iCORE Pathology

Key Services

• Animal Necropsy
• Simple and Complex Histo-Processing (Paraffin & Cryo)
• Embedding
• Sectioning
• H&E Staining
• Special Staining
• Immunohistochemistry (Brightfield & Immunofluorescence)
• Tissue Microarray
• Whole Slide Imaging
• Image Annotation and Image Analysis
• Clinical Chemistry Analysis
• Haematology Analysis
• Urine Analysis
• Animal Pathology Evaluation for Research Cases
• Animal Pathology Evaluation for Veterinary Diagnostics
• Clinical Pathology Evaluation for Research Cases (Human Tissues)
• Animal Pathology Toxicity Assessment
• Animal Pathology Toxicology Consultation
• GLP Training

Key Applications

Histology/Histopathology/clinical pathology supports for

Preclinical & basic research

• Phenotyping of animal models: characterize organs/tissues in knockout, transgenic, disease models
• Mechanism of disease studies: correlate microscopic changes with biochemistry/haematology
• Developmental biology: embryonic and postnatal tissue differentiation and defects

Drug discovery & development

• Safety pharmacology support: correlation of clinical signs with tissue lesions
• Efficacy assessment: histological evidence of treatment response or healing
• Toxicologic pathology : target organ toxicity, dose-response, Reversibility, MTD etc
• Biomarker validation: IHC, ISH, special stains to link structure and functional alterations

Gene, cell, and advanced therapies

• Tissue distribution studies: cell and gene therapy localization
• On-target/off-target effects: tissue-specific toxicity and inflammation
• Tumorigenicity assessments: cell therapy safety

Infectious disease research

• Pathogen localization by special stain, IHC.
• Host-pathogen interaction: inflammation, tissue damage patterns
• Vaccine studies: reaction at injection site, organ response

Device & biomaterial evaluation

• Implant biocompatibility
• Foreign body response, fibrosis, encapsulation

Methodological support

• Tissue processing, embedding, sectioning, special stains
• Immunohistochemistry & morphometry
• Digital pathology for quantitative image analysis

Key Equipment

• Leica Autostainer XL (Automated Slide Stainer)
• Leica CV5030 Coverslipper (Automated Slide Coverslipper)
• Leica CM3050 S Cryostat (Cryostat)
• Sakura Tissue-Tek TEC5 Embedding System (Paraffin Embedding System)
• Leica Bond-Max™ (Automated IHC stainer)
• Leica Bond-III™ (Automated IHC stainer)
• Roche Ventana Discovery Ultra System (Automated IHC stainer)
• Leica IPC Cassette Printer (Cassette Printer)
• Leica IPS Slide Printer (Slide Printer)
• Leica RM2265 (Microtome)
• Leica RM2235 (Microtome)
• Leica RM2255 (Microtome)
• Axioscan 7 Histological Slide Scanning System (Whole Slide Scanning System)
• Sakura Tissue-Tek VIP® 6 (Tissue Processor)
• Sakura Tissue-Tek VIP® 6 AI (Tissue Processor)
• Sysmex XN-1000 Automated Haematology Analyser (Haematology Analyser)
• Roche cobas® c 111 Clinical Chemistry Analyser (Clinical Chemistry Analyser)
• Uri-Trak 120 (Strip Analysis) Urine Analyser
• MTA-1 Beecher Tissue Arrayer (TMA)
• Olympus/Nikon Microscopes

Accreditations

Lab Certification:

• Good Laboratory Practice (GLP)

Board Certifications:

• ACVP (USA)
• DABT (USA)
• ERT (UK)
• RCPath (UK)

Collaboration and Authorship

If there are significant intellectual or scientific contribution by our staff, such as substantial contributions to conception and design, acquisition of data or analysis and interpretation of the data, co-authorship should be offered to the contributing staff and we will share responsibility and scientific accountability for the results.