We are proud to share that two of SIFBI’s scientists, Dr. James Chan, lead of the Bioactives and Human Health platform, and Mr. Sheng Yuan Chin, research officer, have been selected to present their research on Per- and Polyfluorinated Substances (PFAS) at the Society of Toxicology (SoT) 63rd Annual Meeting and ToxExpo in Salt Lake City, UT, US.

Per/PolyFlouroAlkyl Substances (PFAS) are a large, complex group of synthetic chemicals that have been used in various everyday products and have been termed as “forever chemicals” in the human body.
They showcased their research findings on PFAS through physiologically based toxicokinetic modelling and why PFAS persists in the human body. This introduces a pioneering workflow for PFAS screening, offering further insights into toxicology.

In their second poster, they highlighted a collaboration with P&G on the development of read-accoss approach to assess pharmacokinetic (PK) profiles of chemicals. Leveraging on Dr Chan’s virtual human model and PK profiles from source chemicals, they were able to evaluate target chemicals that were lacking of PK data via a read-across approach. Utilizing these virtual human models provides us with valuable human insights during the preclinical stage, a critical step for rapid iteration in product development. This process helps reduce the need for numerous clinical trials and speeds up the time it takes to bring products to market, enabling us to better optimize human health and well-being.

Reach out to us if you would like to know more and explore potential collaborations!