ingredient

Design an efficient downstream sequence for separation, disruption, concentration, purification, extraction and drying—adapted to the product and production organism.

 
Disc-stack and decanter centrifugation Depth and cross-flow filtration Cell disruption and homogenisation Tangential flow filtration Liquid–liquid extraction Chromatography and purification Spray drying and freeze drying DSP for small molecules, proteins and lipids
End-to-End Optimisation
Upstream and downstream, designed together
 

Fermentation performance is evaluated alongside recovery yield, product quality and process economics—helping create a complete bioprocess that is technically robust and commercially relevant.

Application Areas

A flexible platform for diverse products

 

The joint lab supports multiple organisms, product classes and commercial pathways across food, nutrition and the wider bioeconomy.

01
 

Microbial biomass

Develop efficient cultivation and recovery processes for yeast, fungi, bacteria and other production organisms.

Yeast Fungi Bacteria
02
 

Functional ingredients

Scale the production of proteins, lipids, bioactives, flavours and other nutrition-focused ingredients.

Proteins Lipids Bioactives Flavours
03
 

Enzymatic bioprocesses

Design, optimise and intensify enzyme-enabled processes with fit-for-purpose process analytics.

Enzyme-enabled Process intensification Analytics
04
 

Industrial biotechnology

Adapt the platform for consumer care, industrial biotechnology and selected bioeconomy applications.

Consumer care Industrial biotechnology Wellness solution

Work With Us

Bring us your scale-up challenge

Whether you are optimising a new fermentation process, resolving a downstream bottleneck or preparing for commercial transfer, our team can help define the next practical step.

Process development Pilot validation Downstream processing Commercial transfer
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