Dr Wong directs multi-disciplinary research programs with a staff of approximately 50+, comprising two Associate Professors, several Assistant Professors/Lecturers, postdoctoral research fellows, clinical fellows, graduate students, epidemiologists, a team of statisticians and database management, and clinical trials and research assistants. His research is supported by >US$30M in peer-reviewed grant funding from National Institutes of Health (NIH), USA, the National Health and Medical Research Council (NH&MRC), Australia, the Biomedical Medical Research Council (BMRC) and National Medical Research Council (NMRC), Singapore.
1. Retinal Vascular Imaging as a Biological Tool to Study Human Diseases
The objectives of this program, based concurrently at the Singapore Advanced Imaging Laboratory of Ocular Imaging (SAILOR), Singapore and Retinal Vascular Imaging Centre (RetVIC), Melbourne, are to develop state of the art ocular imaging methods to measure retinal vascular changes and other features and to correlate these changes with systemic diseases (diabetes, hypertension, stroke and heart disease) and eye diseases (diabetic retinopathy, AMD, glaucoma).
2. Population-based Studies on Eye Diseases
The objectives of this research program, the Singapore Epidemiology of Eye Disease (SEED) Program, are to capture population data on the prevalence, incidence, risk factors and impact of major eye diseases, including myopia, angle-closure glaucoma, cataract, diabetic retinopathy and age-related macular degeneration (AMD). This program comprises several population-based studies in Singapore, such as the Singapore Malay Eye Study (SiMES), the Singapore Indian Eye Study (SINDI), the Singapore Chinese Eye Study (SCES), and the Singapore Prospective Cohort Study Program (SP2).
3. Clinical and Translational Studies on Retinal Diseases
The objectives of this research program is to determine the clinical features, risk factors, and natural history of, and new therapeutic strategies for, the major retinal diseases, including diabetic retinopathy, age-related macular degeneration (AMD), and retinal vein occlusion. This program comprises several clinical studies in Singapore and Australia, including clinical trials.
- Liu J, Zhang Z, Wong WK, Xu Y, Yin F, Cheng J, Tan NM, Kwoh CK, Xu D, Tham YC, Aung T, Wong TY. Automatic Glaucoma Diagnosis through Medical Imaging Informatics. Journal of the American Medical Informatics Association (In Press, 19 Feb 2013) Abstract
- Ikram MK, Cheung CY, Lorenzi M, Klein R, Jones TL, Wong TY; NIH/JDRF Workshop on Retinal Biomarker for Diabetes Group. Retinal vascular caliber as a biomarker for diabetes microvascular complications. Diabetes Care. 2013 Mar;36(3):750-9. Abstract
- Wu R, Cheung CY, Saw SM, Mitchell P, Aung T, Wong TY. Retinal vascular geometry and glaucoma: the Singapore Malay Eye Study. Ophthalmology. 2013 Jan;120(1):77-83. Abstract
- Cheung CY, Ikram MK, Sabanayagam C, Wong TY. Retinal microvasculature as a model to study the manifestations of hypertension. Hypertension. 2012 Nov;60(5):1094-103. Abstract
- Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet 2012;379(9827):1728-38. Abstract
- Wong TY, Scott IU. Retinal vein occlusion. N Engl J Med 2010:363:2135-44 Abstract
- Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124-36. (IF:28.6) Abstract
- Liew G, Wang JJ, Mitchell P, Wong TY. Retinal vascular imaging: a new tool in microvascular disease research. Circ Cardiovasc Imaging. 2008 Sep;1(2):156-61. Abstract
- Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med 2004;351:2310-7 Abstract
- Wong TY, Klein R, Sharrett AR, et al. Retinal arteriolar narrowing and incident coronary heart disease in men and women: JAMA 2002; 287:1153-9. Abstract