A*STAR Bioinformatics Institute (BII)
The A*STAR Bioinformatics Institute (BII) was set up by the Agency for Science, Technology and Research (A*STAR) in July 2001; it was re-launched with a strong scientific program in 2007. Located in the Biopolis in Singapore, A*STAR BII is conceived as the computational biology research and postgraduate training institute as well as a national resource centre in bioinformatics within the Biomedical Research Council (BMRC) of A*STAR.
The A*STAR Bioinformatics Institute (BII) aims to understand the biomolecular mechanisms that underlie biomedical phenomena by developing sophisticated computational methods to support this discovery process from a secure and sustainable data hub to cross-disciplinary AI/ML analysis and data integration. We analyse a wide spectrum of biological and clinical data, including omics data (biomolecular sequences, expression profiles, epigenetics data), 3D structures of macromolecules, and biological tissue and macroscopic images from local and international academic, hospital and industry collaborators, public resources and from our own experiments. Our applied research diversifies into infectious diseases, computational toxicology, natural product research, precision medicine, cancer research, and drug discovery.
Research Divisions
Biomolecular Sequence to Functions
Biomolecular Structure to Mechanism
Cellular Image Informatics
Biomedical Data Hub
Upcoming Events
Friday, 10 October 2025
BII Seminar: AI and Statistical Models for Guiding Rational Hepatitis C Vaccine Design
Bioinformatics Institute (BII) would like to invite you to attend the following seminar:
Speaker : Dr. Ahmed Quadeer, Senior Research Fellow, University of Melbourne
Host : Dr Sebastian Maurer-Stroh
Tuesday, 14 October 2025
BII Seminar: Sex Effects on Different Layers of the Transcriptome
Bioinformatics Institute (BII) would like to invite you to attend the following seminar:
Speaker : Dr. Emanuele Marchi, Senior Clinical Bioinformatician, University of Oxford
Tuesday, 22 July 2025
BII Seminar: The 5th Paradigm: AI-driven Life Science for Personalized Cancer Vaccine
Speaker : Prof. Xiaolin Andy Li, Chief AI Scientist, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
Title : The 5th Paradigm: AI-driven Life Science for Personalized Cancer Vaccine
Meeting ID : 988 9762 3489
Passcode : 263316
Wednesday, 23 July 2025
BII Seminar: “Bigger is Not Always Better” – Debunking Myths in Computational Chemistry
Speaker : Dr Junming Ho, School of Chemistry, University of South Wales
Title : “Bigger is Not Always Better” – Debunking Myths in Computational Chemistry
Thursday, 21 August 2025
BII Seminar: Combating data and target shifts in visual tasks: Linking medical applications to generalization theories
Speaker : Dr Tan Zhaorui, Computer Science, Facility of Science & Engineering, University of Liverpool
Title : Combating data and target shifts in visual tasks: Linking medical applications to generalization theories
Meeting ID : 917 1469 6202
Passcode : 754331
Monday, 18 August 2025
BII Seminar: Translating AI Research into Scalable Ventures: Lessons from the Lab, the Startup, and the Boardroom
Speaker : Prof. Lawrence Carin, Professor of Engineering, Duke University
Title : Translating AI Research into Scalable Ventures: Lessons from the Lab, the Startup, and the Boardroom
Meeting ID : 950 0105 7908
Passcode : 558120
Monday, 29 September 2025
BII Webinar: Designing generative AI models for drug discovery around real processes
Speaker : Prof Richard Cooper, Associate Professor of Chemistry, University of Oxford
Title : Designing generative AI models for drug discovery around real processes
Meeting ID : 935 4977 9379
Passcode : 177785
Monday, 29 September 2025
BII Seminar: Generative Adversarial Networks and Applications in Biomedical Image Applications
Speaker : Dr. Satish Kumar Singh, Associate Professor, Indian Institute of Information Technology (IIIT)
Title : Generative Adversarial Networks and Applications in Biomedical Image Applications
Meeting ID : 914 8374 2348
Passcode : 534580
Friday, 25 April 2025
BII Seminar: Expediting Hit-to-Lead Progression in Drug Discovery through Reaction Prediction and Multi-Objective Optimization with AI
Speaker : Dr Kenneth Atz, AI Scientist, Roche
Friday, 25 April 2025
BII x AI in Drug Discovery Joint Seminar
Speakers: Dr Matthias Steger (Managing Partner/Founder, Sequel Blu Gmbh) and Dr Kenneth Atz (AI Scientist, Roche).
Tuesday, 22 April 2025
REMINDER: BII Seminar by Dr Weijun Xu
Speaker : Dr Weijun Xu, Principal Scientist, Experimental Drug Development (EDDC)
Title : Computational and Structural Studies Illuminate How Small Molecules Modulate Mucosal-Associated Invariant T (MAIT) Cell Function
Wednesday, 30 April 2025
BII Seminar: Unlocking the Future with Generative Intelligence and Multimodal Learning
Speaker : A.Prof. YANG Guang, Bioengineering Department and Imperial-X, Imperial College London
Thursday, 15 May 2025
BII Webinar: Leveraging protein language models and scoring function for Indel characterisation and transfer learning
Speaker : Dr. Oriol Gracia Carmona, Postdoctoral Researcher, Structural & Molecular Biology, University College of London
Friday, 06 June 2025
BII Webinar: Learning the Language of Life: AI for advancing RNA and Molecular Modeling
Speaker : Dr Mangal Prakash, Principal Scientist, AI/ML, Johnson & Johnson, UK
Wednesday, 28 May 2025
BII Seminar: Cannabinoid use may compromise cancer treatment efficacy
Speaker: Dr. Francesca Picucci
Wednesday, 25 June 2025
BII Seminar: Lessons from Spatial Omics: Do we need Everything Everywhere All at Once?
Speaker : Dr. Sizun Jiang, Assistant Professor, Harvard Medical School and Beth Israel Deaconess Medical Center
Monday, 14 April 2025
BII Seminar: Understanding Treatment Response Heterogeneity in Tuberculosis: Implications for the Drug Development Lifecycle
Speaker : Dr. Rada Savic, Co-Vice Dean, Graduate Pharmacy Education Programs
Meeting ID : 967 9249 1520
Passcode : 434978
Monday, 14 April 2025
BII Seminar: In the age of AlphaFold, why do we need simulations? Molecular simulations for enzyme, mechanisms, dynamics, design and 'computational assays' of activity
Speaker: Prof. Adrian Mulholland, School of Chemistry, Centre for Computational Chemistry, University of Bristol, UK
Meeting ID : 999 4940 6314
Passcode : 971940
Wednesday, 26 February 2025
BII Seminar: CancerModels.Org - an open global cancer research platform for patient-derived cancer models
Bioinformatics Institute (BII) would like to invite you to attend the following seminar:
Speaker : Dr. Zinaida Perova, Project Lead, Cancer Models, European Institute, EMBL-EBI
Meeting ID : 922 5150 3234
Passcode : 726388
Friday, 10 January 2025
BII Seminar: Too Many Clocks, Too Little Time: Selecting the Right Epigenetic Aging Clock for Your Needs
Bioinformatics Institute (BII) would like to invite you to attend the following seminar:
Speaker : Raghav Sehgal, PhD candidate, Yale University
Meeting ID : 912 1803 5042
Passcode : 883249
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