Defining skin microbiome function. We have collected skin physiology, health state, consumer-relevant skin health data, lipid, and microbiome samples from multiple body sites. We are using this metagenomic and lipidomic data to generate functional as well as taxonomic information. To enable further functionalization, we have collected and are investigating a series of Singapore locally isolated trains, and defining Singapore unique activities.
Investigating Natural Life Changes. Puberty and menopause are important biological phases where hormonal changes impact skin physiology and disease predisposition, so we are developing longitudinal data on subjects passing through the phases, and have sampled individuals poised for these hormonal, skin, and microbial changes. We hypothesize the microbial community will change due to changes in sebaceous gland activity, which we will capture in paired lipidomic analyses.
Probing with interventions. We are performing targeted removal of the skin fungal community using Pyrithione Zinc (ZPT), a common anti-fungal ingredient in many consumer care products, to investigate how the fungal community contributes to skin cytokine signaling and “talks” with the immune system.