Nagaendran Kandiah

Nagaendran KANDIAH

nagaendran_kandiah@ntu.edu.sg

Biography

Nagaendran Kandiah is an Associate Professor of Neuroscience and Mental Health at the Lee Kong Chian School of Medicine, NTU, Singapore. He serves as the Director of the Dementia Research Centre (Singapore) and co-director of the LKC Neuroscience Programme. He is a Senior Clinician Scientist with the National Medical Research Council with research interests in fluid biomarkers, digital biomarkers, and neuroimaging of cognitive disorders. He has published over 190 peer reviewed papers in the field of cognitive neurology and neuroscience and leads several major research studies in this field. He co-founded Gray Matter Solutions in 2024 to develop digital solutions for cognitive disorders, both for diagnostics and therapeutics. From a clinical perspective, he is a senior consultant neurologist with the National University Hospital and Khoo Teck Puat Hospital. He was the immediate past chairman of the Singapore Ministry of Health Clinical Practice guidelines for dementia and past president of the chapter of Neurologists, Singapore. He is the current president of the Southeast Asian Consortium on Neurocognitive Disorders and executive board member of Asian Society Against Dementia .

Research Interest

My research focuses on developing novel biomarkers and interventional strategies for mild cognitive impairment and dementia. My lab uses a combination of fluid biomarkers, neuroimaging and neurocognitive panels in investigating Alzheimer's disease, vascular dementia and other related neurodegenerative diseases.

Publications

  • Bhalla G, Tanoto P, Vipin A, Chen XYJ, Leow YJ, Chen C, Yap PLK, Merchant RA, Hilal S, Ong AP, Ampil ER, Idris MI, Looi I, Dominguez J, Yusoff S, Tan MP, Tran CT, Tong MT, Senanarong V, Turana Y, Kandiah N. Current status and future directions for the diagnosis and management of mild cognitive impairment in Southeast Asia: A SEACURE consensus paper. J Prev Alzheimers Dis. 2025 May;12(5):100110. doi: 10.1016/j.tjpad.2025.100110. Epub 2025 Mar 12. PMID: 40082179; PMCID: PMC12183928.
  • Chen JXY, Vipin A, Sandhu GK, Leow YJ, Zailan FZ, Tanoto P, Lee ES, Lee KL, Cheung C, Kandiah N. Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities. J Prev Alzheimers Dis. 2025 Feb;12(2):100029. doi: 10.1016/j.tjpad.2024.100029. Epub 2025 Jan 1. PMID: 39863325; PMCID: PMC12184052.
  • Leow YJ, Soo SA, Kumar D, Zailan FZB, Sandhu GK, Vipin A, Lee FPHE, Ghildiyal S, Liew SY, Dang C, Tanoto P, Tan IYZ, Chong WFW, Mohammed AA, Ng KP, Kandiah N. Mild Behavioral Impairment and Cerebrovascular Profiles Are Associated with Early Cognitive Impairment in a Community-Based Southeast Asian Cohort. J Alzheimers Dis. 2024;97(4):1727-1735. doi: 10.3233/JAD-230898. PMID: 38306040; PMCID: PMC10894567.

  • Leow YJ, Wang JDJ, Vipin A, Sandhu GK, Soo SA, Kumar D, Mohammed AA, Zailan FZB, Lee FPHE, Ghildiyal S, Liew SY, Dang C, Tanoto P, Tan IYZ, Chong WFW, Kandiah N. Biomarkers and Cognition Study, Singapore (BIOCIS): Protocol, Study Design, and Preliminary Findings. J Prev Alzheimers Dis. 2024;11(4):1093-1105. doi: 10.14283/jpad.2024.89. PMID: 39044522; PMCID: PMC11266377.

  • Vipin A, Lee BTK, Kumar D, Soo SA, Leow YJ, Ghildiyal S, Lee FPHE, Hilal S, Kandiah N. The role of perfusion, grey matter volume and behavioural phenotypes in the data-driven classification of cognitive syndromes. Alzheimers Res Ther. 2024 Feb 17;16(1):40. doi: 10.1186/s13195-024-01410-1. PMID: 38368378; PMCID: PMC10874041.

  • Vipin A, Satish V, Saffari SE, Koh W, Lim L, Silva E, Nyu MM, Choong TM, Chua E, Lim L, Ng ASL, Chiew HJ, Ng KP, Kandiah N. Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease. Alzheimers Res Ther. 2021 Nov 30;13(1):195. doi: 10.1186/s13195-021-00936-y. PMID: 34847922; PMCID: PMC8630908.

  • Vipin A, Wong BYX, Kumar D, Low A, Ng KP, Kandiah N. Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional. Aging (Albany NY). 2021 Apr 16;13(8):10973-10988. doi: 10.18632/aging.202977. Epub 2021 Apr 16. PMID: 33861727; PMCID: PMC8109133.

  • Wong FCC, Yatawara C, Low A, Foo H, Wong BYX, Lim L, Wang B, Kumar D, Ng KP, Kandiah N. Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment. Transl Stroke Res. 2021 Apr;12(2):284-292. doi: 10.1007/s12975-020-00847-4. Epub 2020 Sep 7. PMID: 32894401.

  • Kandiah N, Chan YF, Chen C, Dasig D, Dominguez J, Han SH, Jia J, Kim S, Limpawattana P, Ng LL, Nguyen DT, Ong PA, Raya-Ampil E, Saedon N, Senanarong V, Setiati S, Singh H, Suthisisang C, Trang TM, Turana Y, Venketasubramanian N, Yong FM, Youn YC, Ihl R. Strategies for the use of Ginkgo biloba extract, EGb 761® , in the treatment and management of mild cognitive impairment in Asia: Expert consensus. CNS Neurosci Ther. 2021 Feb;27(2):149-162. doi: 10.1111/cns.13536. Epub 2020 Dec 22. PMID: 33352000; PMCID: PMC7816207.

  • Ng KP, Chiew HJ, Hameed S, Ting SKS, Ng A, Soo SA, Wong BYX, Lim L, Yong ACW, Mok VCT, Rosa-Neto P, Dominguez J, Kim S, Hsiung GYR, Ikeda M, Miller BL, Gauthier S, Kandiah N. Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research. Alzheimers Dement (N Y). 2021 Jan 15;6(1):e12085. doi: 10.1002/trc2.12085. PMID: 33490361; PMCID: PMC7810128.

  • Wang BZ, Zailan FZ, Wong BYX, Ng KP, Kandiah N. Identification of novel candidate autoantibodies in Alzheimer's disease. Eur J Neurol. 2020 Nov;27(11):2292-2296. doi: 10.1111/ene.14290. Epub 2020 May 25. PMID: 32356904.

  • Yatawara C, Ng KP, Chander R, Kandiah N. Associations between lesions and domain-specific cognitive decline in poststroke dementia. Neurology. 2018 Jul 3;91(1):e45-e54. doi: 10.1212/WNL.0000000000005734. Epub 2018 May 25. PMID: 29802171.

  • Kandiah N, Zhang A, Bautista DC, Silva E, Ting SK, Ng A, Assam P. Early detection of dementia in multilingual populations: Visual Cognitive Assessment Test (VCAT). J Neurol Neurosurg Psychiatry. 2016 Feb;87(2):156-60. doi: 10.1136/jnnp-2014-309647. Epub 2015 Feb 17. PMID: 25691617