I obtained my Bachelor and Master’s degree from Tianjin University, China and my PhD in Chemical Engineering from National University of Singapore (NUS). Prior to joining Bioinformatics Institute, I completed two years postdoc in Singapore-MIT Alliance (SMA) and subsequently worked as a Senior Research Fellow in the Singapore Eye Research Institute (SERI), where I participated in a large Transitional Clinic Research (TCR) program and developed a multi-disciplinary research expertise in both simulation and experiments. I was awarded with several grants such as the SingHealth start-up grant (2013-2015), a NMRC/NIG grant (2014-2017), a DUKE-NUS Eye ACP internal grant (2018-2019) and recently an A*STAR Career Development Award (CDA).
The research objective is to use our extensive expertise in both simulation and experiments to solve complex chemical and medical problems, with a particular focus on membrane related research such as development of membrane active antibiotics and delivery of drugs across the cytoplasmic membrane. We use multiple tools to rationalize the antibiotic development, such as in silico modelling and simulations (e.g., molecular dynamics and Monte Carlo), in vitro validation (e.g., MIC assay, time killing etc.), organic synthesis, biophysical characterization (fluorescence experiments, ITC etc.) and in vivo evaluation (e.g., mouse infection model, through collaboration with SERI). The insights obtained from different angles can greatly accelerate the drug development process. Besides, we are also interested in understanding protein structural dynamics, protein-ligand binding and protein-protein interactions using modelling and simulations.