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MedTech Polymers
The use of polymers as biomaterials has remarkably impacted the advancement of modern medicine. Particularly, biodegradable polymers provide the significant advantage of being able to be broken down and auto-removed after they have served their function.
Polyesters comprise the earliest and most extensive investigation as biomaterials, showing excellent biocompatibility and controllable degradation by simple hydrolysis and/or enzymatic cleavage in aqueous environments such as body fluids. Polyesters and their functionalized polymeric materials are seen as promising alternatives to clinically established products.
In MedTech Polymer Group, the team focuses on functionalizing polyesters into amphiphilic copolymers and their various self-assembly system towards more advanced therapeutic applications, including stimuli-responsive hydrogels, micelles and nanoparticles for controlled drug-, gene-, co/delivery and bio-imaging etc.
Polyesters comprise the earliest and most extensive investigation as biomaterials, showing excellent biocompatibility and controllable degradation by simple hydrolysis and/or enzymatic cleavage in aqueous environments such as body fluids. Polyesters and their functionalized polymeric materials are seen as promising alternatives to clinically established products.
In MedTech Polymer Group, the team focuses on functionalizing polyesters into amphiphilic copolymers and their various self-assembly system towards more advanced therapeutic applications, including stimuli-responsive hydrogels, micelles and nanoparticles for controlled drug-, gene-, co/delivery and bio-imaging etc.
CAPABILITIES
- Bottom-up design and synthesis of biodegradable amphiphlies using advanced polymer chemistry, including esterification, polyurethane, RAFT, ATRP, OCRP, ROP, “Click”, SET-LRP and its combinations
- Therapeutic formulation using biodegradable polymeric self-assemblies such as hydrogel, micelle, vesicle and nanoparticles etc.
- Structural-property-performance relationship investigation
HIGHLIGHTS AND ACHIEVEMENTS
- Injectable Supramolecular Hydrogels for In Situ Programming of Car-T Cells toward Solid Tumor Immunotherapy, Adv. Mater. 2023, e2310078.
- Machine Learning-Driven Biomaterials Evolution, Adv. Mater. 2022, 34, 2102703.
- Dual Tumor Microenvironment Remodeling by Glucose-Contained Radical Copolymer for MRI-Guided Photoimmunotherapy, Adv. Mater. 2021, 2107674.
- Lonogels: Recent Advances in Design, Material Properties and Emerging Biomedical Applications, Chem. Soc. Rev. 2023, 52, 2497-2527.
- Polyester elastomers for soft tissue engineering, Chem. Soc. Rev. 2018, 47, 4545-4580.
- Water soluble polyhydroxyalkanoates: future materials for therapeutic applications, Chem. Soc. Rev. 2015, 44, 2865-2879.
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