Kah-Hoe Pierce CHOW

Kah-Hoe Pierce CHOW

Professor, Duke-NUS Medical School
Senior Consultant Surgeon, Surgical Oncology, National Cancer Centre Singapore
Senior Consultant Surgeon, HPB and Transplant Surgery, Singapore General Hospital
Senior Clinician Scientist, National Medical Research Council, Singapore

pierce.chow.k.h@nccs.com.sg

 

RESEARCH

Prof Chow leads the Program in Clinical and Translational Liver Research at the National Cancer Center Centre and is Protocol Chair of the Asia-Pacific Hepatocellular Carcinoma Trials Group. His research interests are in hepatocellular carcinoma and steato-hepatitis.

1. Clinical Trials and outcomes research in hepato-pancreato-biliary cancers
2. The genomics and immunology of hepatocellular carcinoma and the applications to personalized medicine
3. Brachytherapy and novel delivery platforms in solid organ cancers.
4. Patient tumour-explant xenografts and novel models in experimental oncology.
5. Metabolic liver disease and the microbiome

Selected Publications

  • Li F, Huynh H, Li X et al. FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors. Cancer Discovery 2015. (IF: 19.453) Abstract
  • Lim, K. C., Wang, V. W., Siddiqui, F. J., Shi, L., Chan, E. S., Oh, H. C., Tan, S. B., and Chow, P. K. (2014) Cost-effectiveness analysis of liver resection versus transplantation for early hepatocellular carcinoma within the Milan criteria, Hepatology. (IF:11.065) Abstract
  • Chow, P. K., Poon, D. Y., Khin, M. W., Singh, H., Han, H. S., Goh, A. S., Choo, S. P., Lai, H. K., Lo, R. H., Tay, K. H., Lim, T. G., Gandhi, M., Tan, S. B., and Soo, K. C. (2014) Multicenter phase II study of sequential radioembolization-sorafenib therapy for inoperable hepatocellular carcinoma, PloS one 9, e90909. (IF: 3.234) Abstract
  • Xu, Q., Leong, J., Chua, Q. Y., Chi, Y. T., Chow, P. K., Pack, D. W., and Wang, C. H. (2013) Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for treatment of human hepatocellular carcinoma, Biomaterials 34, 5149-5162. (IF:8.557) Abstract
  • Chan-On, W., Nairismagi, M. L., Ong, C. K., Lim, W. K., Dima, S., Pairojkul, C., Lim, K. H., McPherson, J. R., Cutcutache, I., Heng, H. L., Ooi, L., Chung, A., Chow, P., Cheow, P. C., Lee, S. Y., Choo, S. P., Tan, I. B., Duda, D., Nastase, A., Myint, S. S., Wong, B. H., Gan, A., Rajasegaran, V., Ng, C. C., Nagarajan, S., Jusakul, A., Zhang, S., Vohra, P., Yu, W., Huang, D., Sithithaworn, P., Yongvanit, P., Wongkham, S., Khuntikeo, N., Bhudhisawasdi, V., Popescu, I., Rozen, S. G., Tan, P., and Teh, B. T. (2013) Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers, Nature genetics 45, 1474-1478. (IF: 29.352) Abstract
  • Lim, K. C., Chow, P. K., Allen, J. C., Siddiqui, F. J., Chan, E. S., and Tan, S. B. (2012) Systematic review of outcomes of liver resection for early hepatocellular carcinoma within the Milan criteria, The British Journal of Surgery 99, 1622-1629. (IF: 5.21) Abstract
  • Huynh, H., Chow, P. K., Tai, W. M., Choo, S. P., Chung, A. Y., Ong, H. S., Soo, K. C., Ong, R., Linnartz, R., and Shi, M. M. (2012) Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma, Journal of Hepatology 56, 595-601. (IF: 11.336) Abstract
  • Lim, K. C., Chow, P. K., Allen, J. C., Chia, G. S., Lim, M., Cheow, P. C., Chung, A. Y., Ooi, L. L., and Tan, S. B. (2011) Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria, Annals of Surgery 254, 108-113. (IF: 8.327) Abstract
  • Chow, P. K., Machin, D., Chen, Y., Zhang, X., Win, K. M., Hoang, H. H., Nguyen, B. D., Jin, M. Y., Lobo, R., Findlay, M., Lim, C. H., Tan, S. B., Gandhi, M., and Soo, K. C. (2011) Randomised double-blind trial of megestrol acetate vs placebo in treatment-naive advanced hepatocellular carcinoma, British Journal of Cancer 105, 945-952. (IF: 4.836) Abstract
  • Eyles, J., Puaux, A. L., Wang, X., Toh, B., Prakash, C., Hong, M., Tan, T. G., Zheng, L., Ong, L. C., Jin, Y., Kato, M., Prevost-Blondel, A., Chow, P., Yang, H., and Abastado, J. P. (2010) Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma, The Journal of clinical investigation 120, 2030-2039. (IF: 13.261) Abstract