Gabriel YAN

Biography

Dr Gabriel YAN graduated from Imperial College, London with an MBBS and BSc (Immunity and Infection), as well as obtaining an MRCP with the Royal College of Physicians (UK) and the FRCPath with the Royal College of Pathologists (UK). He works as a medical specialist in infectious diseases as well as clinical microbiology at the National University Hospital, with joint appointments at the National University of Singapore, as well as the National Public Health Laboratory under the Communicable Diseases Agency. 

Research Focus

Publications

• Yan G et al. Distinguishing Zika from Dengue in Singapore through Simple Clinical Assessment. Emerg Infect Dis. 2018 Aug;24(8):1565-1568. doi: 10.3201/eid2408.171883.
• Yan G et al. Covert COVID-19 and false-positive dengue serology in Singapore. Lancet Infect Dis. 2020 May;20(5):536. doi: 10.1016/S1473-3099(20)30158-4
• Archuleta S, Cross G, Somani J, Lum L, Santosa A, Alagha RA, Allen DM, Ang A, Beh D, Chai L, Chan SM, Lim SM, Olszyna DP, Ong C, Oon J, Salada BMA, Smitasin N, Sun L, Tambyah PA, Tham SM, Yan G et al. Responding to COVID-19: how an academic infectious diseases division mobilized in Singapore. BMC Medicine. 2020 Jun 8; 18(1):179. doi: 10.1186/s12916-020-01641-7
• Dickens BSL, Lim JT, Low JW, Lee CK, Sun YXH, Nasir HBM, Yan G et al. Simple ‘Rule-of-6’ Predicts Severe COVID-19 Disease. Clin Infect Dis. 2020 Jul 6; doi: 10.1093/cid/ciaa938
• Tham SM, Lim WY, Lee CK, Loh J, Premkumar A, Yan B, Kee A, Chai L, Tambyah PA, Yan G. Four Patients with COVID-19 and Tuberculosis, Singapore, April-May 2020. Emerg Infect Dis. 2020 Nov;26(11):2764-2766. doi: 10.3201/eid2611.202752
• Su YCF, Anderson DE, Young BE, Linster M, Zhu F, Jayakumar J, Zhuang Y, Kalimuddin S, Low JGH, Tan CW, Chia WN, Mak TM, Octavia S, Chavatte JM, Lee RTC, Pada S, Tan SY, Sun L, Yan GZ et al. Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2. mBio. 2020 Jul 21;11(4)e01610-20. doi: 10.1128/mBio.01610-20
• CK Lee, JWM Tham, S Png, CN Chai, SC Ng, EJM Tan, LJ Ng, RP Chua, M Sani, Y Seow, G Yan, J Tang. Clinical Performance of Roche cobas 6800, Luminex ARIES, MiRXES Fortitude Kit 2.1, altona RealStar, and Applied Biosystems TaqPath for SARS-CoV-2 Detection in Nasopharyngel Swabs. J Med Virol. 2021 Mar 14. doi: 1002/jmv.26940
• Ooi KH, Liu MM, Tay JWD, Teo SY, Kaewsapsak P, Jin S, Lee CK, Hou J, Maurer-Stroh S, Lin W, Yan B, Yan G, Gao YG, Tan MH. An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing. Nat Commun. 2021 Mar 19;12(1):1739. doi: 10.1038/s41467-021-21996-6
• Puah SR et al. Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore. Sci Rep. 2021 Apr 5;11(1):7477. doi: 10.1038/s41598-021-81377-3
• G Yan et al. Update on Non-Culture-Based Diagnostics for Invasive Fungal Disease. Mycopathologia. 2021 Jul 2. doi: 10.1007/s11046-021-00549-x
• Young et al. Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity. Clin Infect Dis. 2021 Nov;73(9)e2932-e2942. doi: 10.1093/ciaa1280
• J Lee, KJ Puan, LW Wang, KWW Teng, CY Loh, KP Tan, G Carissimo, YH Chan, CM Poh, CYP Lee, SW Fong, NKW Yeo, RSL Chee, SN Amrun, ZW Chang, MZ Tay, A Torres-Ruesta, NL Fernandez, W How, AK Andiappan, W Lee, K Duan, SY Tan, G Yan et al. Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals. Front. Immunol. 2021 Nov; (12) doi: 10.3389/fimmu.2021.710217
• CHY Teo, NHB Norhisham, OF Lee, S Png, CN Chai, G Yan et al. Towards Next-Generation Sequencing for HIV-1 Drug Resistance Testing in a Clinical Setting. Viruses. 2022 Oct 7;14(10):2208. doi: 10.3390/v14102208
• LCW Koh, Y Seow, KW Kong, MLL Lau, SK Kumar, G Yan et al. Sub genomic analysis of SARS-CoV-2 using short read amplicon-based sequencing. Front Genet. 2023 Feb 24;14:1086865. doi: 10.3389/fgene.2023.1086865
• WLC Koh, SE Poh, CK Lee, THM Chan, G Yan et al. Towards a Rapid-Turnaround Low-Depth Unbiased Metagenomics Sequencing Workflow on the Illumina Platforms. Bioengineering. 2023, 10, 520. doi: 10.3390/bioengineering10050520
• MLT Ang, SM Chan, LTE Cheng, HY Cheong, KL Chew, PM Chlebicki, LY Hsu, GJL Kaw, ACL Kee, MCW Ng, RTH Ong, CWM Ong, JL Quah, DB Selvamani, LH Sng, JBX Tan, CH Tan, JY Tay, LLS Teo, KC Thoon, GZ Yan et al. Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease. Ann Acad Med Singap. 2024 Mar 27;53(3):170-186. doi: 10.47102/annals-acadmedsg.2023391
• J Somani, N Fauzi, R Sridhar, HC Chan, IT Low, YLP Lum, R Agrawal, KL Chew, G Yan et al. A need for a global alert system for rapid recall of contaminated products to prevent ongoing hospital outbreaks. Infect Control Hosp Epidemiol. 2024 Sep 18:1-2. doi: 10.1017/ice.2024.87.
• MCY Koh, KMS Sim, BA Mathison, RS Bradbury, JN Ngiam, NJH Chan, JEL Oon, A Wee, GZ Yan. The Brief Case: Incidental finding of a liver fluke following resection of hepatocellular carcinoma. J Clin Microbiol. 2025 Jan 31;63(1):e0130224. doi: 10.1128/jcm.01302-24
• WGW Goh, IKS Ng, MKX Tan, CYK Fong, CYK Chua, GZ Yan et al. Clinical Reasoning: A 26-Year-Old Woman With Headache and Eosinophilia. Neurology. 2025 Mar 25;104(6):e213434. doi: 10.1212/WNL.0000000000213434.
• N. Ngiam and G. Yan. Communicable: David Allen and Modern Infectious Diseases in Singapore. World Scientific Publishing Co Pte Ltd, 2025.