Guide RNA designer tools

Name of software Guide RNA designer tools 
Purpose Design of gRNAs for CRISPR interventions
Name of Contact Chew Wei Leong
Email of technical contact chewwl@gis.a-star.edu.sg
Summary of software function

These are CRISPR gRNA designers. Given a target sequence or genome, the software generates all possible gRNA candidates, evaluates them for specificity (based on edit distance / mismatches with host DNA/RNA sequences), and predicts on-target editing efficiency. These are modular and can plug in with other predictive modules ad hoc.

Patents :
GIS/Z/13167; Guide RNA designer for C-to-G base editors (CGBE)
GIS/Z/12079; CRISPR-Cas13 guide RNA designer

These guide RNA designer tools are freely available for academic research. Commercial usage requires a license.

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