skin ageing


Improving skin health in ageing populations

The Ageing Programme brings together biologists, engineers and clinicians to understand the mechanisms driving skin aging, enabling us to better develop treatments to slow the aging process, treat age related skin disorders and improve patient care.

One of the goals of the Aging Programme is to understand the differences between Asian and Caucasian skin in detail so that more customised treatments can be developed.  As Asian skin differs significantly from Caucasian skin, it ages differently and can be more prone to some skin conditions (e.g. hyper-pigmentation).

Another goal of the aging programme is to understand how genetics, lifestyle and environmental factors impact aging with the goal to develop more effective treatments to delay the aging process and improve skin homeostasis. 

Enhancing skin health

We are exploring how polyamines can promote skin barrier formation and hope to develop polyamine-derived technologies that can enhance skin health. Our research has shown that maintaining appropriate polyamine levels is essential for the formation of a healthy skin barrier and efficient wound healing. Additionally, we are also working on manipulating polyamine levels to improve patient care in the context of certain age associated skin disorders.

For more information, contact Leah Vardy.


Identifying aged cells

Ageing manifests itself in many different ways such as wrinkling and pigmentation. Our goal is to identify aged cells within the skin and explore how the different cell types contribute to each phenomenon of ageing, with the ultimate goal to  remove, or modulate the function of these cells to ameliorate ageing-associated phenotypes. Lastly, we are studying processes that drive the ageing process by exploring diseases characterized by premature ageing.

For more information, contact Oliver Dreesen.


Anti-ageing molecules

We are using 2D and 3D organotypic cultures of primary keratinocytes to study the pathways that regulate their transition from proliferation to differentiation/senescence in the human skin epidermis. Our main areas of investigation are stemness, premature ageing and mechanisms of action of anti-ageing molecules ranging from cell cycle and metabolism regulators to nutraceuticals.

For more information, contact Sophie Bellanger.