The Bioinformatics Institute (BII) was set up by the Agency for Science, Technology and Research (A*STAR) in July 2001; it was re-launched with a strong scientific program in the autumn months of 2007. Located in the Biopolis, BII is conceived as the computational biology research and postgraduate training institute as well as a national resource centre in bioinformatics within the Biomedical Research Council (BMRC) of A*STAR.
The BII focuses on theoretical approaches aimed at understanding biomolecular mechanisms that underlie biological phenomena, the development of computational methods to support this discovery process, and experimental verification of predicted molecular and cellular functions of genes and proteins with biochemical methods.
Together with the BMRC, A*STAR research institutes and multinational R&D organizations in the Biopolis, the BII is situated in a conducive environment for exchange of scientific knowledge and friendly interaction that will prompt greater collaborations, and position the Biopolis as a notable biomedical R&D hub in Asia and in the world.
The Bioinformatics Institute (BII) is dedicated to primarily computational biology/bioinformatics driven life science research aimed at the discovery of biomolecular mechanisms guiding biological phenomena. The final goals are scientific advancement as well as economic and social impact for Singapore. Education of students and young scientists is facilitated by their active involvement in ongoing research projects supervised by international faculty. Sophisticated theoretical and computational approaches including artificial intelligence are applied to analyze all sorts of biological and clinical data, mainly omics data (biomolecular sequences, expression profiles, epigenetics data), 3D structures of macromolecules and biological as well as medical cellular, tissue and macroscopic images from local and international academic, hospital and industry collaborators, public resources and from own experiments. Applied research diversifies into infectious diseases, computational toxicology, natural product research, precision medicine, cancer research, drug discovery, etc. BII houses Singapore’s Natural Organism Library, the Natural Product Discovery Platform and the Secondary Clinical Data Sink, a clinical trial database.