Dorothy NG

Dorothy NG

 
- Consultant, Department of Infectious Diseases, SGH
- Clinical Assistant Professor, Duke-NUS Medical School
- Clinical Senior Lecturer, Department of Medicine, NUS Yong Loo Lin School of Medicine
- Clinical Teacher, Lee Kong Chian School of Medicine
 

Email:  dorothy.ng.h.l@singhealth.com.sg

Biography

Dr Dorothy NG graduated from University College London, UK in 2014 with a MBBS-PhD (Immunity and Infection) degree. She completed Clinician-Scientist Residency Infectious Diseases at SingHealth and works as an Infectious Diseases specialist in Singapore General Hospital. She holds joint positions in Duke-NUS Medical School, NUS Yong Loo Lin School of Medicine, and Lee Kong Chian School of Medicine.

Research Focus

- Non-tuberculous mycobacteria
- Pneumonia

- Immunology of pulmonary infections

Publications

 
  1. Ndungu, F.M., Cadman, E.T., Coulcher, J., Nduati, E., Couper, E., MacDonald, D.W., Ng, D. and Langhorne, J., 2009. Functional memory B cells and long-lived plasma cells are generated after a single Plasmodium chabaudi infection in mice. PLoS Pathog, 5(12), p.e1000690.
  2. Nduati, E.W.*, Ng, D.H.*, Ndungu, F.M., Gardner, P., Urban, B.C. and Langhorne, J., 2010. Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice. PLoS One, 5(11), p.e15007. *co-first author IF: 3.752
  3. Flores-Borja, F., Bosma, A., Ng, D., Reddy, V., Ehrenstein, M.R., Isenberg, D.A. and Mauri, C., 2013. CD19+ CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation. Science Translational Medicine, 5(173), pp.173ra23-173ra23.
  4. Ng, D.H., Skehel, J.J., Kassiotis, G. and Langhorne, J., 2014. Recovery of an antiviral antibody response following attrition caused by unrelated infection. PLoS Pathog, 10(1), p.e1003843. IF: 7.464
  5. Pérez-Mazliah, D., Ng, D.H.L., do Rosário, A.P.F., McLaughlin, S., Mastelic-Gavillet, B., Sodenkamp, J., Kushinga, G. and Langhorne, J., 2015. Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria. PLoS Pathog, 11(3), p.e1004715. IF: 7.464
  6. Aw, D.K.L., Tan, M.Z.W., Yii, A.C.A. and Ng, D.H.L., 2016. Unusual complication of bronchoscopy. Respiratory Medicine Case Reports, 19, pp.173-176. IF: 1.069
  7. Ng, D., Ghosh, A., Jit, M. and Seneviratne, S.L., 2017. Mini-review: Can non-human leucocyte antigen genes determine susceptibility to severe dengue syndromes? Transactions of The Royal Society of Tropical Medicine and Hygiene, 111(9), pp.384-392. IF: 2.82
  8. Ng, D., Chan, T. and Pothiawala, S., 2018. A Human Bite on the Scrotum: Case Report and Review of Management in the Emergency Department. The Journal of Emergency Medicine, Apr;54(4):537-539. IF: 1.5
  9. Ng, D.H., Beh, D.L., Sutjipto, S., Archuleta, S. and Wong, C.S., 2019. The Greying Pandemic: Implications of Ageing Human Immunodeficiency Virus-Positive Population in Singapore. Annals of the Academy of Medicine, Singapore, 48(12), pp.393-395. IF: 8.713
  10. Jit, M., Ng, D.H.L., Luangasanatip, N., Sandmann, F., Atkins, K.E., Robotham, J.V. and Pouwels, K.B., 2020. Quantifying the economic cost of antibiotic resistance and the impact of related interventions: rapid methodological review, conceptual framework and recommendations for future studies. BMC Medicine, 18(1), pp.1-14. IF: 11.8
  11. Choy, M.M.*, Ng, D.H.*, Siriphanitchakorn, T.*, Ng, W.C., Sundstrom, K.B., Tan, H.C., Zhang, S.L., Chan, K.W., Manuel, M., Kini, R.M. and Chan, K.R., 2020. A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine. Cell Reports, 31(6), p.107617. *co-first author. IF: 9.995
  12. Low, J.G., Ng, J.H., Ong, E.Z., Kalimuddin, S., Wijaya, L., Chan, Y.F., Ng, D.H., Tan, H.C., Baglody, A., Chionh, Y.H. and Lee, D.C., 2020. Phase 1 Trial of a Therapeutic Anti–Yellow Fever Virus Human Antibody. New England Journal of Medicine, 383(5), pp.452-459.
  13. Beh, D.L.*, Ng, D.H.*, Ong, S.W., Sutjipto, S., Lee, P.H., Oon, J., Wong, C.S. and Archuleta, S., 2020, July. The Pandemic Academy: Reflections of Infectious Diseases Fellows During COVID-19. In Open Forum Infectious Diseases (Vol. 7, No. 7, p. ofaa256). US: Oxford University Press. *co-first author. IF: 3.835
  14. Seneviratne, C.J., Balan, P., Ko, K.K.K., Udawatte, N.S., Lai, D., Ng, D.H.L., Venkatachalam, I., Lim, K.S., Ling, M.L., Oon, L. and Goh, B.T., 2021. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection, 49(2), pp.305-311.
  15. Ng, D.H.L., Sim, M.Y., Huang, H.H., Sim, J.X.Y., Low, J.G.H., Lim, J.K.S., 2021. Feasibility and utility of facemask sampling in the detection of SARS-CoV-2 during an ongoing pandemic. Eur J Clin Microbiol Infect Dis. 2021 Jul 5. doi: 10.1007/s10096-021-04302-6. Epub ahead of print. IF: 2.837
  16. Lim, D.W.T., Ng, D.H.L. and Low, J.G.H., 2021. Bacillus Calmette–Guérin scar flare after an mRNA SARS-CoV-2 vaccine. CMAJ, 193(30), pp.E1178-E1178. IF: 17.4
  17. Chan, K.R., Koh, C.W., Ng, D.H.L., Qin, S., Ooi, J.S., Ong, E.Z., Zhang, S.L., Sam, H., Kalimuddin, S., Low, J.G. and Ooi, E.E., 2023. Early peripheral blood MCEMP1 and HLA-DRA expression predicts COVID-19 prognosis. EBioMedicine, 89. IF: 11.2
  18. Png, L.H., Ng, D.H.L. and Teo, N.W.Y., 2023. Infectious disease for the rhinologist. Current Opinion in Otolaryngology & Head and Neck Surgery, pp.10-1097. IF: 1.60
  19. Ng, D.H.L., Chia, T.R.T., Young, B.E., Sadarangani, S., Puah, S.H., Low, J.G.H., Yan, G.Z., Mo, Y., Ngiam, N.J., Wang, S.S.Y. and Loo, Y.T., 2024. Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO). BMC Infectious Diseases, 24(1), p.123. IF: 3.7
  20. Tan, S.Y.L., Tan, J.B.X. and Ng, D.H.L., 2024. Stable antimicrobial resistance patterns of Mycobacterium abscessus complex antibiograms in Singapore from 2013 to 2022: a retrospective review. Singapore Medical Journal, pp.10-4103.
  21. Tan, S.Y.L., Ng, D.H.L., Tan, M.G., Goh, G.X.Q., Cao, D.Y.H., Tan, A.L. and Tan, Y.E., 2025. A rare case of coccidioidomycosis in Singapore and challenges faced with laboratory diagnosis in a non-endemic area. Pathology, 57(1), pp.109-112.
  22. Kalimuddin, S., Tham, C.Y., Chan, Y.F., Hang, S.K., Kunasegaran, K., Chia, A., Chan, C.Y., Ng, D.H., Sim, J.X., Tan, H.C. and Syenina, A., 2025. Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans. Nature Microbiology, pp.1-14.
  23. Sng, E.C.Y., Chan, L.L., Conceicao, E.P., Wong, M.J., Ng, D.H.L., Lee, H.K. and Chan, C.Y.Y., 2025, March. Clinicodemographic and Radiological Features of Infective Ring-Enhancing Brain Lesions: A 4-Year Retrospective Study at a Tertiary Referral Center. In Open forum infectious diseases (Vol. 12, No. 3, p. ofaf095). US: Oxford University Press.
  24. Syenina, A., Tan, Y.H., Tng, D.J.H., Sim, S.X.Q., Chew, V.S.Y., Yee, J.X., Ong, E.Z., Ooi, E.E., Low, J.G.H. and Ng, D.H.L., 2025. Transcriptional and cytokine signatures of Mycobacterium abscessus complex pulmonary disease during disease progression and treatment. PLOS Neglected Tropical Diseases, 19(3), p.e0012943.
  25. Pereira, J.V.B., Wong, C.Y.X., Sng, L.H., Low, J.G.H. and Ng, D.H.L., 2025. Longitudinal epidemiology of pulmonary nontuberculous mycobacteria and tuberculosis in Singapore (2006–2024): Emerging dominance of Mycobacterium abscessus. International Journal of Infectious Diseases, p.108054.
  26. Chung, S.J., Thong, S., Ng, D.H.L., Wong, L.J.L., Wong, T.H.N., Tan, T.T., Tan, B.H. and Kwa, A.L., 2025. Adjunctive bacteriophage therapy for refractory/resistant Pseudomonas aeruginosa infections: Bottlenecks and proposed solutions. International Journal of Antimicrobial Agents, 66(6), pp.107629-107629.