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Biosensors and Nanosensors

Biosensors are analytical devices that combine biochemical and biological components with physical transducers for identification and detection of various analytes. Nanomaterials can enable biosensor development as sensing material and/or signal amplifier. Driven by the market demand of portable, rapid, low-cost, sensitive, greener, robust, and high performance analytical devices, we develop optical biosensors and nanosensors to address analytical challenges in following fields:

Medical diagnosis (cancer, infectious disease, and wound)
Environmental monitoring (water, air quality, and surface contamination)
Aquaculture and agriculture (fish farm water, fish disease, pesticide etc)
Food safety (chemical and biological contamination)
Drugs screening and (bio)pharmaceutical process monitoring

Capabilities

1. Nanoparticles and Nanosensors

Inorganic nanoparticles have unique optical properties. They are versatile sensing materials for biosensors development. Our capabilities include:

2. Biosensors and Biophysical Characterization of Biomolecules Interactions

Our lab is well equipped with biophysical analytical equipment, including surface plasmon resonance (SPR) spectroscopy, quartz crystal microbalance (QCM), multifunctional microplate readers, and portable color and Raman detectors, for studying biointerface processes and for biosensor development.

Highlight & Achievements

Nanoparticle-based rapid bacteria sensors (SG10202001326W, SG10201702528R; WO2018182510A1, SG10201908147X, SG10201809275W, US16/166,017)
Non-invasive cancer diagnosis and drug screening (Chem Commn 2019, 55, 15041-15044; Nanoscale 2019, 11, 22152-22171; Chem Commn 2018, 54, 11260-11263).
Flexible and wearable optical sensors for healthcare and food safety, e.g. paper-based colorimetric and Raman sensors for trace chemical analysis and wound monitoring (SG Application No.: 10201801989P.
Biogenic nanoparticles with tunable fluorescent properties, including molecularly engineered metal clusters and carbon dots (bio-dots) with tailored functionalities and structural property from natural biomolecules, e.g. amino acids and nucleotides (Small, 2019, 1903328; Nanoscale Advance, 1, 2250-2257 2019; ACS Appl. Mater. Interfaces, 10 (23), 19881–19888, 2018).