Human skin forms the first line of defence to protect the body from infection. The skin is constantly in contact with infectious agents such as fungi, bacteria, viruses, and parasites. It is colonised by a diverse microbiota that serves as an additional barrier against pathogen invasion. These complex interactions among the skin microbiota, epithelial cells, and cells of the immune system maintain normal host immune homeostasis.
Understanding the mechanisms by which components of the skin microenvironment contribute to the control and/or establishment of an infection and how local immune responses can modulate systemic responses against various pathogens is critical to the development of effective intervention strategies.
Skin Infection & Immunity is one of SRIS 's flagship research programmes. It is a tripartite collaboration primarily driven by NTU's LKC Medicine and our partners A* STAR and NHG. This translational interdisciplinary research brings together research and clinical experts in atopic dermatitis, pigmentary disorders, acne and chronic wounds.
The Skin Infection & Immunity programme focuses on elucidating the key mechanisms that control the immune response in skin infections. We focus on elucidating the mechanisms of immune surveillance and host-pathogen interactions and their relationship to the adaptive immune response. Our research aims to understand the drivers of skin infections and diseases in the broader context of host genetics, immune or barrier defects, the microbiome, and the environment, and to use this knowledge to develop innovative and interventional approaches to treat the target disease.
For more information on the SKIN INFECTION AND IMMUNITY PROGRAMME, please contact Professor Maurice van Steensel, Asst Prof Franklin Zhong Lei and Asst Prof Navin Kumar Verma