17 A*STAR researchers are recognised as the world's most influential scientific minds in 2022. Find out more about their work and what drives them to push the frontiers of scientific excellence! A*STAR’s Highly Cited Researchers of 2022
These are CRISPR gRNA designers. Given a target sequence or genome, the software generates all possible gRNA candidates, evaluates them for specificity (based on edit distance / mismatches with host DNA/RNA sequences), and predicts on-target editing efficiency. These are modular and can plug in with other predictive modules ad hoc.
Patents :GIS/Z/13167; Guide RNA designer for C-to-G base editors (CGBE)GIS/Z/12079; CRISPR-Cas13 guide RNA designer
These guide RNA designer tools are freely available for academic research. Commercial usage requires a license.