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WELCOME FROM THE EXECUTIVE DIRECTOR
The Genome Institute of Singapore (GIS) is Singapore's flagship institute for genomic sciences. With the sequencing of the human genome and the advent of next-generation sequencing, the field of genomics and transcriptomics have taken flight to yield novel insights into how the regulation of DNA and RNA elements impact human health and the living organisms around us.
Since its establishment in 2000, GIS has pushed the frontiers of genomic technologies and algorithms to unveil fresh perspectives into life. Over the years, the increased affordability of sequencing, integration of multimodal data, and the development and application of regenerative AI have greatly increased our understanding of human health and the factors that influence it. New technologies have also revealed novel insights into old challenges, allowing researchers and clinicians to better understand human diseases. Coupled with the development of home-made world-class algorithms including new genome mappers, assemblers, variant callers, error correctors, and algorithms that enable us to study RNA and interpret single cell and spatial data, the new technologies have enabled us to gain unprecedented insights into the evolving biology and human health.
Working in close collaboration with our international and local partners including hospitals and other public agencies and universities, our work in GIS has unveiled seminal discoveries in the life around us, including in areas of human genetics, stem cells, infectious diseases, and cancer. We believe that genomics has the power to unlock the mysteries of human biology and to positively impact the life of every Singaporean. I invite you to join us in this exciting pursuit of genomic sciences.
Dr WAN Yue
Executive Director,
Genome Institute of Singapore
VISION
We read, reveal and (ω)rite DNA for a better Singapore and world.
The Genome Institute of Singapore (GIS) is a national initiative with a global vision that seeks to use genomic sciences to achieve extraordinary improvements in human health and public prosperity.
We are the trusted producer, custodian, and curator of Singapore’s genomic data.
We leverage core capabilities in high quality sequencing and large-scale genome informatics, applied through four nucleic acid domains, to achieve impact for A*STAR, Singapore and the world.
OUR APPROACH AND OUR SCIENCE
Our scientific focus is to investigate questions in the realm of functional genomics and integrative biology. We exploit the intersect between genomics, cell biology, and medicine and take advantage of the contrasting genetic history of Pan-Asian populations to uncover fundamental truths. Our biological focuses on cancer biology, stem cell genomics, cellular pharmacology, and host-pathogen interactions are integrated with technology development in order to create novel solutions to difficult problems.
Consistent with our remit as a national resource, we provide the genomic infrastructure for Singapore and train new talent in this emerging field.
As the nucleating force for collaborative genomic studies in Singapore, the GIS seeks to unite Singaporean scientists around collective projects of significance and extend this partnership internationally in both the academic and commercial sectors.
OUR CULTURE
Our focus on systems and integrative biology requires an organizational structure and social culture that encourages collective effort, and iterative experimentation between the wet laboratory and computational modeling.
For these reasons, we have spent a great deal of energy in crafting the cultural state of our institute which prizes flexibility, individual intensity, and collective impact. The Genome Institute of Singapore specifically recognizes technology-focused scientists to be as important as biology-centric investigators, but we expect that technology experts team with biologists to address fundamental biological questions.
Our scientific leadership structure reflects our diverse capabilities and our efforts to nurture early talent. We have Faculty Members that range in expertise from basic biology to translational and medical fields. Our Platform Leaders handle the latest in technology and comprise some of our early career researchers (Next Generation Sequencing, High-throughput Biology, Genome Engineering, Genotyping, Cytogenetics, Single Cell Genomics). We have a cohort of exceptional young scientists in our GIS Fellows programme who are driving their own research projects that integrate into the larger GIS picture. Together we believe the best ideas can be harnessed and pursued.
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