We know Asian Skin
Located in the heart of Asia, the Asian Skin Biobank (ASB) specialises in a diverse range of Asian skin.
The ASB delivers quality human skin samples and services to support skin research in Singapore and worldwide. The ASB also develops in vitro skin models and assays for collaborative research projects with academia and industry.
Our mission is to improve skin health and quality of life for all in Asia.
The ASB is a registered Tissue Bank, compliant with the Human Biomedical Research Act 2015 and the Human Tissue Framework in Singapore.
All samples are collected, processed and distributed upon Institutional Review Board (IRB) approval. Donors provided voluntary and informed consent for use of the samples in future research studies.
Handling and processing of skin samples are carried out in a lean 10K lab, accessible only to trained personnel, with high GLP/ISO standards, SOPs and an integrated Laboratory Inventory Management System (LIMS).
Collaborative research, consultancy, fee for service and training options are welcomed.
Request human skin samples or models
- Email us to discuss your research needs
- Submit an application form to request skin samples (https://srisasianskinbiobank.weebly.com)
- Provide your ethics application and approval letter
Non-identifiable donor information, sample characteristics and specifications, as well as culture conditions may be provided.
The ASB has contributed to a range of research studies in skin, biology and diseases, skin immunity, inflammation, ageing, stem cells, and 3D in vitro models, including the following selected publications:
Koh R, Szeverényi I, Lee B, Denil SLIJ, Lim SYJ, Benny PA, Grasset N, Tan BK, Lane EB. Oxygen-Mediated Control of the Keratinocyte Proliferation-Differentiation Axis. J Invest Dermatol. 2020 Jan;140(1):235-238.e3. doi: 10.1016/j.jid.2019.05.030. Epub 2019 Jul 5. PMID: 31283927.
Liew WC, Sundaram GM, Quah S, Lum GG, Tan JSL, Ramalingam R, Common JEA, Tang MBY, Lane EB, Thng STG, Sampath P. Belinostat resolves skin barrier defects in atopic dermatitis by targeting the dysregulated miR-335:SOX6 axis. J Allergy Clin Immunol. 2020 Sep;146(3):606-620.e12. doi: 10.1016/j.jaci.2020.02.007. Epub 2020 Feb 21. PMID: 32088305.
Wong CW, LeGrand CF, Kinnear BF, Sobota RM, Ramalingam R, Dye DE, Raghunath M, Lane EB, Coombe DR. In Vitro Expansion of Keratinocytes on Human Dermal Fibroblast-Derived Matrix Retains Their Stem-Like Characteristics. Sci Rep. 2019 Dec 6;9(1):18561. doi: 10.1038/s41598-019-54793-9. PMID: 31811191; PMCID: PMC6897920.
Tan JJY, Common JE, Wu C, Ho PCL, Kang L. Keratinocytes maintain compartmentalization between dermal papilla and fibroblasts in 3D heterotypic tri-cultures. Cell Prolif. 2019 Sep;52(5):e12668. doi: 10.1111/cpr.12668. Epub 2019 Aug 5. PMID: 31379046; PMCID: PMC6797517.
Tan CL, Chin T, Tan CYR, Rovito HA, Quek LS, Oblong JE, Bellanger S. Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes. J Invest Dermatol. 2019 Aug;139(8):1638-1647.e3. doi: 10.1016/j.jid.2019.02.005. Epub 2019 Feb 15. PMID: 30776433. A*STAR Open Access Repository
Chourabi M, Liew MS, Lim S, H'mida-Ben Brahim D, Boussofara L, Dai L, Wong PM, Foo JN, Sriha B, Robinson KS, Denil S, Common JE, Mamaï O, Ben Khalifa Y, Bollen M, Liu J, Denguezli M, Bonnard C, Saad A, Reversade B. ENPP1 Mutation Causes Recessive Cole Disease by Altering Melanogenesis. J Invest Dermatol. 2018 Feb;138(2):291-300. doi: 10.1016/j.jid.2017.08.045. Epub 2017 Sep 28. PMID: 28964717.
Zhong FL, Mamaï O, Sborgi L, Boussofara L, Hopkins R, Robinson K, Szeverényi I, Takeichi T, Balaji R, Lau A, Tye H, Roy K, Bonnard C, Ahl PJ, Jones LA, Baker PJ, Lacina L, Otsuka A, Fournie PR, Malecaze F, Lane EB, Akiyama M, Kabashima K, Connolly JE, Masters SL, Soler VJ, Omar SS, McGrath JA, Nedelcu R, Gribaa M, Denguezli M, Saad A, Hiller S, Reversade B. Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation. Cell. 2016 Sep 22;167(1):187-202.e17. doi: 10.1016/j.cell.2016.09.001. PMID: 27662089.
For more information on the Asian Skin Biobank, please contact Carine Bonnard